Article
Chemistry, Multidisciplinary
Dmitry Yu Aleshin, Rosa Diego, Leoni A. Barrios, Yulia Nelyubina, Guillem Aromi, Valentin V. Novikov
Summary: The study successfully observed the dynamics of two rare spin states, opening up new possibilities for information storage and processing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemical Research Methods
Daniel Jardon-Alvarez, Tahel Malka, Johan van Tol, Yishay Feldman, Raanan Carmieli, Michal Leskes
Summary: This study maps the fluctuations of the magnetic moment of unpaired electron spins by analyzing the ratio between longitudinal and transverse nuclear relaxation times. This analysis helps explain the evolution of NMR lineshapes and DNP enhancements as a function of the concentration of paramagnetic species and temperature.
JOURNAL OF MAGNETIC RESONANCE
(2022)
Article
Chemistry, Multidisciplinary
Shutian Lu, Catherine R. R. Fowler, Brian Ream, Sheela M. M. Waugh, Theresa M. M. Russell, John C. C. Rohloff, Larry Gold, Jason P. P. Cleveland, Stefan Stoll
Summary: Recent developments in aptamer chemistry have provided new opportunities for protein biosensing tools. This study presents a method that uses immobilized slow off-rate modified aptamers (SOMAmers) labeled with a nitroxide radical to detect protein binding. The rotational mobility of the spin label is changed by protein binding, which is detected using solution-state electron paramagnetic resonance (EPR) spectroscopy.
Article
Chemistry, Multidisciplinary
Dmitry Yu Aleshin, Igor Nikovskiy, Valentin V. Novikov, Alexander V. Polezhaev, Elizaveta K. Melnikova, Yulia V. Nelyubina
Summary: In this study, the effects of two chemical modifications and different solvents on the spin-crossover behavior in high-spin iron(II) complexes were investigated using solution NMR spectroscopy. The research revealed that with the recent design of substituents, the first iron(II) complex of N,N'-disubstituted 3-bpp can undergo almost complete spin-crossover in a less polar solvent.
Article
Chemistry, Multidisciplinary
Yunfan Qiu, Asif Equbal, Chenjian Lin, Yuheng Huang, Paige J. Brown, Ryan M. Young, Matthew D. Krzyaniak, Michael R. Wasielewski
Summary: Photoexcited organic chromophores combined with stable radicals can be used as candidates for quantum information applications. In this study, the synthesis and characterization of 1,6,7,12-Tetra-(4-tert-butylphenoxy)-perylene-3,4 : 9,10-bis(dicarboximide) (tpPDI) linked to a partially deuterated alpha,gamma-bisdiphenylene-beta-phenylallyl radical (BDPA-d(16)) were performed using time-resolved optical and electron paramagnetic resonance (EPR) spectroscopies. The results showed efficient generation of a quartet state (Q) followed by a spin-polarized doublet ground state (D-0) upon photoexcitation of tpPDI-BDPA-d(16).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Arianna Actis, Michele Melchionna, Giacomo Filippini, Paolo Fornasiero, Maurizio Prato, Enrico Salvadori, Mario Chiesa
Summary: This study assesses the influence of morphology and light-excitation on the number and chemical nature of radical defects in carbon nitride (CN) and derives the spatial distribution of native radicals in CN using magnetic dipole-dipole coupling.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Wedrychowicz, Bogumil Cieniek, Ireneusz Stefaniuk, Ihor Virt, Romana Sliwa
Summary: In this study, the magnetic properties of lead selenide and indium-doped lead telluride composites were investigated using the EPR technique. The temperature dependence of the EPR spectra was analyzed, and paramagnetic centers of Pb1+ and Pb3+ ions were identified.
Article
Chemistry, Physical
A. M. Panich, A. E. Aleksenskii, E. B. Yudina, A. Ya Vul
Summary: We report a novel approach to determine the spatially resolved nuclear spin-lattice relaxation times and NMR line widths in nanomaterials. We applied this approach to detonation nanodiamonds with manganese ions grafted onto their surface and observed the acceleration of nuclear spin-lattice relaxation and broadening of the resonance line. By using spin dephasing experiments, we were able to determine the contribution of paramagnetic Mn2+ ions to the relaxation time and line width of carbon spins at different depths from the diamond surface. Developed specifically for nanodiamonds, this approach can be applied to study distribution of relaxation rates and line broadening, and map magnetic interactions inside various nanoparticles, making it valuable in nanotechnologies.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Physics, Multidisciplinary
Benjamin Merkel, Pablo Cova Farina, Andreas Reiserer
Summary: Ensembles of dopants have wide applications in quantum technology, but the miniaturization of corresponding devices is hindered by dipolar interactions. Dynamical decoupling can alleviate the decoherence in crystals with strong anisotropic spin-spin interactions, originating from anisotropic g tensor, but cannot fully eliminate it. These findings can be extended to various quantum systems used for quantum sensing, microwave-to-optical conversion, and quantum memory.
PHYSICAL REVIEW LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Jonas C. Ott, Elizaveta A. Suturina, Ilya Kuprov, Joscha Nehrkorn, Alexander Schnegg, Markus Enders, Lutz H. Gade
Summary: In this study, experimental observations of P-31 and H-1 NMR resonances shifted by over 10 000 ppm in a square planar ferrous complex were reported. The influence of magnetic anisotropy and zero-field splitting on paramagnetic shift and relaxation enhancement was investigated using various techniques, and spin dynamics simulations showed the possibility of observing NMR signals of directly metal-bonded atoms even with relatively slow electron spin relaxation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Arnau Bertran, Laura Morbiato, Sara Aquilia, Laura Gabbatore, Marta De Zotti, Christiane R. Timmel, Marilena Di Valentin, Alice M. Bowen
Summary: In this study, we introduce a new photoswitchable spin label that can be used to investigate the orientational effects in pulsed electron paramagnetic resonance dipolar spectroscopy. Furthermore, experiments conducted at temperatures above liquid nitrogen eliminate the need for expensive cryogenic equipment.
Article
Materials Science, Multidisciplinary
A. A. Wood, R. M. Goldblatt, R. P. Anderson, L. C. L. Hollenberg, R. E. Scholten, A. M. Martin
Summary: The interaction between central qubit spin and surrounding bath of spins is crucial for quantum sensing and quantum information processing. By rotating a diamond at speeds up to 300,000 rpm, researchers have found that the interaction between electron spins of nitrogen-vacancy centers and a bath of C-13 nuclear spins introduces decoherence into the system. These findings offer new insights into using physical rotation for quantum control in systems with motional and rotational degrees of freedom.
Article
Multidisciplinary Sciences
Marcin Sarewicz, Mateusz Szwalec, Sebastian Pintscher, Paulina Indyka, Michal Rawski, Rafal Pietras, Bohun Mielecki, Lukasz Koziej, Marcin Jaciuk, Sebastian Glatt, Artur Osyczka
Summary: Plants use solar energy to power cellular metabolism. In photosynthesis, the oxidation of plastoquinol and reduction of plastocyanin by cytochrome b(6)f (Cyt b(6)f) is a key step. The catalytic mechanism in the plastoquinone oxidation site (Q(p)) has been unclear. The study presents high-resolution cryo-EM structures of the spinach Cyt b(6)f homodimer, providing insights into the flow of quinones and proposing a one-way traffic model for efficient quinol oxidation.
Article
Polymer Science
Uwe Lappan, Carolin Naas, Ulrich Scheler
Summary: This study utilizes cationic charged chitosan and weak polyacid poly(ethylene-alt-maleic acid) to create polyelectrolyte multilayers (PEMs). By attaching a nitroxide spin-label to the polyacid, the rotational dynamics of the polymer backbone in the swollen state of the PEMs are studied using electron paramagnetic resonance spectroscopy. The study reveals that PEMs with an even number of layers exhibit a superposition of two spectral components, a major slow-motion component from protonated amino groups compensating chain segments of the chitosan, and a minor fast-motion component believed to originate from loops and tails of the polyacid chain at the PEMs' surface.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Physical
Ira Litvak, Avner Cahana, Yaakov Anker, Sharon Ruthstein, Haim Cohen
Summary: Diamonds contain stable carbon radicals and exposure to polishing or high temperatures affects the concentration and structure of these radicals, resulting in the emission of orange light. Research shows that the polishing process has more effects on the paramagnetic centers than just thermal heating.
Article
Biochemistry & Molecular Biology
Phani R. Potluri, Nicole M. Cordina, Ehsan Kachooei, Louise J. Brown
Article
Biochemistry & Molecular Biology
Khondker Rufaka Hossain, Daniel R. Turkewitz, Stephen A. Holt, Leonie Herson, Louise J. Brown, Bruce A. Cornell, Paul M. G. Curmi, Stella M. Valenzuela
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2019)
Article
Optics
James White, Cyril Laplane, Reece P. Roberts, Louise J. Brown, Thomas Volz, David W. Inglis
Article
Biophysics
Shiying Zhu, Ehsan Kachooei, Jeffrey R. Harmer, Louise J. Brown, Frances Separovic, Marc-Antoine Sani
Summary: The combination of in-cell solid-state dynamic nuclear polarization (DNP) NMR and cryogenic temperatures allows for the delivery of a radical source into cells via nitroxide-tagged peptide, enabling in situ biophysical studies of antimicrobial peptides. This study investigated the structure, localization, and signal enhancement properties of spin-labeled Mac1 analogs within micelles or lipid vesicles, with the double spin-labeled peptide achieving better NMR enhancements. Molecular dynamics simulations supported the observations and provided further structural insights.
BIOPHYSICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Mina Ghanimi Fard, Zahra Khabir, Philipp Reineck, Nicole M. Cordina, Hiroshi Abe, Takeshi Ohshima, Sagar Dalal, Brant C. Gibson, Nicolle H. Packer, Lindsay M. Parker
Summary: This study developed a novel method to target glycan receptors in different brain cell types using lectin-conjugated nanodiamonds. The results demonstrate that the uptake of lectin-conjugated nanodiamonds varies across different types of brain cells.
NANOSCALE ADVANCES
(2022)
Review
Biotechnology & Applied Microbiology
Samuel J. King, Ante Jerkovic, Louise J. Brown, Kerstin Petroll, Robert D. Willows
Summary: Hydrogen is a clean alternative to fossil fuels and has various applications. Currently, hydrogen is mainly produced from coal and natural gas, so developing alternative methods that do not use fossil fuels is necessary. Biological manufacturing of hydrogen using enzymes called hydrogenases shows promise as a clean and renewable solution. However, limitations in the hydrogen production pathways of algae have hindered commercial implementation. Recent advancements in synthetic biology and high-throughput screening assays have shown potential for improving algal hydrogen production efficiency.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nicole M. Cordina, Wei Zhang, Nicolle H. Packer, Yuling Wang
Article
Chemistry, Analytical
Phani R. Potluri, Vinoth Kumar Rajendran, Anwar Sunna, Yuling Wang
Article
Materials Science, Multidisciplinary
T. Boele, D. E. J. Waddington, T. Gaebel, E. Rej, A. Hasija, L. J. Brown, D. R. McCamey, D. J. Reilly
Proceedings Paper
Engineering, Electrical & Electronic
Lindsay M. Parker, Philipp Reineck, Mina Ghanimi-Fard, Emma R. Wilson, Sameera Iqbal, Michael Baratta, Nicole M. Cordina, Anna Guller, Annemarie Nadort, Brant Gibson, Nicolle H. Packer
2019 PHOTONICS & ELECTROMAGNETICS RESEARCH SYMPOSIUM - SPRING (PIERS-SPRING)
(2019)
Article
Materials Science, Biomaterials
Alfonso E. Garcia-Bennett, Arun Everest-Dass, Irene Moroni, Ishan Das Rastogi, Lindsay M. Parker, Nicolle H. Packer, Louise J. Brown
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)