Article
Biochemistry & Molecular Biology
Tingyan Chen, Yilin Zheng, Yu Gao, Haijun Chen
Summary: A NIR-II heptamethine cyanine dye 4 with improved photostability and photothermal properties has been synthesized, showing potential for further photo-therapeutic applications.
BIOORGANIC CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Haoran Shi, Xiao Tan, Ping Wang, Jieling Qin
Summary: A newly designed near-infrared trifluoromethyl-heptamethine cyanine (TFHC) dye was synthesized, which can serve as a mitochondrial-targeting sonosensitizer for sonodynamic therapy and a photothermal therapy agent for photothermal therapy. TFHC has good biocompatibility and can efficiently kill cancer cells under near-infrared and ultrasound irradiation without significant side effects.
MATERIALS TODAY ADVANCES
(2022)
Article
Engineering, Environmental
Zhuang Hu, Ruihan Li, Xinyue Cui, Changjun Hu, Zilin Chen
Summary: This study reports the development of a tridentate molecular probe called PROTAC-Cy7, which integrates a warhead that binds to MCL-1, the E3 ligase ligand pomalidomide, and a heptamethine cyanine linker into the same scaffold. Bovine serum albumin nanoparticles (NPs) were used to manufacture water-insoluble PROTAC-Cy7. These NPs demonstrated tumor targeting and efficient degradation of MCL-1 through specific binding to MCL-1 receptors. Moreover, PROTAC-Cy7@BSA NPs showed excellent performance in near-infrared-II (NIR-II) noninvasive biomedical vascular imaging and tumor resection guided by intraoperative real-time imaging, as well as synergistic Chemo-Phototherapy with high tumor suppression.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Jianv Wang, Hongye Liao, Jieming Ban, Sen Li, Xia Xiong, Qingqing He, Xinyu Shi, Hongping Shen, Sijin Yang, Changzhen Sun, Li Liu
Summary: In this study, a new near-infrared dye called IR-817 was combined with bovine serum albumin (BSA) to create BSA@IR-817 nanoparticles. The nanoparticles showed improved water solubility, stability, and potential for tumor imaging and photothermal therapy. In addition, in vitro and in vivo experiments demonstrated its strong therapeutic effect on melanoma without significant toxicity.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hiroki Masuoka, Yasuhiro Kubota, Toshiyasu Inuzuka, Kazumasa Funabiki
Summary: A new anionic heptamethine cyanine (HMC) dye with two trifluoromethyl groups has been synthesized, which selectively absorbs near-infrared light. Compared with previously studied anionic HMC dyes with substituents such as methyl, phenyl, and pentafluorophenyl groups, the trifluoromethylated dye exhibits a red-shifted maximum absorption wavelength (e.g. 948 nm in CH2Cl2) and enhanced photostability. Furthermore, HMC dyes with broad absorption in the near-infrared region are synthesized by combining a trifluoromethylated anionic HMC dye with a cationic HMC dye as a counterion.
Review
Nanoscience & Nanotechnology
Yue Qiu, Bo Yuan, Yi Cao, Xuelu He, Ozioma Udochukwu Akakuru, Liheng Lu, Nengwen Chen, Mengting Xu, Aiguo Wu, Juan Li
Summary: Recently, near-infrared fluorescence heptamethine cyanine dyes have shown significant value in cancer diagnosis and treatment due to their excellent fluorescence property and biocompatibility. Diverse structures and chemical properties of heptamethine cyanine dyes have been designed to develop novel functional molecules and nanoparticles, presenting great promise in photodynamic and/or photothermal cancer therapies. This review provides a comprehensive scope of the structures, comparisons, and applications of heptamethine cyanine dyes-based molecules and nanoparticles in tumor treatment and imaging.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Deanna Broadwater, Hyllana C. D. Medeiros, Matthew Bates, Amir Roshanzadeh, Shao Thing Teoh, Martin P. Ogrodzinski, Babak Borhan, Richard R. Lunt, Sophia Y. Lunt
Summary: Photodynamic therapy (PDT), which combines photoactive agents and light, has the potential to enhance cancer treatment by providing dual selectivity. However, current limitations of PDT, such as low tissue penetration and insufficient phototoxicity, can hinder its effectiveness. In this study, researchers developed a platform that can modulate the properties of photoactive ions, and demonstrated its utility in vivo using a mouse model of breast cancer. By pairing a near-infrared (NIR) photoactive cation with specific counterions, the researchers successfully generated a selectively phototoxic photosensitizer that inhibits tumor growth with minimal side effects. This work provides a proof of concept for improving cancer photosensitizers using the counterion pairing platform.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Medicinal
Shaohui Zhang, Xin Ji, Rong Zhang, Weili Zhao, Xiaochun Dong
Summary: The near-infrared fluorescent heptamethylamine dye A1, modified by tyrosine or N-Boc tyrosine via ether linkage, shows enhanced imaging performance and faster response and stronger fluorescence emission compared to FDA-approved ICG.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Engineering, Biomedical
Yang Xu, Jiaying Yu, Jinzhong Hu, Kai Sun, Wenjun Lu, Fenglian Zeng, Jian Chen, Min Liu, Zhuoer Cai, Xiaofan He, Wanying Wei, Baiwang Sun
Summary: A series of dimeric heptamethine cyanine photosensitizers with an aromatic diphenol linker at the meso position were developed for improved photothermal conversion efficiency. The screened 26NA-NIR and 44BP-NIR showed high PCE, bright NIR fluorescence, excellent ROS generation capability, and improved photostability. In vivo and in vitro experiments demonstrated their outstanding performance in imaging-guided PDT-PTT synergistic therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiang Xia, Chao Shi, Shan He, Ran Wang, Zongwei Zhang, Yingqi Hu, Jianfang Cao, Ting Liu, Danhong Zhou, Wen Sun, Jiangli Fan, Xiaojun Peng
Summary: Introducing electron withdraw groups (EWGs) into heptamethine cyanines (Cy7) at the meso position allows optimization of S-1 decay via nonradiative relaxation, improving photostability and photothermal conversion efficiency. Combining the modified dye with a carrier and toll-like receptor agonist enables synergistic photothermal immunotherapy against tumors.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Lijun Zhu, Ting Yan, Gulinigaer Alimu, Linxue Zhang, Rong Ma, Nuernisha Alifu, Xueliang Zhang, Duoqiang Wang
Summary: The combination of near-infrared fluorescence imaging and chemotherapy is a promising method for precise diagnosis and treatment of cervical cancer. Therapeutic nanoparticles with detection abilities show significant chemotherapeutic effects.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Liang Peng, Ying-Hsia Shih, Ping-Fang Chiang, Chun-Tang Chen, Ming-Cheng Chang
Summary: The study demonstrated a radionuclide-labeled heptamethine cyanine based probe that provides multifunctional modalities for imaging and therapies of cancer. This probe enables real-time monitoring of tumor accumulation and cancer therapy using near-infrared fluorescence and nuclear imaging, guiding surgery or photothermal therapy of tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Young-Suk Cho, Manh-Hung Do, Hien Duong Thanh, Changjong Moon, Kwonseop Kim, Sang-Hee Cho, Hangun Kim, Hyung-Ho Ha, Chaeyong Jung
Summary: This study demonstrates that the near-infrared dye MHI-148 specifically reacts to mouse splenocytes with known MDSC-specific markers and a subpopulation of immature myeloid cells acquired from cancer patients. The dye could be a novel tool to detect MDSCs and predict the prognosis of human cancer patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Engineering, Biomedical
Yu Li, Jing Zhang, Lijun Zhu, Mou Jiang, Changsheng Ke, Hanxiong Long, Ruoyun Lin, Chaohui Ye, Xin Zhou, Zhong-Xing Jiang, Shizhen Chen
Summary: Developing a theranostic system that integrates multimodal imaging, synergistic therapeutic, and formulation entities is a promising strategy for efficient cancer treatment. In this study, versatile all-in-one heptamethine cyanine amphiphiles (PEG-Cy-Fs) were developed for the convenient construction of theranostic platforms. These amphiphiles self-assembled with a chemotherapy drug tamoxifen (TAM) into stable nanoparticles (SoFoTm/PEG-Cy-F-18) with multiple capabilities, enabling the targeted chemo-photodynamic-photothermal therapy of breast cancer with high therapeutic index in mice.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Rong Ma, Nuernisha Alifu, Zhong Du, Shuang Chen, Youqiang Heng, Jing Wang, Lijun Zhu, Cailing Ma, Xueliang Zhang
Summary: Indocyanine green (ICG) is a favorable fluorescence nanoprobe known for its strong NIR-I fluorescence emission and good photothermal capabilities. To enhance its therapeutic efficiency, ICG was encapsulated with bovine serum albumin (BSA) and loaded with the chemotherapeutic drug doxorubicin (DOX) to form the BSA@ICG-DOX theranostic nanoplatform. The resulting nanoplatform showed strong NIR-I fluorescence emission, excellent photothermal properties, biocompatibility, and tumor targeting ability, making it a promising tool for combined diagnosis and therapy of subcutaneous cervical tumors.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Chemistry, Applied
Farzad Seidi, Mohsen Khodadadi Yazdi, Maryam Jouyandeh, Sajjad Habibzadeh, Muhammad Tajammal Munir, Henri Vahabi, Babak Bagheri, Navid Rabiee, Payam Zarrintaj, Mohammad Reza Saeb
Summary: This review focuses on the crystallization of polysaccharides and their applications, specifically discussing cellulose, chitin, chitosan, and starch. It also provides an overview of the applications of crystalline polysaccharides and nano-polysaccharides, as well as their physical and chemical interactions. The review aims to offer a comprehensive understanding of the relationship between crystallization and properties in polysaccharides.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Kangmin Noh, Saji Uthaman, Chung-Sung Lee, Yugyeong Kim, Shameer Pillarisetti, Hee Sook Hwang, In-Kyu Park, Kang Moo Huh
Summary: In this study, tumor intracellular microenvironment-responsive nanoparticles were developed for tumor-targeted anti-cancer therapy and exhibited a contrast effect in magnetic resonance imaging.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Review
Immunology
Srinivasan Sabitha, Nagarajan Shobana, Pandurangan Prakash, Sathiyamoorthy Padmanaban, Mahendran Sathiyashree, Subramanian Saigeetha, Srikumar Chakravarthi, Saji Uthaman, In-Kyu Park, Antony Samrot
Summary: This article discusses the impact of the novel coronavirus on top nations worldwide and the vaccines used for prevention. It provides insight into different COVID-19 vaccine platforms, including their preparation, working, efficacy, and side effects.
Review
Nanoscience & Nanotechnology
Saji Uthaman, Gabriel Cutshaw, Saman Ghazvini, Rizia Bardhan
Summary: This tutorial review summarizes the recent advances in using nanoparticles to label NK cells for immunoimaging or deliver treatment to activate NK cells and induce long-term immunity against tumors. The key properties of nanoparticles for overcoming challenges in NK cell-based diagnostics and therapeutics are discussed. The review concludes with an outlook on future directions in NP-NK cell hybrid interfaces and the need to address their overall clinical impact and patient response.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Biomaterials
Saji Uthaman, Shameer Pillarisetti, Youn-Mook Lim, Jin-Oh Jeong, Rizia Bardhan, Kang Moo Huh, In-Kyu Park
Summary: A study has reported the synthesis of novel co-operative immuno-photodynamic nanoparticles that can selectively target tumor-associated macrophages (TAMs) and repolarize them into tumoricidal cells. These nanoparticles also demonstrated an adaptive immune response and effectively inhibited tumor growth and metastasis. The findings suggest the potential importance of these nanoparticles in cancer immunotherapy.
BIOMATERIALS SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Gabriel Cutshaw, Saji Uthaman, Nora Hassan, Siddhant Kothadiya, Xiaona Wen, Rizia Bardhan
Summary: With the rapid development of omics technologies, precision medicine is being greatly influenced. Raman spectroscopy (RS) is highlighted as an emerging omics technology for clinically relevant applications. It can be used as a label-free approach to detect intrinsic metabolites and as a labeled approach for tracking protein biomarkers. Machine learning algorithms are utilized for accurate detection of treatment response in diseases like cancer and neurodegenerative diseases. Integration of RS with established omics approaches is also discussed for holistic diagnostic information.
Article
Chemistry, Multidisciplinary
Xiaona Wen, Luping Ou, Gabriel Cutshaw, Saji Uthaman, Yu-Chuan Ou, Tian Zhu, Sarah Szakas, Brandon Carney, Jacob Houghton, Alexander Gundlach-Graham, Marjan Rafat, Kai Yang, Rizia Bardhan
Summary: This study demonstrates the unexpected breakdown of functionalized gold nanostars (F-AuNSs) conjugated with antibodies and Cu-64 radiolabels in vivo and in artificial lysosomal fluid ex vivo. The short-term biodistribution of F-AuNSs is influenced by the route of systemic delivery, while the long-term fate is controlled by the tissue type in vivo. In vitro and in vivo studies show that F-AuNSs dynamics are governed by their physicochemical properties and route of delivery.
Article
Nanoscience & Nanotechnology
Lilly Synan, Saman Ghazvini, Saji Uthaman, Gabriel Cutshaw, Che-Yu Lee, Joshua Waite, Xiaona Wen, Soumik Sarkar, Eugene Lin, Mark Santillan, Donna Santillan, Rizia Bardhan
Summary: Preterm birth is a major cause of infant mortality globally. Current clinical measures often fail to identify women who may deliver preterm, making accurate screening tools essential. This study uses Raman spectroscopy to predict preterm birth by examining differences in the maternal metabolome. Fifteen statistically significant metabolites were identified as predictors of preterm birth. The integration of Raman and clinical data with machine learning achieved an unprecedented 85.1% accuracy in risk stratification of preterm birth in the first trimester.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Shameer Pillarisetti, Veena Vijayan, Jayakumar Rangasamy, Rizia Bardhan, Saji Uthaman, In-Kyu Park
Summary: We report a multi-stimulus responsive alginate nanogel that responds to changes in pH and redox potential in the tumor microenvironment. Combined with chemotherapy and photodynamic therapy (PDT), this nanogel enhances the therapeutic effect in breast cancer and melanoma by releasing a hydrophobic photosensitizer and a cytotoxic agent.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Chemistry, Analytical
Gabriel Cutshaw, Nora Hassan, Saji Uthaman, Xiaona Wen, Bhuminder Singh, Anwesha Sarkar, Rizia Bardhan
Summary: Resistance to cancer therapies is a significant challenge in cancer management. Rapid and sensitive diagnostic tools are needed to predict treatment response early and make accurate clinical decisions.
ANALYTICAL CHEMISTRY
(2023)
Article
Urology & Nephrology
Taehee Kim, Ho Seok Chung, Hyun-Suk Lee, Saji Uthaman, In-Kyu Park, Kwangsung Park
Summary: This study aimed to develop HA-based, RA-containing nanomicelles and investigate their effects on regeneration of the vaginal epithelium and AQP3 expression in a murine menopause model. After 4 weeks of treatment, the thickness of the vaginal mucosal epithelial layer and AQP3 expression was increased in the HA-C18-RA group compared with the HA-C18 vehicle group.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Materials Science, Biomaterials
Veena Vijayan, Aravindkumar Sundaram, Arathy Vasukutty, Rizia Bardhan, Saji Uthaman, In-Kyu Park
Summary: Magnetic hyperthermia, a noninvasive cancer therapy with deep tissue penetration and minimal damage to healthy tissues, has attracted significant attention. This study developed targeted Fe nanorings (TF) for tumor-targeted magnetic hyperthermia-induced tumor ablation by fusing cancer cell membrane fragments with lipids and cloaking them on magnetic nanorings. The TF showed high tumor uptake and induced tumor cell death under an external alternating magnetic field. These findings demonstrate the potential and efficiency of TF as a nanosystem for tumor-targeted theranostics.
BIOMATERIALS SCIENCE
(2023)
Review
Materials Science, Biomaterials
Babak Bagheri, Sachin S. Surwase, Su Sam Lee, Heewon Park, Zahra Faraji Rad, Natalie L. Trevaskis, Yeu-Chun Kim
Summary: Carbon-based nanostructures have attracted significant interest in drug delivery applications due to their unique features. However, their synthesis, surface modification techniques, and compatibility with biological systems still require further development and investigation.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)