Article
Anatomy & Morphology
Yoshiko Takeda-Uchimura, Kazuchika Nishitsuji, Midori Ikezaki, Tomoya O. Akama, Yoshito Ihara, Fabrice Allain, Kenji Uchimura
Summary: KS glycan is crucially attached to proteoglycans in the adult brain. Beta3Gn-T7, encoded by B3gnt7, is identified as a major enzyme for KS synthesis in neuropils and the perineuronal region. This suggests that Beta3Gn-T7 in oligodendrocyte lineage cells may play a significant role in forming neuropils and perineuronal nets in the adult brain.
FRONTIERS IN NEUROANATOMY
(2022)
Review
Medicine, Research & Experimental
Jiaxiang Hu, Chen Xue, Qingqing Wang
Summary: The reversible post-transcriptional modification of RNA called N6-methyladenosine (m6A) plays a crucial regulatory role in various eukaryotic activities, including the development and progression of tumors. The tumor immune microenvironment (TIME), consisting of immune cells, cytokines, and cell surface molecules, has a significant impact on tumor immunity. Reshaping the TIME is essential for cancer treatment, and this article reviews how RNA m6A modification affects the TIME and discusses the potential benefits of using m6A regulator inhibitors as a treatment strategy, either alone or in combination with immune checkpoint blockade therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Reina F. Osuka, Masamichi Nagae, Akito Ohuchi, Shiho Ohno, Yoshiki Yamaguchi, Yasuhiko Kizuka
Summary: In this study, it was found through molecular dynamics simulations and biochemical experiments that residues outside the catalytic pocket of GnT-V are likely involved in the recognition of the core part of N-glycan. Additionally, the simulation suggested that UDP binding affects the orientation of the acceptor due to conformational changes. These findings provide new insights into how GnT-V recognizes its glycoprotein substrates.
Review
Cell Biology
Karolina Nowak, Ewa Jablonska, Wioletta Ratajczak-Wrona
Summary: This review focuses on the effects of xenoestrogens (XEs) on the NF-kappa B signaling pathway in immune cells. The findings suggest that XEs generally activate NF-kappa B and play a crucial role in the development and functioning of the immune system.
Article
Mathematics, Interdisciplinary Applications
Yuyuan Liu, Linjie Liu, Ruqiang Guo, Liang Zhang
Summary: This study introduces the conditional investment strategy and government management into a repeated trust game, and finds that the introduction of conditional investment strategy and incentives can promote the evolution of trust. Additionally, as punishment intensity increases, trust can emerge and investment behavior can be maintained. These theoretical results are further verified by numerical simulations.
CHAOS SOLITONS & FRACTALS
(2023)
Article
Biology
Charlotte Toustou, Marie-Laure Walet-Balieu, Marie-Christine Kiefer-Meyer, Marine Houdou, Patrice Lerouge, Francois Foulquier, Muriel Bardor
Summary: N-glycosylation is an important post-translational modification that is highly conserved in eukaryotes, bacteria, and archaea. The processing of N-glycans in eukaryotes is sequential and involves specific steps in the secretory pathway. Recent research has also highlighted the regulation of N-glycosylation, including the biosynthesis of complex-type N-glycans and the role of TMEM165 in different eukaryotic clades.
BIOLOGICAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Greg M. Allen, Nicholas W. Frankel, Nishith R. Reddy, Hersh K. Bhargava, Maia A. Yoshida, Sierra R. Stark, Megan Purl, Jungmin Lee, Jacqueline L. Yee, Wei Yu, Aileen W. Li, K. Christopher Garcia, Hana El-Samad, Kole T. Roybal, Matthew H. Spitzer, Wendell A. Lim
Summary: In this study, we engineered circuits in CAR T cells to locally induce production of the cytokine IL-2 using tumor-specific synNotch receptors. These circuits enhance CAR T cell infiltration and clearance of immunosuppressive tumors, without causing systemic toxicity. The most effective IL-2 induction circuit acts in an autocrine and TCR- or CAR-independent manner, bypassing key tumor suppression mechanisms.
Article
Energy & Fuels
Yahui Wang, Qihuang Huo, Hongjun Fan, Jiancheng Wang, Liping Chang
Summary: This study theoretically investigates the mercury removal mechanism of CuS nanomaterials and finds that their excellent removal performance is related to strong adsorption of Hg-0 on the clusters. The introduction of graphene does not destroy the removal ability of CuS nanomaterials, consistent with experimental studies. The study reveals that Hg chemically adsorbs on (CuS)(n) clusters, expanding the Cu-core and further stabilized by bridging S atoms.
Review
Pharmacology & Pharmacy
Raziye Mohammapdour, Hamidreza Ghandehari
Summary: Research has elucidated the cellular and molecular mechanisms of interaction between inorganic nanoparticles and the immune system, with a specific focus on the immune response to the degradation products. The importance of designing new methods and instruments for assessing the safety of inorganic nanoparticles was emphasized.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Inorganic & Nuclear
Iurii A. Orlov, Tatiana P. Sankova, Alexey N. Skvortsov, Sergey A. Klotchenko, Elena I. Sakhenberg, Aleksandra A. Mekhova, Irina V. Kiseleva, Ekaterina Yu. Ilyechova, Ludmila V. Puchkova
Summary: High-affinity copper transporter 1 (CTR1) is essential for transferring copper from the extracellular environment into cells, but the mechanism of copper transfer via CTR1 is not well understood. Mutations or dysregulation of CTR1 expression can result in copper imbalance, leading to various physiological effects.
DALTON TRANSACTIONS
(2023)
Article
Physics, Applied
V Ryzhii, M. Ryzhii, A. Satou, T. Otsuji, V Mitin, M. S. Shur
Summary: This study reveals that drag caused by interband tunneling has a significant influence on the current-voltage characteristics and impedance of graphene tunneling transistor structures, potentially leading to plasma instability and self-excitation of plasma oscillations in the terahertz frequency range.
PHYSICAL REVIEW APPLIED
(2021)
Article
Pharmacology & Pharmacy
Tingting Fu, Su Zeng, Qingchuan Zheng, Feng Zhu
Summary: This review collects structural information on ABC and SLC transporters and describes the application of computational methods in structure prediction. Using P-glycoprotein and serotonin transporter as examples, it assesses the pivotal role of structure in transport mechanisms, drug selectivity, the molecular mechanisms of drug-drug interactions, and differences caused by genetic polymorphisms.
DRUG METABOLISM AND DISPOSITION
(2023)
Article
Biochemical Research Methods
Jeong Yeh Yang, Stephanie M. Halmo, Jeremy Praissman, Digantkumar Chapla, Danish Singh, Lance Wells, Kelley W. Moremen, William N. Lanzilotta
Summary: The study focuses on the canonical O-mannosylation pathway in humans, emphasizing the importance of functional glycosylation of alpha-dystroglycan. POMGNT2 plays a pivotal role in this process, and its activity and structural changes are crucial for understanding the mechanism of dystroglycanopathies.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2021)
Article
Veterinary Sciences
Ruyi Gao, Min Gu, Liwei Shi, Kaituo Liu, Xiuli Li, Xiaoquan Wang, Jiao Hu, Xiaowen Liu, Shunlin Hu, Sujuan Chen, Daxin Peng, Xinan Jiao, Xiufan Liu
Summary: The glycosylation at site 158 of HA plays a crucial role in the assembly and replication of H5N6 viruses, while also increasing pathogenicity and sensitivity to heat. Lack of glycosylation at this site triggers host immune response, making viral pathogenicity milder.
VETERINARY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
R. R. Mohanty, B. M. Padhy, S. Das, B. R. Meher
Summary: Since November 2019, the COVID-19 pandemic caused by SARS Coronavirus 2 has affected over 195 nations, with higher mortality rates among the elderly population due to acute respiratory distress syndrome (ARDS). Excessive immune activation and cytokine storm are potential causes of lung injury in COVID-19, which may be attributed to an imbalance in redox homeostasis. The antioxidant and free radical scavenging properties of NAC could potentially decrease disease severity by reducing cytokine storm.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yue Hao, Patricia M. Blair, Abhishek Sharma, Douglas A. Mitchell, Satish K. Nair
ACS CHEMICAL BIOLOGY
(2015)
Article
Multidisciplinary Sciences
Yue Hao, Elizabeth Pierce, Daniel Roe, Maho Morita, John A. McIntosh, Vinayak Agarwal, Thomas E. Cheatham, Eric W. Schmidt, Satish K. Nair
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Chemistry, Multidisciplinary
Debosmita Sardar, Yue Hao, Zhenjian Lin, Maho Morita, Satish K. Nair, Eric W. Schmidt
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Multidisciplinary
Maho Morita, Yue Hao, Jouni K. Jokela, Debosmita Sardar, Zhenjian Lin, Kaarina Sivonen, Satish K. Nair, Eric W. Schmidt
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Multidisciplinary
Paola Estrada, Maho Morita, Yue Hao, Eric W. Schmidt, Satish K. Nair
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Immunology
Sarah Jill de Jong, Amandine Crequer, Irina Matos, David Hum, Vignesh Gunasekharan, Lazaro Lorenzo, Fabienne Jabot-Hanin, Elias Imahorn, Andres A. Arias, Hassan Vahidnezhad, Leila Youssefian, Janet G. Markle, Etienne Patin, Aurelia D'Amico, Claire Q. F. Wang, Florian Full, Armin Ensser, Tina M. Leisner, Leslie V. Parise, Matthieu Bouaziz, Nataly Portilla Maya, Xavier Rueda Cadena, Bayaki Saka, Amir Hossein Saeidian, Nessa Aghazadeh, Sirous Zeinali, Peter Itin, James G. Krueger, Lou Laimins, Laurent Abel, Elaine Fuchs, Jouni Uitto, Jose Luis Franco, Bettina Burger, Gerard Orth, Emmanuelle Jouanguy, Jean-Laurent Casanova
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Multidisciplinary Sciences
Yue Hao, Whitney Purtha, Christa Cortesio, Huan Rui, Yan Gu, Hao Chen, E. Allen Sickmier, Paolo Manzanillo, Xin Huang
Article
Pharmacology & Pharmacy
Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith, Brooke M. Rock
DRUG METABOLISM AND DISPOSITION
(2019)
Article
Multidisciplinary Sciences
Yue Hao, Xinchao Yu, Yonghong Bai, Helen J. McBride, Xin Huang
Article
Medicine, Research & Experimental
Karim Mahiddine, Adam Blaisdell, Stephany Ma, Amandine Crequer-Grandhomme, Clifford A. Lowell, Adrian Erlebacher
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Biochemistry & Molecular Biology
Daisuke Fujinami, Chantal V. Garcia de Gonzalo, Subhanip Biswas, Yue Hao, Huan Wang, Neha Garg, Tiit Lukk, Satish K. Nair, Wilfred A. van der Donk
Summary: In this study, two S-glycosyltransferases were characterized for their selective glycosylation of sulfur atoms in peptides, showing an unusual architecture combining a glycosyltransferase type A fold and additional structural domains. The formation of dimers by these enzymes creates an extended cavity for substrate peptides, resembling functional analogy with O-glycosyltransferases involved in cell wall biosynthesis.
CELL CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Manuel A. Ortega, Yue Hao, Mark C. Walker, Stefano Donadio, Margherita Sosio, Satish K. Nair, Wilfred A. van der Donk
CELL CHEMICAL BIOLOGY
(2016)