Article
Pharmacology & Pharmacy
Roshni Iyer, Harish Ramachandramoorthy, Trinh Nguyen, Cancan Xu, Huikang Fu, Tanviben Kotadia, Benjamin Chen, Yi Hong, Debabrata Saha, Kytai Truong Nguyen
Summary: Lung cancer is a major cause of cancer-related deaths worldwide. Conventional clinical therapies have limitations in treating lung cancer, but a new study has developed dual-stimuli nanoparticles that target cancer cells and release chemotherapy drugs and radiation sensitizer, potentially improving treatment efficacy and reducing side effects.
Article
Chemistry, Multidisciplinary
Xiyang Sun, Ye Xu, Qingkui Guo, Ning Wang, Bin Wu, Chen Zhu, Wen Zhao, Wenliang Qiang, Min Zheng
Summary: This study successfully constructed a targeted nanoprobe that can efficiently load the photosensitive drug ICG into lung cancer cells. The nanoprobe not only has excellent ICG loading and stability, but also improves the efficiency of thermal conversion and singlet oxygen generation, resulting in optimal photothermal/photodynamic therapy effects.
Article
Oncology
Celia Nieto, Milena A. Vega, Eva Martin del Valle
Summary: Novel nanoparticles loaded with paclitaxel and trastuzumab showed more remarkable antitumor activity and lower toxicity to normal tissues than previous nanosystems, offering a promising strategy to improve current HER2-positive breast cancer therapies.
Article
Engineering, Biomedical
Junmei Zhang, Bo Wang, Hui Wang, Zheng Wang, Pan Zhang, Xin Huang, Hongliang Qian, Dechun Huang, Wei Chen, Yinan Zhong
Summary: In this study, a reversibly double-locked hydroxycamptothecin (HCPT) prodrug nanoparticle was developed for safe and efficient chemotherapy of orthotopic lung cancer. The nanoparticle demonstrated high stability against dilution and acid-triggered drug release, leading to targeted tumor treatment.
ACTA BIOMATERIALIA
(2023)
Review
Oncology
Jessica E. Holder, Christopher Ferguson, Elisabete Oliveira, Carlos Lodeiro, Carol M. Trim, Lee J. Byrne, Emilia Bertolo, Cornelia M. Wilson
Summary: Lung cancer is a global health problem, and non-small cell lung cancer is the most common form with conventional treatments often resulting in high rates of recurrence and adverse effects. Nanotechnology offers a potential solution by using nanoparticles to improve drug delivery and targeting to tumors, allowing for increased efficacy and reduced toxicity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Abhishesh Kumar Vikas, Abhishesh Kumar Mehata, Matte Kasi Viswanadh, Ankit Kumar Malik, Aseem Setia, Pooja Kumari, Sanjeev Kumar Mahto, Madaswamy S. Muthu
Summary: This research developed redox-sensitive dual-receptor-targeted nanoparticles loaded with cabazitaxel, showing significantly improved cellular uptake and anticancer activity against A549 lung cancer cells.
Article
Pharmacology & Pharmacy
Jamileh Kadkhoda, Ayuob Aghanejad, Banafsheh Safari, Jaleh Barar, Seyed Hossien Rasta, Soodabeh Davaran
Summary: This study successfully developed a targeted photothermal therapy with a multifunctional drug delivery platform. The Mucin1 (MUC1) aptamer-modified poly (ethylene glycol)-gold nanoparticle system loaded with Paclitaxel (PTX) showed selective cytotoxicity towards MUC1-positive breast cancer cells and exhibited excellent cellular uptake ability when combined with near-infrared (NIR) irradiation. The synergistic effect of PTX/PEG-AuNPs@antiMUC1 was observed, leading to increased cell death compared to either photothermal therapy or chemotherapy alone. Protein expression analysis confirmed the potential of this synergistic combinational system in cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mohammad Irani, Sina Mohammadrezaei Nodeh
Summary: This study investigates the capability of composite and core-shell nanofibers for targeted delivery of anticancer drugs in lung cancer treatment. The results demonstrate that the simultaneous loading of CMPT and PTX anticancer drugs and Au nanoparticles in core-shell nanofibers is more beneficial for lung cancer treatment.
Article
Pharmacology & Pharmacy
Nasrul Wathoni, Lisa Efriani Puluhulawa, I. Made Joni, Muchtaridi Muchtaridi, Ahmed Fouad Abdelwahab Mohammed, Khaled M. Elamin, Tiana Milanda, Dolih Gozali
Summary: Lung cancer, the second most common type of cancer, has the highest mortality rate. Nanoparticle technology is being developed for lung cancer therapies, but specific ligands are needed to enhance drug delivery precision. Monoclonal antibodies can actively target nanoparticles to cancer cells, but they have drawbacks. Formulating antibodies in nanoparticles can minimize these drawbacks and enhance drug targeting.
Article
Multidisciplinary Sciences
Xiqi Peng, Songsong Tang, Daitian Tang, Dewang Zhou, Yangyang Li, Qiwei Chen, Fangchen Wan, Heather Lukas, Hong Han, Xueji Zhang, Wei Gao, Song Wu
Summary: Researchers have developed an autonomous nanorobot capable of delivering drugs to mitochondria, which leads to improved anticancer effects and suppression of cancer cell metastasis. The nanorobot utilizes catalytic activity to decompose hydrogen peroxide in tumor cells, allowing effective delivery of drugs to mitochondria. In vivo experiments demonstrate the effectiveness of the nanorobot in subcutaneous and orthotopic breast tumor models. This breakthrough introduces a new era of precision therapy with organelle-level resolution.
Article
Pharmacology & Pharmacy
Joaquin Bonelli, Maria Velasco-de Andres, Neus Isidro, Cristina Bayo, Sergi Chumillas, Laura Carrillo-Serradell, Sergi Casado-Llombart, Cheryl Mok, Daniel Benitez-Ribas, Francisco Lozano, Josep Rocas, Vicente Marchan
Summary: This study reports a technology that encapsulates water-soluble bioactive compounds in double-walled polyurethane-polyurea hybrid nanocapsules (NCs) loaded with indocyanine green (ICG). The NCs demonstrate specific accumulation in tumor tissues while avoiding premature clearance in the bloodstream, making them promising for cancer theragnosis.
Article
Cell & Tissue Engineering
Zhengui Sun, Leilei Zang, Yusheng Cheng, Lilong Qin
Summary: Lung cancer is a serious health issue and the current chemotherapy drug, paclitaxel (PTX), is hindered by poor solubility and targetability. This study utilized cancer exosomes derived from the lung cancer cell line A549 to load PTX (CE/PTX) and create a drug delivery system (DDS) for treating A549 tumors in a mouse model. The DDS showed superior inhibition of both A549 cells and tumors compared to the commercial PTX formulation (Taxol). Therefore, this strategy holds promise for improved cancer treatment and should be considered for clinical trials.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Sasivimon Pramual, Kriengsak Lirdprapamongkol, Korakot Atjanasuppat, Papada Chaisuriya, Nuttawee Niamsiri, Jisnuson Svasti
Summary: Drug resistance and metastasis are major challenges in cancer chemotherapy. This study demonstrated the potential of paclitaxel-encapsulated PLGA-lipid hybrid nanoparticles (PLHNPs) to eradicate anoikis-resistant lung cancer cells during metastasis. The PLHNPs significantly improved the efficacy of paclitaxel in both attached and floating cells.
Article
Biophysics
Karthik Thangavel, Asha Lakshmikuttyamma, Chellappagounder Thangavel, Sunday A. Shoyele
Summary: The study evaluated the potential of multifunctional nanomedicines targeted towards CD44-positive NSCLC for image-guided drug delivery, showing promising results for their application in imaging and treatment of NSCLC.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
He Wang, Wenwen Shi, Danning Zeng, Qiudi Huang, Jiacui Xie, Huaying Wen, Jinfang Li, Xiyong Yu, Linghao Qin, Yi Zhou
Summary: In this study, an acid-activated mitochondria-targeting and redox-responsive drug nanocarrier was constructed to deliver paclitaxel (PTX) for enhancing therapeutic efficacy in drug-resistant lung cancer. The nanocarrier demonstrated selective mitochondrial targeting and inhibition of P-glycoprotein activity, leading to the suppression of drug resistance and cancer metastasis. The promising results suggest that this nanocarrier represents a significant advancement in cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)