Article
Immunology
Jose M. Rodrigo-Munoz, Marta Gil-Martinez, Clara Lorente-Sorolla, Raquel Garcia-Latorre, Marcela Valverde-Monge, Santiago Quirce, Joaquin Sastre, Victoria del Pozo
Summary: MicroRNA miR-144-3p is identified as a potential diagnostic biomarker for severe asthma, as its expression is associated with the severity of the disease and corticosteroid treatment. It is increased in asthmatic lungs and serum, correlating with blood eosinophilia and genes involved in asthma pathophysiology. This miRNA shows promise as a novel biomarker for severe asthma previously treated with higher doses of corticosteroids.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ye Huang, Liang Wang, Di Liu
Summary: Colorectal cancer is a common malignancy with limited therapeutic options, leading to delayed treatment and increased risk of tumor recurrence. Long noncoding RNAs play important roles in the development and progression of colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Sofia Elena Tesolato, Daniel Gonzalez-Gamo, Ana Barabash, Paula Claver, Sofia Cristina de la Serna, Inmaculada Dominguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio Jose Torres, Pilar Iniesta
Summary: This study aims to analyze and correlate the expression levels of four miRNAs associated with cancer and obesity in colorectal cancer (CRC) patients and a control group. The results indicate the significance of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC.
Article
Oncology
Li Wang, Xingguo Song, Miao Yu, Limin Niu, Yajing Zhao, Youyong Tang, Baibing Zheng, Xianrang Song, Li Xie
Summary: This study identified downregulated exosomal miR-377-3p and miR-381-3p in CRC patients, serving as circulating biomarkers for the diagnosis of CRC, especially for early-stage detection.
Article
Cardiac & Cardiovascular Systems
Lorena Perez-Carrillo, Ignacio Sanchez-Lazaro, Juan Carlos Trivino, Sandra Feijoo-Bandin, Francisca Lago, Jose Ramon Gonzalez-Juanatey, Luis Martinez-Dolz, Manuel Portoles, Estefania Tarazon, Esther Rosello-Lleti
Summary: Noninvasive approaches for early diagnosis of acute cellular rejection (ACR) in cardiac transplantation are important. This study identified serum miR-144-3p as a potential biomarker for ACR, with excellent diagnostic accuracy and predictive value for the presence of rejection episodes.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cell Biology
Taiyuan Li, Cheng Tan, Zhixiang Huang, Lingling Yang, Hua Dai, Bo Tang, Benping Xiao, Jianfeng Li, Xiong Lei
Summary: miR-144-3p is down-regulated in colorectal adenocarcinoma, and its low expression is associated with adverse clinicopathologic characteristics and poor prognosis. By targeting ZEB1/2, miR-144-3p can inhibit cell proliferation, invasion, and EMT in CRA.
Article
Cell Biology
Xisheng Liu, Xiaole Meng, Xiao Peng, Qianlan Yao, Fangming Zhu, Zhongyi Ding, Hongze Sun, Xueni Liu, Dan Li, Ying Lu, Huamei Tang, Bin Li, Zhihai Peng
Summary: The global downregulation of miRNA expression, potentially due to defects in miRNA processing machinery, is a hallmark of human cancer. In colorectal cancer (CRC), downregulation of the key regulator of miRNA processing, Argonaute 2 (AGO2), has been found to promote epithelial-mesenchymal transition (EMT) and indicate poor prognosis. Knockdown of AGO2 in CRC cells enhanced migration, invasion, and metastasis, while integrated analyses revealed neuropilin 1 (NRP1) as a new substrate of AGO2 via miR-185-3p. Therapeutically targeting the AGO2/miR-185-3p/NRP1 axis may offer a potential treatment approach for CRC.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Fei Gao, Jianjun Han, Li Jia, Jun He, Yun Wang, Mi Chen
Summary: This study reveals the role of circ_0001982 in breast cancer development. It shows that circ_0001982 regulates the miR-144-3p-GSE1 axis, affecting cell proliferation, migration, invasion, and glycolysis in breast cancer cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Oncology
Congjing An, Zhigang Hu, Yuehong Li, Pengxin Zhao, Runtian Liu, Qing Zhang, Peiling Zhu, Yanting Li, Ying Wang
Summary: The study identified that LINC00662 is overexpressed in breast cancer and promotes cancer cell progression by competitively binding to miR-144-3p to upregulate SOX2 expression. This suggests that LINC00662 could be a potential therapeutic target for breast cancer treatment.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Junqiang Liu, Zhiyuan Chou, Chun Li, Kai Huang, Xuejian Wang, Xiunan Li, Chuanchun Han, Abdullah Al-Danakh, Xiaodong Li, Xishuang Song
Summary: This study reveals the function and molecular mechanism of ZBTB7A in bladder cancer. The results indicate that ZBTB7A promotes tumorigenesis of bladder cancer through downregulating HIC1 expression.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Yentl Y. van der Zee, Lars M. T. Eijssen, Philipp Mews, Aarthi Ramakrishnan, Kelvin Alvarez, Casey K. Lardner, Hannah M. Cates, Deena M. Walker, Angelica Torres-Berrio, Caleb J. Browne, Ashley Cunningham, Flurin Cathomas, Hope Kronman, Eric M. Parise, Laurence de Nijs, Li Shen, James W. Murrough, Bart P. F. Rutten, Eric J. Nestler, Orna Issler
Summary: This study explored the potential use of miRNAs as biomarkers for MDD and its treatment. The findings showed that there were significant differences in blood miRNA signatures between stress-resilient and stress-susceptible mice after an incubation period. Additionally, ketamine treatment was more effective than imipramine at re-establishing baseline miRNA expression levels in mice that responded behaviorally to the drug. The study also identified miR-144-3p as a candidate biomarker for depression diagnosis and predicting ketamine treatment response.
MOLECULAR PSYCHIATRY
(2022)
Article
Cell Biology
Baoxiang Chen, Yuntian Hong, Rui Gui, Huabin Zheng, Shunhua Tian, Xiang Zhai, Xiaoyu Xie, Quanjiao Chen, Qun Qian, Xianghai Ren, Lifang Fan, Congqing Jiang
Summary: Circular RNAs play a critical regulatory role in colorectal cancer (CRC) by modulating metabolic reprogramming. The circ_0003215 circRNA inhibits cell proliferation, migration, and invasion, and suppresses the malignant phenotype of CRC through the miR-663b/DLG4/G6PD axis.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Yixun Lu, Benlong Zhang, Baohua Wang, Di Wu, Chuang Wang, Yunhe Gao, Wenquan Liang, Hongqing Xi, Xinxin Wang, Lin Chen
Summary: This study found that miR-144-3p is downregulated in gastric cancer and acts as a tumor suppressor by inhibiting cancer growth and stemness through regulating GLI2 expression. Experimental results demonstrated that miR-144-3p reduces proliferation and migration of gastric cancer cells by targeting GLI2.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Dan Song, Qian Zhang, Hao Zhang, Liangliang Zhan, Xinchen Sun
Summary: The study reveals that miR-130b-3p is upregulated in colorectal cancer (CRC) tissues and cells and can be detected in the feces of CRC patients. Inhibition of miR-130b-3p suppresses CRC cell proliferation and tumor growth in vivo. The mechanism involves direct targeting of chromodomain helicase DNA binding protein 9 (CHD9) by miR-130b-3p.
Article
Biochemistry & Molecular Biology
Paulina Gil-Kulik, Alicja Petniak, Natalia Kluz, Grzegorz Wallner, Tomasz Skoczylas, Aleksander Ciechanski, Janusz Kocki
Summary: Colorectal cancer is the second leading cause of cancer-related death worldwide, often diagnosed at an advanced stage due to being asymptomatic. The expression of miR-3613-3p is downregulated in colorectal cancer cells and tumors, but increased in surrounding tissue and after radiotherapy, showing potential as a therapeutic target for CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)