期刊
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
卷 118, 期 -, 页码 245-253出版社
ELSEVIER
DOI: 10.1016/j.jtice.2021.01.016
关键词
Electrochemical aptasensor; Cellulose acetate-molybdenum disulfide hybrid; Acute myocardial infarction; Troponin I
资金
- Universiti Teknologi Petronas (UTP) through URIF Grant [015LBO-021]
The novel aptamer-based CA-MoS2 hybrid biosensor showed excellent detection performance and selectivity for AMI diagnosis, with the potential to revolutionize medical diagnosis by enabling multiple biomolecule detection on a single sensing platform.
In this work, a novel aptamer-based CA-MoS2 hybrid biosensor was developed for diagnosis of Acute Myocardial Infraction (AMI). Specifically, a novel petal-like MoS2 nanoflower was used as the active material on the Screen-Printed Electrode (SPE) for AMI biomarker determination. The aptamer-based CA-MoS2-24 hybrid was able to attain a low limit of detection (LOD) and sensitivity to 10 fM at a linear range from 10 fM to 1 nM with good reproducibility based on an electrochemical impedance spectroscopy and a similar to 4 folds higher selectivity of troponin I compared to the signal from other biomolecules in human serum, retaining a 91% stability after 6 weeks. This novel CA-MoS2 aptamer-based biosensor with a 2.3% RSD value has the potential to revolutionize medical diagnosis by conducting multiple biomolecule detection on a single sensing platform. (c) 2021 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
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