Article
Emergency Medicine
Xinxian Meng, Zhixi Yu, Wanyu Xu, Jun Chai, Shuo Fang, Peiru Min, Yunsheng Chen, Yixin Zhang, Zheng Zhang
Summary: This study confirms the link between augmented glycolysis and fibrotic activity in hypertrophic scars and proposes a method of controlling scar formation through regulation of glycolysis. The introduction of IR780 effectively down-regulated glycolysis and suppressed fibrotic activity, both in vitro and in vivo, by targeting activated fibroblasts.
Review
Pharmacology & Pharmacy
Dan Zhang, Bo Li, Muxin Zhao
Summary: Hypertrophic scar and keloid are fibroproliferative disorders of the skin caused by aberrant wound healing, with inflammation being recognized as the initiator of their formation. Interleukins, known for their role in inflammatory and immune responses, are being explored as potential therapeutic targets for their treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sebastian P. Nischwitz, Julia Fink, Marlies Schellnegger, Hanna Luze, Vladimir Bubalo, Carolin Tetyczka, Eva Roblegg, Christian Holecek, Martin Zacharias, Lars-Peter Kamolz, Petra Kotzbeck
Summary: Persistent inflammation during wound healing is identified as a precipitating factor in the development of hypertrophic scars. However, lack of standardized models and limited evidence for therapeutic approaches hinder research progress. This study aimed to investigate scar formation mechanisms and develop a method for generating standardized hypertrophic scars through prolonged inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hui Song Cui, Dong Hyun Kim, So Young Joo, Yoon Soo Cho, June-Bum Kim, Cheong Hoon Seo
Summary: In this study, it was found that exosomes derived from hypertrophic scar fibroblasts can change fibrosis-related signaling pathways in normal fibroblasts, leading to increased cell proliferation, migration, and epithelial-mesenchymal transition, as well as increased expression of fibronectin, type I collagen, and type III collagen.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biotechnology & Applied Microbiology
Yunxian Dong, Dongming Lv, Zirui Zhao, Zhongye Xu, Zhicheng Hu, Bing Tang
Summary: This study found that lycorine has the potential to be an anti-fibrotic drug for the intervention of hypertrophic scars. Lycorine selectively decreases the viability of fibroblasts and induces apoptosis. Additionally, lycorine inhibits the migration and contraction of fibroblasts and reduces the expression of collagen and alpha-SMA.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Surgery
Walker D. Short, Xinyi Wang, Hui Li, Ling Yu, Aditya Kaul, Gisele A. Calderon, Jamie Gilley, Paul L. Bollyky, Swathi Balaji, Sundeep G. Keswani
Summary: The study aimed to demonstrate the impact of IL-10 producing T lymphocytes on mediating dermal scarring. The results showed that IL-10 producing CD4(+) T lymphocyte subsets can promote wound healing and reduce fibrosis.
Article
Biochemistry & Molecular Biology
Zuhan Chen, Fang Xie, Tian Xia, Xiaoen Bian, Shichen Zhang, Jie Cai, Yanfeng Wang
Summary: Early application of quaternized chitin can effectively reduce scar hypertrophy, inhibit HS formation through regulating IL-6 expression, and may be a beneficial method in clinical wound management.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Rheumatology
Barbara Russo, Nicolo C. Brembilla, Carlo Chizzolini
Summary: The cellular pathogenesis of fibrotic disorders remains speculative, but evidence suggests that keratinocytes may contribute to skin fibrosis.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bok Ki Jung, Tai Suk Roh, Hyun Roh, Ju Hee Lee, Chae-Ok Yun, Won Jai Lee
Summary: In this study, the role of mortalin in scar formation and its association with interleukin-1 alpha receptor were explored. The results showed that mortalin treatment increased the expression of scar formation-related proteins in human dermal fibroblasts. In a rat incisional wound model, mortalin-specific shRNA significantly reduced scar size and the expression of related proteins. Blocking mortalin could be a potential therapeutic target for scar formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
David Dolivo, Adrian Rodrigues, Lauren Sun, Chun Hou, Yingxing Li, Eugene Chung, Kai Leung, Robert Galiano, Thomas Mustoe, Seok Jong Hong
Summary: The study found that topical application of 10% simvastatin cream can reduce scar hypertrophy, but creams containing the other two drugs are ineffective. It also found that the use of simvastatin cream can result in dryness and trans-epidermal water loss, but discontinuation of the treatment can restore the skin's protective barrier.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Surgery
Chio-Hou Chong, Jia-Ming Sun, Yu-Xin Liu, Yi-Tung Tsai, Dan-Ning Zheng, Yi-Fan Zhang, Li Yu
Summary: This study demonstrated the antifibrotic effect of Sal-B on hypertrophic scars in both in vitro and in vivo experiments. Sal-B inhibited the proliferation and migration of hypertrophic scar-derived fibroblasts in vitro and reduced scar size and fibrotic marker expression in vivo. These findings suggest that Sal-B can inhibit fibroblast proliferation and migration and attenuate hypertrophic scar formation.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Dermatology
Liu Yang, Yajuan Song, Tong Wang, Zhiwei Cui, JunZheng Wu, Yi Shi, Zhou Yu, Baoqiang Song
Summary: This study found that c-Maf positive macrophages promote hypertrophic scar formation by regulating the proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts, through the secretion of TGF-beta 1.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Thanh-Diep Ly, Christopher Lindenkamp, Eva Kara, Vanessa Schmidt, Anika Kleine, Bastian Fischer, Doris Hendig, Cornelius Knabbe, Isabel Faust-Hinse
Summary: This study investigates the impact of inflammation on the expression of XYLT1 and XT-I activity, revealing a previously unknown regulatory mechanism involving components of the inflammasome pathway CTSB and caspase-1. These findings contribute to a better understanding of the inflammatory regulation of XT-I.
Article
Biochemistry & Molecular Biology
Hui Song Cui, So Young Joo, Seung Yeol Lee, Yoon Soo Cho, Dong Hyun Kim, Cheong Hoon Seo
Summary: It is unclear how scar fibroblasts (SFs) affect keratinocytes in hypertrophic scars (HTS) through cell-cell interaction. This study investigated the effects of HTS-derived exosomes on the proliferation and differentiation of normal human keratinocytes (NHKs) and compared them with normal fibroblasts (NFs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jiarong Yu, Zhigang Mao, Zengding Zhou, Bo Yuan, Xiqiao Wang
Summary: The study found that there is a dysbiosis in the microbiome of hypertrophic scars, with Staphylococcus aureus as the dominant species, which is closely associated with chronic inflammation and scar formation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Yan Li, Wei Zhang, Jianxin Gao, Jiaqi Liu, Hongtao Wang, Jun Li, Xuekang Yang, Ting He, Hao Guan, Zhao Zheng, Shichao Han, Maolong Dong, Juntao Han, Jihong Shi, Dahai Hu
STEM CELL RESEARCH & THERAPY
(2016)
Article
Pathology
Julei Zhang, Qiao Qiao, Mengdong Liu, Ting He, Jihong Shi, Xiaozhi Bai, Yijie Zhang, Yan Li, Weixia Cai, Shichao Han, Hao Guan, Dahai Hu
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Yanhui Jia, Zhenzhen Li, Weixia Cai, Dan Xiao, Shichao Han, Fu Han, Xiaozhi Bai, Kejia Wang, Yang Liu, Xiaoqiang Li, Hao Guan, Dahai Hu
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Medicine, Research & Experimental
Jihong Shi, Houan Xiao, Jun Li, Julei Zhang, Yan Li, Jian Zhang, Xujie Wang, Xiaozhi Bai, Ke Tao, Dahai Hu, Hao Guan
LABORATORY INVESTIGATION
(2018)
Correction
Medicine, Research & Experimental
Bin Zhao, Hao Guan, Jia-Qi Liu, Zhao Zheng, Qin Zhou, Jian Zhang, Lin-Lin Su, Da-Hai Hu
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2020)
Article
Multidisciplinary Sciences
Huayu Zhu, Jun Li, Yize Li, Zhao Zheng, Hao Guan, Hongtao Wang, Ke Tao, Jiaqi Liu, Yunchuan Wang, Wanfu Zhang, Chao Li, Jie Li, Lintao Jia, Wendong Bai, Dahai Hu
Summary: This study reveals the roles of glucocorticoid in cellular mechanotransduction and a novel lncRNA-dependent GMD mechanism, offering a potential strategy for early intervention in mechanical disorder-associated diseases.
Article
Surgery
Jun Zhang, Wanfu Zhang, Huihui Zhou, Lin Sang, Lina Liu, Yuanyuan Sun, Xue Gong, Hao Guan, Ming Yu
Summary: 2D-SWE is a safe and noninvasive imaging technique that can quantitatively measure tissue stiffness. The study found that there was no significant difference in muscle elasticity values between genders and age groups in healthy volunteers, but a significant increase in elasticity values was observed in muscles on the affected side in patients with ACS. This suggests that 2D-SWE may be a valuable tool for diagnosing and treating ACS.
Article
Dermatology
Ke Tao, Xiaozhi Bai, Peng Ji, Yue Zhang, Tao Cao, Fu Han, Zhi Zhang, Hao Guan, Dahai Hu
Summary: This study demonstrates the effectiveness of ADSCs treated with amnion and HGF- and 5 alpha-DHT-gelatin microspheres in promoting wound healing and restoring sebaceous glands.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Chemistry, Analytical
Xiaoping Zhao, Zhiwei Yang, Ruoxin Niu, Ye Tang, Heng Wang, Rui Gao, Yizhen Zhao, Xunan Jing, Daquan Wang, Peng Lin, Hao Guan, Lingjie Meng
Summary: In this study, a new type of biosensor was constructed using nanozymes, which can detect the COVID-19 virus with high sensitivity and visualization. The biosensor has the characteristics of ultrafast and ultrasensitive detection, and it can detect various variants of the SARS-CoV-2 virus.
ANALYTICAL CHEMISTRY
(2022)