Article
Engineering, Environmental
Hsuan-Cheng Lu, Anupama Kumar, Steven D. Melvin, Shima Ziajahromi, Peta A. Neale, Frederic D. L. Leusch
Summary: In this study, the effects of irregular shaped polyethylene microplastics (MPs) on Chironomus tepperi were investigated. The parental generation showed decreased survival and emergence rates at high MP concentrations, while growth-related endpoints were only affected at the highest concentration. Metabolite analysis revealed lower abundances of amino acid and energy metabolism-related metabolites at the highest exposure concentration, suggesting an impact on bioenergetics. However, no significant effects were observed in the continuous exposure of the first filial generation.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Bin Kang, Li Lin, Yuan Li, Xin Peng, Jiachen Sun
Summary: China is one of the largest waste importers and producers in the world, with land-based discharges and fishery-related activities being the main sources of marine debris. Marine debris poses risks to the ecological environment, economic benefits, and human health. China has implemented comprehensive countermeasures with remarkable results, but greater commitment and stronger execution are needed.
MARINE POLLUTION BULLETIN
(2022)
Article
Multidisciplinary Sciences
Stefano Cannicci, Shing Yip Lee, Henrique Bravo, Jaime Ricardo Cantera-Kintz, Farid Dahdouh-Guebas, Sara Fratini, Marco Fusi, Pedro J. Jimenez, Inga Nordhaus, Francesca Porri, Karen Diele
Summary: Deforestation leads to habitat fragmentation, reduced diversity, and functional degradation in mangroves. A global dataset of mangrove invertebrate fauna revealed that despite low redundancy, even small mangrove patches host truly multifunctional faunal assemblages crucial for ecosystem services. The study suggests that even a modest loss of invertebrate diversity could have significant negative consequences for mangroves and adjacent ecosystems.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Food Science & Technology
Millena Cristina Barros Santos, Luciana Ribeiro da Silva Lima, Carolina Thomaz dos Santos D'Almeida, Veronica Cristina Mayrinck Victorio, Luiz Claudio Cameron, Claire Bourlieu-Lacanal, Mariana Simoes Larraz Ferreira
Summary: This study comprehensively characterized phenolic compounds (PC) in 14 wheat flours from different Brazilian genotypes and technological qualities, revealing their significant impact on the quality and nutritional importance of wheat products, with distinct effects observed among genotypes.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Microbiology
Ran Wu, Jiri Patocka, Eugenie Nepovimova, Patrik Oleksak, Martin Valis, Wenda Wu, Kamil Kuca
Summary: Antimicrobial peptides are important components of organisms' innate immune system, with broad-spectrum activities against bacteria, viruses, and tumors, without harming the organisms themselves. Unlike traditional antibiotics, they do not lead to drug resistance and have a unique antibacterial mechanism.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biology
Bernardo Duarte, Eduardo Feijao, Ricardo Cruz de Carvalho, Irina A. Duarte, Ana Patricia Marques, Marisa Maia, Jasmine Hertzog, Ana Rita Matos, Maria Teresa Cabrita, Isabel Cacador, Andreia Figueiredo, Marta Sousa Silva, Carlos Cordeiro, Vanessa F. Fonseca
Summary: Pharmaceutical compounds may have unknown and undesirable effects on non-target organisms. This study used metabolomics to uncover the mode of action of fluoxetine, an antidepressant, in diatoms, as well as identify potential biomarkers of exposure. The findings highlight the importance of understanding the ecotoxicology of marine organisms and the value of metabolomics approaches.
Article
Biotechnology & Applied Microbiology
Hao Zhang, Bowei Gu, Youping Zhou, Xiao Ma, Tianqi Liu, Hongkai Xu, Zhangxian Xie, Kailin Liu, Dazhi Wang, Xiaomin Xia
Summary: This study investigates the variations of protein and metabolite profiles in a marine dinoflagellate across different temperatures. The findings suggest that amino acids may serve as nitrogen storage pools at lower temperatures, and proteins related to photoreaction and protein homeostasis are highly expressed at higher temperatures.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Microbiology
Peng Jin, Zhe Liang, Hua Lu, Jinmei Pan, Peiyuan Li, Quanting Huang, Yingyan Guo, Jiahui Zhong, Futian Li, Jiaofeng Wan, Sebastian Overmans, Jianrong Xia
Summary: This study analyzed the lipidomic responses of a marine diatom to long-term ocean acidification conditions, revealing significant changes in lipid metabolites with down-regulation of MGDG and up-regulation of PG. The results suggest that lipid remodeling is an adaptation strategy of marine diatoms to ongoing ocean acidification, emphasizing the importance of understanding long-term lipid adaptation in marine producers for predicting ecological consequences of climate change.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Physical
He Tian, Zhen Ni, Sin Man Lam, Wenxi Jiang, Fengjuan Li, Jie Du, Yuan Wang, Guanghou Shui
Summary: This study develops a robust metabolomics approach for accurate quantitation and precise profiling of metabolomes. By introducing isotope-labeled standards (ISs) and refining the selection of appropriate ISs, this approach successfully reduces COVs and facilitates the identification of additional metabolites. The approach reveals perturbations in various metabolic pathways across aging, providing clues for the prevention and treatment of age-related diseases.
Article
Neurosciences
Ao Qi, Lulu Liu, Junjie Zhang, Simei Chen, Simin Xu, Yusen Chen, Lijiang Zhang, Chun Cai
Summary: Parkinson's disease (PD) is a progressive neurodegenerative disorder with no clear clinical biomarkers. In this study, plasma metabolites were analyzed and short-chain fatty acids showed differences between PD patients and healthy controls. Acetic acid was higher in PD, while propanoic acid and 2,3,4-trihydroxybutyric acid were lower. Acetic acid and propanoic acid were found to be potential biomarkers for differentiating PD from health, with propanoic acid showing the highest sensitivity and specificity.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ivonne Lozano-Munoz, Jurij Wacyk, Cristina Kretschmer, Yesseny Vasquez-Martinez, Marcelo Cortez-San Martin
Summary: Aquaculture is crucial for food security and nutrition, with salmonids being an important source of protein and nutrients. However, challenges such as fish diseases and antibiotic resistance in Chilean salmon farming need to be addressed urgently. Efforts to reduce antibiotic use in aquaculture are necessary to prevent the spread of resistant bacteria and protect human and environmental health.
Article
Environmental Sciences
Hafiz Sohaib Ahmed Saqib, Ye Yuan, Syed Shabi Ul Hassan Kazmi, Muhammad Tayyab, Zifei Xiang, Mhd Ikhwanuddin, Hongyu Ma
Summary: By using DNA-based techniques, this study examines the impact of salinity gradients on the trophic networks of mud crabs in marine ecosystems. The results reveal the dietary spectrum of mud crabs and the influence of salinity gradients on their prey items. Additionally, mud crabs exhibit adaptive feeding behavior according to environmental constraints.
FRONTIERS IN MARINE SCIENCE
(2023)
Review
Environmental Sciences
Nan Hu, Paul E. Bourdeau, Christian Harlos, Ying Liu, Johan Hollander
Summary: Climate change is affecting marine ecosystems by causing trophic differences in response to stressors, with higher trophic level species showing greater tolerance to ocean acidification but greater sensitivity to warming. In contrast, marine herbivores are the most vulnerable trophic level to both acidification and warming, suggesting possible disruptions to ecosystem function and community destabilization under ocean climate change.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Salazar-Orbea, Rocio Garcia-Villalba, Luis M. Sanchez-Siles, Francisco A. Tomas-Barberan, Carlos J. Garcia
Summary: This research used a non-targeted metabolomics approach to study the impact of fruit processing on metabolic profiles, identifying markers for strawberry and apple puree processing and confirming a temperature-dependent effect on metabolic profiles. Seven metabolites were identified as processing markers, potentially clarifying the narrative on ultra-processed foods.
Article
Biotechnology & Applied Microbiology
Carla Teresinha Endres, Graziela Vargas Rigo, Luciana Angelo Loges, Melissa Fontes Landell, Denise Brentan Silva, Alexandre Jose Macedo, Tiana Tasca
Summary: This study evaluated the anti-Trichomonas vaginalis activity of fungi associated with marine invertebrates and found that certain compounds from these fungi show potential for overcoming drug resistance in T. vaginalis infections.
MARINE BIOTECHNOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Chien H. Thai, A. J. M. Ferreira, H. Nguyen-Xuan, Lieu B. Nguyen, P. Phung-Van
Summary: This paper proposes a nonlocal strain gradient meshfree plate approach for the bending and free vibration analyses of laminated composite and sandwich nanoplates. The deflection and natural frequency of the plates are significantly influenced by the nonlocal and strain gradient parameters. The results show that both models coincide when the nonlocal and strain gradient parameters are taken as zero.
ENGINEERING WITH COMPUTERS
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Matos, Pedro Adragao, Cristiano Pisani, Vinicius Hatanaka, Pedro Freitas, Francisco Costa, Muhiedinne Chokr, Carina Hardy, Antonio Miguel Ferreira, Pedro Carmo, Sissy Laura, Francisco Morgado, Diogo Cavaco, Miguel Mendes, Mauricio Scanavacca
Summary: The study compared the efficacy and safety of combined (C-ABL) and non-combined (NC-ABL) endo-epicardial ventricular tachycardia (VT) ablation. The results showed that a combined or sequential ablation strategy was associated with lower VT recurrence and lower all-cause death in patients with ischemic heart disease and non-ischemic cardiomyopathy undergoing repeated procedures. Both approaches seemed equally safe.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jimena Perez-Vargas, Tirosh Shapira, Andrea D. Olmstead, Ivan Villanueva, Connor A. H. Thompson, Siobhan Ennis, Guang Gao, Joshua De Guzman, David E. Williams, Meng Wang, Aaleigha Chin, Diana Bautista-Sanchez, Olga Agafitei, Paul Levett, Xuping Xie, Genoveffa Nuzzo, Vitor F. Freire, Jairo I. Quintana-Bulla, Darlon I. Bernardi, Juliana R. Gubiani, Virayu Suthiphasilp, Achara Raksat, Pornphimol Meesakul, Isaraporn Polbuppha, Sarot Cheenpracha, Wuttichai Jaideej, Kwanjai Kanokmedhakul, Chavi Yenjai, Boonyanoot Chaiyosang, Helder Lopes Teles, Emiliano Manzo, Angelo Fontana, Richard Leducn, Pierre-Luc Boudreault, Roberto G. S. Berlinck, Surat Laphookhieo, Somdej Kanokmedhakul, Ian Tietjen, Artem Cherkasov, Mel Krajden, Ivan Robert Nabi, Masahiro Niikura, Pei-Yong Shi, Raymond J. Andersen, Francois Jean
Summary: The COVID-19 pandemic remains a global health crisis, but certain natural products have been found to possess antiviral properties against SARS-CoV-2, which is crucial for developing effective therapeutics and understanding the mechanisms of infection for SARS-CoV-2 variants.
ANTIVIRAL RESEARCH
(2023)
Article
Medical Laboratory Technology
Tayla C. S. Pereira, Alzenir R. Souza, Paula B. Daltro, Maria G. A. Carosio, Antonio G. Ferreira, Regina V. Oliveira, Vitor Fortuna, Paulo R. Ribeiro
Summary: Individuals with sickle cell disease often experience vaso-occlusive crisis events, leading to severe damage of organs such as avascular necrosis. This study used an untargeted metabolomics approach to assess metabolic changes in blood plasma and bone marrow interstitial fluid samples of sickle cell disease patients with osteonecrosis. The analysis identified potential biomarkers and key metabolites associated with different stages of the disease. While limited by sample sizes and absence of a validation cohort, the study provided valuable insights into the complex metabolic regulation system for osteonecrosis.
CLINICA CHIMICA ACTA
(2023)
Correction
Chemistry, Multidisciplinary
G. Logan Bartholomew, Filippo Carpaneto, Richmond Sarpong
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Correction
Pharmacology & Pharmacy
Jimena Perez-Vargas, Tirosh Shapira, Andrea D. Olmstead, Ivan Villanueva, Connor A. H. Thompson, Siobhan Ennis, Guang Gao, Joshua De Guzman, David E. Williams, Meng Wang, Aaleigha Chin, Diana Bautista-Sanchez, Olga Agafitei, Paul Levett, Xuping Xie, Genoveffa Nuzzo, Vitor F. Freire, Jairo I. Quintana-Bulla, Darlon I. Bernardi, Juliana R. Gubiani, Virayu Suthiphasilp, Achara Raksat, Pornphimol Meesakul, Isaraporn Polbuppha, Sarot Cheenpracha, Wuttichai Jaidee, Kwanjai Kanokmedhakul, Chavi Yenjai, Boonyanoot Chaiyosang, Helder Lopes Teles, Emiliano Manzo, Angelo Fontana, Richard Leduc, Pierre-Luc Boudreault, Roberto G. S. Berlinck, Surat Laphookhieo, Somdej Kanokmedhakul, Ian Tietjen, Artem Cherkasov, Mel Krajden, Ivan Robert Nabi, Masahiro Niikura, Pei-Yong Shi, Raymond J. Andersen, Francois Jean
ANTIVIRAL RESEARCH
(2023)
Article
Chemistry, Organic
Emanuele F. Pissinati, Jose A. C. Delgado, Pedro A. M. Moro, Jose T. M. Correia, Roberto G. S. Berlinck, Marcio W. Paixao
Summary: A carbamoylation strategy that is selectively targeted at specific sites has been developed. This method offers mild reaction conditions, compatibility with various functional groups, and a wide range of functionalized carbamoyl radicals. It enables the synthesis of peptides, pharmaceuticals, natural N-4-asparagine conjugates, and enantioenriched unnatural N-4-asparagines.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Marcelo R. de Amorim, Camila de S. Barbosa, Tiago A. Paz, Laura P. Ioca, Karen J. Nicacio, Lucianne F. P. de Oliveira, Mirian O. Goulart, Julia M. Paulino, Mateus O. da Cruz, Antonio G. Ferreira, Maysa Furlan, Simone P. de Lira, Raquel A. dos Santos, Andre Rodrigues, Rafael V. C. Guido, Roberto G. S. Berlinck
Summary: Bioassay-guided investigation of the EtOAc-soluble extract of a culture of the marine-derived fungus Peroneutypa sp.M16 led to the discovery of seven new polyketide- and terpenoid-derived metabolites (1, 2, 4-8), alongside known polyketides (3, 9-13). The structures of compounds 1, 2, and 4-8 were determined through analysis of spectroscopic data, while the absolute configurations of compounds 1, 2, 4, 6, 7, and 8 were determined by comparing experimental ECD spectra with calculated CD data. Compound 5 exhibited moderate antiplasmodial activity against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Applied
Daniele de Oliveira Silva, Mario Ferreira Conceicao Santos, Karen de Jesus Nicacio, Albert Katchborian Neto, Joao Henrique Ghilardi Lago, Daniela Aparecida Chagas-Paula, Danielle F. F. Dias, Marisi G. G. Soares
Summary: This study aimed to identify compounds responsible for the anti-inflammatory activity of A. polyphylla through phytochemical analysis. Among the evaluated fractions, the BH fraction showed the highest percentage of PGE(2) inhibition, indicating its excellent potential for anti-inflammatory activity. Astragalin and a new compound were isolated from the A. polyphylla extract, contributing to the phytochemical studies of this plant and confirming its anti-inflammatory potential.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
Lucero Martinez-Fructuoso, S. J. Ryan Arends, Vitor F. Freire, Jason R. Evans, Sean DeVries, Brian D. Peyser, Rhone K. Akee, Christopher C. Thornburg, Rohitesh Kumar, Susan Ensel, Gina M. Morgan, Grant D. McConachie, Nathan Veeder, Leonard R. Duncan, Tanja Grkovic, Barry R. O'Keefe
Summary: The emergence of antibiotic resistance emphasizes the need for new chemotypes with antimicrobial activity. A large-scale screening of natural product samples led to the identification of over 3000 fractions with antifungal and/or antibacterial activity. Further purification of active fractions revealed the chemical structures responsible for the antimicrobial activity, identifying previously unreported chemotypes.
ACS INFECTIOUS DISEASES
(2023)
Article
Plant Sciences
Leandro da Silva Oliveira, Camila M. M. Crnkovic, Marcelo R. R. de Amorim, Armando Navarro-Vazquez, Tiago A. A. Paz, Vitor F. F. Freire, Mirelle Takaki, Tiago Venancio, Antonio G. G. Ferreira, Renata de Freitas Saito, Roger Chammas, Roberto G. S. Berlinck
Summary: Metabolomics analyses and optimization of growth conditions were used to diversify phomactin terpenoids produced by the fungus Biatriospora sp. CBMAI 1333. Molecular networking results visualized on Gephi software facilitated the observation of phomactin diversification and guided the isolation and identification of a new nitrogen-bearing phomactin variant, phomactinine (1), with a rearranged carbon skeleton. The combination of metabolomics and chemometrics strategies can be expanded to integrate bioassay potency, structural novelty, and metabolic diversification, with or without genomic analyses.
JOURNAL OF NATURAL PRODUCTS
(2023)
Correction
Plant Sciences
Marcelo R. de Amorim, Camila de S. Barbosa, Tiago A. Paz, Laura P. Ioca, Karen J. Nicacio, Lucianne F. P. de Oliveira, Mirian O. Goulart, Julia M. Paulino, Mateus O. da Cruz, Antonio G. Ferreira, Maysa Furlan, Simone P. de Lira, Raquel A. dos Santos, Andreï Rodrigues, Rafael V. C. Guido, Roberto G. S. Berlinck
JOURNAL OF NATURAL PRODUCTS
(2023)
Review
Chemistry, Multidisciplinary
Ian Bakanas, Robert F. Lusi, Stefan Wiesler, Jack Hayward Cooke, Richmond Sarpong
Summary: The oxidation of unactivated C-H bonds has greatly influenced the synthesis of complex molecules, providing more options for starting materials and simplifying the synthesis planning process. This Review classifies and analyzes different types of C-H oxidation reactions based on their strategic purpose and provides case studies to demonstrate their applications in recent total syntheses.
NATURE REVIEWS CHEMISTRY
(2023)
Article
Chemistry, Applied
Tatiane Cristina Silva Maiolini, Karen de Jesus Nicacio, Welton Rosa, Daniel de Oliveira Miranda, Mario Ferreira Conceicao Santos, Paula Carolina Pires Bueno, Joao Henrique Ghilardi Lago, Patricia Sartorelli, Danielle Ferreira Dias, Daniela Aparecida Chagas de Paula, Marisi Gomes Soares
Summary: This study evaluated the anti-inflammatory activity of essential oils from 18 species of Myrtaceae and found that 6 species displayed anti-inflammatory activity, with corresponding biomarkers identified.
NATURAL PRODUCT RESEARCH
(2023)
