Article
Endocrinology & Metabolism
Zhiwei Zhang, Hui Zhao, Aixia Wang
Summary: The study found that oleuropein can effectively alleviate symptoms of GDM and improve gestational outcomes in a mouse model by reducing oxidative stress and inflammation. The activation of the AMPK signaling pathway may play a role in this process.
ENDOCRINE CONNECTIONS
(2021)
Article
Pharmacology & Pharmacy
Shuyun Zhang, Yunjie Wang, Ling Zhou, Ziyang Yu, Aihua Gao
Summary: IRF2BP2 ameliorates the outcomes of GDM and suppresses inflammation in mice with GDM through activation of AMPK signaling, reducing blood glucose and insulin levels, improving lipid metabolism, and ameliorating histopathological changes in the islets.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Maria Jose Bendek, Gisela Canedo-Marroquin, Ornella Realini, Ignacio N. Retamal, Marcela Hernandez, Anilei Hoare, Dolores Busso, Lara J. Monteiro, Sebastian E. Illanes, Alejandra Chaparro
Summary: Periodontitis is a chronic inflammatory immune disease that can result in periodontal tissue destruction and tooth loss in susceptible hosts, leading to a systemic pro-inflammatory state associated with increased risk of various systemic diseases like type 2 diabetes. The mechanistic link between periodontitis and gestational diabetes mellitus remains unclear, with potential involvement of new molecular participants such as extracellular vesicles and non-coding RNAs in the association.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Weixia Chen, Huiqin Wang, Jing Liu, Kaixia Li
Summary: This study investigated the role of Kruppel-like factor 9 (KLF9) in gestational diabetes mellitus (GDM). The researchers found that interference of KLF9 could alleviate cell apoptosis, inflammation, and oxidative stress in GDM by upregulating DDAH2, which may guide targeted therapies against GDM.
Article
Pharmacology & Pharmacy
Rong Huang, Yang Chen, Mei Tu, Wei Wang
Summary: This study assessed the correlations between novel pro-inflammatory indexes (MHR and MAR) and bone mineral density, bone turnover markers in Chinese postmenopausal women with T2DM. The results showed that MHR and MAR were significantly associated with osteoporosis, suggesting that they may be ideal markers to reflect bone homeostasis imbalance caused by chronic inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Katarzyna Piotrowska, Katarzyna Zgutka, Marta Tkacz, Maciej Tarnowski
Summary: Diabetes is a major healthcare problem, especially for pregnant women, and requires an appropriate approach. Gestational diabetes mellitus and type 2 diabetes mellitus share many similarities and induce oxidative stress and cellular stress signaling. The risk of diabetes during pregnancy can lead to complications for both the mother and fetus. Physical activity is not only important for treating the negative effects of diabetes, but also for preventing its progression and reversing changes. Regular training sessions have a positive effect on the immune status of diabetic patients, mothers, and fetuses, causing changes in immune cell levels, cytokine activation, production and secretion, as well as microRNA, which improve overall well-being.
Article
Endocrinology & Metabolism
Xinmei Huang, Bingbing Zha, Manna Zhang, Yue Li, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Cuijun Gao, Zaoping Chen, Heyuan Ding, Ling Ma, Yanquan Zhang, Shufei Zang, Tie-Ning Zhang, Jun Liu
Summary: The study found that decreased monocyte count throughout pregnancy was closely associated with the development of gestational diabetes mellitus (GDM), macrosomia, and the chronic inflammatory state of GDM. First-trimester monocyte count performed better as a risk factor and diagnostic predictor of GDM and macrosomia compared to second and third trimester counts.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medical Laboratory Technology
Ercan Saruhan, Emre Ispir, Yalcin Basaran, Eren Akbaba, Kursad Tosun, Mutay Aslan
Summary: This study compared serum levels of LDL subfractions, betatrophin, and GPIHBP1 between patients with gestational diabetes mellitus (GDM) and healthy pregnant women. The results showed that GDM group had higher levels of LDL6 subfraction, betatrophin, and GPIHBP1 compared to the control group. This suggests a possible association between GDM and insulin resistance, and further research is needed to fully understand the mechanisms of this relationship in larger sample sizes.
CLINICAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Xinli Song, Cheng Wang, Tingting Wang, Senmao Zhang, Jiabi Qin
Summary: Genetically predicted causal associations were found between general and central obesity and GDM, with circulating lipids acting as potential mediators. The results indicated a direct effect of obesity on GDM risk, with lipid metabolism playing a role in the relationship.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Medicine, Research & Experimental
Yajing Gao, Yanhua Hu, Lan Xiang
Summary: This study found a positive association between remnant cholesterol (RC) levels in early pregnancy and the risk of gestational diabetes mellitus (GDM) in pregnant women. RC serves as an early warning indicator of GDM, especially for pregnant women with normal levels of HDL-c, LDL-c, and TC that can easily be overlooked. Pregnant women with RC levels exceeding 24.30 mg/dL have a higher risk of developing GDM.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Marie-Eve Tremblay, Zakaria A. Almsherqi, Yuru Deng
Summary: Fatty acids and phospholipids play essential roles in the structure and function of cell membranes. Recent research has focused on two subclasses of ether phospholipids, platelet activating factor (PAF) and its precursor plasmalogen, due to their association with several chronic inflammatory, neurodegenerative, and metabolic disorders. Inflammatory conditions often involve an excess of PAF or decreased levels of plasmalogens. The exact mechanisms of plasmalogens in inflammation are not yet fully understood. Anti-inflammatory responses are likely mediated by the plasmalogen signaling pathway, while pro-inflammatory responses involve the release of arachidonic acid from membrane phospholipids, particularly derived from the hydrolysis of plasmalogens. Changes in plasmalogen levels can affect cell membrane properties and impact signaling pathways involved in inflammatory cascades and immune responses. Plasmalogen replacement therapy shows promise as an anti-inflammatory strategy for treating chronic diseases with an inflammatory component.
Article
Biochemistry & Molecular Biology
Yadi Zheng, Na Zhu, Jing Wang, Na Zhao, Chun Yuan
Summary: The study demonstrated the protective effect of crocetin against STZ-induced GDM in rats by suppressing inflammatory, oxidative, and apoptosis parameters. Crocetin showed antioxidant and anti-inflammatory effects and could be used as a preventive medication for gestational diabetes mellitus.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Colm J. McElwain, Fergus P. McCarthy, Cathal M. McCarthy
Summary: Gestational diabetes mellitus is a pregnancy complication that can lead to maternal hyperglycemia and immune dysregulation, impacting fetal health and increasing the risk of developing diabetes. Understanding the origins and evolution of these pathways is crucial for improving therapeutic interventions and outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Amin Ullah, Jing Zhao, Rajeev K. Singla, Bairong Shen
Summary: This review discusses the role of CXC and CX3CL1 chemokines and their receptors in the pathophysiology of preeclampsia and gestational diabetes mellitus (GDM) and investigates the potential of CXC-based therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Hongying Liu, Aizhong Liu, Atipatsa C. Kaminga, Judy McDonald, Shi Wu Wen, Xiongfeng Pan
Summary: This meta-analysis indicates the presence of abnormal concentrations of various chemokines in patients with GDM, which are closely associated with the development of GDM. Additionally, the subgroup analysis highlights the importance of investigating the potential mechanisms underlying this association to develop individualized clinical and therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)