Article
Oncology
Chen Wang, Xiangfeng Meng, Yu Zhou, Jing Yu, Qing Li, Zhicong Liao, Yuanyuan Gu, Jiayi Han, Shuo Linghu, Zichen Jiao, Tao Wang, Chen-Yu Zhang, Xi Chen
Summary: A novel lncRNA, CTD-2245E15.3, has been identified to promote lung tumorigenesis by regulating key metabolic enzymes, ACC1 and PC.
Review
Gastroenterology & Hepatology
Renate A. A. A. Ruigrok, Rinse K. Weersma, Arnau Vich Vila
Summary: The review highlights the importance of studying the microbial communities in the small intestine, which has been largely overlooked compared to the fecal microbiota. It provides an overview of methods for studying the composition and dynamics of the small intestinal microbiota and discusses its role in maintaining physiological functions and the development of diseases. Understanding and characterizing the small intestinal microbiota has the potential to advance gut microbiome research and the development of diagnostic and therapeutic approaches for diseases.
Review
Gastroenterology & Hepatology
Vicente Arroyo, Paolo Angeli, Richard Moreau, Rajiv Jalan, Joan Claria, Jonel Trebicka, Javier Fernandez, Thierry Gustot, Paolo Caraceni, Mauro Bernardi
Summary: Systemic inflammation may be a key feature of acute decompensation of cirrhosis, affecting organ system function through various mechanisms and working synergistically with traditional pathways to contribute to the development of AD. It can exacerbate splanchnic vasodilation by overactivating the endogenous vasoconstrictor systems, leading to hypoperfusion in certain vascular beds such as the renal circulation. Additionally, systemic inflammation may cause immune-mediated tissue damage and induce significant metabolic changes.
JOURNAL OF HEPATOLOGY
(2021)
Article
Medicine, Research & Experimental
Nneka Southwell, Guido Primiano, Viraj Nadkarni, Nabeel Attarwala, Emelie Beattie, Dawson Miller, Sumaitaah Alam, Irene Liparulo, Yevgeniya Shurubor, Maria Lucia Valentino, Valerio Carelli, Serenella Servidei, Steven S. Gross, Giovanni Manfredi, Qiuying Chen, Marilena D'Aurelio
Summary: Mitochondrial diseases are a group of disorders caused by impaired oxidative phosphorylation, which often affects skeletal muscle due to its high energy dependency. However, the metabolic drivers of muscle degeneration in these diseases are not well understood, leading to a lack of effective treatments. This study identifies systemic metabolic mechanisms underlying mitochondrial myopathies and potential new targets for intervention.
EMBO MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jing Zhang, Jia-Yi Qian, Yue-Hong Bian, Xiao Liu, Chun-Lei Wang
Summary: This study analyzed the transcriptome profiles of pear seeds during cold stratification, revealing the crucial role of hormones, carbohydrate metabolism, transcription factors, and lipid metabolism in the release of pear seed dormancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kiran Hasygar, Onur Deniz, Ying Liu, Josef Gullmets, Riikka Hynynen, Hanna Ruhanen, Krista Kokki, Reijo Kakela, Ville Hietakangas
Summary: Energy storage and growth in animals are coordinated in response to nutrient status, with nutrient-regulated signaling pathways controlling these processes. ERK7 has been identified as an atypical MAP kinase inhibitor of adiposity and growth in Drosophila, with its mutant larvae showing increased lipid stores and accelerated growth. Moreover, ERK7 expression is elevated during fasting conditions, and ERK7 mutant larvae display impaired survival during nutrient deprivation.
Review
Biochemistry & Molecular Biology
Jordi Badia-Ramentol, Jenniffer Linares, Andrea Gomez-Llonin, Alexandre Calon
Summary: The progression from localized cancer to metastatic disease involves cancer cells spreading through the bloodstream to distant organs. Metastases originate from circulating tumor cells capable of surviving and extravasating into distant tissue, which may enter a state of dormancy. Cancer dormancy, associated with minimal residual disease, is a reversible condition that can persist for years and is linked to poor prognosis in all cancers.
Article
Biology
Roberto F. Nespolo, Carlos Mejias, Francisco Bozinovic
Summary: This study estimated the relationship between daily energy expenditure of hibernation (DEEH) and body mass. The results showed that DEEH scales isometrically with mass, meaning that hibernating animals have similar metabolism regardless of their body size. Additionally, the study found the minimum mass where energy savings by hibernation are zero.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Orthopedics
Zhenglin Zhu, Yi Chen, Jing Zou, Shengqiang Gao, Dandong Wu, Xuelun Li, Ning Hu, Jinzhong Zhao, Wei Huang, Hong Chen
Summary: This study investigated whether lactate mediates the beneficial effects of high-intensity interval training (HIIT) on bone density, microarchitecture, and biomechanical properties. The findings suggest that lactate may have mediated the bone anabolic effect of HIIT in osteoporotic mice, potentially through enhanced osteoblast differentiation and mineralization.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Biochemistry & Molecular Biology
Quentin de Roux, Fanny Lidouren, Agathe Kudela, Lina Slassi, Matthias Kohlhauer, Emilie Boissady, Matthieu Chalopin, Geraldine Farjot, Catherine Billoet, Patrick Bruneval, Bijan Ghaleh, Nicolas Mongardon, Renaud Tissier
Summary: The inhalation of argon and administration of the HMGB1 inhibitor glycyrrhizin both attenuated multiorgan failure after experimental aortic cross-clamping, leading to improved cardiac output, ameliorated metabolic acidosis, reduced norepinephrine requirement, decreased interleukin-6 and HMGB1 plasma concentration, as well as alleviated end-organ damages in the liver and kidney. Argon inhalation was able to reduce HMGB1 blood levels after aortic cross-clamping and provided similar benefits to direct HMGB1 inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Horticulture
Jose A. Hernandez, Pedro Diaz-Vivancos, Gema Martinez-Sanchez, Nuria Alburquerque, Domingo Martinez, Gregorio Barba-Espin, Jose Ramon Acosta-Motos, Esther Carrera, Jesus Garcia-Brunton
Summary: The study identified interactions among starch, sugars, plant hormones, and antioxidant enzymes during bud dormancy release in a low chill peach variety. The changes in abscisic acid and bioactive gibberellins levels were closely related to dormancy release, with a decrease in ABA/GAs ratio being a key factor. Additionally, glucose levels correlated with chill accumulation, peak at ecodormancy and dormancy release, accompanied by increases in antioxidant enzymes.
SCIENTIA HORTICULTURAE
(2021)
Review
Microbiology
Michael Hemkemeyer, Sanja A. Schwalb, Stefanie Heinze, Rainer Georg Joergensen, Florian Wichern
Summary: While research has primarily focused on the cycling of carbon, nitrogen, and phosphorus in soil microbial communities, it is known that other elements play a significant role in microbial functioning. This knowledge has yet to be fully synthesized for soil microorganisms.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Anna Katarzyna Wronska, Agata Kaczmarek, Justyna Sobich, Sylwia Grzelak, Mieczyslawa Irena Bogus
Summary: Invertebrates are increasingly used for studying the immune system, as their innate immunity shows similarity to mammals. This study aimed to develop a protocol for detecting cytokines in Galleria mellonella larvae hemocytes using flow cytometry. The study successfully developed a reproducible protocol by optimizing various steps, which will facilitate further immunological research using insect cells.
Article
Multidisciplinary Sciences
Zehan Hu, Chenlu Zhang, Luis Sifuentes-Dominguez, Christina M. Zarek, Daniel C. Propheter, Zheng Kuang, Yuhao Wang, Mihir Pendse, Kelly A. Ruhn, Brian Hassell, Cassie L. Behrendt, Bo Zhang, Prithvi Raj, Tamia A. Harris-Tryon, Tiffany A. Reese, Lora Hooper
Summary: SPRR2A is an intestinal antibacterial protein that selectively kills Gram-positive bacteria by disrupting their membranes. It shapes the composition of intestinal microbiota, restricts bacterial association with the intestinal surface, and protects against Listeria monocytogenes infection. Additionally, SPRR2A is induced by type 2 cytokines during helminth infection and protects against bacterial invasion of intestinal tissue during this process.
Article
Plant Sciences
Yue Wang, Tao Liu, Changjian Ma, Guoqing Li, Xinhong Wang, Jianghui Wang, Jin Chang, Cong Guan, Huimin Yao, Xuehui Dong
Summary: Starch and sucrose showed opposing trends during dormancy release in P. kingianum rhizome bud, while galactose and raffinose increased. Glucose, cellulose, mannose, arabinose, rhamnose, and stachyose exhibited various changes. The metabolism of carbohydrates may shift from anaerobic oxidation to the tricarboxylic acid cycle and pentose phosphate pathway during dormancy release. Gene co-expression analysis indicated interactions between sugar and hormone signaling pathways in the regulatory network of dormancy release in P. kingianum rhizome buds.
Article
Gastroenterology & Hepatology
Cristina Lopez-Vicario, David Sebastian, Mireia Casulleras, Marta Duran-Guell, Roger Flores-Costa, Ferran Aguilar, Juan Jose Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Claria
Summary: In this study, the researchers investigated the effect of changes in essential fatty acid-derived lipid autacoids on hepatocyte mitochondrial bioenergetics and metabolic efficiency. They found that transgenic mice with altered fatty acid composition exhibited improved mitochondrial function, including enhanced oxygen consumption rate and fatty acid beta-oxidation. These mice also had a higher content of specific lipid autacoids, which rescued hepatocytes from mitochondrial dysfunction induced by TNFa. Furthermore, the transgenic mice were protected against mitochondrial injury caused by obesogenic and fibrogenic insults. These findings highlight the importance of a lipid membrane composition rich in specific fatty acids and its derivatives for optimal hepatic mitochondrial and metabolic efficiency.
Article
Gastroenterology & Hepatology
Giacomo Zaccherini, Maurizio Baldassarre, Manuel Tufoni, Silvia Nardelli, Salvatore Piano, Carlo Alessandria, Sergio Neri, Francesco Giuseppe Foschi, Fabio Levantesi, Giorgio Bedogni, Marco Domenicali, Mauro Bernardi, Paolo Caraceni
Summary: This study assessed the impact of long-term albumin administration on hyponatremic patients with ascites enrolled in the ANSWER trial. The normalization rate of baseline hyponatremia and the 18-month incidence rate of at least moderate hyponatremia were evaluated. The results showed that albumin treatment had a higher hyponatremia normalization rate compared to standard medical treatment (45% vs 28%, P = 0.042 at 1 month). Long-term albumin administration ensured a lower incidence of at least moderate hyponatremia than standard medical treatment (incidence rate ratio: 0.245 [CI 0.167-0.359], P < 0.001).
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Alberto Queiroz Farias, Anna Curto Vilalta, Patricia Momoyo Zitelli, Gustavo Pereira, Luciana L. Goncalves, Aldo Torre, Juan Manuel Diaz, Adrian C. Gadano, Angelo Z. Mattos, Liliana S. C. Mendes, Mario R. Alvares-da-Silva, Paulo L. Bittencourt, Carlos Benitez, Claudia Alves Couto, Manuel Mendizabal, Claudio L. Toledo, Daniel F. C. Mazo, Mauricio Castillo Barradas, Eva M. Uson Raposo, P. Martin Padilla-Machaca, Adelina Zarela Lozano Miranda, Rene Male-Velazquez, Andre Castro Lyra, Milagros B. Davalos-Moscol, Jose L. Perez Hernandez, Rafael O. Ximenes, Giovanni Faria Silva, Oscar A. Beltran-Galvis, Maria S. Gonzalez Huezo, Fernando Bessone, Tarciso D. S. Rocha, Eduardo Fassio, Carlos Terra, Juan I. Marin, Patricia Sierra Casas, Carlos de la Pena-Ramirez, Ferran Aguilar Parera, Flavia Fernandes, Maria da Penha Zago-Gomes, Osvely Mendez-Guerrero, Sebastian Marciano, Angelo A. Mattos, Joao C. Oliveira, Gabriel T. S. Guerreiro, Liana Codes, Marco Arrese, Mateus J. Nardelli, Marcelo O. Silva, Renato Palma-Fernandez, Camila Alcantara, Cristina Sanchez Garrido, Jonel Trebicka, Thierry Gustot, Javier Fernandez, Joan Claria, Rajiv Jalan, Paolo Angeli, Vicente Arroyo, Richard Moreau, ACLARA Study Collaborators
Summary: This study investigated the association of genetic ancestry and race with acute-on chronic liver failure (ACLF). The results showed that Latin American patients with higher Native American genetic ancestry and Native American race were more likely to develop ACLF. This suggests that genetic ancestry and race may be associated with the risk of ACLF.
Article
Gastroenterology & Hepatology
Emmanuel Weiss, Carlos de la Pena-Ramirez, Ferran Aguilar, Juan-Jose Lozano, Cristina Sanchez-Garrido, Patricia Sierra, Pedro Izquierdo-Bueno Martin, Juan Manuel Diaz, Francois Fenaille, Florence A. Castelli, Thierry Gustot, Wim Laleman, Agustin Albillos, Carlo Alessandria, Marco Domenicali, Paolo Caraceni, Salvatore Piano, Faouzi Saliba, Stefan Zeuzem, Alexander L. Gerbes, Julia A. Wendon, Christian Jansen, Wenyi Gu, Maria Papp, Raj Mookerjee, Carmine Gabriele Gambino, Cesar Jimenez, Ilaria Giovo, Giacomo Zaccherini, Manuela Merli, Antonella Putignano, Frank Erhard Uschner, Thomas Berg, Tony Bruns, Christian Trautwein, Alexander Zipprich, Rafael Banares, Jose Presa, Joan Genesca, Victor Vargas, Javier Fernandez, Mauro Bernardi, Paolo Angeli, Rajiv Jalan, Joan Claria, Christophe Junot, Richard Moreau, Jonel Trebicka, Vicente Arroyo
Summary: This study aimed to identify metabolites associated with short-term death in patients with acutely decompensated cirrhosis and design metabolomic prognostic models. Three prognostic metabolites strongly associated with death were selected and two models were built, which were found to be more accurate in predicting death within 7, 14, and 28 days compared to traditional scoring systems.
Article
Gastroenterology & Hepatology
European Assoc Study Liver, Richard Moreau, Marta Tonon, Aleksander Krag, Paolo Angeli, Marina Berenguer, Annalisa Berzigotti, Javier Fernandez, Claire Francoz, Thierry Gustot, Rajiv Jalan, Maria Papp, Jonel Trebicka
Summary: Acute-on-chronic liver failure (ACLF) is a severe form of acutely decompensated cirrhosis characterized by organ system failure(s) and high short-term mortality. Patients with ACLF may benefit from liver transplantation and should be promptly stabilized for transplantation by treating identified precipitants and providing intensive care support. These guidelines aim to help clinicians recognize ACLF, make triage decisions, manage acute precipitants, support organ systems, determine futility of intensive care, and identify potential indications for liver transplantation.
JOURNAL OF HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Giulia Iannone, Enrico Pompili, Matteo Renzulli, Paolo Caraceni
Summary: Peri-stomal variceal bleeding is a complication that is often overlooked in patients with colostomy and portal hypertension. The optimal treatment for this condition is still a matter of debate due to the limited number of reported cases. In this report, we present a case in which TIPS placement proved to be effective.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Joan Claria, Vicente Arroyo, Richard Moreau
Summary: Acute-on-chronic liver failure (ACLF) is the most severe form of acutely decompensated cirrhosis and is characterized by intense systemic inflammation and various mechanisms that lead to organ failures, including vasodilation, neutrophil migration, microthrombi formation, hepatic encephalopathy, and energy competition.
Article
Gastroenterology & Hepatology
Enrico Pompili, Maurizio Baldassarre, Giorgio Bedogni, Giacomo Zaccherini, Giulia Iannone, Clara De Venuto, Dario Pratelli, Francesco Palmese, Marco Domenicali, Paolo Caraceni
Summary: The PREDICT study found that acutely decompensated patients with cirrhosis can have three different clinical trajectories: pre-ACLF, unstable decompensated cirrhosis (UDC), and stable decompensated cirrhosis (SDC). This study aimed to validate these trajectories and identify predictors for each trajectory.
LIVER INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Ruben Hernaez, Hai Li, Richard Moreau, Minneke J. Coenraad
Summary: This narrative review discusses the definition of acute-on-chronic liver failure, its association with high short-term mortality in patients with chronic liver disease and/or cirrhosis, and the differences in definitions between the East and the West. Despite the variations, all definitions have clinical utility and serve different purposes. The review also provides epidemiological data to illustrate how these definitions apply in different regions.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Gautam Mehta, Antonio Riva, Maria Pilar Ballester, Eva Uson, Montserrat Pujadas, Angela Carvalho-Gomes, Ivan Sahuco, Ariadna Bono, Federico D'Amico, Raffaela Vigano, Elena Diago, Beatriz Tormo Lanseros, Elvira Inglese, Dani Martinez Vazquez, Rajni Sharma, Hio Lam Phoebe Tsou, Nicola Harris, Annelotte Broekhoven, Marjolein Kikkert, Shessy P. Torres Morales, Sebenzile K. Myeni, Mar Riveiro-Barciela, Adriana Palom, Nicola Zeni, Alessandra Brocca, Annarosa Cussigh, Sara Cmet, Desamparados Escudero-Garcia, Matteo Stocco, Leonardo Antonio Natola, Donatella Ieluzzi, Veronica Paon, Angelo Sangiovanni, Elisa Farina, Clara di Benedetto, Yolanda Sanchez-Torrijos, Ana Lucena-Varela, Eva Roman, Elisabet Sanchez, Ruben Sanchez-Aldehuelo, Julia Lopez-Cardona, Itzel Canas-Perez, Christine Eastgate, Dhaarica Jeyanesan, Alejandro Esquivel Morocho, Simone Di Cola, Lucia Lapenna, Giacomo Zaccherini, Deborah Bongiovanni, Paola Zanaga, Katia Sayaf, Sabir Hossain, Javier Crespo, Mercedes Robles-Diaz, Antonio Madejon, Helena Degroote, Javier Fernandez, Marko Korenjak, Xavier Verhelst, Javier Garcia-Samaniego, Raul J. Andrade, Paula Iruzubieta, Gavin Wright, Paolo Caraceni, Manuela Merli, Vishal C. Patel, Amir Gander, Agustin Albillos, German Soriano, Maria Francesca Donato, David Sacerdoti, Pierluigi Toniutto, Maria Buti, Christophe Duvoux, Paolo Antonio Grossi, Thomas Berg, Wojciech G. Polak, Massimo Puoti, Anna Bosch-Comas, Luca Belli, Patrizia Burra, Francesco Paolo Russo, Minneke Coenraad, Jose Luis Calleja, Giovanni Perricone, Marina Berenguer, Joan Claria, Richard Moreau, Vicente Arroyo, Paolo Angeli, Cristina Sanchez, Javier Ampuero, Salvatore Piano, Shilpa Chokshi, Rajiv Jalan
Summary: This study aimed to measure humoral responses to COVID-19 vaccine among liver patients and determine the factors predicting breakthrough infection. The results showed that liver transplant patients had the lowest response to the vaccine, while reduced response in cirrhosis patients was associated with age, stage of liver disease, and systemic inflammation.
HEPATOLOGY COMMUNICATIONS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Giulia Iannone, Clara De Venuto, Salvatore Piano, Antonino Lombardo, Davide Bitetto, Stefania Gioia, Giacomo Zaccherini, Roberta Gagliardi, Vincenza Calvaruso, Enrico Pompili, Marta Tonon, Maurizio Baldassarre, Silvia Nardelli, Pierluigi Toniutto, Vito Di Marco, Paolo Angeli, Paolo Caraceni
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Wim Laleman, Jonel Trebicka, Giacomo Zaccherini, Paolo Caraceni, Dirk Steffen Schmidt, Joana Rodrigues, Kyle Rodney, Sofia Schweiger, Paolo Angeli
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Enrico Pompili, Maurizio Baldassarre, Giorgio Bedogni, Giacomo Zaccherini, Giulia Iannone, Clara De Venuto, Francesco Palmese, Manuel Tufoni, Marco Domenicali, Paolo Caraceni
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Elisa Pose, Cesar Jimenez, Giacomo Zaccherini, Daniela Campion, Salvatore Piano, Frank Erhard Uschner, Koos de Wit, Olivier Roux, Kohilan Gananandan, Wim Laleman, Cristina Sole, Sonia Alonso, Berta Cuyas, Xavier Ariza, Adria Juanola, Ann T. Ma, Laura Napoleone, Jordi Gratacos, Marta Tonon, Enrico Pompili, Jordi Sanchez-Delgado, Marta Carol, Martina Perez, Nuria Fabrellas, Judit Pich, Claudia Martell, Georgina Casanovas, Gemma Domenech, Ferran Torres, Victor Manuel, Vargas Blasco, Paolo Caraceni, Carlo Alessandria, Paolo Angeli, Jonel Trebicka, Ulrich Beuers, Claire Francoz, Raj Mookerjee, Rafael Banares, German Soriano, Ruben Hernaez, Andrew S. Allegretti, Manuel Morales-Ruiz, Miquel Serra, Hugh Watson, Juan G. Abraldes, Patrick S. Kamath, Pere Gines
JOURNAL OF HEPATOLOGY
(2023)