Regulation of the First Committed Step in Lipopolysaccharide Biosynthesis Catalyzed by LpxC Requires the Essential Protein LapC (YejM) and HslVU Protease

Heat-shock proteases promote survival of Pseudomonas aeruginosa during growth arrest

(2020) David W. Basta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an Inner Membrane Protein Required for PhoPQ-Regulated Increases in Outer Membrane Cardiolipin

(2020) Junping Fan et al.   mBio

YejM Modulates Activity of the YciM/FtsH Protease Complex To Prevent Lethal Accumulation of Lipopolysaccharide

(2020) Randi L. Guest et al.   mBio

An Essential Membrane Protein Modulates the Proteolysis of LpxC to Control Lipopolysaccharide Synthesis in Escherichia coli

(2020) Elayne M. Fivenson et al.   mBio

YejM controls LpxC levels by regulating Protease Activity of the FtsH/YciM Complex of Escherichia coli

(2020) Daniel Nguyen et al.   JOURNAL OF BACTERIOLOGY

Structure of the essential inner membrane lipopolysaccharide–PbgA complex

(2020) Thomas Clairfeuille et al.   NATURE

Multicopy Suppressor Analysis of Strains Lacking Cytoplasmic Peptidyl-Prolyl cis/trans Isomerases Identifies Three New PPIase Activities in Escherichia coli That Includes the DksA Transcription Factor

(2020) Pawel Wojtkiewicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The essential inner membrane protein YejM is a metalloenzyme

(2020) Uma Gabale et al.   Scientific Reports

Regulated Assembly of LPS, Its Structural Alterations and Cellular Response to LPS Defects

(2019) Gracjana Klein et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intricate Crosstalk Between Lipopolysaccharide, Phospholipid and Fatty Acid Metabolism in Escherichia coli Modulates Proteolysis of LpxC

(2019) Nikolas Thomanek et al.   Frontiers in Microbiology

The tetratricopeptide-repeat motif is a versatile platform that enables diverse modes of molecular recognition

(2019) Albert Perez-Riba et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Genomic Characterization of Arcobacter butzleri Isolated From Shellfish: Novel Insight Into Antibiotic Resistance and Virulence Determinants

(2019) Francesca Fanelli et al.   Frontiers in Microbiology

Salmonella enterica Serovar Typhimurium Uses PbgA/YejM To Regulate Lipopolysaccharide Assembly during Bacteremia

(2019) Melina B. Cian et al.   INFECTION AND IMMUNITY

Proteomic analysis of Escherichia coli detergent-resistant membranes (DRM)

(2019) José E. Guzmán-Flores et al.   PLoS One

Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis

(2018) Mina Mostafavi et al.   mSphere

Multiple Transcriptional Factors Regulate Transcription of therpoEGene inEscherichia coliunder Different Growth Conditions and When the Lipopolysaccharide Biosynthesis Is Defective

(2016) Gracjana Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis inEscherichia coli

(2016) Akintunde Emiola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-performance hybrid Orbitrap mass spectrometers for quantitative proteome analysis: Observations and implications

(2016) James C. Williamson et al.   PROTEOMICS

Structural insights into cardiolipin transfer from the Inner membrane to the outer membrane by PbgA in Gram-negative bacteria

(2016) Haohao Dong et al.   Scientific Reports

An Unexpected Duo: Rubredoxin Binds Nine TPR Motifs to Form LapB, an Essential Regulator of Lipopolysaccharide Synthesis

(2015) Chelsy Prince et al.   STRUCTURE

Regulated Control of the Assembly and Diversity of LPS by Noncoding sRNAs

(2015) Gracjana Klein et al.   Biomed Research International

Assembly of Lipopolysaccharide inEscherichia coliRequires the Essential LapB Heat Shock Protein

(2014) Gracjana Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC

(2013) Chul-Jin Lee et al.   ACS Chemical Biology

FtsH-Mediated Coordination of Lipopolysaccharide Biosynthesis in Escherichia coli Correlates with the Growth Rate and the Alarmone (p)ppGpp

(2013) M. Schakermann et al.   JOURNAL OF BACTERIOLOGY

Molecular and Structural Basis of Inner Core Lipopolysaccharide Alterations inEscherichia coli

(2013) Gracjana Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of Interaction Strengths between Chaperones and Tetratricopeptide Repeat Domain-containing Membrane Proteins

(2013) Regina Schweiger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutants Resistant to LpxC Inhibitors by Rebalancing Cellular Homeostasis

(2013) Daina Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

yciMis an essential gene required for regulation of lipopolysaccharide synthesis inEscherichia coli

(2013) S. Mahalakshmi et al.   MOLECULAR MICROBIOLOGY

Structural and Functional Discussion of the Tetra-Trico-Peptide Repeat, a Protein Interaction Module

(2012) Natalie Zeytuni et al.   STRUCTURE

Molecular Basis of Lipopolysaccharide Heterogeneity inEscherichia coli

(2011) Gracjana Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Lipopolysaccharide Biosynthesis by FtsH-Mediated Proteolysis of LpxC Is Conserved in Enterobacteria but Not in All Gram-Negative Bacteria

(2010) S. Langklotz et al.   JOURNAL OF BACTERIOLOGY

Replacement of Lipopolysaccharide with Free Lipid A Molecules inEscherichia coliMutants Lacking All Core Sugars

(2009) C. Michael Reynolds et al.   BIOCHEMISTRY

Escherichia coliK-12 Suppressor-free Mutants Lacking Early Glycosyltransferases and Late Acyltransferases

(2009) Gracjana Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism and Inhibition of LpxC: An Essential Zinc-Dependent Deacetylase of Bacterial Lipid A Synthesis

(2008) Pei Zhou et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Genetic Interaction Between the Escherichia coli AcpT Phosphopantetheinyl Transferase and the YejM Inner Membrane Protein

(2008) N. R. De Lay et al.   GENETICS