Metals in Imaging of Alzheimer’s Disease

Amyloid‐β Oligomer‐Targeted Gadolinium‐Based NIR/MR Dual‐Modal Theranostic Nanoprobe for Alzheimer's Disease

(2020) Chengke Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer’s Pathogenesis

(2020) Botond Penke et al.   MOLECULES

Hypoxia imaging and theranostic potential of [64Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention mechanisms

(2020) Tengzhi Liu et al.   EJNMMI Research

Insight into the Development of PET Radiopharmaceuticals for Oncology

(2020) Joseph Lau et al.   Cancers

Synthesis, biological evaluation and preclinical study of a novel 99mTc-peptide: A targeting probe of amyloid-β plaques as a possible diagnostic agent for Alzheimer’s disease

(2020) Safura Jokar et al.   BIOORGANIC CHEMISTRY

Metal complexes that bind to the amyloid-β peptide of relevance to Alzheimer’s disease

(2020) Luiza M.F. Gomes et al.   COORDINATION CHEMISTRY REVIEWS

Copper Bis(thiosemicarbazonato)-stilbenyl Complexes That Bind to Amyloid-β Plaques

(2020) Asif Noor et al.   INORGANIC CHEMISTRY

Development and long-term evaluation of a new 68Ge/68Ga generator based on nano-SnO2 for PET imaging

(2020) Eduardo Romero et al.   Scientific Reports

18F-Florbetaben Amyloid PET Imaging: A Chinese Study in Cognitive Normal Controls, Mild Cognitive Impairment, and Alzheimer’s Disease Patients

(2020) Yan Chang et al.   Frontiers in Neuroscience

In vivo Retinal Fluorescence Imaging With Curcumin in an Alzheimer Mouse Model

(2020) Ahmad Sidiqi et al.   Frontiers in Neuroscience

Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging

(2020) Mootaz M. Salman et al.   Frontiers in Bioengineering and Biotechnology

Remarkable Brain Penetration of Cyclopentadienyl M(CO)3+ (M = 99mTc, Re) Derivatives of Benzothiazole and Benzimidazole Paves the Way for Their Application as Diagnostic, with Single-Photon-Emission Computed Tomography (SPECT), and Therapeutic Agents for Alzheimer’s Disease

(2019) Marina Sagnou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potential Diagnostic Imaging of Alzheimer’s Disease with Copper-64 Complexes That Bind to Amyloid-β Plaques

(2019) Lachlan E. McInnes et al.   INORGANIC CHEMISTRY

Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups

(2019) Brett M. Paterson et al.   INORGANIC CHEMISTRY

Advances in Microfluidic Blood–Brain Barrier (BBB) Models

(2019) Arianna Oddo et al.   TRENDS IN BIOTECHNOLOGY

A Picture of Modern Tc-99m Radiopharmaceuticals: Production, Chemistry, and Applications in Molecular Imaging

(2019) Alessandra Boschi et al.   Applied Sciences-Basel

Novel 99mTc-2-arylimidazo[2,1-b]benzothiazole derivatives as SPECT imaging agents for amyloid-β plaques

(2019) Sajjad Molavipordanjani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, physicochemical and biological evaluation of tacrine derivative labeled with technetium-99m and gallium-68 as a prospective diagnostic tool for early diagnosis of Alzheimer’s disease

(2019) Ewa Gniazdowska et al.   BIOORGANIC CHEMISTRY

[18F]Florbetapir PET/MR imaging to assess demyelination in multiple sclerosis

(2019) Antonio Carotenuto et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Serum and brain natural copper stable isotopes in a mouse model of Alzheimer’s disease

(2019) Frédéric Moynier et al.   Scientific Reports

Gallium-68 and scandium-44 labelled radiotracers based on curcumin structure linked to bifunctional chelators: Synthesis and characterization of potential PET radiotracers

(2019) Giulia Orteca et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Amyloid β-targeted metal complexes for potential applications in Alzheimer's disease

(2018) Hao Liu et al.   Future Medicinal Chemistry

Rhenium and technetium complexes of thioamide derivatives of pyridylhydrazine that bind to amyloid-β plaques

(2018) Scott P. Fletcher et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

(2018) Kun Zhang et al.   Neural Regeneration Research

Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective

(2018) Quanguo He et al.   Cells

Coordination Chemistry of Bifunctional Chemical Agents Designed for Applications in 64Cu PET Imaging for Alzheimer’s Disease

(2017) Anuj K. Sharma et al.   INORGANIC CHEMISTRY

Evaluation of 64Cu-Based Radiopharmaceuticals that Target Aβ Peptide Aggregates as Diagnostic Tools for Alzheimer’s Disease

(2017) Nilantha Bandara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

2-(4′-Aminophenyl)benzothiazole Labeled with 99mTc-Cyclopentadienyl for Imaging β-Amyloid Plaques

(2017) Christos Kiritsis et al.   ACS Medicinal Chemistry Letters

Synthesis and biological evaluation of novel technetium-99m-labeled phenylquinoxaline derivatives as single photon emission computed tomography imaging probes targeting β-amyloid plaques in Alzheimer's disease

(2017) Shimpei Iikuni et al.   RSC Advances

68Ga-Bivalent Polypegylated Styrylpyridine Conjugates for Imaging Aβ Plaques in Cerebral Amyloid Angiopathy

(2016) Zhihao Zha et al.   BIOCONJUGATE CHEMISTRY

99mTc-Labeled 2-Arylbenzothiazoles: Aβ Imaging Probes with Favorable Brain Pharmacokinetics for Single-Photon Emission Computed Tomography

(2016) Xiaoyang Zhang et al.   BIOCONJUGATE CHEMISTRY

Synthesis and evaluation of copper-64 labeled benzofuran derivatives targeting β-amyloid aggregates

(2016) Hiroyuki Watanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of Oxorhenium(V) and Oxotechnetium(V) Complexes That Bind to Amyloid-β Plaques

(2016) David J. Hayne et al.   INORGANIC CHEMISTRY

Affinity of nat/68Ga-Labelled Curcumin and Curcuminoid Complexes for β-Amyloid Plaques: Towards the Development of New Metal-Curcumin Based Radiotracers

(2016) Sara Rubagotti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A gallium(III) Schiff base-curcumin complex that binds to amyloid-β plaques

(2016) Jaclyn L. Lange et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis and Evaluation of a Zr-89-Labeled Monoclonal Antibody for Immuno-PET Imaging of Amyloid-β Deposition in the Brain

(2016) Jens Fissers et al.   MOLECULAR IMAGING AND BIOLOGY

Imaging of Cerebral Amyloid Angiopathy with Bivalent 99mTc-Hydroxamamide Complexes

(2016) Shimpei Iikuni et al.   Scientific Reports

Curcumin Attenuates Amyloid-β Aggregate Toxicity and Modulates Amyloid-β Aggregation Pathway

(2015) Arjun Thapa et al.   ACS Chemical Neuroscience

Rhenium and technetium complexes that bind to amyloid-β plaques

(2015) David J. Hayne et al.   DALTON TRANSACTIONS

99mTc-labeled-2-arylbenzoxazole derivatives as potential Aβ imaging probes for single-photon emission computed tomography

(2015) Xuedan Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chemical Fluorescent Probe for Detection of Aβ Oligomers

(2015) Chai Lean Teoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gallium-68 Complexes Conjugated to Pittsburgh Compound B: Radiolabeling and Biological Evaluation

(2015) Damien Cressier et al.   MOLECULAR IMAGING AND BIOLOGY

99mTc(CO)3-Labeled Benzothiazole Derivatives Preferentially Bind Cerebrovascular Amyloid: Potential Use as Imaging Agents for Cerebral Amyloid Angiopathy

(2015) Jianhua Jia et al.   MOLECULAR PHARMACEUTICS

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system

(2014) Muna Aryal et al.   ADVANCED DRUG DELIVERY REVIEWS

Novel hexadentate and pentadentate chelators for 64Cu-based targeted PET imaging

(2014) Inseok Sin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A 68Ga complex based on benzofuran scaffold for the detection of β-amyloid plaques

(2014) Hiroyuki Watanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Gadolinium-based contrast agents targeted to amyloid aggregates for the early diagnosis of Alzheimer's disease by MRI

(2014) Guillaume Bort et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Characterization of 68Ga-Labeled Curcumin and Curcuminoid Complexes as Potential Radiotracers for Imaging of Cancer and Alzheimer’s Disease

(2014) Mattia Asti et al.   INORGANIC CHEMISTRY

Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity

(2014) Anuj K. Sharma et al.   INORGANIC CHEMISTRY

Enhancement of Binding Affinity for Amyloid Aggregates by Multivalent Interactions of 99mTc-Hydroxamamide Complexes

(2014) Shimpei Iikuni et al.   MOLECULAR PHARMACEUTICS

68Ga based probe for Alzheimer's disease: synthesis and preclinical evaluation of homodimeric chalcone in β-amyloid imaging

(2014) Kanchan Chauhan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

Clinical applications of Gallium-68

(2013) Sangeeta Ray Banerjee et al.   APPLIED RADIATION AND ISOTOPES

99mTc-labeled dibenzylideneacetone derivatives as potential SPECT probes for in vivo imaging of β-amyloid plaque

(2013) Yanping Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Gd3+ complexes conjugated to Pittsburgh compound B: potential MRI markers of β-amyloid plaques

(2013) André F. Martins et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Diagnostic Imaging Agents for Alzheimer’s Disease: Copper Radiopharmaceuticals that Target Aβ Plaques

(2013) James L. Hickey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper induces the accumulation of amyloid-beta in the brain

(2013) Dong-Kyeong Kim et al.   Molecular & Cellular Toxicology

Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later

(2013) C. M. Roe et al.   NEUROLOGY

99mTc-labeled benzothiazole and stilbene derivatives as imaging agents for Aβ plaques in cerebral amyloid angiopathy

(2013) Jianhua Jia et al.   MedChemComm

PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of β-Amyloid Plaques

(2013) André F. Martins et al.   ACS Medicinal Chemistry Letters

Curcumin as an amyloid-indicator dye in E. coli

(2012) Oscar A. McCrate et al.   CHEMICAL COMMUNICATIONS

Novel Cyclopentadienyl Tricarbonyl Complexes of 99mTc Mimicking Chalcone as Potential Single-Photon Emission Computed Tomography Imaging Probes for β-Amyloid Plaques in Brain

(2012) Zijing Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide

(2012) Anuj K. Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gadolinium-based contrast agents for magnetic resonance cancer imaging

(2012) Zhuxian Zhou et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Synthesis and evaluation of analogues of HYNIC as bifunctional chelators for technetium

(2011) Levente K. Meszaros et al.   DALTON TRANSACTIONS

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques

(2010) SinChun Lim et al.   CHEMICAL COMMUNICATIONS

Low-frequency sonophoresis: application to the transdermal delivery of macromolecules and hydrophilic drugs

(2010) Baris E Polat et al.   Expert Opinion on Drug Delivery

Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention

(2010) Leonid Bartik et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

In vivo, in vitro and in silico methods for small molecule transfer across the BBB

(2009) Jurgen Mensch et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Prodrug Approaches for CNS Delivery

(2008) Jarkko Rautio et al.   AAPS Journal