Article
Medicine, General & Internal
Jun-Xiang Li, Peng Zhou, De-Hua Chang, Yao Tong, Yan Bao, Yu-Dong Xiao, Shi Zhou, Wen-Wu Cai
Summary: This study compared the prognosis of liver resections (IPLRs) between the Barcelona Clinic Liver Cancer (BCLC) staging and the Hong Kong Liver Cancer (HKLC) staging systems and found that IPLRs in the BCLC staging system had a better prognosis. However, IPLRs in the HKLC staging system but beyond the BCLC staging may have equivalent prognosis if the tumor size is <= 5 cm and liver cirrhosis is absent.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Chih-Wen Lin, Yaw-Sen Chen, Gin-Ho Lo, Tsung-Chin Wu, Jen-Hao Yeh, Ming-Lun Yeh, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Lewis Roberts, Dae Won Jun, Hidenori Toyoda, Satoshi Yasuda, Mindie H. Nguyen, Ming-Lung Yu
Summary: This study established a new subclassification system for BCLC-C HCC, dividing patients into C0 to C4 sub-stages, to better predict overall survival and tailor therapy.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Oncology
Feiqian Wang, Kazushi Numata, Atsuya Takeda, Katsuaki Ogushi, Hiroyuki Fukuda, Hiromi Nihonmatsu, Koji Hara, Makoto Chuma, Yuichirou Tsurugai, Shin Maeda
Summary: RFA and SBRT treatment may be potential options for patients with multifocal HCC in BCLC stage A4-B1 due to favorable prognosis and safety. Prospective, controlled, large-scale studies are needed to further confirm these conclusions before clinical application.
Article
Oncology
Yang Huang, Liangliang Xu, Min Huang, Li Jiang, Mingqing Xu
Summary: This study compared the long-term outcomes of patients with recurrent and multifocal hepatocellular carcinoma (HCC) meeting the Barcelona Clinic Liver Cancer (BCLC) stage A who underwent repeat hepatectomy (RH) or RH combined with intraoperative radiofrequency ablation (RFA). The results showed no significant difference in overall survival and recurrence-free survival between the two treatment groups. However, for patients whose tumors were located in the same lobe, RH alone was associated with better recurrence-free survival than combination treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Siwei Yang, Zhiyuan Zhang, Tianhao Su, Qiyang Chen, Haochen Wang, Long Jin
Summary: This study compares the prognostic role of tumor volume and linear measurement in patients with early-stage hepatocellular carcinoma (HCC). The volumetric measurement is found to be more accurate than linear measurement and has significant predictive value in assessing tumor burden and survival stratification.
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ming Chao Tsai, Chee-Chien Yong, Chih-Che Lin, Wei-Chen Lee, Chih-Chi Wang, Chao-Hung Hung, I-Hsuan Chen, Yu-Fan Cheng, Chang-Chun Hsiao, Tsung-Hui Hu, Chao-Long Chen
Summary: The study found that LDLT may be a valuable therapeutic option for selected patients with BCLC stage B HCC, as patients treated with LDLT achieved better overall survival compared to the non-LDLT group. Age, NLR, and LRT before LDLT were identified as independent risk factors for HCC recurrence and overall survival.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Oncology
Gun Ha Kim, Jin Hyoung Kim, Heung Kyu Ko, Hee Ho Chu, Seong Ho Kim, Ji Hoon Shin, Dong Il Gwon, Gi-Young Ko, Hyun-Ki Yoon, Ki-Hun Kim, Ju Hyun Shim, Nayoung Kim
Summary: Surgical resection plus intraoperative radiofrequency ablation has shown better survival outcomes in patients with intermediate-stage hepatocellular carcinoma, compared to transarterial chemoembolization. This study suggests that surgical resection plus intraoperative radiofrequency ablation may provide a curative treatment option for selected patients who are only eligible for palliative treatment.
Article
Gastroenterology & Hepatology
Won Ick Chang, Byoung Hyuck Kim, Yoon Jun Kim, Jung-Hwan Yoon, Yong Jin Jung, Eui Kyu Chie
Summary: This study aimed to investigate the clinical benefits of locoregional radiation therapy (RT) before, after, and concurrent with sorafenib therapy for Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) patients. The results showed that locoregional RT was associated with significantly longer survival in BCLC stage C HCC patients who were treated with sorafenib, especially in patients treated with sorafenib for 12 weeks or more. Incorporating locoregional RT could improve the dismal prognosis for these patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Masaya Sato, Makoto Moriyama, Tsuyoshi Fukumoto, Tomoharu Yamada, Taijiro Wake, Ryo Nakagomi, Takuma Nakatsuka, Tatsuya Minami, Koji Uchino, Kenichiro Enooku, Hayato Nakagawa, Shuichiro Shiina, Kazuhiko Koike, Mitsuhiro Fujishiro, Ryosuke Tateishi
Summary: This study developed a transformer model to predict overall survival in HCC patients treated with RFA and compared its performance with a deep learning model. The transformer-based model showed better discrimination performance and the ability to stratify patients into different risk groups. It also provided personalized cumulative recurrence prediction for each patient.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Oncology
Feng Xia, Zhiyuan Huang, Qiao Zhang, Elijah Ndhlovu, Mingyu Zhang, Xiaoping Chen, Yifa Chen, Bixiang Zhang, Peng Zhu
Summary: Ruptured hepatocellular carcinoma (rHCC) typically has a poor prognosis. This study aimed to evaluate the impact of rHCC and the effectiveness of hepatectomy in patients with Barcelona Clinic Liver Cancer (BCLC) stage 0/A rHCC. The results showed that patients with BCLC stage 0/A rHCC treated with surgery had worse prognosis compared to patients with BCLC stage 0/A non-rHCC treated with surgery. However, the prognosis of patients with BCLC stage 0/A rHCC who underwent surgery was comparable to patients with BCLC stage B HCC who underwent surgery or TACE.
Article
Oncology
Shuyang Hu, Wei Gan, Liang Qiao, Cheng Ye, Demin Wu, Boyi Liao, Xiaoyu Yang, Xiaoqing Jiang
Summary: PA-TACE has been found to have independent prognostic value for patients with BCLC stage B, and a nomogram developed in this study outperformed other scoring systems in predicting HCC recurrence risk.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuan Guo, Hong Tao Hu, Shi Jun Xu, Wei Li Xia, Yan Li, Jun Lu, Xiao Hui Zhao, Yan Zhao, Fang Ting Li, Hai Liang Li
Summary: This study investigated the clinical relevance of serum chemokine ligand 14 (sCCL14) in hepatocellular carcinoma (HCC) patients and the effect of transarterial chemoembolization (TACE) on sCCL14 expression and the immune microenvironment. The results showed that patients with BCLC Stage C HCC had lower sCCL14 levels compared to patients with BCLC Stages A and B HCC. sCCL14 levels were higher in the first week after TACE treatment compared to before. Higher baseline sCCL14 levels were associated with complete response after TACE treatment and longer progression-free survival (PFS). sCCL14 levels correlated with immune cell proportions. These findings suggest that sCCL14 may be a predictive biomarker of TACE effectiveness.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Medicine, General & Internal
Hyo-Sin Kim, Soo Jin Na Choi, Ho Kyun Lee, Korean Liver Canc Assoc Korean Liver Canc Assoc
Summary: The purpose of this study was to evaluate the proper position of single large hepatocellular carcinoma (HCC) in the Barcelona Clinic Liver Cancer (BCLC) staging system. The findings suggest that single large HCC should be relocated to BCLC stage B rather than BCLC stage A.
Article
Multidisciplinary Sciences
Yi-Hao Yen, Yu-Fan Cheng, Jing-Houng Wang, Chih-Che Lin, Chien-Hung Chen, Chih-Chi Wang
Summary: The study reported treatment adherence to the modified BCLC guidelines at a high-volume liver surgery center in Taiwan and found that non-adherence to the modified BCLC staging system was common in treating stage B and C patients.
Review
Oncology
Peiman Habibollahi, Rahul A. Sheth, Erik N. K. Cressman
Summary: Liver cancer is a growing global concern with limited treatment options. The most common treatment methods are ablation techniques such as radiofrequency ablation and microwave ablation. However, difficulties in completely identifying residual cancer cells remain in these procedures, highlighting the need for further advancements in treatment strategies.
Article
Gastroenterology & Hepatology
Shu-Yein Ho, Mei-Hsia Yuan, Po-Hong Liu, Chia-Yang Hsu, Yi-Hsiang Huang, Jia- Liao, Chien-Wei Su, Chia-Lin Wang, Ming-Chih Hou, Teh-la Huo
Summary: Patients with cryptogenic HCC have larger tumor burden and advanced cancer stage at disease presentation compared to those with viral HCC. ALBI and EZ-ALBI scores are robust models to evaluate liver functional reserve for these patients independent of treatment modality.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Nursing
Yueh-Ling Liao, Tsae-Jyy Wang, Chien-Wei Su, Shu-Yuan Liang, Chieh-Yu Liu, Jun-Yu Fan
Summary: The study found that decision support intervention had a positive effect on improving treatment knowledge and reducing decisional conflict in patients with hepatocellular cancer (HCC). However, it did not significantly impact decision self-efficacy and decision satisfaction.
CLINICAL NURSING RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Pei-Chien Tsai, Hsing-Tao Kuo, Chao-Hung Hung, Kuo-Chih Tseng, Hsueh-Chou Lai, Cheng-Yuan Peng, Jing-Houng Wang, Jyh-Jou Chen, Pei-Lun Lee, Rong-Nan Chien, Chi-Chieh Yang, Gin-Ho Lo, Jia-Horn Kao, Chun-Jen Liu, Chen-Hua Liu, Sheng-Lei Yan, Ming-Jong Bair, Chun-Yen Lin, Wei-Wen Su, Cheng-Hsin Chu, Chih-Jen Chen, Shui-Yi Tung, Chi-Ming Tai, Chih-Wen Lin, Ching-Chu Lo, Pin-Nan Cheng, Yen-Cheng Chiu, Chia-Chi Wang, Jin-Shiung Cheng, Wei-Lun Tsai, Han-Chieh Lin, Yi-Hsiang Huang, Ming-Lun Yeh, Chung-Feng Huang, Meng-Hsuan Hsieh, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chung, Chi-Yi Chen, Ming-Lung Yu
Summary: Metformin use reduces hepatocellular carcinoma (HCC) risk in individuals with diabetes mellitus (DM) and chronic hepatitis C (CHC) after successful antiviral therapy. A simple risk model comprising cirrhosis and DM non-metformin use can predict long-term outcomes in individuals with CHC after sustained virological response (SVR).
JOURNAL OF HEPATOLOGY
(2023)
Article
Environmental Sciences
Thomas Cole-Hunter, Jiawei Zhang, Rina So, Evangelia Samoli, Shuo Liu, Jie Chen, Maciej Strak, Kathrin Wolf, Gudrun Weinmayr, Sophia Rodopolou, Elizabeth Remfry, Kees de Hoogh, Tom Bellander, Jorgen Brandt, Hans Concin, Emanuel Zitt, Daniela Fecht, Francesco Forastiere, John Gulliver, Barbara Hoffmann, Ulla A. Hvidtfeldt, Karl-Heinz Jockel, Laust H. Mortensen, Matthias Ketzel, Diego Yacaman Mendez, Karin Leander, Petter Ljungman, Elodie Faure, Pei-Chen Lee, Alexis Elbaz, Patrik K. E. Magnusson, Gabriele Nagel, Goran Pershagen, Annette Peters, Debora Rizzuto, Roel C. H. Vermeulen, Sara Schramm, Massimo Stafoggia, Klea Katsouyanni, Bert Brunekreef, Gerard Hoek, Youn-Hee Lim, Zorana J. Andersen
Summary: In this study, the link between long-term exposure to ambient air pollution, specifically PM2.5, and mortality from Parkinson's Disease (PD) was investigated in seven European cohorts. The results suggest that long-term exposure to PM2.5 may contribute to PD mortality, even at levels below current EU air pollution limits.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Chia-Chu Fu, Cheng-Yi Wei, Chi-Jen Chu, Pei-Chang Lee, Teh-Ia Huo, Yi-Hsiang Huang, Yee Chao, Ming-Chih Hou, Jaw-Ching Wu, Chien-Wei Su
Summary: This study retrospectively enrolled 2198 patients with HCC and normal serum AFP levels. The results showed that liver functional reserve, anti-viral therapy, tumor size, vascular invasion, and treatment modalities were prognostic factors for HCC patients with normal serum AFP levels, while serum AFP levels themselves were not associated with prognosis.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Virology
Kwong-Ming Kee, Chien-Hung Chen, Jui-Ting Hu, Yi-Hsiang Huang, Tsang-En Wang, Gar-Yang Chau, Kuo-Hsin Chen, Yao-Li Chen, Chih-Che Lin, Chien-Fu Hung, Shiu-Feng Huang, Tsang-Wu Liu, Hsiu-Ying Ku, Bing-Shen Huang, Yi-Pin Wang, Hui-Ping Tseng, Chun-Ju Chiang, Sheng-Nan Lu
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death in Taiwan. This study aimed to investigate the secular trends of HCC characteristics and survival in recent decades. The overall survival of HCC in Taiwan has been improving, possibly due to increased early-stage patients and the aging population. The proportion of viral-related HCC is decreasing, while nonviral-related HCC is increasing.
Article
Oncology
Jia- Liao, Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-Hsiang Huang, Chien-Wei Su, Ming-Chih Hou, Teh-Ia Huo
Summary: Ascites is highly prevalent in patients with hepatocellular carcinoma (HCC) and is associated with increased mortality. The albumin-bilirubin (ALBI) grade and EZ (easy)-ALBI grade are used to assess liver dysfunction in HCC, and both can stratify overall survival in HCC patients with ascites. Factors such as serum bilirubin level, creatinine level, alpha-fetoprotein level, tumor volume, vascular invasion, distant metastasis, performance status, and treatment type are independently associated with increased mortality in ascitic HCC patients.
Article
Gastroenterology & Hepatology
Wei-Yu Kao, Elise Chia-Hui Tan, Hsin-Lun Lee, Yi-Hsiang Huang, Teh-Ia Huo, Chun-Chao Chang, Jeng-Fong Chiou, Ming-Chih Hou, Jaw-Ching Wu, Chien-Wei Su
Summary: This study compared the prognoses of patients with HBV-related HCC after hepatectomy who received ETV or TDF treatment and found that both treatments showed similar health benefits in terms of tumor recurrence and overall survival.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Chih-Wei Huang, Bethany C. Y. Wu, Phung Anh Nguyen, Hsiao-Han Wang, Chih-Chung Kao, Pei-Chen Lee, Annisa Ristya Rahmanti, Jason C. Hsu, Hsuan-Chia Yang, Yu-Chuan Jack Li
Summary: This study demonstrates the application of artificial empathy based on facial emotion recognition to evaluate doctor-patient relationships. The results showed that doctors expressed more emotions than patients, and patients felt happier towards the end of the session, indicating a good doctor-patient relationship.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Gastroenterology & Hepatology
Te-Sheng Chang, Chung-Feng Huang, Hsing-Tao Kuo, Ching-Chu Lo, Chien-Wei Huang, Lee-Won Chong, Pin-Nan Cheng, Ming-Lun Yeh, Cheng-Yuan Peng, Chien-Yu Cheng, Jee-Fu Huang, Ming-Jong Bair, Chih-Lang Lin, Chi-Chieh Yang, Szu-Jen Wang, Tsai-Yuan Hsieh, Tzong-Hsi Lee, Pei-Lun Lee, Wen-Chih Wu, Chih-Lin Lin, Wei-Wen Su, Sheng-Shun Yang, Chia-Chi Wang, Jui-Ting Hu, Lein-Ray Mo, Chun-Ting Chen, Yi-Hsiang Huang, Chun-Chao Chang, Chia-Sheng Huang, Guei-Ying Chen, Chien-Neng Kao, Chi-Ming Tai, Chun-Jen Liu, Mei-Hsuan Lee, Pei-Chien Tsai, Chia-Yen Dai, Jia-Horng Kao, Han-Chieh Lin, Wang-Long Chuang, Chi-Yi Chen, Kuo-Chih Tseng, Chao-Hung Hung, Ming-Lung Yu
Summary: The study analyzed the data of Taiwanese patients with chronic hepatitis C infection receiving 8-week glecaprevir/pibrentasvir therapy. The results showed good treatment efficacy with minimal adverse events. This is of great significance for the treatment of patients with compensated cirrhosis.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Oncology
Y. Linda Wu, Grace van Hyfte, Umut Ozbek, Marlene Reincke, Anuhya Gampa, Yehia I. Mohamed, Naoshi Nishida, Brooke Wietharn, Suneetha Amara, Pei-Chang Lee, Bernhard Scheiner, Lorenz Balcar, Matthias Pinter, Arndt Vogel, Arndt Weinmann, Anwaar Saeed, Anjana Pillai, Lorenza Rimassa, Abdul Rafeh Naqash, Mahvish Muzaffar, Yi-Hsiang Huang, Ahmed O. Kaseb, Masatoshi Kudo, David J. Pinato, Celina Ang
Summary: Beta blocker use was not associated with overall survival, progression-free survival, or objective response rate in patients with unresectable hepatocellular carcinoma treated with immune checkpoint inhibitors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mei-Hsuan Lee, Ping-Feng Wu, Tzu- Chen, Chi Chan, Hsi-Hsun Lin, Yi-Hsiang Huang, Hsuan-Yu Chen, Yi-Tsung Lin, Chien-Jen Chen
Summary: This study suggests that the use of antiretroviral therapy containing tenofovir can reduce the risk of hepatocellular carcinoma among people living with HIV with hepatitis B or C coinfection.
Article
Oncology
Ya-Wen Hung, I-Cheng Lee, Chen-Ta Chi, Rheun-Chuan Lee, Chien-An Liu, Nai-Chi Chiu, Hsuen-En Hwang, Yee Chao, Ming-Chih Hou, Yi-Hsiang Huang
Summary: This study investigated the influence of radiologic morphology on the outcomes of initial and subsequent transarterial chemoembolization (TACE) for intermediate-stage hepatocellular carcinoma (HCC). The results showed that radiologic morphology was significantly associated with treatment response rate and overall survival. Systemic therapy should be considered for patients with unfavorable radiologic patterns of intermediate-stage HCC after TACE.
Article
Surgery
Hsin-Ju Tsai, Ming-Ju Wu, Cheng-Hsu Chen, Sheng-Shun Yang, Yi-Hsiang Huang, Yan-Zin Chang, Horng-Rong Chang, Teng-Yu Lee
Summary: This hospital-based retrospective cohort study found that the prophylaxis strategy for HBV reactivation in kidney transplant recipients with resolved HBV infection remains unclear. The absence of anti-HBs antibody and the use of high-dose steroids were identified as independent risk factors for HBV reactivation. Therefore, the strategy of HBV antiviral prophylaxis may be defined according to the risk stratification.
TRANSPLANT INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Yu-Hsuan Tseng, Chuen-Huei Liu, Chun-Yang Lee, Nai-Chi Chiu, Chien-Wei Su
Summary: This article presents a rare but potentially life-threatening complication of acute pancreatitis - splenic artery pseudoaneurysm. The patient had mild symptoms on admission but experienced severe complications during hospitalization. Despite treatment with embolization and splenectomy, the patient eventually died from severe sepsis.
ADVANCES IN DIGESTIVE MEDICINE
(2023)
