期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 51, 页码 21548-21555出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c11025
关键词
-
资金
- Swiss National Science Foundation (SNSF) [184658]
Unprotected, primary 2-azidoamines are versatile precursors to vicinal diamines, which are among the most common motifs in biologically active compounds. Herein, we report their operationally simple synthesis through an iron-catalyzed difunctionalization of alkenes. A wide array of alkene substrates are tolerated, including complex drug-like molecules and a tripeptide. Facile derivatizations of the azidoamine group demonstrate the versatility of this masked diamine motif in chemoselective, orthogonal transformations. Applications of the methodology in the concise synthesis of RO 20-1724 as well as in the formal total syntheses of both (+/-)-hamacanthin B and (+/-)-quinagolide further demonstrate the broad synthetic potential of this highly functional-group-tolerant reaction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据