期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 15, 期 -, 页码 10385-10399出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S277645
关键词
gambogic acid; anti-cancer activities; drug delivery systems; combination therapy
资金
- National Natural Science Foundation of China [81803743]
- Basic Research Foundation of the China Academy of Chinese Medical Sciences [ZZ13-YQ-041]
- National Major Scientific and Technological Special Project for Significant New Drugs Development [2019ZX09301160, 2019ZX09721001-005-002]
Gambogic acid (GA), a kind of dry resin secreted by the Garcinia hanburyi tree, is a natural active ingredient with various biological activities, such as anti-cancer, anti-inflammatory, antioxidant, anti-bacterial effects, etc. An increasing amount of evidence indicates that GA has obvious anti-cancer effects via various molecular mechanisms, including the induction of apoptosis, autophagy, cell cycle arrest and the inhibition of invasion, metastasis, angiogenesis. In order to improve the efficacy in cancer treatment, nanometer drug delivery systems have been employed to load GA and form micelles, nanoparticles, nanofibers, and so on. In this review, we aim to offer a summary of chemical structure and properties, anti-cancer activities, drug delivery systems and combination therapy of GA, which might provide a reference to promote the development and clinical application of GA.
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