Article
Nutrition & Dietetics
Alyann Otrante, Amal Trigui, Roua Walha, Hicham Berrougui, Tamas Fulop, Abdelouahed Khalil
Summary: EVOO intake improves cholesterol efflux capacity of HDL in elderly subjects by modulating the distribution of HDL subclasses, leading to enhanced anti-atherogenic activity of HDL.
Article
Endocrinology & Metabolism
Safwaan Adam, Jan H. Ho, Yifen Liu, Tarza Siahmansur, Kirk Siddals, Zohaib Iqbal, Shazli Azmi, Siba Senapati, John New, Maria Jeziorska, Basil J. Ammori, Akheel A. Syed, Rachelle Donn, Rayaz A. Malik, Paul N. Durrington, Handrean Soran
Summary: Roux-en-Y gastric bypass (RYGB) enhances HDL functionality while reducing adipose tissue and systemic inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Zhi-Wei Mo, Yue-Ming Peng, Yi-Xin Zhang, Yan Li, Bi-Ang Kang, Ya-Ting Chen, Le Li, Mary G. G. Sorci-Thomas, Yi-Jun Lin, Yang Cao, Si Chen, Ze-Long Liu, Jian-Jun Gao, Zhan-Peng Huang, Jia-Guo Zhou, Mian Wang, Guang-Qi Chang, Meng-Jie Deng, Yu-Jia Liu, Zhen-Sheng Ma, Zuo-Jun Hu, Yu-Gang Dong, Zhi-Jun Ou, Jing-Song Ou
Summary: This study identified a long non-coding RNA, HDRACA, that plays a crucial role in the regulation of angiogenesis by HDL. Normal HDL downregulates the expression of HDRACA, while HDL from patients with coronary artery disease fails to inhibit HDRACA expression effectively, which explains the decreased ability of dysfunctional HDL to stimulate angiogenesis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Medicine, General & Internal
Johanna C. Andersson-Assarsson, Rosanne C. van Deuren, Felipe M. Kristensson, Marloes Steehouwer, Kajsa Sjoholm, Per-Arne Svensson, Marc Pieterse, Christian Gilissen, Magdalena Taube, Peter Jacobson, Rosie Perkins, Han G. Brunner, Mihai G. Netea, Markku Peltonen, Bjorn Carlsson, Alexander Hoischen, Lena M. S. Carlsson
Summary: This study investigated the relationship between the growth of hematopoietic clones of different sizes and age and metabolic dysregulation in obese individuals receiving usual care or bariatric surgery treatment. The results showed that the size of clones in obese individuals increased with age, but not in those who underwent bariatric surgery. Furthermore, low HDL cholesterol levels were negatively associated with clone growth.
Article
Endocrinology & Metabolism
Himani Thakkar, Vinnyfred Vincent, Sakshi Sukhla, Manraj Sra, Uma Kanga, Sandeep Aggarwal, Archna Singh
Summary: The study found that bariatric surgery led to significant improvements in BMI, insulin sensitivity, and inflammation, as well as increased cholesterol efflux capacity (CEC) of HDL in individuals with obesity. The improvement in CEC was associated with changes in apo A-I and adiponectin levels, suggesting that enhancing adipose tissue health and insulin sensitivity may be important in reducing obesity-related cardiovascular disease risk.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Biochemistry & Molecular Biology
Petra Keul, Susann Peters, Karin von Wnuck Lipinski, Nathalie H. Schroeder, Melissa K. Nowak, Dragos A. Duse, Amin Polzin, Sarah Weske, Markus H. Graeler, Bodo Levkau
Summary: Research indicates that elevated endogenous S1P levels can promote the development of atherosclerosis, hinder cholesterol efflux, and cause genuine plaque rupture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yasuhiro Endo, Masanori Fujita, Katsunori Ikewaki
Summary: Cardiovascular disease (CVD) is the leading cause of death in Western countries. Recent epidemiology studies have shown a U-shaped relationship between high-density lipoprotein cholesterol (HDL-C) levels and CVD mortality, with increased mortality in patients with extremely high HDL-C levels. HDL-C raising therapy using nicotinic acids or CETP inhibitors has shown limited efficacy in reducing CVD events. As a result, the focus has shifted to evaluating HDL functionality as a novel biomarker for CVD risk. This review provides an overview of the current status and future perspectives on HDL functions, based on findings from basic research and clinical trials.
Article
Surgery
Ezequiel Lozano Chiappe, Maximiliano Martin, Andrea Iglesias Molli, Andrea Millan, Walter Tetzlaff, Eliana Botta, Florencia Ferraro, Maria S. Saez, Maria V. Lorenzon Gonzalez, Laura Boero, Patricia Sorroche, Axel Beskow, Mercedes Gutierrez, Gloria Cerrone, Susana Gutt, Gustavo Frechtel, Fernando Brites
Summary: The results of the study indicate a favorable effect of bariatric surgery on markers of carbohydrate metabolism and lipid risk factors for cardiovascular disease. Patients experienced improvements in insulin resistance markers, inflammation levels, and lipid profile after the surgery.
Article
Biochemistry & Molecular Biology
Julia T. Stadler, Hubert Scharnagl, Christian Wadsack, Gunther Marsche
Summary: Preeclampsia is associated with increased cardiovascular risk for both mother and child. This study investigated the effects of preeclampsia on lipid metabolism, HDL composition, and function in mothers and neonates. Preeclampsia was linked to dyslipidemia in mothers, including high triglycerides and low HDL-cholesterol levels. Mothers with preeclampsia showed shifts in HDL subclasses and increased levels of HDL-associated apolipoprotein C-II. Neonates born to mothers with preeclampsia had increased total cholesterol levels and reduced HDL cholesterol efflux capacity. These findings suggest that preeclampsia affects both maternal and neonatal lipoprotein metabolism.
Article
Biochemistry & Molecular Biology
Canxia Huang, Jie Zhang, Jingjing Huang, Hongwei Li, Kexin Wen, Jinlan Bao, Xiaoying Wu, Runlu Sun, Ayiguli Abudukeremu, Yue Wang, Zhijian He, Qiaofei Chen, Xinyi Huang, Hong Wang, Yuling Zhang
Summary: This study investigated the proteomic and functional analyses of high density lipoprotein (HDL) subclasses, and found that the protein changes in different subclasses are correlated with their functions. The proteomic components and functions of HDL subclasses differ during HDL maturation in humans and rats. The medium HDL (M-HDL) subclass is enriched with proteins involved in lipid metabolism and antioxidation.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Chemistry, Medicinal
Saba Soltani, Motahareh Boozari, Arrigo F. G. Cicero, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: HDL plays a crucial role in cardiovascular diseases, while phytochemicals have the potential to enhance cholesterol efflux. Current research mostly focuses on preclinical studies, indicating a need for more clinical research to develop novel clinical applications.
PHYTOTHERAPY RESEARCH
(2021)
Article
Medicine, General & Internal
Idoia Genua, Nuria Puig, Inka Minambres, Sonia Benitez, Pedro Gil, Margarida Grau-Agramunt, Andrea Rivas-Urbina, Carme Balague, Sonia Fernandez-Alanin, Alvaro Garcia-Osuna, Antonio Perez, Jose Luis Sanchez-Quesada
Summary: The effects of bariatric surgery on lipid profile and lipoprotein characteristics in morbidly obese patients were analyzed. The surgery led to normalization of lipid levels and improved properties of lipoproteins. Compared to healthy subjects, obese patients showed multiple alterations in lipoprotein properties, which were mostly reversed by bariatric surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shiva Ganjali, Susan Hosseini, Manfredi Rizzo, Anatol Kontush, Amirhossein Sahebkar
Summary: This study evaluated the capacity of high-density lipoprotein (HDL) to transport cholesterol from lipid-loaded macrophages and aimed to find a reliable and low-cost biomarker for assessing the risk of premature cardiovascular events in patients with familial hypercholesterolemia (FH). HDL subfractions (HDL2 and HDL3) were isolated and their cholesterol efflux capacity (CEC%) was measured in FH patients and healthy subjects. The results showed that both HDL2 and HDL3 had reduced CEC% in homozygous FH patients compared to heterozygous FH patients and healthy subjects. Logistic regression analysis revealed a strong inverse association between CEC% and the homozygous form of FH. Decreased HDL cholesterol efflux capacity may help identify homozygous FH patients at increased risk for premature cardiovascular diseases. Prospective studies are needed to further evaluate this hypothesis.
Article
Cardiac & Cardiovascular Systems
Damien Denimal, Serge Monier, Isabelle Simoneau, Laurence Duvillard, Bruno Verges, Benjamin Bouillet
Summary: This study found that the improvement of cholesterol efflux capacity (CEC) of high-density lipoproteins (HDLs) in relation to a decrease in the carbamylation of HDLs may contribute to reducing cardiovascular risk in type 1 diabetes (T1D) patients.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Nutrition & Dietetics
Fu Chen, Bingyang Liu
Summary: This study aimed to investigate the effects of sleeve gastrectomy (SG) on hypercholesterolemia and hepatic cholesterol accumulation in a type 2 diabetes mellitus (T2DM) rat model. The results showed that SG partially alleviated hypercholesterolemia and hepatic cholesterol accumulation by inhibiting hepatic de novo cholesterogenesis.
Article
Biochemistry & Molecular Biology
Manuela Strahlhofer-Augsten, Carolin Schliefsteiner, Silvija Cvitic, Meekha George, Ingrid Lang-Olip, Birgit Hirschmugl, Gunther Marsche, Uwe Lang, Boris Novakovic, Richard Saffery, Gernot Desoye, Christian Wadsack
Summary: The study demonstrates differential expression of SR-BI in ECA and ECV in the feto-placental vasculature, leading to distinct regulation of local cholesterol homeostasis. The difference in SR-BI expression in the two types of endothelial cells mainly affects the uptake of fetal HDL cholesteryl esters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gunther Marsche, Julia T. Stadler, Julia Kargl, Michael Holzer
Summary: Atherosclerosis is a disease characterized by increased oxidative stress, leading to modifications of proteins and lipids in the blood vessel wall. Myeloperoxidase (MPO), an enzyme mainly found in neutrophils and monocytes, plays a crucial role in this oxidative process. Research has shown that MPO interacts with lesion derived high-density lipoprotein (HDL) and modifies its components, leading to dysfunction of HDL. Understanding the impact of MPO-induced changes on the structure and function of HDL is important for the future use of HDL in diagnostics and therapy.
Article
Biochemistry & Molecular Biology
Julia T. Stadler, Sonja Lackner, Sabrina Morkl, Nathalie Meier-Allard, Hubert Scharnagl, Alankrita Rani, Harald Mangge, Sieglinde Zelzer, Sandra J. Holasek, Gunther Marsche
Summary: Anorexia nervosa has detrimental effects on lipid metabolism and increases atherosclerotic risk factors.
Article
Biochemistry & Molecular Biology
Michael Holzer, Senka Ljubojevic-Holzer, Douglas Ricardo Souza Junior, Julia T. Stadler, Alankrita Rani, Hubert Scharnagl, Graziella Eliza Ronsein, Gunther Marsche
Summary: This study compares the effects of three common methods for HDL isolation on the composition and function of HDL. The results show that different isolation methods result in HDL samples with different protein compositions and subclass distributions, as well as functional differences.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Julia T. Stadler, Harald Mangge, Alankrita Rani, Pero Curcic, Markus Herrmann, Florian Prueller, Gunther Marsche
Summary: This study evaluates the impact of COVID-19 infection on HDL function and metabolism, and finds that low HDL cholesterol efflux capacity is associated with increased mortality risk in COVID-19 patients, independent of HDL-cholesterol levels.
Article
Biochemistry & Molecular Biology
Iva Klobucar, Julia T. Stadler, Lucija Klobucar, Margarete Lechleitner, Matias Trbusic, Gudrun Pregartner, Andrea Berghold, Hansjoerg Habisch, Tobias Madl, Gunther Marsche, Sasa Frank, Vesna Degoricija
Summary: Metabolic syndrome (MS) affects the association between HDL and endothelial function, as well as between EL and HDL. HDL cholesterol efflux capacity and arylesterase activity, as well as EL serum levels, are not correlated with endothelial function in both healthy volunteers (HV) and MS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Julia T. Stadler, Mireille N. M. van Poppel, Christian Wadsack, Michael Holzer, Anja Pammer, David Simmons, David Hill, Gernot Desoye, Gunther Marsche
Summary: Pregravid obesity is a major risk factor for pregnancy complications and cardiovascular events in children. However, the biological mechanisms underlying these adverse outcomes are not well understood. Impairment of HDL function in obese and GDM-complicated pregnancies may have long-term effects on maternal and offspring health.
Review
Pharmacology & Pharmacy
Alankrita Rani, Gunther Marsche
Summary: High-density lipoproteins (HDL) are complex nanoparticles involved in important metabolic and vascular functions. Dysregulation of HDL can lead to inflammatory remodeling and dysfunction. Monocytes and macrophages play a critical role in vascular inflammation. HDL-based nanotherapeutics show potential in treating vascular diseases by targeting these cells.
Article
Biochemistry & Molecular Biology
Julia T. Stadler, Hubert Scharnagl, Christian Wadsack, Gunther Marsche
Summary: Preeclampsia is associated with increased cardiovascular risk for both mother and child. This study investigated the effects of preeclampsia on lipid metabolism, HDL composition, and function in mothers and neonates. Preeclampsia was linked to dyslipidemia in mothers, including high triglycerides and low HDL-cholesterol levels. Mothers with preeclampsia showed shifts in HDL subclasses and increased levels of HDL-associated apolipoprotein C-II. Neonates born to mothers with preeclampsia had increased total cholesterol levels and reduced HDL cholesterol efflux capacity. These findings suggest that preeclampsia affects both maternal and neonatal lipoprotein metabolism.
Article
Biochemistry & Molecular Biology
Nejra Cosic-Mujkanovic, Paulina Valadez-Cosmes, Kathrin Maitz, Anna Lueger, Zala N. Mihalic, Marah C. Runtsch, Melanie Kienzl, Michael J. Davies, Christine Y. Chuang, Akos Heinemann, Rudolf Schicho, Gunther Marsche, Julia Kargl
Summary: This study shows that myeloperoxidase (MPO), a neutrophil-derived enzyme, promotes the proliferation and inhibits the apoptosis of lung cancer cells. It functions by increasing the phosphorylation of AKT and ERK, and can be found inside the cells and in the nucleus. Blocking MPO uptake or inhibiting its enzymatic activity reduces its effects on cancer cell function. Animal experiments demonstrate that tumor-bearing mice treated with the MPO inhibitor 4-ABAH have reduced tumor burden.
Article
Biochemistry & Molecular Biology
Julia T. Stadler, Hansjoerg Habisch, Florian Prueller, Harald Mangge, Thomas Baernthaler, Julia Kargl, Anja Pammer, Michael Holzer, Sabine Meissl, Alankrita Rani, Tobias Madl, Gunther Marsche
Summary: This study compares the lipoprotein and metabolic profiles of COVID-19-infected patients and non-COVID-19 pneumonia patients, and finds significant differences in HDL-related parameters between the two groups. The cholesterol efflux capacity (CEC) shows the strongest negative association with COVID-19 mortality.