Article
Engineering, Multidisciplinary
Qiusheng Wang, Shuiqing Zhou, Lu Wang, Renchuan You, Shuqin Yan, Qiang Zhang, Mingzhong Li
Summary: This study presents a novel bioactive scaffold designed with biomimetic technology by mimicking the chemical components and biophysical nanostructures of extracellular matrix. The scaffold showed better cytocompatibility to support cell spread, proliferation and differentiation. In vivo experiments demonstrated that the scaffold with nanofibers as a template not only accelerated wound healing but also regulated collagen arrangement to inhibit scar formation.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Mohamed R. El-Aassar, Nagham G. El-Beheri, Mona M. Agwa, Hoda M. Eltaher, Mostafa Alseqely, Wagih S. Sadik, Labiba El-Khordagui
Summary: The study innovatively functionalized nanofibers with a combination of new ZnO NPs and cinnamon essential oil, showing great potential for wound healing. The combinational approach of metal NPs/essential oil functionalization of nanofibers is promising as an emerging antibiotic-free method for effective and safer wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Huda S. AlSalem, Abeer Abdulaziz H. Bukhari
Summary: Three biodegradable wound dressings were successfully prepared using freeze drying technique. The dressings were based on binary Collagen (COL), Hyaluronic acid (HA) crosslinked and loaded with silver nanoparticles (AgNPs), Gentamicin (GENT), or AgNPs/GENT. The dressings showed physically interaction between polymer network and the loaded antibiotic, superior swelling properties, and rapid degradation. They exhibited antibacterial activity against G+, G-, yeast, and fungi. Cytotoxicity and wound healing evaluations showed superior results for all dressings except the one mixed with AgNPs and Gentamicin. The results recommended individually loaded COL/HA with either AgNPs or Gentamicin as antibacterial and wound healing dressings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Kummara Madhusudana Rao, Eunbi Kim, Hyeon Jin Kim, Uluvangada Thammaiah Uthappa, Sung Soo Han
Summary: A water-soluble hyaluronic acid-quercetin (HA-Q) pendant drug conjugate was synthesized and evaluated for its potential wound-healing properties. The conjugation was confirmed using FTIR, UV-Vis, and NMR spectroscopy techniques. HA-Q showed good biocompatibility, supported cell growth and migration, and exhibited improved radical scavenging capacity compared to quercetin alone. These results confirm the potential role of HA-Q in wound healing applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Min Wang, Juanjuan Hu, Yangcen Ou, Xueling He, Yanjun Wang, Chenyu Zou, Yanlin Jiang, Feng Luo, Dan Lu, Zhen Li, Jiehua Li, Hong Tan
Summary: There is an urgent need for wound dressings that can promote quick hemostasis and efficient wound healing in response to increasing clinical demands. This study presents a versatile method for constructing biodegradable hybrid cryogels that can rapidly stop bleeding. The cryogel's specific macroporous structure allows for stable fixation and quick swelling, making it ideal for minimally invasive surgery. Furthermore, the cryogel exhibits excellent biocompatibility and activates the endogenous coagulation system, leading to fast blood coagulation. In in vivo evaluations, the cryogel demonstrated great potential in promoting wound healing, reducing immune inflammation, and inducing angiogenesis and hair follicle regeneration. These findings highlight the high-performance capabilities of the cryogel as a wound dressing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Oana Maria Ionescu, Arn Mignon, Andreea Teodora Iacob, Natalia Simionescu, Luminita Georgeta Confederat, Cristina Tuchilus, Lenuta Profire
Summary: The study incorporated natural active components such as propolis and Calendula officinalis into hyaluronic acid/poly(ethylene)oxide-based electrospun nanofiber membranes to design innovative wound-dressing biomaterials. The nanofiber membranes showed best antioxidant activity, cytocompatibility, and antimicrobial properties, making them suitable for clinical use as wound dressings.
Article
Biochemistry & Molecular Biology
D. Pawcenis, M. Lesniak, M. Szumera, M. Sitarz, J. Profic-Paczkowska
Summary: Nanocelluloses have attracted much attention due to their mechanical properties, high surface area, and porosity. Sulfuric acid is commonly used for the production of cellulose nanocrystals, but it leads to cellulose esterification and lower thermal stability. Hydrochloric acid hydrolysis does not result in functionalization of the nanocellulose surface, but it lacks ionic interactions and causes poor colloidal stability. This study aimed to obtain stable aqueous suspensions of cellulose nanofibrils (CNF) through hydrochloric acid hydrolysis. The best stabilizing effect was achieved at pH 5-9 and with nonionic surfactants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Carolini Mendes, Anand Thirupathi, Rubya Pereira Zaccaron, Maria Eduarda Anastacio Borges Correa, Joao V. S. Bittencourt, Laura de Roch Casagrande, Anadhelly C. S. de Lima, Lara L. de Oliveira, Thiago A. M. de Andrade, Yaodong Gu, Paulo Emilio Feuser, Ricardo A. Machado-de-Avila, Paulo Cesar Lock Silveira
Summary: This study aimed to investigate the effects of iontophoresis and hyaluronic acid (HA) combined with a gold nanoparticle (GNP) solution in an excisional wound model. The results demonstrate that the combination therapy group showed better results in anti-inflammation and tissue repair process compared to the single therapy group.
Review
Materials Science, Paper & Wood
Mehran Alavi, Ali Nokhodchi
Summary: The anti-bacterial activities of nanofiber scaffolds composed of natural occurring polymers are discussed in this review, emphasizing the importance of considering antimicrobial and skin reconstruction properties in the design of wound dressings for infected wounds. Incorporating water-soluble polymers into polymeric nanofiber scaffolds can improve the release profile of antibacterial agents and enhance wound healing.
Article
Engineering, Biomedical
Yihao Liu, Haoyi Niu, Chengwei Wang, Xiaoxiao Yang, Wentao Li, Yuxin Zhang, Xiaojun Ma, Yuanjing Xu, Pengfei Zheng, Jinwu Wang, Kerong Dai
Summary: This study developed a new hydrogel material with biocompatibility, easy degradation, and wound healing properties using physical electrostatic cross-linking and freeze-drying. The material showed excellent antibacterial and pro-coagulation abilities, promoting hemostasis and reducing blood loss in both in vitro and in vivo experiments. Additionally, it exhibited superior cytocompatibility and biodegradability. Therefore, this material has great potential for clinical application as a hemostatic and wound healing material.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Zijian Wang, Wenjie You, Wang Wang, Weiqun Tian, Fangjin Chen, Yu Xiao, Yun Chen, Xinghuan Wang
Summary: This study successfully improved wound healing effects through a novel nanofiber material, which exhibited multifunctional properties and showed promising results in experimental animal models.
ADVANCED FIBER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hongyu Lv, Meng Zhao, Yiran Li, Kun Li, Shaojuan Chen, Wenwen Zhao, Shaohua Wu, Yantao Han
Summary: This study developed a novel nanofibrous dressing for the treatment of hard-to-heal diabetic wounds. The dressing exhibited multiple biological functions, including anti-inflammation, antioxidation, pro-angiogenesis, and hemostasis.
Review
Biochemistry & Molecular Biology
Mohammad Ebrahim Astaneh, Narges Fereydouni
Summary: Diabetic wounds pose a significant clinical challenge due to impaired healing and increased risk of complications. Nanofiber-based wound dressings, particularly those containing hyaluronic acid, show promise in promoting wound healing by enhancing skin hydration, controlling inflammation, and facilitating revascularization. However, challenges and limitations, such as reproducibility and proper characterization, exist in the field of nanofiber technology. Future directions involve addressing these issues and optimizing nanofiber formulations for improved efficacy in diabetic wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Paper & Wood
Gulsum Acar, Bengi Ozkahraman, Zehra Ozbas
Summary: In this study, thymol-containing wound dressing films were prepared using polysaccharide polymers. The films exhibited suitable swelling ratios, hydrolytic degradation, and water vapor transmission rates for wound healing applications. The addition of thymol increased the elongation at break value of the films and influenced the release amount of thymol. Furthermore, the films showed good biocompatibility and enhanced migration and proliferation of fibroblast cells.
Article
Materials Science, Paper & Wood
Gulsum Acar, Bengi Ozkahraman, Zehra Ozbas
Summary: Thymol-containing wound dressing films were prepared using polysaccharide polymers by solvent casting technique. The films showed adequate swelling ratios, moderate water vapor transmission rates, and increased elongation at break value with the addition of thymol. In vitro tests demonstrated improved migration and proliferation of fibroblast cells, indicating the potential of these films as wound dressing materials.
Article
Pharmacology & Pharmacy
Samar A. Salim, Samah A. Loutfy, Esmail M. El-Fakharany, Tarek H. Taha, Yasmen Hussien, Elbadawy A. Kamoun
Summary: The 3D scaffolds made of PVA/HA nanofiber mats, optimized with chitosan and hydroxyapatite, demonstrated improved biocompatibility and mechanical stability. The different compositions of nanofiber mats showed high cell viability and adhesion in cell evaluation and in vitro experiments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sara Nageeb El-Helaly, Eman Abd-Elrasheed, Samar A. Salim, Rania H. Fahmy, Salwa Salah, Manal M. EL-Ashmoony
Summary: Green nanotechnology was used to develop eco-friendly nanocarrier systems for enhancing the solubility and bioavailability of Raloxifene (RLX) through novel solid dispersed nanofibers. The modified emulsion electrospinning technique resulted in superior RLX-loaded nanofibers formula E2, showing significantly increased drug release, mucoadhesion time, and relative bioavailability compared to oral dispersion. This study demonstrated the potential of green nanotechnology in improving drug delivery systems for better therapeutic outcomes.
Article
Engineering, Electrical & Electronic
Ahmed Ali, Samar A. Salim, Elbadawy A. Kamoun
Summary: Metal oxide-loaded hydrogel membranes and crosslinked hydride composite hydrogel membranes were successfully prepared by dip coating method and solution-casting method, respectively. The samples were characterized and showed a polycrystalline structure with nanoparticles, nanoscale grains, and homogeneous nature. Optical measurements of the composite blended membranes revealed their optical parameters, and the complex dielectric constants were calculated. The experimental data indicated the direct energy band gap of the nanoparticle composites, and the metal oxide loading improved the dielectric behavior.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Pharmacology & Pharmacy
Samar A. Salim, Ahmed Aboueloyoun Taha, Ehab E. Khozemy, Shahira H. EL-Moslamy, Elbadawy A. Kamoun
Summary: In this study, metal-organic frameworks (MOFs)-loaded nanofiber scaffolds were constructed for bone regeneration, exhibiting excellent morphological structure and properties of slow-sustained swelling and gradual weight loss. The scaffold treated with 0.8% MOF also showed efficient antimicrobial activities.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Samar A. Salim, Elbadawy A. Kamoun, Stephen Evans, Tarek H. Taha, Esmail M. El-Fakharany, Mohamed M. Elmazar, A. F. Abdel-Aziz, R. H. Abou-Saleh, Taher A. Salaheldin
Summary: The study successfully synthesized PVP-hydrogen peroxide complex and incorporated it into PMMA nanofibrous scaffold. The optimized ratio of 1:1.5 PHP complex exhibited ideal oxygen release effects and high selectivity for cancer cells, especially breast cancer cells. The PMMA-10% PHP nanofibers showed the highest concentration of released-oxygen and potential for enhancing cancer treatment effects.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
