Review
Biochemistry & Molecular Biology
Carmine Stolfi, Teresa Pacifico, Anderson Luiz-Ferreira, Giovanni Monteleone, Federica Laudisi
Summary: Despite recent advances in treatment approaches, cancer remains a major cause of death worldwide. The restoration of tumor immune surveillance has shown promising results in overcoming resistance to conventional therapies and improving the clinical management of advanced disease. However, only a fraction of patients benefits from cancer immunotherapy, due to mechanisms that allow tumors to escape immune surveillance. Research on drug repositioning has suggested that anthelmintic drugs, in addition to their antineoplastic effects, have significant immunomodulatory actions on specific subsets of immune cells and pathways. This review examines the impact of anthelmintic drugs on host immunity and their potential implications in cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Estevao Brasiliense de Souza, Aguinaldo Roberto Pinto, Gislaine Fongaro
Summary: Bacteriophages, as bacteria-specific viruses, have shown promise in countering bacterial resistance and directly affecting bacterial behavior. Further investigations are needed to understand the interactions between bacteriophages and eukaryotic cells, as they have potential clinical applications.
Article
Oncology
Dali Tong
Summary: In this review, the roles of estrogen and estrogen receptors in prostate cancer and the tumor immune microenvironment were examined. The potential use of selective estrogen receptor modulators in combination with immunotherapy for prostate cancer treatment was proposed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Microbiology
Eric Russ, Sergey Iordanskiy
Summary: Endogenous retroviruses (ERVs) are highly prevalent in mammalian genomes and have important biological functions in the innate immune response. Human ERVs (HERVs) account for approximately 8.3% of the genome and can be induced under certain stresses, leading to the accumulation of viral transcripts and functional viral components. This review explores the implications of HERVs in innate immunity and their association with various pathological diseases.
Review
Biochemistry & Molecular Biology
Myriam Catalano, Carmela Serpe, Cristina Limatola
Summary: Microglial-derived extracellular vesicles (EVs) play important roles in glioblastoma, contributing to tumor growth and invasion by modifying cellular phenotype and activity. These EVs may serve as important diagnostic markers and therapeutic targets, but further research is needed to fully understand their biological effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mohamed O. Radwan, Sultan F. Kadasah, Salha M. Aljubiri, Abdulmajeed F. Alrefaei, Mahmoud H. El-Maghrabey, Mohamed A. El Hamd, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita
Summary: In this review, the modulation of metabolic nuclear receptors by oleanolic acid (OA) and its semi-synthetic derivatives is highlighted. OA exhibits tissue-specific pharmacological effects on various nuclear receptors, showing potential therapeutic applications in metabolic diseases.
Article
Biochemistry & Molecular Biology
Anton De Spiegeleer, Amelie Descamps, Srinath Govindarajan, Julie Coudenys, Kevin van der Borght, Hannah Hirmz, Nele van den Noortgate, Dirk Elewaut, Bart De Spiegeleer, Evelien Wynendaele
Summary: This study discovered the potential of quorum-sensing peptides to modulate the immune system in microbiome-host interactions. Through screening 89 peptides, four of them were found to activate immune cells in vitro, and one of them was detected in human plasma. These findings are biologically significant and reveal the immunomodulatory potential of quorum-sensing peptides.
Article
Chemistry, Medicinal
Gyorgy Szabo, Oliver Elias, Peter Erdelyi, Attila Potor, Gyorgy I. . Turos, Benedek I. Karolyi, Gabor Varro, Agnes Gy. Vasko, Imre Bata, Gabor L. Kapus, Zoltan Dohanyos, Amrita A. . Bobok, Laszlo Fodor, Marta Than, Monika Vastag, Zsolt Komlodi, Soukupne Rita E. Kedves, Eva Mako, Brigitta Suveges, Greiner Istvan
Summary: This study discloses the discovery and characterization of novel naphthyridine derivatives with selective alpha 5-GABA(A)R negative allosteric modulator (NAM) activity. By utilizing a scaffold-hopping strategy, fused [6 + 6] bicyclic scaffolds were designed and synthesized. Among these, 1,6-naphthyridinones were identified as potent and selective alpha 5-GABA(A)R NAMs with improved profile. Compound 20, with the most balanced profile, demonstrated in vivo proof of concept (POC) for the new scaffold in animal models of cognitive impairment associated with schizophrenia (CIAS).
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Polymer Science
Emma J. Murphy, Gustavo Waltzer Fehrenbach, Ismin Zainol Abidin, Ciara Buckley, Therese Montgomery, Robert Pogue, Patrick Murray, Ian Major, Emanuele Rezoagli
Summary: The prevention and treatment of diseases require effective functioning immune systems, which can be achieved by eliminating infections and abnormal cells. Immune or biological therapy can stimulate or inhibit the immune system depending on the circumstances. Polysaccharides, abundant biomacromolecules in plants, animals, and microbes, interact with and affect the immune response, playing a crucial role in treating various human illnesses. There is an urgent need to identify natural biomolecules that can prevent infection and treat chronic diseases. This article discusses the therapeutic potential of naturally occurring polysaccharides, extraction methods, and immunological modulatory capabilities.
Review
Immunology
Nathan Calzadilla, Shane M. M. Comiskey, Pradeep K. K. Dudeja, Seema Saksena, Ravinder K. K. Gill, Waddah A. A. Alrefai
Summary: Bile acids play a critical role in lipid and fat-soluble vitamin digestion and absorption, but they also act as signaling molecules. Disturbances in bile acid homeostasis can contribute to the development of Inflammatory Bowel Diseases (IBD). Studies have shown that different bile acids have different effects on the inflammatory response and intestinal permeability, suggesting a potential link between bile acid changes and the development of IBD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Marina Lasa, Constanza Contreras-Jurado
Summary: The reciprocal interaction between the endocrine and immune systems is well documented, but the connection between the immune system and thyroid hormones is still unclear. This review highlights the importance of thyroid hormones in the molecular mechanisms of inflammation, particularly in various infectious and/or pathological processes. The findings suggest potential opportunities for improving therapeutic strategies for inflammation associated with infections and diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Plant Sciences
Nova Syafni, Maria Teresa Faleschini, Aleksandra Garifulina, Ombeline Danton, Mahabir P. Gupta, Steffen Hering, Matthias Hamburger
Summary: Compounds isolated from Casearia corymbosa leaves showed allosteric potentiation of the GABA signal in GABAA receptors. The activity was confirmed through cell-based assays and voltage clamp studies.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Giulia Miglietta, Marco Russo, Renee C. Duardo, Giovanni Capranico
Summary: The study found that two unrelated G4 ligands can significantly activate innate immune genes at non-cytotoxic concentrations, triggering the activation of cytoplasmic STING signaling pathway and leading to an increase in micronuclei. Ligand activity can also induce type I interferon production and activation of innate immune genes.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Immunology
Qifeng Ou, Rachael Power, Matthew D. Griffin
Summary: Regulatory T cells (Treg) play a critical role in maintaining immune homeostasis and have direct modulatory effects on innate immune responses in various acute and chronic diseases. Therapeutic interventions aimed at enhancing Treg numbers or potency show promising outcomes in autoimmunity and allogeneic transplants. Furthermore, interactions between Treg and innate immune effectors significantly impact disease severity and treatment. Treg-based therapeutic strategies hold potential for globally impactful inflammatory conditions such as type 2 diabetes, ischemia reperfusion injury, and atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Xi Zhou, Qing Ye
Summary: The severity of COVID-19 is mainly related to host factors, especially cellular immune responses in patients. Treatment recommendations are tailored based on the dynamics of immune responses, including administering appropriate medications at different stages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mallika Ghosh, Jaganathan Subramani, M. Mamunur Rahman, Linda H. Shapiro
JOURNAL OF IMMUNOLOGY
(2015)
Article
Peripheral Vascular Disease
Rebecca E. Conway, Camilo Rojas, Jesse Alt, Zora Novakova, Spencer M. Richardson, Tori C. Rodrick, Julio L. Fuentes, Noah H. Richardson, Jonathan Attalla, Samantha Stewart, Beshoy Fahmy, Cyril Barinka, Mallika Ghosh, Linda H. Shapiro, Barbara S. Slusher
Article
Cardiac & Cardiovascular Systems
Flavia E. Pereira, Chunxia Cronin, Mallika Ghosh, Si-Yuan Zhou, Mariela Agosto, Jaganathan Subramani, Ruibo Wang, Jian-Bing Shen, Wolfgang Schacke, Brannen Liang, Tie Hong Yang, Beata McAulliffe, Bruce T. Liang, Linda H. Shapiro
CARDIOVASCULAR RESEARCH
(2013)
Article
Immunology
Mallika Ghosh, Claire Gerber, M. Mamunur Rahman, Kaitlyn M. Vernier, Flavia E. Pereira, Jaganathan Subramani, Leslie A. Caromile, Linda H. Shapiro
Article
Biochemistry & Molecular Biology
Cheryl Habrukowich, David K. Han, Andrew Le, Karim Rezaul, Wei Pan, Mallika Ghosh, Zaiguo Li, Kimberly Dodge-Kafka, Xuejun Jiang, Robert Bittman, Timothy Hla
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Sung-Hee Chang, Yi-Chien Lu, Xi Li, Wan-Ying Hsieh, Yuquan Xiong, Mallika Ghosh, Todd Evans, Olivier Elemento, Timothy Hla
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Medicine, Research & Experimental
Mallika Ghosh, Hector Leonardo Aguila, Jason Michaud, Youxi Ai, Ming-Tao Wu, Annabrita Hemmes, Ari Ristimaki, Caiying Guo, Henry Furneaux, Timothy Hla
JOURNAL OF CLINICAL INVESTIGATION
(2009)
Article
Immunology
Mallika Ghosh, Beata McAuliffe, Jaganathan Subramani, Sreyashi Basu, Linda H. Shapiro
JOURNAL OF IMMUNOLOGY
(2012)
Article
Immunology
Jaganathan Subramani, Mallika Ghosh, M. Mamunur Rahman, Leslie A. Caromile, Claire Gerber, Karim Rezaul, David K. Han, Linda H. Shapiro
JOURNAL OF IMMUNOLOGY
(2013)
Article
Cell & Tissue Engineering
M. Mamunur Rahman, Mallika Ghosh, Jaganathan Subramani, Guo-Hua Fong, Morgan E. Carlson, Linda H. Shapiro
Article
Physiology
M. Mamunur Rahman, Jaganathan Subramani, Mallika Ghosh, Jiyeon K. Denninger, Kotaro Takeda, Guo-Hua Fong, Morgan E. Carlson, Linda H. Shapiro
FRONTIERS IN PHYSIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Mallika Ghosh, Robin Lo, Ivan Ivic, Brian Aguilera, Veneta Qendro, Charan Devarakonda, Linda H. Shapiro
Article
Cell Biology
Feria A. Ladha, Ketan Thakar, Anthony M. Pettinato, Nicholas Legere, Shahnaz Ghahremani, Rachel Cohn, Robert Romano, Emily Meredith, Yu-Sheng Chen, J. Travis Hinson
Summary: This study used CRISPR, pluripotent stem cells, and BioID to study actinin interactomes in human cardiomyocytes, identifying 324 actinin proximity partners and revealing a network of RNA-binding proteins with RNA localization functions. The research uncovered the role of IGF2BP2 in metabolic adaptation and its crosstalk with sarcomeres, further expanding the functional knowledge of actinin and uncovering potential implications for human disease.