Article
Clinical Neurology
Lipeng Ning, Yogesh Rathi, Tracy Barbour, Nikos Makris, Joan A. Camprodon
Summary: This study utilized novel dMRI analysis to investigate microstructural changes related to rTMS treatment response in 21 MDD patients, finding that rTMS significantly affected the white matter microstructure in the anterior-medial prefrontal fiber bundles, while changes in lateral prefrontal tracts were correlated with treatment response. Further research with larger datasets is needed to fully understand the impact of rTMS on structural connectivity in MDD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Hannah Alfonsa, Richard J. Burman, Paul J. N. Brodersen, Sarah E. Newey, Kashif Mahfooz, Tomoko Yamagata, Marios C. Panayi, David M. Bannerman, Vladyslav V. Vyazovskiy, Colin J. Akerman
Summary: Extended wakefulness leads to reduced performance and increased sleep pressure, which results in changes in network activity in the cortex. These changes are influenced by waking experience and are regulated by intracellular chloride, which affects the strength of GABA(A) receptor-mediated inhibition in cortical pyramidal neurons. The shift in GABA(A) receptor equilibrium potential during wakefulness reflects local activity-dependent processes and is mediated by changes in chloride cotransporter activity. These findings highlight the importance of chloride regulation in linking sleep-wake history, cortical activity, and behavior.
NATURE NEUROSCIENCE
(2023)
Article
Biology
Mohammad Ali Salehinejad, Elham Ghanavati, Joerg Reinders, Jan G. Hengstler, Min-Fang Kuo, Michael A. Nitsche
Summary: Sleep deprivation increases cortical excitability while decreasing inhibitory function, leading to impaired cognitive performance such as memory, learning, and attention. These changes may be associated with increased EEG theta oscillations caused by sleep pressure.
Review
Clinical Neurology
Annie H. Roliz, Sanjeev Kothare
Summary: The purpose of this review is to examine the relationship between sleep, neurodevelopment, and epilepsy and explore the underlying physiological mechanisms. Recent studies have enhanced our understanding of the role of sleep in early brain development and epileptogenesis. Neurodevelopmental impairments in epilepsy may be explained by a failure in normal synaptic and homeostatic plasticity processes that depend on sleep. The recently discovered glymphatic system, a waste clearance system in the central nervous system, has been proposed as a potential mechanism linking sleep and seizures, and may explain the association between sleep deprivation and increased seizure risk.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2023)
Article
Clinical Neurology
Carrie A. Hinchman, Peter J. Fried, Ali Jannati, Daniel Z. Press, Alvaro Pascual-Leone, Adam P. Stern
Summary: This study aimed to investigate whether modulation of corticomotor excitability by rTMS predicts response to rTMS treatment for treatment-resistant depression (TRD). The results showed that higher post-10 Hz MEP change predicted greater improvement on the Beck Depression Inventory II (BDI-II) and Hamilton Depression Rating Scale (HAM-D). However, this relationship was not observed with intermittent theta-burst stimulation (iTBS).
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Jin Seung Choung, Sohom Bhattacharjee, Jeong Pyo Son, Jong Moon Kim, Dong Sik Cho, Choon Sik Cho, MinYoung Kim
Summary: Repetitive transcranial magnetic stimulation (rTMS) is being explored as a new treatment technique for brain lesions, but the effects in animals cannot directly represent the effects in humans due to differences in size and mechanistic characteristics. This study aimed to develop a mouse rTMS device to simulate clinical application. The magnetic field intensity generated by the mouse coil was lower than that by the human coil, and the predicted simulation values matched the measured intensity in vivo. Further research using miniaturized rTMS devices for mice should be conducted to make the findings more relevant to humans.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Xiangyang Xiong, Yan Zuo, Lu Cheng, Zhenyu Yin, Tianpeng Hu, Mengtian Guo, Zhaoli Han, Xintong Ge, Wenzhu Li, Yan Wang, Dong Wang, Conglin Wang, Lan Zhang, Yaodan Zhang, Qiang Liu, Fanglian Chen, Ping Lei
Summary: This study found that modafinil improves learning and memory, reduces inflammation, and inhibits neuronal pyroptosis. It also upregulates brain-derived neurotrophic factor and synaptic activity. These findings suggest that modafinil can alleviate cognitive decline following sleep deprivation.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Maximilian Lenz, Amelie Eichler, Andreas Vlachos
Summary: Inflammation affects neuronal plasticity, and inflammation-induced alterations in synaptic plasticity are associated with the development of neuropsychiatric symptoms. Current diagnostic and intervention strategies are limited in restoring inflammation-induced deficits in synaptic plasticity.
Article
Neurosciences
Hui Gao, Yuxin Zhang, Danlei Luo, Jing Xu, Shuwen Tan, Ying Li, Wanling Qi, Qian Zhai, Qiang Wang
Summary: Sleep loss has become common in modern society and has a significant impact on cognitive abilities. Activation of the dopamine receptor D2 (DRD2) has been found to play a specific role in cognition, but the exact mechanism of how DRD2 affects cognition after sleep deprivation is still unclear. This study observed cognitive impairment and impaired synaptic plasticity in mice with chronic sleep restriction (CSR), including downregulation of synaptophysin and PSD95, decreased postsynaptic density thickness, neuron complexity, and spine density. The study also found downregulation of hippocampal DRD2 and Cryab expression in CSR mice, as well as neuroinflammation indicated by NF-κB translocation. However, treatment with the DRD2 agonist quinpirole effectively reversed these changes, both in vitro and in vivo, suggesting a potential anti-neuroinflammatory effect of Drd2/Cryab/NF-κB in CSR mice.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Psychiatry
Jeffrey D. Voigt, Andrew F. Leuchter, Linda L. Carpenter
Summary: Through analyzing data from multiple randomized controlled trials, this study found that theta burst stimulation (TBS) is superior to sham treatment in treating major depressive disorder, and is noninferior to standard rTMS therapy (high frequency stimulation over the left prefrontal cortex). These results support the continued development of TBS as a treatment for depression.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Jin-Xiang Cheng, Xianchao Zhao, Jian Qiu, Yingcong Jiang, Jiafeng Ren, Shuyu Sun, Rong Wang, Changjun Su
Summary: The study shows that transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) can improve cognition following sleep deprivation, including attention, memory, executive function, and processing speed. This stimulation does not disrupt recovery sleep, and cognitive performance after recovery sleep returns to baseline levels.
Article
Behavioral Sciences
Chenyi Gao, Yue Cao, Mengying He, Xuemin Zhang, Qi Zhong, Lijuan Tang, Ting Chen, Zongze Zhang
Summary: Sleep deprivation has negative effects on learning and memory in adolescent mice, but treatment with a Shh agonist can prevent these effects.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Multidisciplinary Sciences
Janna D. Lendner, Niels Niethard, Bryce A. Mander, Frank J. van Schalkwijk, Sigrid Schuh-Hofer, Hannah Schmidt, Robert T. Knight, Jan Born, Matthew P. Walker, Jack J. Lin, Randolph F. Helfrich
Summary: The study shows that non-oscillatory brain activity during REM sleep plays a key role in the sleep-dependent recalibration of neural population dynamics. The extent of REM sleep recalibration predicts the success of overnight memory consolidation by favoring remembering over forgetting. This non-oscillatory mechanism explains how REM sleep enhances long-term memory in humans.
Article
Clinical Neurology
A. M. Heath, M. Brewer, J. Yesavage, M. W. McNerney
Summary: This study demonstrates that repetitive transcranial magnetic stimulation (rTMS) applied between learning and retrieval phases can effectively improve memory in mice by promoting synaptic connections and maintaining key pathways in neurons.
Article
Clinical Neurology
Giuseppina Natale, Micol Colella, Maria De Carluccio, Daniele Lelli, Alessandra Paffi, Filippo Carducci, Francesca Apollonio, Daniela Palacios, Maria Teresa Viscomi, Micaela Liberti, Veronica Ghiglieri
Summary: This study reveals that intermittent theta-burst stimulation (iTBS) has specific effects on astrocytes, improving motor performance in rats with Parkinson's disease. Furthermore, numerical dosimetry and biological findings allow us to predict electrical stimulation induced in different brain areas and associate it with functional and molecular changes.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Kai Spiegelhalder, Fee Benz, Bernd Feige, Dieter Riemann
Summary: This article reviews five exemplary classifications of insomnia subtypes and critically discusses the temporal stability of subtype membership as well as the clinical relevance of subtype classifications.
Article
Neurosciences
Michael Orth, Carole Wagnon, Elisabeth Neumann-Dunayevska, Christoph Phillipp Kaller, Stefan Kloeppel, Beat Meier, Katharina Henke, Jessica Peter
Summary: The role of hemispheric lateralization in the prefrontal cortex in memory formation, especially for emotionally valenced information, is debated. By modulating the activity of the left or right dorsolateral prefrontal cortex during encoding, the study found that enhancing left DLPFC activity improved encoding and free recall performance, particularly for semantically processed words. Additionally, left DLPFC stimulation increased memory formation for positive content, while right DLPFC stimulation increased memory formation for negative content. The study suggests that hemispheric laterlization plays a role in establishing successful episodic memories.
Article
Psychology, Multidisciplinary
Nadine Schmidt, Maximilian Haas, Christine Krebs, Stefan Kloppel, Matthias Kliegel, Jessica Peter
Summary: In laboratory time-based prospective memory tasks, older adults perform worse than younger adults. Less frequent clock checking due to executive function problems may be responsible. This study aimed to investigate the role of clock checking in older adults' time-based prospective memory and whether executive functions would be associated with clock checking and time-based prospective memory. The results showed that time-based prospective memory declined with age due to less frequent clock checking. The link between executive functions and clock checking or time-based prospective memory was only found when not controlling for age.
CURRENT PSYCHOLOGY
(2023)
Review
Clinical Neurology
Celine J. Zeller, Marc A. Zust, Marina Wunderlin, Christoph Nissen, Stefan Kloppel
Summary: Dementia is a major cause of death and disability in older individuals, and is associated with sleep fragmentation and loss of slow-wave sleep. Auditory stimulation has shown promise in enhancing sleep quality and potentially ameliorating cognitive decline. However, tailored approaches for older adults and further studies on the downstream effects are still needed before recommending portable auditory stimulation devices as clinical intervention tools.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Fee Benz, Dieter Riemann, Katharina Domschke, Kai Spiegelhalder, Anna F. Johann, Nathaniel S. Marshall, Bernd Feige
Summary: The objective of this study was to assess the agreement and linear relationships amongst multiple measures of sleep duration in patients with insomnia disorder and good sleeper controls. The results suggest that subjective and objective measures capture different aspects of sleep, even when addressing the same value. It is important to consider the population being studied and the assessment method when interpreting results.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Florian Holub, Roxana Petri, Julian Schiel, Bernd Feige, Martin K. Rutter, Sandra Tamm, Dieter Riemann, Simon D. Kyle, Kai Spiegelhalder
Summary: This study investigates the associations between insomnia symptoms and resting-state functional connectivity at the whole-brain level using a large sample size. The results suggest that frequent insomnia symptoms are associated with altered functional connectivity between brain networks, which may contribute to dysfunctional affective and cognitive processing and impaired sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Letter
Biochemistry & Molecular Biology
Dominique Endres, Katharina von Zedtwitz, Horst Urbach, Rick Dersch, Kimon Runge, Bernd Feige, Kathrin Nickel, Miriam A. Schiele, Harald Pruess, Katharina Domschke, Marco Reisert, Volker A. Coenen
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Lukas Frase, Bernd Feige, Isabella Gioia, Viveka K. Loeck, Katharina Domschke, Raphael J. Dressle, Hannah Kilian, Kai Spiegelhalder, Thomas Schlaepfer, Dieter Riemann
Summary: This study examined three potential markers of LC NE activity and found no significant differences between insomniacs and good sleeping controls on these markers.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Raphael J. J. Dressle, Dieter Riemann, Kai Spiegelhalder, Lukas Frase, Michael L. L. Perlis, Bernd Feige
Summary: According to the hyperarousal model, insomnia is characterized by increased arousal in the cortical, cognitive, and physiological domains. However, the interaction between these arousal domains is poorly understood. This observational case-control study investigated cortical arousal during the night, pre-sleep cognitive arousal, and their relationship in patients with insomnia disorder (ID). The study found that patients with ID exhibited increased cortical and cognitive arousal, particularly in the gamma power of EEG spectral analysis. The findings suggest a potential association between pre-sleep worry and rumination and the elicitation of cortical arousal during the night.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Johanna Ell, Julian E. Schiel, Bernd Feige, Dieter Riemann, Casandra C. Nyhuis, Julio Fernandez-Mendoza, Celine Vetter, Martin K. Rutter, Simon D. Kyle, Kai Spiegelhalder
Summary: This study examined the long-term effects of sleep health and shift work on cognitive performance in middle-aged and older adults using data from the UK Biobank. The results indicated that poor sleep health and shift work significantly predicted lower cognitive performance in this population.
Article
Psychiatry
Kimon Runge, Marco Reisert, Bernd Feige, Kathrin Nickel, Horst Urbach, Nils Venhoff, Andreas Tzschach, Miriam A. A. Schiele, Luciana Hannibal, Harald Pruess, Katharina Domschke, Ludger Tebartz van Elst, Dominique Endres
Summary: This study aimed to determine whether a comprehensive screening approach such as the Freiburg-Diagnostic-Protocol for patients with OCD (FDP-OCD) is effective in detecting organic OCD forms. Results showed that out of the 61 patients analyzed, 5 were suspected to have organic OCD, including 3 with autoimmune OCD and 2 with newly diagnosed genetic syndromes. The study also revealed the presence of immunological abnormalities, particularly decreased neurovitamin levels and increased streptococcal and antinuclear antibodies, in the entire patient group.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Laura Luisa Bielinski, Gwendolyn Walchli, Christoph Nissen, Thomas Berger, Franz Moggi
Summary: This study aims to examine the feasibility and preliminary evidence for effectiveness of a web-based emotion regulation intervention provided as an add-on to acute psychiatric inpatient care. The study will randomly allocate 60 patients to either treatment as usual (TAU) or the intervention group, which will receive TAU plus access to a web-based intervention focusing on emotion regulation. The primary outcome is symptom severity, and secondary outcomes include emotion regulation parameters and patient satisfaction.
JMIR RESEARCH PROTOCOLS
(2023)
Review
Clinical Neurology
Lukas Frase, Christoph Nissen, Kai Spiegelhalder, Bernd Feige
Summary: The importance of polysomnography (PSG) in the diagnosis and treatment of insomnia disorder (ID) is a highly debated topic. This review provides a summary of the current scientific knowledge on PSG indications and findings in ID, and the guidelines for conducting PSG in ID. It also discusses important questions regarding ID subtyping to guide personalized pharmacological and psychotherapeutic treatment approaches.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Psychiatry
Dominik Denzel, Kimon Runge, Bernd Feige, Benjamin Pankratz, Karoline Pitsch, Andrea Schlump, Kathrin Nickel, Ulrich Voderholzer, Ludger Tebartz van Elst, Katharina Domschke, Miriam A. Schiele, Dominique Endres
Summary: This systematic literature review found an association between OCD and autoantibodies in rare cases, with some patients benefiting from immunotherapy. Further studies comparing autoantibodies in patients with OCD and healthy controls are needed.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Julian E. Schiel, Sandra Tamm, Florian Holub, Roxana Petri, Hassan S. Dashti, Katharina Domschke, Bernd Feige, Matthew O. Goodman, Samuel E. Jones, Jacqueline M. Lane, Pietro-Luca Ratti, David W. Ray, Susan Redline, Dieter Riemann, Martin K. Rutter, Richa Saxena, Claire E. Sexton, Masoud Tahmasian, Heming Wang, Michael N. Weedon, Antoine Weihs, Simon D. Kyle, Kai Spiegelhalder
Summary: Investigating associations between sleep health and grey matter volume in over 33,000 individuals, the study found that insomnia symptoms do not directly affect brain morphometry. Long sleep duration was associated with larger grey matter volume of basal ganglia substructures, possibly indicating early stage sleep apnoea in old age. The importance of sleep health in future morbidity and mortality is highlighted.
BRAIN COMMUNICATIONS
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
