Article
Nutrition & Dietetics
Huijun Lin, Junru Chen, Shujuan Ma, Rongjing An, Xingli Li, Hongzhuan Tan
Summary: This study found that microbiota dysbiosis in PIH patients begins in the first trimester of pregnancy, and this may be associated with the occurrence of PIH. Changes in different microorganisms may affect the blood pressure of pregnant women by affecting the metabolism of vitamin K-2, sphingolipid, lipid acid, and glycine.
Article
Nutrition & Dietetics
Tong Liu, Xiaomeng Wang, Pingping Jia, Chenan Liu, Yaping Wei, Yun Song, Shuqun Li, Lishun Liu, Binyan Wang, Hanping Shi
Summary: There is a positive association between serum arginine levels and the risk of cancer, with higher levels of arginine being associated with a higher risk of overall, digestive system, and colorectal cancer in hypertensive individuals.
FRONTIERS IN NUTRITION
(2022)
Article
Peripheral Vascular Disease
Eva Munoz Aguilera, Jean Suvan, Marco Orlandi, Queralt Miro Catalina, Jose Nart, Francesco D'Aiuto
Summary: Recent evidence suggests a close relationship between hypertension and periodontitis, with individuals suffering from periodontitis showing higher systolic and diastolic blood pressure compared to those without. The diagnosis of periodontitis is associated with higher systolic blood pressure independently from common cardiovascular risk factors. Promoting periodontal and systemic health strategies may help reduce the burden of hypertension and its complications.
Article
Multidisciplinary Sciences
Satoshi Yokoyama, Chihiro Nakagawa, Kouichi Hosomi
Summary: This study investigated the association between statins and open-angle glaucoma (OAG) in Japanese patients with dyslipidemia. The results showed that there was no significant relationship between statin use and the occurrence of OAG in this population.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Nick Daneman, Yi Cheng, Tara Gomes, Jun Guan, Muhammad M. Mamdani, Farah E. Saxena, David N. Juurlink
Summary: The study revealed that metronidazole is associated with an increased risk of adverse peripheral and central nervous system events compared to clindamycin, with an overall low incidence of neurological events in metronidazole recipients.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Nutrition & Dietetics
Zhuo Wang, Shiyu Hu, Yun Song, Lishun Liu, Zhengzheng Huang, Ziyi Zhou, Yaping Wei, Tengfei Lin, Meiqing Huang, Hao Zhang, Huiyuan Guo, Yong Sun, Binyan Wang, Xianhui Qin, Xiping Xu, Feng Chi, Bohua Ren, Lijie Ren
Summary: This study investigates the relationship between plasma selenium (Se) concentration and ischemic stroke risk in a large-scale Chinese community-based population. It finds a significant inverse association between plasma Se and the risk of first ischemic stroke, particularly among those with lower low-density lipoprotein cholesterol (LDL-C) and homocysteine levels.
FRONTIERS IN NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Woo-Ri Lee, Jun Hyuk Koo, Ji Yun Jeong, Min Su Kim, Ki-Bong Yoo
Summary: This study aims to explore regional health disparities in hypertension-related hospitalizations and confirm this difference according to the states of continuity of care (COC). The study used National Health Insurance Service National Sample Cohort data from 2002 to 2019. The results showed that hypertensive patients had a higher odds of hypertension-related hospitalization in rural areas compared to urban areas, but the difference decreased as the COC increased. This suggests that to reduce regional health disparities, both the promotion of COC and the improvement of primary care quality must be achieved.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Hematology
Mulugeta M. Zegeye, Jonas S. O. Andersson, Patrik Wennberg, Dirk Repsilber, Allan Sirsjo, Liza U. Ljungberg
Summary: This study reveals a significant association between IL-6 binary complex concentration and future myocardial infarction (MI), and suggests that plasma IL-6 and IL-6 binary complex concentration may partly explain the increased risk of MI in smokers and hypertensive participants.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, General & Internal
So Young Kim, Dae Myoung Yoo, Juyong Chung, Hyo Geun Choi
Summary: This study evaluated the relationship between psoriasis and the risk of thyroid cancer in adults. The results showed that psoriasis was not related to the risk of thyroid cancer in the overall adult population. However, young adults and populations without hypothyroidism had an elevated risk of thyroid cancer associated with psoriasis.
Article
Oncology
Hehao Zhu, Yaping Wei, Qiangqiang He, Yun Song, Lishun Liu, Yong Sun, Hao Zhang, Huiyuan Guo, Xiping Xu, Binyan Wang
Summary: This study found a nonlinear association between plasma iron concentrations and cancer risk in Chinese adults with hypertension. Higher plasma iron levels were associated with an increased risk of digestive system cancers, while lower iron levels were associated with an increased risk of non-digestive system cancers.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Timo Partonen, Elena Toffol, Antti Latvala, Oskari Heikinheimo, Jari Haukka
Summary: Limited evidence suggests that the use of hormonal contraception may be associated with insomnia. A nationwide study of women aged 15-49 found significant associations between hormonal contraception use and insomnia. Specific products, such as drospirenone and ethinylestradiol, were associated with decreased odds of insomnia, while levonorgestrel-releasing intrauterine devices and vaginal rings with etonogestrel and ethinylestradiol were associated with increased odds of insomnia.
Article
Surgery
Eray Celikturk, Omer Salt, Mustafa Burak Sayhan, Ilker Dibirdik
Summary: This study aimed to measure plasma YKL-40 levels and investigate their diagnostic value in patients with acute cholecystitis. The results showed a significant difference in YKL-40 protein levels between patients with acute cholecystitis and healthy volunteers, and a positive correlation with ALT, AST, LDH, and GGT levels. Therefore, plasma YKL-40 levels can be effectively used in the diagnosis of acute cholecystitis when evaluated together with physical examination, radiological imaging, and other laboratory parameters.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Obstetrics & Gynecology
K. Hilden, A. Magnuson, S. Montgomery, E. Schwarcz, U. Hanson, D. Simmons, H. Backman
Summary: This study investigates the associations between pre-eclampsia, gestational diabetes mellitus (GDM), and cardiovascular disease (CVD). The results show that both pre-eclampsia and GDM are independent risk factors for later CVD. The association between pre-eclampsia and CVD is not modified by body mass index (BMI). Effective CVD preventive programs for high-risk women are urgently needed.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Oncology
Erik Lundqvist, Ida Hed Myrberg, Sol Erika Boman, Deborah Saraste, Caroline E. Weibull, Kalle Landerholm, Staffan Haapaniemi, Anna Martling, Paer Myrelid, Caroline Nordenvall
Summary: A study in Sweden found that metabolic disease and inflammatory bowel disease are risk factors for early onset colorectal cancer (EOCRC), while non-IBD autoimmune disease is not associated with an increased incidence of EOCRC.
Article
Peripheral Vascular Disease
Yexiu Sun, Ying Guo, He Xu, Ji Zhao, Di Wu, Jianwei Hu, Dandan Wang, Lei Wu, Hao Peng, Hongmei Li
Summary: This study aimed to investigate the relationship between AVP gene polymorphism and plasma copeptin concentration with the occurrence of hypertension in pregnancy. The results showed that higher plasma copeptin and AVP gene variants are associated with the occurrence of gestational hypertension and preeclampsia with chronic hypertension. The detection of copeptin and AVP gene in the early second trimester improves the predictive ability of traditional factors for gestational hypertension and preeclampsia with chronic hypertension.
JOURNAL OF HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Yiming Jia, Rong Wang, Lulu Sun, Daoxia Guo, Mengyao Shi, Kaixin Zhang, Pinni Yang, Yu Wang, Fanghua Liu, Guo-Chong Chen, Yonghong Zhang, Zhengbao Zhu
Summary: By conducting a Mendelian randomization study, we identified three potential causal mediators, including docosahexaenoic acid, arachidonate, and 1-arachidonoyl-GPE, in the development of atopic dermatitis. Docosahexaenoic acid and arachidonate were found to have beneficial or detrimental effects on multiple diseases beyond atopic dermatitis, while no adverse side effects were predicted for 1-arachidonoyl-GPE. These findings provide valuable insights for the prevention and treatment of atopic dermatitis.
HUMAN MOLECULAR GENETICS
(2023)
Article
Peripheral Vascular Disease
Yujia Zhai, Bizhong Che, Yang Liu, Hao Peng, Aili Wang, Yanbo Peng, Jing Chen, Yonghong Zhang, Tan Xu, Chongke Zhong, Jiang He
Summary: This study investigated whether different blood pressure management strategies should be used for acute stroke patients with or without impaired renal function. The results showed that early antihypertensive treatment had no effect on clinical outcomes in ischemic stroke patients with different renal function status.
Article
Immunology
Jun Zhou, Shan Yan, Xu Guo, Yanguo Gao, Shiqi Chen, Xiaohan Li, Yonghong Zhang, Qibin Wang, Tao Zheng, Li Chen
Summary: This study investigated the effects of salidroside (SAL) on pancreatic beta-cell pyroptosis in diabetic mice. The results showed that SAL can protect beta-cells against pyroptosis by activating AMPK and inhibiting NLRP3/GSDMD signaling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Zhengbao Zhu, Daoxia Guo, Kaixin Zhang, Pinni Yang, Yiming Jia, Mengyao Shi, Yanbo Peng, Jing Chen, Aili Wang, Tan Xu, Yonghong Zhang, Jiang He
Summary: Plasma osteoprotegerin is associated with poor prognosis of ischemic stroke. High levels of plasma osteoprotegerin are associated with increased risk of death and major disability. Genetically determined high plasma osteoprotegerin is associated with an increased risk of primary outcome.
Article
Clinical Neurology
Jigang Du, Yan Wang, Bizhong Che, Mengyuan Miao, Anran Bao, Yanbo Peng, Zhong Ju, Tan Xu, Jiang He, Yonghong Zhang, Chongke Zhong
Summary: This study utilized repeated measures of the National Institutes of Health Stroke Scale (NIHSS) to identify different trajectories of neurological function after stroke and investigated their association with long-term clinical outcomes. The findings revealed that trajectories characterized by persistent severe and moderate neurological impairment were associated with increased risk of cardiovascular events. These results suggest that evaluating the neurological function trajectories of stroke patients through repeated NIHSS measurements can provide additional predictive information and aid in predicting long-term clinical outcomes.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Yinwei Zhu, Lulu Sun, Tiansheng Huang, Yiming Jia, Pinni Yang, Qi Zhang, Chongquan Fang, Mengyao Shi, Daoxia Guo, Yanbo Peng, Anushka Aghi, Jing Chen, Aili Wang, Jiang He, Yonghong Zhang, Tan Xu, Zhengbao Zhu
Summary: A multicenter cohort study found that elevated serum BDNF concentrations were associated with decreased risks of adverse outcomes after ischemic stroke, suggesting that serum BDNF may be a potential biomarker for prognosis after ischemic stroke.
Article
Immunology
Qiongyu Chen, Yan Zhao, Yonghong Zhang, Jianbo Zhang, Wenshu Lu, Chih-Hao Chang, Shisong Jiang
Summary: The human immunodeficiency virus (HIV) is a global pandemic with no cure identified yet. HIV-induced death of lymphocytes involves both necrosis and apoptosis. A pro-apoptotic TNF peptide (P13) inhibits HIV-related cell death and viral transmission, while a pro-necrotic TNF peptide (P16) has little effect. Understanding cell death mechanisms may provide drug targets to reduce CD4(+) cell loss and viral reservoir formation in HIV infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yonghong Zhang, Zhaozhao Liu, Haixiang Sun
Summary: A successful human pregnancy requires the maternal immune system to recognize and tolerate the semi-allogeneic fetus. Dysfunctional maternal-fetal interactions might be associated with the development of pregnancy complications. This review elaborates the interactions between trophoblasts and decidual immune cells, and the role of commensal bacteria in promoting pregnancy progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Zhuo Wang, Wenjie Ge, Yonghong Zhang, Bo Liu, Bin Liu, Shikai Jin, Yuzhu Li
Summary: Animal joint motion is a combination of rotation and translational motion, bringing advantages such as high stability and energy utilization. However, the simple motion characteristic of the hinge joint limits the improvement of the robot's motion performance. In this paper, a new bionic geared five-bar knee joint mechanism based on the kangaroo knee joint is proposed to improve energy utilization and reduce power demand.
BIOENGINEERING-BASEL
(2023)
Article
Oncology
Hao Peng, Helena Palma-Gudiel, Carolina Soriano-Tarraga, Jordi Jimenez-Conde, Mingzhi Zhang, Yonghong Zhang, Jinying Zhao
Summary: Altered DNA methylation of TRIM6, FLRT2, SOX1, SOX17, AGBL4, and FAM84A genes (increased) and TLN2 gene (decreased) were found to be associated with ischemic stroke in Chinese populations. Experimental evidence suggests these genes may be involved in endothelial cell adhesion and atherosclerosis.
CLINICAL EPIGENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Fanghua Liu, Pinni Yang, Yinan Wang, Mengyao Shi, Ruirui Wang, Qingyun Xu, Yanbo Peng, Jing Chen, Jintao Zhang, Aili Wang, Tan Xu, Yonghong Zhang, Jiang He
Summary: This study investigated the relationship between baseline platelet count and HS-CRP on clinical outcomes in patients with ischemic stroke. The results showed an interaction effect between platelet count and HS-CRP on adverse clinical outcomes. Elevated platelet count was significantly associated with adverse clinical outcomes in patients with high HS-CRP levels. Strategies for anti-inflammatory and antiplatelet therapy should be developed based on platelet and HS-CRP testing results.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Immunology
Yonghong Zhang, Huiyan Wang, Panpan Qiu, Jingwen Jiang, Xuhong Wu, Jie Mei, Haixiang Sun
Summary: Placental trophoblasts play a role in the regulation of regulatory T cells through the PD-1/PD-L1 pathway, and decreased expression of PD-L1 in trophoblasts is associated with Treg deficiency in pregnancy failure. YY1 modulates the expression of PD-L1 in trophoblasts, and elevated levels of NO from M1 macrophages may lead to reduced YY1 expression in recurrent miscarriage.
FRONTIERS IN IMMUNOLOGY
(2023)
Correction
Immunology
Yonghong Zhang, Zhaozhao Liu, Haixiang Sun
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Yonghong Zhang
Article
Oncology
Yu Wang, Fanghua Liu, Lulu Sun, Yiming Jia, Pinni Yang, Daoxia Guo, Mengyao Shi, Aili Wang, Guo-Chong Chen, Yonghong Zhang, Zhengbao Zhu
Summary: This study conducted a systematic Mendelian randomization analysis to identify potential causal mediators for breast cancer. The findings suggest that high-density lipoprotein cholesterol (HDL-C) and acetate may play a role in the risk of developing breast cancer. Furthermore, the analysis of side effects indicates that lowering HDL-C may have negative effects on the circulatory system and foreign body injury, while lowering acetate may have negative effects on mental disorders disease.
BREAST CANCER RESEARCH
(2023)
