Article
Nutrition & Dietetics
Lucrecia Carrera-Quintanar, Lorena Funes, Maria Herranz-Lopez, Nestor Vicente-Salar, Raul Bonet-Garcia, Carles Blasco-Peris, Vicente Micol, Antoni Pons, Enrique Roche
Summary: This study aimed to investigate the influence of different polyphenolic antioxidant-rich beverages on five-a-side/futsal players. The results showed that oxidative stress markers significantly increased in the blood after the match, while the almond-based beverage supplemented group had significantly lower malondialdehyde levels in neutrophils compared to the control group. In conclusion, polyphenolic antioxidant and anti-inflammatory supplements could aid in optimal recovery after high-intensity futsal games.
Article
Medicine, General & Internal
Maria Isabel Delgado Dolset, David Obeso, Juan Rodriguez-Coira, Alma Villasenor, Heleia Gonzalez Cuervo, Ana Arjona, Coral Barbas, Domingo Barber, Teresa Carrillo, Maria M. Escribese
Summary: Asthma is a multifactorial and heterogeneous disease. This study identified specific inflammatory pathways activated by allergy and found higher levels of IgE and earlier onset ages in allergic asthmatic patients.
FRONTIERS IN MEDICINE
(2022)
Article
Medical Laboratory Technology
Mariam Ammar, Najla Bahloul, Oumayma Amri, Ribh Omri, Hanene Ghozzi, Samy Kammoun, Khaled Zeghal, Lobna Ben Mahmoud
Summary: This study evaluates markers of oxidative stress in Tunisian asthmatic patients and finds that these markers are correlated with uncontrolled asthma. Asthmatic patients have higher levels of MDA and AOPP, lower levels of GSH and GPx activity, and higher SOD activity. Uncontrolled asthma patients exhibit increased levels of MDA and AOPP and SOD activity, as well as decreased GSH level and GPx activity.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Allergy
Maria Isabel Delgado-Dolset, David Obeso, Juan Rodriguez-Coira, Carlos Tarin, Ge Tan, Jose A. Cumplido, Ana Cabrera, Santiago Angulo, Coral Barbas, Milena Sokolowska, Domingo Barber, Teresa Carrillo, Alma Villasenor, Maria M. Escribese
Summary: Asthma is a complex disease often linked with sensitization to house dust mites. Some patients do not respond to available treatments, showing higher exacerbations and worse quality of life. Metabolic and immunologic routes underlying poor asthma control were elucidated, revealing a unique pro-inflammatory fingerprint in uncontrolled patients.
Review
Nutrition & Dietetics
Hanna Sikorska-Szaflik, Joanna Polomska, Barbara Sozanska
Summary: This article discusses the increasing prevalence of asthma and obesity in the pediatric population, and highlights the worse symptoms and treatment response in obese children with asthma. The shared genetic and immunologic origin of asthma and obesity is suggested. Diet plays a crucial role in controlling both diseases.
Article
Environmental Sciences
Zhixin Guo, Jingli Lv, Xiaoxing Dong, Nanshan Du, Fengzhi Piao
Summary: Research has shown that GABA enhances cucumber tolerance to PHE stress by increasing antioxidant enzyme activity and improving GSH homeostasis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Engineering, Marine
Shengjie Zhou, Ninglu Zhang, Zhengyi Fu, Gang Yu, Zhenhua Ma, Lei Zhao
Summary: This study investigated the changes in antioxidation ability of yellowfin tuna under different salinity environments and found that low salinity may influence the antioxidant function of yellowfin tuna. However, yellowfin tuna juveniles have strong adaptability to a salinity of 29 parts per thousand. Nevertheless, excessive stress may deplete the body's reserves and reduce its resistance.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Aysegul Karaca, Seval Yilmaz, Emre Kaya, Serdar Altun
Summary: Oxidative damage caused by aflatoxin (AF) in rat liver tissue was investigated, and the inhibitory effect of lycopene against this injury was demonstrated. Lycopene reduced malondialdehyde levels, increased glutathione levels, and enhanced antioxidant enzyme activities in the liver. This study suggests that lycopene can prevent AFB1-induced hepatotoxicity.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Oncology
Isabell Goetting, Safa Larafa, Katharina Eul, Mikhail Kunin, Burkhard Jakob, Johann Matschke, Verena Jendrossek
Summary: Aberrant activation of AKT affects cellular antioxidant defense and radiosensitivity. TRAMPC1 cells overexpressing the clinically relevant AKT variant AKT-E17K exhibit improved antioxidant defense and increased radiation resistance. This change is associated with AKT-dependent regulation of cellular levels of reduced glutathione (GSH), both directly and indirectly. Pharmacological inhibition of AKT-dependent metabolic enzymes supporting defense against oxidative stress, such as glutathione synthase and glutathione reductase, enhances the eradication of clonogenic tumor cells, particularly those overexpressing AKT-E17K.
FRONTIERS IN ONCOLOGY
(2022)
Article
Environmental Sciences
Dong Yan, Kuke Ding, Yingxue He, Li Fan, Yongfei Che, Yingjun Zhao, Xiaoyan Jiang
Summary: Human activities increase the risk of stable and radioactive strontium isotopes entering the environment and food chain. This study investigates the effects of strontium on lettuce by analyzing nutrient uptake, physiological responses, and the distribution of strontium in lettuce leaves. The results show significant differences in nutrient uptake, biomass, photosynthetic pigment contents, and antioxidant enzyme activities under different strontium treatment concentrations and times. The distribution of strontium in lettuce leaf tissues is also examined.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Raffaele Cordiano, Mario Di Gioacchino, Rocco Mangifesta, Claudia Panzera, Sebastiano Gangemi, Paola Lucia Minciullo
Summary: MDA is a biomarker used to measure oxidative stress in patients with various diseases. It appears to worsen in the presence of other allergic airway diseases and in relation to disease severity in asthmatic patients. However, the role of MDA in cutaneous allergic diseases is controversial due to small studies and heterogeneity of samples and patients.
Article
Environmental Sciences
Xin Meng, Shilei Luo, Mohammed Mujitaba Dawuda, Xueqin Gao, Shuya Wang, Jianming Xie, Zhongqi Tang, Zeci Liu, Yue Wu, Li Jin, Jian Lyu, Jihua Yu
Summary: The application of silicon (Si) improved the growth and antioxidant capacity of cucumber seedlings under cinnamic acid (CA) stress, mitigating the negative effects of CA on the plants. This study suggests that exogenous Si enhances CA tolerance in cucumber seedlings by protecting photosystem II activity, upregulating the Ascorbate-Glutathione pathway, and reducing reactive oxygen species (ROS) levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Muhammad Ishtiaq, Muhammad Waqas Mazhar, Mehwish Maqbool, Tanveer Hussain, Syed Atiq Hussain, Ryan Casini, Ahmed M. Abd-ElGawad, Hosam O. Elansary
Summary: In this study, the use of selenium nanoparticles (SeNPs) as seed priming agents for enhancing drought tolerance in tomatoes was investigated. Four different SeNPs priming regimes were tested at different concentrations, along with a control treatment. The results showed that seed priming with 75 ppm SeNPs improved tomato crop performance under drought stress. The treatment reduced hydrogen peroxide and malondialdehyde levels, while increasing the functions of superoxide dismutase and catalase. Additionally, it increased the content of various beneficial compounds in tomatoes and upregulated the functions of enzymes involved in antioxidant defense. Seed priming with SeNPs is a promising strategy for sustainable tomato production in arid areas.
Review
Biochemistry & Molecular Biology
Mojgan Morvaridzadeh, Ehsan Sadeghi, Shahram Agah, Siavash Fazelian, Mehran Rahimlou, Ferdinand Georg Kern, Shilan Heshmati, Amirhosein Omidi, Emma Persad, Javad Heshmati
Summary: The study provides convincing evidence supporting the efficacy of ginger supplementation in improving oxidative stress levels, including an increase in antioxidant enzyme activity and total antioxidant capacity, as well as a decrease in malondialdehyde levels.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Agronomy
Hassan S. Al-Zahrani, Kamrun Nahar, Hesham F. Alharby, Hameed Alsamadany, Khalid Rehman Hakeem, Mirza Hasanuzzaman
Summary: This study examined the role of zinc (Zn) in salt-stressed soybean plants. The results showed that zinc supplementation improved plant growth, antioxidant defenses, and ion homeostasis by reducing ion toxicity and increasing glutathione (GSH) levels. Zinc also enhanced glyoxalase activity, leading to the scavenging of toxic metabolites. Furthermore, zinc supplementation helped in the recovery of photosynthetic pigment levels, proline accumulation, and leaf relative water content, indicating improved salt stress tolerance.
Article
Medicine, General & Internal
Sengul Beyaz, Erdem Akbal
Summary: This study investigated circulating levels of nesfatin-1 in patients with inflammatory bowel diseases (IBD), showing significantly elevated levels during active disease periods with good diagnostic value for IBD. Nesfatin-1 could serve as an additional inflammatory marker for the diagnosis of IBD.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Allergy
Nida Oztop, Semra Demir, Sengul Beyaz, Derya Unal, Bahauddin Colakoglu, Suna Buyukozturk, Asli Gelincik
Summary: This study investigated the influence of mental health problems developed during the COVID-19 pandemic on the course of mastocytosis. The study found that fear of COVID-19 and mental health status were more severe in patients during the lockdown period (LP) compared to the return to normal period (RTNP), and there was a positive correlation between mental health status and exacerbation of mastocytosis symptoms. Therefore, providing psychological support during the pandemic is important in controlling the severity of mastocytosis symptoms.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Anesthesiology
Sengul Beyaz, Raif Coskun, Nida Oztop, Evren Aygun, Mukadder Orhan Sungur, Tulay Ozkan Seyhan, Semra Demir, Muge Olgac, Derya Unal, Bahauddin Colakoglu, Suna Buyukozturk, Asli Gelincik
Summary: This study aims to evaluate the negative predictive value of skin tests for common general anesthetic drugs in atopic patients and patients with previous drug allergies. The results show a high negative predictive value for skin tests with general anesthetic drugs and a low rate of allergic reactions during surgery.
BRAZILIAN JOURNAL OF ANESTHESIOLOGY
(2022)
Article
Dermatology
Muge Olgac, Osman Ozan Yegit, Sengul Beyaz, Nida Oztop, Can Tuzer, Deniz Eyice, Pelin Karadag, Raif Coskun, Semra Demir, Bahaauddin Colakoglu, Suna Buyukozturk, Asli Gelincik
Summary: The impact of the COVID-19 pandemic on the course of refractory chronic spontaneous urticaria (CSU) was investigated in this study. It was found that disease activity and levels of anxiety and depression were higher during the quarantine period. Some patients discontinued or prolonged the interval of omalizumab treatment. Therefore, it is recommended for patients to continue their omalizumab treatment and consider prolonging the interval based on disease control.
ANAIS BRASILEIROS DE DERMATOLOGIA
(2023)
Review
Pharmacology & Pharmacy
Sengul Beyaz, Asli Gelincik
Summary: Anaphylaxis is often under-recognized, missed in diagnosis, and delayed in treatment, despite advances in the field of allergy. The symptoms range in severity and the condition is heterogeneous, necessitating a special approach in patient groups at high risk. The present review addresses these risk populations and provides treatment strategies.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Neurosciences
Sevilay Goktas Sahoglu, Yusuf Enes Kazci, Behnaz Karadogan, Mehmet Serif Aydin, Aylin Nebol, Mehmet Ugurcan Turhan, Gurkan Ozturk, Esra Cagavi
Summary: The sensory nervous system is crucial for maintaining cardiac function. However, our understanding of cardiac afferents is limited. In this study, we mapped the VGLUT2-expressing cardiac afferent fibers and found that the dorsal side of the heart has higher nerve density compared to the ventral side. We also observed a diverse range of spinal afferent nerve endings that innervate different parts of the heart. In a chronic myocardial infarct model, we observed hyperinnervation at the infarct border zone and denervation at distal sites of the ischemic area. These findings highlight the importance of further studying the functional and physiological consequences of sensory innervation remodeling after ischemic injury.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Allergy
Ali Can, Raif Coskun, Deniz Eyice Karabacak, Ozdemir Can Tuzer, Osman Ozan Yegit, Pelin Karadag, Nida Oztop, Sengul Beyaz, Gulfer Okumus, Semra Demir, Asli Gelincik
Summary: This study evaluated the association between chronic spontaneous urticaria (CSU) and sleep disturbance. The results showed that patients with CSU and allergic rhinitis had poor sleep quality, impaired sleep hygiene, increased daytime sleepiness, and intermediate type of circadian rhythm. These sleep problems may affect the patients' quality of life and treatment success.
ALLERGY AND ASTHMA PROCEEDINGS
(2023)
Article
Allergy
Osman Ozan Yegit, Pelin Karadag, Deniz Eyice, Nida Oztop, Sengul Beyaz, Ozdemir Can Tuzer, Ali Can, Semra Demir, Derya Erdogdu, Halim Issever, Sema Genc, Beyhan Omer, Stephen Jolles, Asli Gelincik Akkor
Summary: This study aimed to validate CG as a screening test for antibody deficiency (AD) in Turkish adult patients by comparing its role with gamma globulin analysis in protein electrophoresis. The determined CG cut-off value of <20 g/L showed 83.8% sensitivity and 74.9% specificity, and can be used as a screening test in Turkish adult patients.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Allergy
Gulfem Elif Celik, Omur Aydin, Derya Gokmen, Gozde Koycu Buhari, Zeynep Celebi Sozener, Bilun Gemicioglu, Ismet Bulut, Sengul Beyaz, Cihan Orcen, Secil Kepil Ozdemir, Metin Keren, Ebru Damadoglu, Tugce Yakut, Ayse Fusun Kalpaklioglu, Ayse Baccioglu, Sumeyra Alan Yalim, Insu Yilmaz, Ilkay Koca Kalkan, Mehmet Atilla Uysal, Elif Yelda Niksarlioglu, Ali Fuat Kalyoncu, Gul Karakaya, Muge Erbay, Sibel Nayci, Fatma Merve Tepetam, Asli Akkor Gelincik, Hulya Dirol, Ozlem Goksel, Selen Karaoglanoglu, Ferda Oner Erkekol, Sacide Rana Isik, Fusun Yildiz, Yasemin Yavuz, Dilek Karadogan, Nurgul Bozkurt, Ummuhan Seker, Ipek Kivilcim Oguzulgen, Ilknur Basyigit, Serap Argun Baris, Elif Yilmazel Ucar, Tuba Erdogan, Mehmet Polatli, Dane Ediger, Fatma Esra Gunaydin, Murat Turk, Leyla Pur, Zeynep Yegin Katran, Yonca Sekibag, Enes Furkan Aykac, Dilsad Mungan, Ozcan Gul, Ali Cengiz, Bulent Akkurt, Seyma Ozden, Semra Demir, Derya Unal, Ayse Feyza Aslan, Ali Can, Reyhan Gumusburun, Gulhan Bogatekin, Hatice Serpil Akten, Sinem Inan, Munevver Erdinc, Aliye Candan Ogus, Murat Kavas, Demet Polat Yulug, Mehmet Erdem Cakmak, Saltuk Bugra Kaya, Gulistan Alpagat, Eylem Sercan Ozgur, Oguz Uzun, Sule Tas Gulen, Gulseren Pekbak, Deniz Kizilirmak, Yavuz Havlucu, Halil Donmez, Bahar Arslan, Gulden Pacaci Cetin, Sadan Soyyigit, Bilge Yilmaz Kara, Gulden Pasaoglu Karakis, Adile Berna Dursun, Resat Kendirlinan, Ayse Bilge Ozturk, Can Sevinc, Gokcen Omeroglu Simsek, Oznur Abadoglu, Pamir Cerci, Taskin Yucel, Irfan Yorulmaz, Zahide Ciler Tezcaner, Emel Cadalli Tatar, Ahmet Emre Suslu, Serdar Ozer, Engin Dursun, Arzu Yorgancioglu
Summary: The Turkish Adult Asthma Registry was developed to gather information about asthma patients in Turkey. The registry showed a predominance of middle-aged obese women with moderate-to-severe asthma, mostly allergic and eosinophilic in nature. Risk factors for uncontrolled asthma included low education level, severe asthma attacks, low FEV1 values, chronic rhinosinusitis, and living in specific regions. These findings provide valuable insights for improving asthma service delivery.
Article
Allergy
Sadan Soyyigit, Sengul Beyaz, Zeynep Celebi Sozener
Summary: This study retrospectively evaluated the frequency and severity of COVID-19 in patients using biological agents for severe allergic diseases. The results showed that the risk of severe COVID-19 in patients using biological agents was quite low, and eosinopenia that developed after mepolizumab treatment did not constitute a risk factor for the severity of COVID-19.
ASTIM ALLERJI IMMUNOLOJI
(2023)
Article
Allergy
Sengul Beyaz, Neyran Serbetci, Zeynep Turkan Fendoglu, Esra Nur Bulbul, Zeynep Hancioglu, Dilek Oksuzer Cimsir, Ozge Ozturk Aktas, Zeynep Celebi Sozener, Sadan Soyyigit
Summary: This study found that COVID-19 vaccines may trigger or worsen symptoms in patients with CSU. However, exacerbations or relapses associated with the vaccines can be easily controlled with treatments and do not affect subsequent doses.
ASTIM ALLERJI IMMUNOLOJI
(2023)
Article
Allergy
Sengul Beyaz, Serkan Belkaya, Nida Oztop
Summary: This study aimed to determine the plasma levels of PTX3 as an inflammation marker in CSU and its correlation with disease activity and other clinical parameters. The results showed that PTX3 levels were significantly associated with CRP and D-dimer levels and were elevated in CSU patients, indicating their utility as inflammatory markers in CSU.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2023)
Article
Allergy
Nida Oztop, Sengül Beyaz
Summary: This study aimed to examine the relationship between the onset of chronic spontaneous urticaria (CSU) in the elderly and previous stressful life events, disease activity, and perceived general stress. A total of 164 elderly patients with CSU were included in the study. The results showed a strong correlation between having stress and the onset of CSU. Conclusion: Stressful life events and perceived high stress may act as triggers for CSU in the elderly.
ALERGOLOGIA POLSKA-POLISH JOURNAL OF ALLERGOLOGY
(2023)
Meeting Abstract
Oncology
Simge Erdem, Metban Guzel Mastanzade, Pelin Karaca Ozer, Okan Cetin, Ali Cem Hacialioglu, Mehmet Aydogan, Gulcin Yegen, Sengul Beyaz, Sevgi Kalayoglu-Besisik
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)
Review
Allergy
Zeynep Celebi Sozener, Sengul Beyaz, Sadan Soyyigit
Summary: Symptoms can guide whether rhinitis is allergic or non-allergic. Sneezing, eye symptoms, and itching are common in allergic rhinitis patients, while nasal obstruction and postnasal drip are more common in non-allergic rhinitis. The presence of nasal obstruction and postnasal drip may indicate that the disease is more persistent, more severe, and often accompanied by chronic rhinosinusitis, nasal polyposis, and asthma.
ASTIM ALLERJI IMMUNOLOJI
(2022)
