Article
Gastroenterology & Hepatology
Laura Prospero, Giuseppe Riezzo, Michele Linsalata, Antonella Orlando, Benedetta D'Attoma, Marta Di Masi, Manuela Martulli, Francesco Russo
Summary: In IBS-D patients, those with high somatization showed impaired intestinal barrier function, increased zonulin levels, enhanced inflammation response, and a more pronounced imbalance compared to those with low somatization.
BMC GASTROENTEROLOGY
(2021)
Review
Microbiology
Jun-Jie Hou, Xin Wang, Yu-Ming Wang, Bang-Mao Wang
Summary: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disease that is closely associated with abnormal changes in gut microbiota and bile acids (BAs) metabolism. Recent research progress supports the potential of new therapeutic strategies targeting the microbiota-BAs axis for the treatment of IBS-D and other related diseases.
CRITICAL REVIEWS IN MICROBIOLOGY
(2022)
Article
Cell Biology
Karem Awad, Christian Barmeyer, Christian Bojarski, Oliver Nagel, In-Fah M. Lee, Michal R. Schweiger, Joerg-Dieter Schulzke, Roland Buecker
Summary: This study investigated the pathophysiological mechanisms of diarrhea, constipation, and antigen uptake in mixed-type irritable bowel syndrome (IBS-M). The findings showed that in IBS-M, chloride secretion was reduced and antigen permeability was increased, which contributed to a low-grade inflammation in the colon mucosa.
Article
Biochemistry & Molecular Biology
Sholpan Omarova, Karem Awad, Verena Moos, Christoph Puening, Greta Goelz, Jorg-Dieter Schulzke, Roland Buecker
Summary: This study observed patients with persistent PI-IBS symptoms after C. jejuni infection and found that the epithelial resistance of the colon epithelium was unaltered, but the permeability of HRP increased and some inflammation-related markers were elevated. Therefore, targeting these mechanisms caused by the infection may help reduce sequelae such as PI-IBS.
Article
Gastroenterology & Hepatology
Xuemei Li, Kuiyu Ren, Xiaojuan Hong, Sha Guo, Shuguang Yu, Sha Yang
Summary: Electroacupuncture (EA) at ST25 and ST37 has therapeutic effects on intestinal low-grade inflammation (LGI) in a rat model of Diarrhea-predominant irritable bowel syndrome (IBS-D), possibly by upregulating the expression of occludin protein and dilating the intestinal microvascular diameter.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S. Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R. DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A. Houghton
Summary: This study found that patients with irritable bowel syndrome (IBS) had a stronger symptom response to small intestinal lipid infusion, which was associated with the expression of TRPV channels, suggesting that TRPV-mediated small intestinal chemosensitivity may play a role in post-meal symptoms in IBS.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Nutrition & Dietetics
Claudia Di Rosa, Annamaria Altomare, Vittoria Terrigno, Florencia Carbone, Jan Tack, Michele Cicala, Michele Pier Luca Guarino
Summary: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and altered bowel habits. The exact cause of IBS is not fully understood, but it is believed to involve a combination of factors such as abnormal gut motility, inflammation, increased intestinal permeability, and sensitivity. Diet and gut microbiota have also been identified as important contributors to IBS. This review examines the effects of dietary components, functional foods, prebiotics, probiotics, and symbiotics on symptoms and gut microbiota in individuals with IBS-C.
Article
Microbiology
Jingze Yang, Peng Wang, Tong Liu, Lin Lin, Lixiang Li, Guanjun Kou, Ruchen Zhou, Pan Li, Yanqing Li
Summary: This study found differences in the microbial composition of the caecum and descending colon in IBS-D patients, with increased numbers of EC cells and higher TPL1 expression levels compared to controls. The Ruminococcus torques group and Dorea appear to be promising targets for future research in treating IBS-D patients.
Review
Nutrition & Dietetics
Annamaria Altomare, Claudia Di Rosa, Elena Imperia, Sara Emerenziani, Michele Cicala, Michele Pier Luca Guarino
Summary: The study explores the effects of different nutritional protocols on IBS-D symptoms and intestinal microbiota variations. An ideal nutritional protocol does not yet exist for IBS-D patients, but it is crucial to consider the impact of different nutritional approaches on the composition of the intestinal microbiota for better management of this functional disorder.
Article
Gastroenterology & Hepatology
Constanza Ciriza de los Rios, Blanca Serrano Falcon, Federico Arguelles-Arias, Esperanza Perez, Carlos Teruel, Fernando Geijo, Enrique Rey
Summary: Treating IBS-D patients with XG-PPT-XOS in a clinical setting for 6 months showed effective and safe long-term outcomes. The treatment effectively improved symptoms such as diarrhea, pain, and bloating.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Plant Sciences
Yan Chen, Fuhao Chu, Jie Lin, Zeqi Su, Mengting Liao, Tao Li, Yuan Li, Nadia Johnson, Haocheng Zheng, Xia Ding
Summary: The study demonstrated that WeiChang'An Pill (WCAP) may alleviate symptoms of diarrhoea and visceral sensitivity in patients with diarrhoea-predominant irritable bowel syndrome (IBS-D) by regulating the cAMP signalling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Giusi Desire Sciume, Ginevra Berti, Christian Lambiase, Italia Paglianiti, Vincenzo Villanacci, Francesco Rettura, Antonio Grosso, Angelo Ricchiuti, Nicola de Bortoli, Paolo Usai Satta, Gabrio Bassotti, Massimo Bellini
Summary: Irritable bowel syndrome with predominant diarrhea (IBS-D) and functional diarrhea (FD) are disorders of gut-brain interaction that have a significant impact on the patient's quality of life. Bile acid malabsorption (BAM) and microscopic colitis (MC) are often responsible for the lack of response to conventional treatments in these patients. Therefore, considering these factors and finding appropriate treatments should be part of the diagnostic process.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Karolina S. Jabbar, Brendan Dolan, Lisbeth Eklund, Catharina Wising, Anna Ermund, Asa Johansson, Hans Tornblom, Magnus Simren, Gunnar C. Hansson
Summary: The study found potentially pathogenic Brachyspira species in a subset of patients with IBS, with a significantly higher prevalence of Brachyspira colonization in IBS patients compared to healthy volunteers, especially in IBS-D patients. Brachyspira colonization was associated with accelerated oro-anal transit, mild mucosal inflammation, mast cell activation, and alterations of molecular pathways linked to bacterial uptake and ion-fluid homeostasis.
Article
Gastroenterology & Hepatology
Wei Wei, Huifen Wang, Yanli Zhang, Yu Zhang, Bingyu Niu, Shuo Chen, Wenxue Zhang, Shukun Yao
Summary: The expression levels of TGR5 in colonic mucosa were significantly higher in IBS-D patients compared to controls, while VDR levels showed no significant difference. Patients with more severe or frequent abdominal pain had higher levels of TGR5. Primary BAs in feces were increased in IBS-D patients and correlated with the severity of diarrhea. The level of TGR5 was positively associated with primary BAs and negatively associated with secondary BAs in participants providing both mucosal and stool samples.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Florian Mourey, Amelie Decherf, Jean-Francois Jeanne, Mathieu Clement-Ziza, Marie-Lise Grisoni, Francois Machuron, Sophie Legrain-Raspaud, Arnaud Bourreille, Pierre Desreumaux
Summary: This study confirmed the efficacy of S. cerevisiae I-3856 in managing gastrointestinal symptoms in IBS-C, particularly in alleviating abdominal pain. The relief of abdominal pain was associated with improved quality of life.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Cell Biology
Rirong Chen, Xiaobai Pang, Li Li, Zhirong Zeng, Minhu Chen, Shenghong Zhang
Summary: This article explores the role of deubiquitinases in inflammatory bowel disease (IBD), including their regulation of inflammation signalling pathways, impact on genetic susceptibility and intestinal barrier function, and influence on the immune system and gut microbiota. These studies provide important insights and potential therapeutic solutions for understanding and treating IBD.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Xiaojun Zhuang, Baili Chen, Shanshan Huang, Jing Han, Gaoshi Zhou, Shu Xu, Minhu Chen, Zhirong Zeng, Shenghong Zhang
Summary: This study explores the interaction between transcription factor SOX9 and claudins (CLDNs) in the context of Crohn's disease (CD). The upregulation of SOX9 is associated with intestinal mucosa injury in CD patients and mice. It negatively regulates the expression of CLDN8, leading to reduced intestinal permeability. Aberrant downregulation of miR-145-5p, caused by hypermethylation of its promoter, disrupts the SOX9-CLDN8 pathway. Targeting the miR-145-5p/SOX9/CLDN8 pathway holds promise as a therapeutic strategy for CD.
Review
Cell Biology
Xiaoling Li, Mudan Zhang, Gaoshi Zhou, Zhuo Xie, Ying Wang, Jing Han, Li Li, Qirui Wu, Shenghong Zhang
Summary: Rho GTPases serve as molecular switches in cellular signaling regulation and are involved in the pathogenesis of inflammatory bowel disease (IBD). IBD, including Crohn's disease and ulcerative colitis, is a complex disease involving genetics, intestinal microbiota, immune system, and environment. Recent studies have identified new pathogenic components and potential therapeutic targets for IBD, particularly focusing on Rho GTPases. This review discusses the possible mechanisms of Rho GTPases in IBD pathogenesis and explores their therapeutic potential.
CELL DEATH DISCOVERY
(2023)
Article
Medicine, General & Internal
Shu Xu, Xiaozhi Li, Shenghong Zhang, Cancan Qi, Zhenhua Zhang, Ruiqi Ma, Liyuan Xiang, Lianmin Chen, Yijun Zhu, Ce Tang, Arno R. Bourgonje, Miaoxin Li, Yao He, Zhirong Zeng, Shixian Hu, Rui Feng, Minhu Chen
Summary: This study used a multi-omics summary data-based Mendelian randomization (SMR) approach to identify the role and mechanism of oxidative stress (OS) genes in Crohn's disease (CD). The results indicated that OS genes are regulated by DNA methylation and host-microbiota interactions, providing evidence for future therapeutic interventions and disease prevention research.
Article
Medicine, General & Internal
Shenghong Zhang, Baili Chen, Bangmao Wang, Hong Chen, Yan Li, Qian Cao, Jie Zhong, Ming-Jium Shieh, Zhihua Ran, Tongyu Tang, Ming Yang, Beibei Xu, Qiang Wang, Yunjie Liu, Lijia Ma, Xiaolin Wang, Nan Zhang, Su Zhang, Wenyu Guo, Liang Huang, Stefan Schreiber, Minhu Chen
Summary: This study aimed to assess the effect of olamkicept as induction therapy in patients with active ulcerative colitis. The study found that biweekly intravenous infusion of 600 mg olamkicept was more likely to result in clinical response at 12 weeks compared with placebo. However, further research is needed to validate its long-term efficacy and safety.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Gastroenterology & Hepatology
Rirong Chen, Yizhe Tie, Xi Zhang, Li Li, Minhu Chen, Shenghong Zhang
Summary: This post-hoc analysis investigated whether fecal lactoferrin (FL) concentration could predict long-term therapeutic outcomes in patients with ulcerative colitis receiving biologics. The results showed that a high FL level at week 4 was associated with poor long-term clinical, endoscopic, and histologic outcomes. Additionally, FL concentration provided prognostic value in combination with fecal calprotectin and clinical/endoscopic scores. Furthermore, patients with FL concentration ≥20.1 μg/mL had a significantly higher risk of colectomy.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Yiwei Chen, Qiongdan Mai, Zixu Chen, Tao Lin, Yongjie Cai, Jing Han, Ying Wang, Mudan Zhang, Shimin Tan, Zhiying Wu, Lingming Chen, Zhiyi Zhang, Yi Yang, Taimei Cui, Beiyin Ouyang, Yue Sun, Lijia Yang, Lin Xu, Sien Zhang, Jian Li, Hongbo Shen, Linna Liu, Lingchan Zeng, Shenghong Zhang, Gucheng Zeng
Summary: The magnitude and diversity of gut microbiota and metabolic systems are essential in maintaining human health. This study demonstrates that intestinal dysbacteriosis, inflammation, and abnormal lipid metabolism contribute to the failure of anti-TNF-a therapy in inflammatory bowel disease (IBD) patients. Dietary supplementation of palmitoleic acid (POA) repairs the gut mucosal barriers, reduces inflammation, and improves the efficacy of anti-TNF-a therapy in mouse models. Mechanistically, POA selectively promotes the growth of Akkermansia muciniphila in the gut microbiota and reprograms its composition and structures.
Article
Immunology
Ying Wang, Xuanzhi Huang, Gaoshi Zhou, Jing Han, Zhuo Xie, Mudan Zhang, Xiaoling Li, Qi-rui Wu, Li Li, Ziyin Ye, Minhu Chen, Yun Qiu, Shenghong Zhang
Summary: This study aimed to generate nomograms for the prediction of treatment failures (TFs) in ulcerative colitis (UC) patients. Based on clinical features and mucus integrity, predictive nomograms for TFs were developed and evaluated for performance. These nomograms can serve as practical tools for identifying high-risk subgroups and facilitating timely intervention.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Cell Biology
Rirong Chen, Qia Chen, Jieqi Zheng, Zhirong Zeng, Minhu Chen, Li Li, Shenghong Zhang
Summary: Inflammatory bowel diseases (IBD) is a gastrointestinal inflammatory disease with alternating recurrence and remission. Serum amyloid A (SAA) plays a significant role in IBD through its involvement in immune-mediated inflammatory processes. SAA acts as a dual-function protein, stimulating pro-inflammatory cytokines and promoting pathogenic cell differentiation, while also assisting in lipid removal and tissue repair. Clinical studies have utilized SAA as a biomarker for diagnosis, disease activity assessment, and prognosis prediction in IBD. Additionally, a drug targeting SAA has shown promising anti-inflammatory effects in animal models, offering potential therapeutic options for IBD.
CELL DEATH DISCOVERY
(2023)
Editorial Material
Medicine, General & Internal
Yizhe Tie, Minhu Chen, Shenghong Zhang
CHINESE MEDICAL JOURNAL
(2023)
Review
Gastroenterology & Hepatology
Yizhe Tie, Yongle Huang, Rirong Chen, Li Li, Minhu Chen, Shenghong Zhang
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, and patients with IBD may also experience extra-intestinal manifestations (EIMs). This review discusses the potential involvement of the gut microbiota in the pathogenesis of EIMs, including impaired gut barrier, microbial translocation, molecular mimicry, dysregulation of microbiota-related metabolites, and activation of immunocytes and release of pro-inflammatory cytokines. The review also summarizes microbiota-related therapies for better management of IBD-associated EIMs.
Review
Cell Biology
Zhuo Xie, Gaoshi Zhou, Mudan Zhang, Jing Han, Ying Wang, Xiaoling Li, Qirui Wu, Manying Li, Shenghong Zhang
Summary: Inflammatory bowel diseases (IBDs) are chronic intestinal disorders characterized by relapsing inflammation, which can lead to colitis-associated colorectal cancer. Biologic agents targeting specific pathways in IBD pathogenesis have shown more success than conventional therapies. Bone morphogenetic proteins (BMPs) and BMP antagonists have been identified as promising candidates for IBD treatment. This review provides an updated overview on the involvement of BMPs and BMP antagonists in IBD pathogenesis and their role in regulating intestinal stem cells, highlighting potential therapeutic strategies.
CELL DEATH DISCOVERY
(2023)
Article
Gastroenterology & Hepatology
Rirong Chen, Chao Li, Kang Chao, Yizhe Tie, Jieqi Zheng, Huili Guo, Zhirong Zeng, Li Li, Minhu Chen, Shenghong Zhang
Summary: This retrospective cohort study investigated the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in Crohn's disease (CD) patients with isolated anastomotic lesions (iAL). The results showed that NLR > 2.45 was an independent risk factor for clinical recurrence, and a risk score based on NLR and age at surgery could further stratify patients. These findings suggest that NLR may be a promising prognostic biomarker for CD patients with iAL, and the utilization of NLR and the risk score can facilitate personalized management.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Liguo Zhu, Zhuo Xie, Guang Yang, Gaoshi Zhou, Li Li, Shenghong Zhang
Summary: This study found that STC1 is upregulated in Crohn's disease patients and chemically-induced mice colitis models. Intestinal-specific Stc1 knockout mice showed resistance to DSS-induced colitis. STC1 mediates oxidative stress-associated parthanatos and aggravates inflammation via the STC1-PARP1-JNK interactions and subsequent JNK pathway activation.
Article
Gastroenterology & Hepatology
Gaoshi Zhou, Rirong Chen, Yueyun Jiang, Li Li, Jieqi Zheng, Chao Li, Shenghong Zhang, Minhu Chen
Summary: This study developed and validated a diagnostic model based on non-invasive biomarkers to identify endoscopic recurrence in patients with Crohn's disease. The diagnostic model demonstrated good predictive ability and calibration.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
