Inhibition of the FGF/FGFR System Induces Apoptosis in Lung Cancer Cells via c-Myc Downregulation and Oxidative Stress

FGF trapping inhibits multiple myeloma growth through c-Myc degradation-induced mitochondrial oxidative stress

(2020) Roberto Ronca et al.   CANCER RESEARCH

Antitumor activity of crizotinib in lung cancers harboring a MET exon 14 alteration

(2020) Alexander Drilon et al.   NATURE MEDICINE

Multicenter Phase I Study of Erdafitinib (JNJ-42756493), Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors

(2019) Rastilav Bahleda et al.   CLINICAL CANCER RESEARCH

Future applications of FGF/FGFR inhibitors in cancer

(2018) Gaia Cristina Ghedini et al.   Expert Review of Anticancer Therapy

Fibroblast growth factor receptors as treatment targets in clinical oncology

(2018) Masaru Katoh   Nature Reviews Clinical Oncology

Lung cancer: current therapies and new targeted treatments

(2017) Fred R Hirsch et al.   LANCET

Fibroblast growth factors (FGFs) in cancer: FGF traps as a new therapeutic approach

(2017) Marco Presta et al.   PHARMACOLOGY & THERAPEUTICS

c-Myc Alteration Determines the Therapeutic Response to FGFR Inhibitors

(2016) Hongyan Liu et al.   CLINICAL CANCER RESEARCH

Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors

(2016) Riccardo Castelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

New and emerging targeted treatments in advanced non-small-cell lung cancer

(2016) Fred R Hirsch et al.   LANCET

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

(2016) Joshua D Campbell et al.   NATURE GENETICS

Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results

(2016) Nuria Mut-Salud et al.   Oxidative Medicine and Cellular Longevity

Blocking the FGF/FGFR system as a ⿿two-compartment⿿ antiangiogenic/antitumor approach in cancer therapy

(2016) Arianna Giacomini et al.   PHARMACOLOGICAL RESEARCH

Characterization of FGFR1 Locus in sqNSCLC Reveals a Broad and Heterogeneous Amplicon

(2016) Claire Rooney et al.   PLoS One

Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy

(2015) Roberto Ronca et al.   CANCER CELL

Design, Synthesis, in Vitro, and in Vivo Anticancer and Antiangiogenic Activity of Novel 3-Arylaminobenzofuran Derivatives Targeting the Colchicine Site on Tubulin

(2015) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies

(2014) M. W. Wynes et al.   CLINICAL CANCER RESEARCH

First-Line Crizotinib versus Chemotherapy in ALK-Positive Lung Cancer

(2014) Benjamin J. Solomon et al.   NEW ENGLAND JOURNAL OF MEDICINE

In vivoantitumor effect of an intracellular single-chain antibody fragment against the E7 oncoprotein of human papillomavirus 16

(2013) Luisa Accardi et al.   INTERNATIONAL JOURNAL OF CANCER

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Blockade of Nonhormonal Fibroblast Growth Factors by FP-1039 Inhibits Growth of Multiple Types of Cancer

(2013) T. C. Harding et al.   Science Translational Medicine

Cell-Autonomous and Non-Cell-Autonomous Mechanisms of Transformation by Amplified FGFR1 in Lung Cancer

(2013) F. Malchers et al.   Cancer Discovery

Fibroblast Growth Factor Receptor Inhibitors as a Cancer Treatment: From a Biologic Rationale to Medical Perspectives

(2013) Maria Vittoria Dieci et al.   Cancer Discovery

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

(2012) Martin Peifer et al.   NATURE GENETICS

Fibroblast growth factors and their receptors in cancer

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Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer

(2011) Amit Dutt et al.   PLoS One

Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

(2010) J. Weiss et al.   Science Translational Medicine

Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition

(2008) Hendrik Fischer et al.   MOLECULAR CANCER THERAPEUTICS