Article
Developmental Biology
Robin M. Perelli, Matthew L. O'Sullivan, Samantha Zarnick, Jeremy N. Kay
Summary: The exposure of excess oxygen in neonatal mice disrupts the formation of astrocyte template, leading to their excessive proliferation and interference with retinal angiogenesis upon return to normal oxygen levels. This dysregulation of astrocyte proliferation may contribute to vascular defects resembling ROP.
Article
Immunology
Syed A. H. Zaidi, Tahira Lemtalsi, Zhimin Xu, Isabella Santana, Porsche Sandow, Leila Labazi, Robert W. Caldwell, Ruth B. Caldwell, Modesto A. Rojas
Summary: This study investigates the efficacy of targeting the cholesterol metabolizing enzyme ACAT1 in limiting pathological retinal neovascularization during ischemic retinopathy. The results show that inhibiting ACAT1 can reduce the expression of inflammatory mediators and the formation of pathological retinal neovascularization. ACAT1 is therefore identified as an important regulator of cholesterol metabolism in ischemic retinopathy.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Pharmacology & Pharmacy
Etelka Poestyeni, Alma Ganczer, Andrea Kovacs-Valasek, Robert Gabriel
Summary: The presence of neuropeptides in the mammalian retina has significant effects on normal retinal processes and physiology, and they play a crucial role in fighting various retinal pathologies. Genetically manipulated mouse models have helped to better understand the molecular background of retinal diseases. Neuropeptides have been found to be important in diabetic retinopathy and ischemia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Eduardo Sanches, Yohan van de Looij, Sadou Sow, Audrey Toulotte, Analina da Silva, Laura Modernell, Stephane Sizonenko
Summary: This study demonstrates that lactoferrin (Lf) supplementation attenuates acute and long-term cerebral injuries caused by hypoxia-ischemia in a dose-dependent manner. The optimal dose of 1 g/kg of Lf showed the best effects, reducing brain volume decreases and other detrimental effects. The research emphasizes the need for better understanding of Lf's effects and potential harmful effects on immature brains.
Article
Genetics & Heredity
Wensi Chen, Shiping He, Daoman Xiang
Summary: Hypoxia promotes the secretion of bFGF in retinal pigment epithelium, playing a critical role in retinopathy of prematurity. The study found that hypoxia-induced RPE-derived bFGF can promote the migration and angiogenesis of HUVECs through regulating the TGF-81/smad2/3 pathway.
Article
Pediatrics
William Hellstrom, Lisa M. Hortensius, Chatarina Lofqvist, Gunnel Hellgren, Maria Luisa Tataranno, David Ley, Manon J. N. L. Benders, Ann Hellstrom, Isabella M. Bjorkman-Burtscher, Rolf A. Heckemann, Karin Savman
Summary: This study investigates the association between growth factors and brain volumes in preterm infants at term equivalent age. The results show that higher levels of insulin-like growth factor (IGF)-1 are independently associated with increased brain volumes in extremely preterm infants.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yi Zhang, Dan Chen, Yiwei Wang, Xingzao Wang, Zhong Zhang, Ying Xin
Summary: This study investigated the role of melatonin in regulating mitophagy through NLRX1 in hypoxic-ischemic brain damage (HIBD). Results showed that melatonin protected neonates from HIBD by promoting NLRX1-mediated mitophagy, increasing the expression of Beclin-1 and ATG7, and decreasing the expression of mTOR and TIM23. Silencing NLRX1 abolished the neuroprotective effects of melatonin.
Article
Neurosciences
Ayumi Usui-Ouchi, Kevin Eade, Sarah Giles, Yoichiro Ideguchi, Yasuo Ouchi, Edith Aguilar, Guoqin Wei, Kyle V. Marra, Rebecca B. Berlow, Martin Friedlander
Summary: In this study, the role of Tgf beta signaling in pathological neovascularization (NV) was investigated using a mouse model and human iPSC-derived microglia. The results showed that Tgf beta signaling in microglia repressed leukostasis and expression of the pro-angiogenic factor Igf1. It was also found that Tgf beta signaling played a regulatory role in hypoxia-induced NV. Furthermore, Tgf beta signaling was essential for microglial homeostasis.
Article
Ophthalmology
Natasha F. S. Da Cruz, Jesse D. Sengillo, Jason Fan, Catherin I. Negron, Marley B. Felder, Audina M. Berrocal
Summary: The purpose of this study is to investigate the association between optic nerve hypoplasia (ONH), peripheral retinal nonperfusion, and secondary complications in pediatric patients. The study found that all eyes exhibited peripheral retinal nonperfusion on fluorescein angiography (FA), with varying degrees of severity. The overall assessment of the importance of this research is scored as 8 out of 10.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Pharmacology & Pharmacy
Anamika Sharma, Nikhlesh K. K. Singh
Summary: Retinopathy refers to eye disorders caused by damage to the retina's vascular system, leading to vision loss and sometimes blindness. Recent advancements in high-throughput sequencing have facilitated the discovery of lncRNAs, which are critical regulators of biological processes. Bioinformatics has identified lncRNAs that may have a role in retinal disorders, and using lncRNA transcripts for diagnosis and therapy can provide long-term benefits compared to traditional medicines. This article discusses different lncRNAs that influence various retinopathies and how they can be utilized for identification and treatment.
Review
Biochemistry & Molecular Biology
Xudong Wang, Tianxi Wang, Enton Lam, David Alvarez, Ye Sun
Summary: The eye has immune privilege to protect retinal neural cells from immune provocation. However, breach of this privilege can lead to acute inflammatory responses and chronic inflammation, causing ocular diseases and vision loss. This review discusses the features of immune privilege in the retina, the inflammatory responses and factors involved when immune privilege fails, as well as recent advances in ocular immunity and ocular vascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mariana I. Holubiec, Juan I. Romero, Claudia Urbainsky, Manuela Gellert, Pablo Galeano, Francisco Capani, Christopher Horst Lillig, Eva-Maria Hanschmann
Summary: Nucleoredoxin (Nrx), a member of the Thioredoxin protein family, plays a crucial role in redox-mediated signal transduction. It regulates cell differentiation and is essential for maintaining cell morphology. Nrx is involved in increasing the number of glial cells and replenishing neurons lost due to hypoxic insult. These regulatory changes are related to VEGF but not the Wnt/beta-catenin pathway.
Article
Biochemistry & Molecular Biology
Fan Zhang, Bingying Lin, Siyu Huang, Pengsen Wu, Min Zhou, Jing Zhao, Xiangqing Hei, Yu Ke, Yiting Zhang, Danping Huang
Summary: Retinal ischemia-reperfusion (RIR) injury caused by high intraocular pressure (IOP) leads to retinal ganglion cell (RGC) death and eventually blindness. Ferroptosis, a form of programmed cell death, is involved in RGC death. Melatonin (MT) shows neuroprotective effects against RIR injury by inhibiting p53-mediated ferroptosis.
Article
Multidisciplinary Sciences
Linus G. Jansen, Payal Shah, Bettina Wabbels, Frank G. Holz, Robert P. Finger, Maximilian W. M. Wintergerst
Summary: The study evaluated the feasibility of upskilling alternative healthcare cadres in smartphone-based fundus imaging (SBFI) and found that with relatively short training, both ophthalmic assistants and ophthalmologists showed improved examination time, usable field-of-view, and image quality. The results suggest that SBFI is highly learnable and can produce comparable results across different healthcare cadres, aiding in the implementation and planning of future SBFI field studies.
SCIENTIFIC REPORTS
(2021)
Review
Health Care Sciences & Services
Fangjun Huang, Yang He, Meng Zhang, Keren Luo, Jiawen Li, Jiali Li, Xinyu Zhang, Xiaoyan Dong, Jun Tang
Summary: With the advancement of medical technology, the survival rate of premature and low-birth-weight infants has increased, along with the occurrence of various diseases such as hypoxic-ischemic encephalopathy and retinopathy of prematurity. Stem cells, with their unique properties, have shown potential in treating these neonatal refractory diseases. This review provides an overview of research progress on stem cells and their secretome in neonatal diseases, aiming to offer new insights for future treatments and discuss the challenges and perspectives in stem cell therapy.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
Jianqiang Lin, Kaixuan Cui, Yue Xu, Xiaoyu Tang, Yuxun Shi, Xi Lu, Boyu Yang, Qingjing He, Shanshan Yu, Xiaoling Liang
Summary: The study found that CD146 is involved in retinal neovascularization via the VEGFR2 pathway. Anti-CD146 may provide a new direction for the treatment of PDR and other ocular neovascular diseases.
ACTA OPHTHALMOLOGICA
(2022)
Article
Cell Biology
Jia Li, Xi Lu, Liqing Wei, Dan Ye, Jianqiang Lin, Xiaoyu Tang, Kaixuan Cui, Shanshan Yu, Yue Xu, Xiaoling Liang
Summary: The study demonstrates that PHD2 plays a crucial role in maintaining the functions of hRMECs under hyperglycemic conditions by inhibiting HIF-1 activity, suggesting that it could be a potential novel target for the treatment of DME or other diseases with a similar pathogenesis.
INFLAMMATION RESEARCH
(2022)
Article
Ophthalmology
Xinyu Zhao, Jianqiang Lin, Shanshan Yu, Liqiong Xie, Ling Jin, Kun Xiong, Ching-Kit Tsui, Yue Xu, Benjuan Wu, Bin Liu, Wei Wang, Nathan Congdon, Wenyong Huang, Mingguang He, Xiaoling Liang
Summary: This study aimed to report the 6-year incidence, causes, and risk factors for vision loss (visual impairment and blindness) among elderly adults in rural southern China. The study found that cataract and refractive errors were the most common causes of vision loss. Older age, female sex, lower education, living alone, and longer axial length were significantly associated with greater incident vision loss.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Endocrinology & Metabolism
Shanshan Yu, Kaixuan Cui, Peiqi Wu, Benjuan Wu, Xi Lu, Rong Huang, Xiaoyu Tang, Jianqiang Lin, Boyu Yang, Jinfeng Zhao, Qingjing He, Xiaoling Liang, Yue Xu
Summary: This study suggests that melatonin could be a promising and safe therapeutic strategy for central serous chorioretinopathy (CSC) patients. Melatonin administration inhibited choroidal thickening, vasodilation, and inflammation in an experimental CSC rat model.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Thermodynamics
Changxin Liu, Huaan Li, Shanshan Yu, Guanghao Qu, Wenxiang Ye, Zhitao Han, Minyi Xu, Xinxiang Pan
Summary: The TEG-ORC combined cycle is a promising method for utilizing waste heat from multiple vessels. By using low toxicity and environmental friendly R245fa as the working fluid, and controlling different bottom cycle ratios and superheating, the system's net power output and thermal efficiency can be improved while reducing the power-production cost.
INTERNATIONAL JOURNAL OF GREEN ENERGY
(2023)
Article
Hematology
Peiyu Yang, Haimin Chen, Xinyue Liang, Weiling Xu, Shanshan Yu, Wenyang Huang, Xingcheng Yi, Qiang Guo, Mengru Tian, Tingting Yue, Mengyao Li, Yingjie Zhang, Mengxue Zhang, Yurong Yan, Zhongli Hu, Shaji K. Kumar, Fan Zhou, Yun Dai, Fengyan Jin
Summary: This study retrospectively analyzed the impact of +1q on the outcomes of 934 newly diagnosed multiple myeloma patients. The results showed that +1q was associated with inferior overall survival, and the concomitance of other high-risk cytogenetic abnormalities further exacerbated the outcomes. A risk-scoring algorithm based on four risk variates was developed to estimate the outcomes of +1q patients.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Ophthalmology
Boyu Yang, Shaowen Wu, Shanshan Yu, Xiaoling Liang, Qifa Liu, Fen Huang, Lingyi Liang
Summary: This study aimed to investigate the posterior segment complications (PSC) and risk factors in patients after allogeneic hematopoietic stem cell transplantation (HSCT). The study found that PSC was more common in post-HSCT patients and was associated with unrelated or HLA-mismatched donors.
Article
Oncology
Anli Wang, Linyi Li, Xuehong Wu, Jianping Zhu, Shanshan Yu, Xi Chen, Jianhua Li, Hongtao Zhu
Summary: This article proposes a new method for entity relation extraction based on data augmentation. The experiments show that deep learning models using data augmentation perform better than models without augmentation, and reinforcement learning-based data augmentation further enhances the performance. The findings highlight the importance of data augmentation in handling unbalanced datasets in the medical field.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Chen-Xi Cai, Xiao-Mei Xiong, Tao Li, Bing-Qian Liu, Xin-Hua Huang, Shan-Shan Yu, Zhen-Qiang Lin, Qiang Wang, Jin-Li Cui, Lin Lu, Ying Lin
Summary: ICGA can be used to evaluate the differences in filling degree and appearance of vortex veins in various eye diseases. The CVVD and MDPTB were significantly increased in the PCV compared with those in the AMD group; the CVVD, MRAV, and PVVA were significantly increased in the PCV compared with those in the healthy group. The vortex vein branches in PCV eyes were significantly dilated in the posterior pole, and the lower proportion of type IV vortex veins may be pathognomonic for PCV.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Ophthalmology
Tingxin Cui, Duoru Lin, Shanshan Yu, Xinyu Zhao, Zhenzhe Lin, Lanqin Zhao, Fabao Xu, Dongyuan Yun, Jianyu Pang, Ruiyang Li, Liqiong Xie, Pengzhi Zhu, Yuzhe Huang, Hongxin Huang, Changming Hu, Wenyong Huang, Xiaoling Liang, Haotian Lin
Summary: This study explores the performance of a deep learning system (DLS) for multiple retinal lesion screening using ultra-widefield (UWF) fundus images from patients in rural areas. The findings indicate that the DLS exhibits excellent performance as a screening tool for detecting retinal lesions in a rural setting, although factors such as poor image quality, diverse lesion proportions, and complex lesion composition may have reduced its performance.
JAMA OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Zhonghua Luo, Yue Xu, Kun Xu, Matthew Fan, Ching-Kit Tsui, Xi Lu, Benjuan Wu, Xinyu Zhao, Xiaoyu Tang, Peiqi Wu, Kaixuan Cui, Shanshan Yu, Xiaoling Liang
Summary: This study evaluated the differences in the choroidal vortex vein drainage system between patients with CSC and healthy individuals using UWF-OCTA. The results showed that CSC eyes have an asymmetric vortex vein drainage system, with the superotemporal drainage system being the preferential route for submacular choroidal drainage.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Editorial Material
Ophthalmology
Xinqi Ma, Shanshan Yu
OPHTHALMOLOGY RETINA
(2023)
Article
Cell Biology
Xinyu Zhao, Zhenzhe Lin, Shanshan Yu, Jun Xiao, Liqiong Xie, Yue Xu, Ching-Kit Tsui, Kaixuan Cui, Lanqin Zhao, Guoming Zhang, Shaochong Zhang, Yan Lu, Haotian Lin, Xiaoling Liang, Duoru Lin
Summary: An artificial intelligence system called Ai-Doctor was developed to interpret fundus fluorescein angiography (FFA) images for the diagnosis and treatment of ischemic retinal diseases (IRDs). The system performed well in various tasks, such as image identification, diabetic retinopathy and branch retinal vein occlusion diagnosis, and non-perfusion area segmentation. It was also able to expand its capabilities to previously unencountered IRDs. A new clinically applicable ischemia index was proposed to assess the degree of ischemia and guide laser therapy.
CELL REPORTS MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yumei Li, Tianyi Chen, Ying Xue, Yuan Wang, Li Peng, Chenglong Wang, Shanshan Yu
Summary: DJ-1 has been found to have neuroprotective effects and can inhibit ferroptosis. This study revealed that the neuroprotective effect of DJ-1 is closely related to the ATF4/HSPA5 pathway.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Ophthalmology
Xiaoyu Tang, Kaixuan Cui, Xi Lu, Peiqi Wu, Shanshan Yu, Boyu Yang, Yue Xu, Xiaoling Liang
Summary: Using animal models and in vitro cell experiments, it was found that KC7F2 effectively inhibits retinal neovascularization by suppressing the HIF1α-VEGF pathway.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)