Article
Oncology
Stephanie A. Sheehan, Kelly L. Hamilton, Edward P. Retzbach, Premalatha Balachandran, Harini Krishnan, Paola Leone, Moises Lopez-Gonzalez, Shraddha Suryavanshi, Pradeep Kumar, Riccardo Russo, Gary S. Goldberg
Summary: COVID-19 was declared a global public health emergency and pandemic in 2020, with over 125 million confirmed cases and 2.7 million deaths worldwide as of March 2021. The SARS-CoV-2 virus causing COVID-19 infects host cells by binding its spike protein to the ACE2 receptor, which is also found in oral mucosa cells. Maackia amurensis seed lectin (MASL) has shown potential as an antiviral agent by targeting the ACE2 receptor, reducing ACE2 expression and glycosylation, inhibiting SARS-CoV-2 spike protein binding, and decreasing inflammation in oral epithelial cells and kidney epithelial cells.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Immunology
Fanping Wang, Yonghui Yang, Zhixin Li, Yan Wang, Zhenchao Zhang, Wei Zhang, Yonghui Mu, Jingwen Yang, Lili Yu, Mingyong Wang
Summary: This study found that MBL regulates the balance between Th17 and Treg cells to resist Candida albicans infection, possibly through IL-6- and TGF-beta-mediated JAK/STAT and TGF-beta/SMAD signaling pathways.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Engku Nasiha Engku Ngah Sayuddin, Muhammad Taher, Mohd Hafiz Arzmi, Nor Aszlitah Burhanudin, Muhamad Ashraf Rostam
Summary: This article reviews the role of podoplanin in oral cancer and its potential as a therapeutic agent. High expression of podoplanin has been observed in oral cancer and pre-cancerous lesions, suggesting that inhibitors targeting podoplanin could be effective in treating oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Qifeng Geng, Jing Wang, Wei Zhang, Wei Zhou, Genxiong Tang, Mingyan Gu
Summary: This study found that the expression of Oncostatin M receptor is upregulated in oral squamous cell carcinoma and is associated with overall survival of patients. The expression of Oncostatin M receptor has the potential to become an effective prognostic biomarker for oral squamous cell carcinoma patients.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Kamila Ociepa, Marian Danilewicz, Malgorzata Wagrowska-Danilewicz, Roza Peterson-Jeckowska, Angelika Wojcicka-Rubin, Natalia Lewkowicz, Radoslaw Zajdel, Agnieszka Zebrowska
Summary: The JAK/STAT signaling pathway plays a crucial role in autoimmune bullous diseases, and the expression of JAK/STAT proteins could serve as potential therapeutic targets for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Junwu Xu, Zhiyuan Wu, Jian Huang
Summary: Flavopereirine demonstrated anti-cancer activity in oral cancer by inhibiting cell proliferation, invasion, migration, and promoting apoptosis. Additionally, it was found to inhibit the progression of oral cancer by regulating the JAK/STAT signaling pathway, making it a potential anti-cancer agent for oral cancer.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Immunology
Yanhong Ni, Jun T. Low, John Silke, Lorraine A. O'Reilly
Summary: This article introduces the signaling mechanisms between cytokines and receptors, and discusses the effects of dysregulation of the JAK/STAT and TNF signaling pathways on cell functions and tumor development. The molecular mechanisms regulating these signaling pathways are also explored, and the development of therapeutic applications targeting the JAK/STAT or TNF signaling pathways in cancer treatment is highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Khaled Ezzedine, Elena Peeva, Yuji Yamaguchi, Lori Ann Cox, Anindita Banerjee, George Han, Iltefat Hamzavi, Anand K. Ganesan, Mauro Picardo, Diamant Thaci, John E. Harris, Jung Min Bae, Katsuhiko Tsukamoto, Rodney Sinclair, Amit G. Pandya, Abigail Sloan, Dahong Yu, Kavita Gandhi, Michael S. Vincent, Brett King
Summary: This study evaluated the efficacy and safety of oral JAK3/TEC inhibitor ritlecitinib in patients with active nonsegmental vitiligo. The results showed that ritlecitinib demonstrated significant efficacy and good tolerability in treating vitiligo.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Correction
Oncology
Yao-Yin Li, Chuan-Xiang Zhou, Yan Gao
Summary: This article points out an error in Figure 7 and provides a corrected version. However, this error does not affect the interpretation of the figure and does not impact the conclusions of the study.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Peng Zhang, Yanfei Zhang, Liang Wang, Weihua Lou
Summary: The study revealed an increase in type 2 macrophages and PDL-1 expression in laryngeal squamous cell carcinoma (LSCC), correlating with poor prognosis. Tumor cells induced macrophages into type 2 differentiation through TGF-beta/Smad3 signaling, leading to immunosuppression. Inhibition of JAK/STAT signaling enhanced tumor cell sensitivity to immune cell killing by regulating PDL-1 expression. Targeting TGF-beta or IL-10 could synergistically enhance sensitivity to chemotherapy in tumors.
Article
Biochemistry & Molecular Biology
Paloma Lequerica-Fernandez, Julian Suarez-Canto, Tania Rodriguez-Santamarta, Juan Pablo Rodrigo, Faustino Julian Suarez-Sanchez, Veronica Blanco-Lorenzo, Francisco Dominguez-Iglesias, Juana Maria Garcia-Pedrero, Juan Carlos de Vicente
Summary: This study found that TILs in OSCC patients were associated with PD-L1 expression and CSC markers. CD4(+) and CD8(+) TILs were related to smoking and alcohol habits. High infiltration of CD4(+) and CD8(+) TILs was significantly associated with tumors harboring positive PD-L1 expression.
Article
Dermatology
Didem Dincer Rota, Mehmet Ali Can Emeksiz, Fatma Gulru Erdogan, Dilsun Yildirim
Summary: Alopecia areata and its generalized form, universalis, are common causes of noncicatricial alopecia. Tofacitinib has shown more promising results in treating AA patients compared to AU patients, with relapse observed in some cases after discontinuation of treatment. Early initiation of therapy may lead to more successful outcomes, and it is important to inform patients about the possibility of relapse to manage expectations.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Se-Young Park, Sun Kyoung Lee, Mihwa Lim, Bomi Kim, Byeong-Oh Hwang, Eunae Sandra Cho, Xianglan Zhang, Kyung-Soo Chun, Won-Yoon Chung, Na-Young Song
Summary: Oral squamous cell carcinoma (OSCC) is often diagnosed at an advanced stage with metastasis. Platelets play a crucial role in cancer metastasis. This study found that platelets can upregulate PDPN and integrin beta 1 expression and promote invasiveness in OSCC cells. PDPN may be a potential target for regulating platelet-tumor interaction and metastasis.
BIOMOLECULES & THERAPEUTICS
(2022)
Article
Oncology
Qianbiao Wu, Yibo Yan, Shuo Shi, Quan Qi, Jiahui Han
Summary: This study reveals that DNMT3b-mediated hypermethylation of the SPAG6 promoter activates the JAK/STAT pathway to promote the progression of lung squamous cell carcinoma (LUSC). In addition, the expression of SPAG6 is related to immune infiltration and cancer cell stemness in LUSC.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Simone E. S. Faustino, Kellen C. Tjioe, Agnes Assao, Michele C. Pereira, Andre L. Carvalho, Luiz P. Kowalski, Denise T. Oliveira
Summary: ILVD and PLVD showed no significant association with occult lymph node metastasis or clinical follow-up, but ILVD was significantly associated with regional recurrence. PLVD was related to perineural invasion and had significant associations with disease-specific and disease-free survivals.
Review
Oncology
Rita Nahta, Fand Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Rafaela Andrade-Vieira, Sarah Bay, Dustin G. Brown, Gloria M. Calaf, Robert C. Castellino, Karine A. Cohen-Solal, Annamaria Colacci, Nichola Cruickshanks, Paul Dent, Riccardo Di Fiore, Stefano Forte, Gary S. Goldberg, Roslida A. Hamid, Harini Krishnan, Dale W. Laird, Ahmed Lasfar, Paola A. Marignani, Lorenzo Memeo, Chiara Mondello, Christian C. Naus, Richard Ponce-Cusi, Jayadev Raju, Debasish Roy, Rabindra Roy, Elizabeth P. Ryan, Hosni K. Salem, A. Ivana Scovassi, Neetu Singh, Monica Vaccari, Renza Vento, Jan Vondracek, Mark Wade, Jordan Woodrick, William H. Bisson
Article
Oncology
Harini Krishnan, Edward P. Retzbach, Maria I. Ramirez, Tong Liu, Hong Li, W. Todd Miller, Gary S. Goldberg
EXPERIMENTAL CELL RESEARCH
(2015)
Article
Clinical Neurology
Kushal Kolar, Moises Freitas-Andrade, John F. Bechberger, Harini Krishnan, Gary S. Goldberg, Christian C. Naus, Wun Chey Sin
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2015)
Article
Oncology
Jhon A. Ochoa-Alvarez, Harini Krishnan, John G. Pastorino, Evan Nevel, David Kephart, Joseph J. Lee, Edward P. Retzbach, Yongquan Shen, Mahnaz Fatahzadeh, Soly Baredes, Evelyne Kalyoussef, Masaru Honma, Martin E. Adelson, Mika K. Kaneko, Yukinari Kato, Mary Ann Young, Lisa Deluca-Rapone, Alan J. Shienbaum, Kingsley Yin, Lasse D. Jensen, Gary S. Goldberg
Article
Oncology
Thaiomara A. Silva, Basilio Smuczek, Iuri C. Valadao, Luciana M. Dzik, Rebeca P. Iglesia, Mario C. Cruz, Andre Zelanis, Adriane S. de Siqueira, Solange M. T. Serrano, Gary S. Goldberg, Ruy G. Jaeger, Vanessa M. Freitas
Review
Oncology
Harini Krishnan, Julie Rayes, Tomoyuki Miyashita, Genichiro Ishii, Edward P. Retzbach, Stephanie A. Sheehan, Ai Takemoto, Yao-Wen Chang, Kazue Yoneda, Jun Asai, Lasse Jensen, Lushun Chalise, Atsushi Natsume, Gary S. Goldberg
Review
Oncology
Edward P. Retzbach, Stephanie A. Sheehan, Evan M. Nevel, Amber Batra, Tran Phi, Angels T. P. Nguyen, Yukinari Kato, Soly Baredes, Mahnaz Fatahzadeh, Alan J. Shienbaum, Gary S. Goldberg
Review
Pharmacology & Pharmacy
Harini Krishnan, W. Todd Miller, Francisco J. Blanco, Gary S. Goldberg
DRUG DISCOVERY TODAY
(2019)
Article
Multidisciplinary Sciences
Ana Carolina Lima Ralph, Iuri Cordeiro Valadao, Elaine Cristina Cardoso, Vilma Regina Martins, Luanda Mara Silva Oliveira, Estela Maris Andrade Forell Bevilacqua, Murilo Vieira Geraldo, Ruy Gastaldoni Jaeger, Gary S. Goldberg, Vanessa Morais Freitas
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Stephanie A. Sheehan, Kelly L. Hamilton, Edward P. Retzbach, Premalatha Balachandran, Harini Krishnan, Paola Leone, Moises Lopez-Gonzalez, Shraddha Suryavanshi, Pradeep Kumar, Riccardo Russo, Gary S. Goldberg
Summary: COVID-19 was declared a global public health emergency and pandemic in 2020, with over 125 million confirmed cases and 2.7 million deaths worldwide as of March 2021. The SARS-CoV-2 virus causing COVID-19 infects host cells by binding its spike protein to the ACE2 receptor, which is also found in oral mucosa cells. Maackia amurensis seed lectin (MASL) has shown potential as an antiviral agent by targeting the ACE2 receptor, reducing ACE2 expression and glycosylation, inhibiting SARS-CoV-2 spike protein binding, and decreasing inflammation in oral epithelial cells and kidney epithelial cells.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Cell Biology
Stephanie A. Sheehan, Edward P. Retzbach, Yongquan Shen, Harini Krishnan, Gary S. Goldberg
Summary: N-Cadherin plays a crucial role in mediating contact normalization between nontransformed cells and transformed cells, inhibiting tumor cell proliferation by reducing PDPN expression. Cadherin junctions formed between nontransformed and transformed cells are essential for regulating the growth and progression of cancer cells.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Edward P. Retzbach, Stephanie A. Sheehan, Harini Krishnan, Haiyan Zheng, Caifeng Zhao, Gary S. Goldberg
Summary: A study found that Src tyrosine kinase can promote anchorage independent cell growth in the absence of Pdpn expression, but cannot promote cell migration. The continued activity of Src kinase is also important for cells to maintain a transformed morphology. Additionally, 28 proteins phosphorylated in a Pdpn-dependent manner were identified in Src transformed cells.
MOLECULAR CARCINOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Kelly L. Hamilton, Amanda A. Greenspan, Alan J. Shienbaum, Bradford D. Fischer, Andrea Bottaro, Gary S. Goldberg
Summary: This study found that MASL, which targets PDPN, can be administered orally to ameliorate joint malformation and increase velocity of movement in TNF-Tg mouse model. These results support the consideration of MASL as a potential treatment for rheumatoid arthritis.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Education, Scientific Disciplines
Kelly L. Hamilton, Yu-Chun Kuo, Peter Horneffer, T. Peter Stein, Gary S. Goldberg
Summary: Problem-based learning (PBL) is a self-directed strategy that relies on group participation. In this study, curated educational videos were incorporated into the PBL curriculum to help students without a background in biology or medicine. The students who were given a list of suggested videos scored higher in their learning experience, perception of feeling prepared, and participating in the group PBL experience.
JOURNAL OF MEDICAL EDUCATION AND CURRICULAR DEVELOPMENT
(2023)