Article
Biochemistry & Molecular Biology
Camila Cimadamore-Werthein, Stephany Jaiquel Baron, Martin S. King, Roger Springett, Edmund R. S. Kunji
Summary: The mitochondrial ADP/ATP carrier plays a crucial role in oxidative phosphorylation by importing ADP into the mitochondrial matrix and exporting ATP. Recent studies have revealed that the carrier functions as a monomer with a single substrate binding site and operates with a ping-pong kinetic mechanism. These findings reconcile the discrepancy between the previous assumptions and provide insights into the alternating access mechanism of the carrier.
Review
Cell Biology
Elena Frigo, Ludovica Tommasin, Giovanna Lippe, Michela Carraro, Paolo Bernardi
Summary: This article introduces the formation of Ca2+-activated, high-conductance channels by F1FO (F)-ATP synthase and adenine nucleotide translocase (ANT) in the inner membrane of mitochondria from various eukaryotes. The permeability transition (PT), a Ca2+-dependent increase in permeability in the inner mitochondrial membrane, and its molecular mechanisms have been challenging for scientists for the past 70 years. The features of the PT (or lack thereof) in mammals, yeast, fruit flies, brine shrimp, and nematodes, as well as the intrinsic pathway of apoptosis and other forms of cell death, are discussed in this review.
Article
Pharmacology & Pharmacy
Takeshi Nii, Ryota Eguchi, Soichiro Yamaguchi, Ken-ichi Otsuguro
Summary: The study found that H2S indirectly inhibits ATP-induced Ca2+ signaling in astrocytes by releasing Ca2+ from the endoplasmic reticulum. This mechanism may influence intercellular communication between astrocytes and neurons, thus impacting neuronal signaling in the nervous system.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yingfei Chen, Leshuang Wu, Jun Liu, Li Ma, Wenli Zhang
Summary: This review summarizes the recent advances in the research on adenine nucleotide translocases (ANTs) and their potential implications for various diseases. The structures, functions, modifications, regulators, and pathological implications of ANTs are extensively discussed. ANT impairment leads to mitochondrial dysfunction and bioenergetic failure, contributing to the pathogenesis of diseases such as diabetes, heart disease, Parkinson's disease, Sengers Syndrome, cancer, Alzheimer's Disease, Progressive External Opthalmoplegia, and Fascioscapulohumeral muscular dystrophy. This review enhances our understanding of the role of ANT in the pathogenesis of human diseases and provides insights for the development of novel therapeutic strategies targeting ANTs.
Review
Biochemistry & Molecular Biology
Paolo Bernardi, Michela Carraro, Giovanna Lippe
Summary: The basis of mitochondrial permeability transition, a Ca2+-dependent permeability increase of the inner membrane, has been successfully defined, and it has been recognized as a regulator of mitochondrial ion homeostasis and a mechanism of cell death. However, there are still controversial mechanisms regarding the permeability transition that require further research for explanation.
Article
Neurosciences
Ankit Dhoundiyal, Vanessa Goeschl, Stefan Boehm, Helmut Kubista, Matej Hotka
Summary: Electrical activity in neurons is accompanied by an increase in cytosolic Ca2+ concentration, which is crucial for securing energy supply. The glycerol-3-phosphate shuttle (G3PS) plays a significant role in neuronal energy supply when other energy transfer pathways are not available.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Plant Sciences
Ha N. Duong, Sung-Hwan Cho, Limin Wang, An Q. Pham, Julia M. Davies, Gary Stacey
Summary: Extracellular ATP is regarded as a danger signal in plants and animals, and its recognition by the PM-localized receptor P2K1 leads to a rapid increase in cytoplasmic calcium levels through the crucial involvement of CNGC6. Mutations in the CNGC6 gene decrease plant responses to eATP, including reduced MAPK activation, gene expression, and increased susceptibility to pathogens.
Review
Biochemistry & Molecular Biology
Qiuyan Dong, Lukas Wallrad, Bader O. Almutairi, Joerg Kudla
Summary: Adverse variations of abiotic environmental cues can cause stress to plants, leading to reduced crop yield and negative impact on ecosystem stability. Ca2+ plays multifaceted roles in abiotic stress responses, serving as a versatile second messenger and connecting stress perception to signal transduction.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anna Atlante, Daniela Valenti
Summary: The mitochondrial adenine nucleotide translocator (ANT) acts as a gatekeeper for cellular energy flow, exchanging ADP for ATP across the inner mitochondrial membrane.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hannes G. Roggenkamp, Imrankhan Khansahib, Lola C. C. Hernandez, Yunpeng Zhang, Dmitri Lodygin, Aileen Krueger, Feng Gu, Franziska Moeckl, Anke Loehndorf, Valerie Wolters, Daniel Woike, Anette Rosche, Andreas Bauche, Daniel Schetelig, Rene Werner, Hartmut Schlueter, Antonio Failla, Chris Meier, Ralf Fliegert, Timothy F. Walseth, Alexander Fluegel, Bjoern-Philipp Diercks, Andreas H. Guse
Summary: This study identified a new NAADP-binding protein, HN1L/JPT2, which connects NAADP formation with the activation of RYR channels, facilitating Ca2+ release. This protein plays a crucial role in the earliest phase of T cell activation.
Article
Plant Sciences
Jian Sun, Youzheng Ning, Limin Wang, Katie A. Wilkins, Julia M. Davies
Summary: Extracellular ATP (eATP) is considered a constitutive damage-associated molecular pattern (DAMP) that is released in response to injury, herbivory, or pathogen attack. Its concentration must be tightly regulated to prevent cell death. In Arabidopsis thaliana, the perception of eATP is mediated by plasma membrane receptors and involves cyclic nucleotides, potentially leading to an increase in cytosolic-free Ca2+ as a second messenger.
FRONTIERS IN PLANT SCIENCE
(2021)
Letter
Plant Sciences
Philippe Fuchs, Elisenda Feixes-Prats, Paulo Arruda, Elias Feitosa-Araujo, Alisdair R. Fernie, Christopher Grefen, Sophie Lichtenauer, Nicole Linka, Ivan de Godoy Maia, Andreas J. Meyer, Soeren Schilasky, Lee J. Sweetlove, Stefanie Wege, Andreas P. M. Weber, A. Harvey Millar, Olivier Keech, Igor Florez-Sarasa, Pedro Barreto, Markus Schwarzlaender
Summary: UCP2 is localized to the Golgi, unlike its close homolog UCP1, which is abundant in the mitochondria.
Article
Biology
Michael W. Country, Michael G. Jonz
Summary: By studying the responses of goldfish and rainbow trout retinal cells to hypoxia, it was found that goldfish maintain [Ca2+](i) stably by using mitochondrial ATP-dependent K+ channels (mK(ATP)) to resist excitotoxicity, while rainbow trout experience a rapid increase in [Ca2+](i) during hypoxia, which can be life-threatening.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Roberto Docampo, Guozhong Huang
Summary: Trypanosoma cruzi and the T. brucei group of parasites are neglected diseases affecting millions of people globally. These microorganisms have complex life cycles involving insect vectors and mammalian hosts, and possess unique signaling pathways and receptor adaptations that differentiate them from their mammalian counterparts.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Pavla Pruchova, Klara Gotvaldova, Katarina Smolkova, Lukas Alan, Blanka Holendova, Jan Tauber, Alexander Galkin, Petr Jezek, Martin Jaburek
Summary: This study reveals the antioxidant and anti-inflammatory roles of iPLA(2)gamma in the brain. It demonstrates that iPLA(2)gamma is activated by tert-butylhydroperoxide and releases free fatty acids, which leads to an increase in respiratory rate and a decrease in mitochondrial superoxide production. It also shows that iPLA(2)gamma plays a key role in the remodeling of cardiolipins in the brain.
Article
Plant Sciences
Simone Sello, Jennifer Perotto, Luca Carraretto, Ildiko Szabo, Ute C. Vothknecht, Lorella Navazio
JOURNAL OF EXPERIMENTAL BOTANY
(2016)
Article
Plant Sciences
Henning Ruge, Sandra Flosdorff, Ingo Ebersberger, Fatima Chigri, Ute C. Vothknecht
JOURNAL OF EXPERIMENTAL BOTANY
(2016)
Article
Biochemistry & Molecular Biology
Nargis Parvin, Chris Carrie, Isabelle Pabst, Antonia Laesser, Debabrata Laha, Melanie V. Paul, Peter Geigenberger, Ralf Heermann, Kirsten Jung, Ute C. Vothknecht, Fatima Chigri
Article
Plant Sciences
Simone Sello, Roberto Moscatiello, Norbert Mehlmer, Manuela Leonardelli, Luca Carraretto, Enrico Cortese, Filippo G. Zanella, Barbara Baldan, Ildiko Szabo, Ute C. Vothknecht, Lorella Navazio
Article
Biochemistry & Molecular Biology
Agostinho G. Rocha, Norbert Mehlmer, Simon Stael, Andrea Mair, Nargis Parvin, Fatima Chigri, Markus Teige, Ute C. Vothknecht
BIOCHEMICAL JOURNAL
(2014)
Article
Biochemistry & Molecular Biology
Esther Dolze, Fatima Chigri, Timo Hoewing, Georg Hierl, Erika Isono, Ute C. Vothknecht, Christine Gietl
PLANT MOLECULAR BIOLOGY
(2013)
Article
Plant Sciences
Stephanie Otters, Paula Braun, Johanna Hubner, Gerhardt Wanner, Ute C. Vothknecht, Fatima Chigri
Article
Biochemistry & Molecular Biology
Julia Walter, Khaled A. Selim, Francisco Leganes, Francisca Fernandez-Pinas, Ute C. Vothknecht, Karl Forchhammer, Eva-Mari Aro, Peter J. Gollan
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2019)
Article
Plant Sciences
Edoardo Cutolo, Nargis Parvin, Henning Ruge, Niloufar Pirayesh, Valentin Roustan, Wolfram Weckwerth, Markus Teige, Michele Grieco, Veronique Larosa, Ute C. Vothknecht
FRONTIERS IN PLANT SCIENCE
(2019)
Review
Cell Biology
Ute C. Vothknecht, Ildiko Szabo
Article
Plant Sciences
Sakil Mahmud, Chhana Ullah, Annika Kortz, Sabarna Bhattacharyya, Peng Yu, Jonathan Gershenzon, Ute C. Vothknecht
Summary: This study investigates the impact of altered levels of the enzyme JASMONATE RESISTANT 1 (JAR1) on Arabidopsis thaliana plants. The findings suggest that increased production of JA-Ile improves drought stress tolerance and affects plant development, while reduced JA-Ile content results in increased sensitivity to drought. The study also provides insights into the molecular changes caused by alterations in JA-Ile content and highlights the potential role of JA-Ile in abiotic stress response.
PLANT CELL AND ENVIRONMENT
(2022)
Review
Plant Sciences
Andras Bittner, Agata Ciesla, Kristina Gruden, Tjasa Lukan, Sakil Mahmud, Markus Teige, Ute C. Vothknecht, Bernhard Wurzinger
Summary: This article reviews the interactions between organelles and plant hormones, focusing on stress-related hormones such as abscisic acid, jasmonates, salicylic acid, and ethylene. The coordination between organelles and phytohormones is crucial for regulating plant growth and development in response to environmental changes. Understanding the relationship between organelle functions and phytohormone signaling can provide insights into plant stress tolerance.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Plant Sciences
Jose Manuel Ugalde, Philippe Fuchs, Thomas Nietzel, Edoardo A. Cutolo, Maria Homagk, Ute C. Vothknecht, Loreto Holuigue, Markus Schwarzlaender, Stefanie J. Mueller-Schuessele, Andreas J. Meyer
Summary: Metabolic fluctuations in chloroplasts and mitochondria can trigger retrograde signals which modify nuclear gene expression through the involvement of reactive oxygen species (ROS). The use of biosensors revealed the role of redox buffers in plant stress response mechanisms.
Article
Plant Sciences
Enrico Teardo, Luca Carraretto, Roberto Moscatiello, Enrico Cortese, Mattia Vicario, Margherita Festa, Lorenzo Maso, Sara De Bortoli, Tito Cali, Ute C. Vothknecht, Elide Formentin, Laura Cendron, Lorella Navazio, Ildiko Szabo