Article
Multidisciplinary Sciences
Amira A. Al Harethi, Qais Y. M. Abdullah, Hala J. Al Jobory, Samar A. Al Aquil, Ramadan A. Arafa
Summary: This study successfully isolated and identified Phytophthora infestans in Yemen using advanced methods, providing fundamental data for the prevention and control of late blight.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Abbas El-Hasan, Grace Ngatia, Tobias Link, Ralf T. Voegele
Summary: Late blight of potato caused by Phytophthora infestans is one of the most damaging diseases affecting potato production worldwide. In this study, 357 root fungal endophytes isolated from four solanaceous plant species obtained from Kenya were evaluated for their antagonistic activity against P. infestans. Three endophytes with pronounced inhibitory activity against P. infestans were identified, suggesting their potential use in late blight control strategies.
Review
Agriculture, Multidisciplinary
Suo-meng Dong, Shao-qun Zhou
Summary: This article summarizes the molecular pathogenesis of potato late blight and current control strategies, emphasizing the importance of continuous improvement in efficient and sustainable management.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2022)
Article
Plant Sciences
Yumeng Xiong, Di Zhao, Shengnan Chen, Lan Yuan, Die Zhang, Hongyang Wang
Summary: This study focuses on a nuclear-targeted effector Pi07586 released by the highly destructive plant oomycete pathogen Phytophthora infestans. It is found that Pi07586 can effectively suppress plant immunity by inhibiting the expression of specific genes and reducing the levels of plant hormones. These findings enhance our understanding of the intricate relationship between P. infestans and host plants and shed new light on plant immune modulation.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Sandrine Troussieux, Annabelle Gilgen, Jean-Luc Souche
Summary: This study demonstrates the efficacy of the lysate of the amoeba Willaertia magna C2c Maky in protecting potatoes against late blight. The active substance exhibits both plant elicitor and antifungal effects, effectively reducing disease and increasing yield in greenhouse and field trials.
Article
Plant Sciences
Willmer Perez, Lesly Alarcon, Tania Rojas, Yanina Correa, Henry Juarez, Jorge L. Andrade-Piedra, Noelle L. Anglin, David Ellis
Summary: This study evaluated the resistance to late blight in 508 potato accessions and identified novel sources of resistance in wild potato species and landraces endemic to South America. The study also found that altitude and bioclimatic variables cannot predict the resistance level in these accessions. Furthermore, there is a high risk of genetic erosion in potato biodiversity in the Andes due to susceptibility to late blight in native landraces.
Article
Biochemistry & Molecular Biology
Kangkai Zheng, Jie Lu, Jie Li, Yin Yu, Jia Zhang, Ziwei He, Omayma M Ismail, Jie Wu, Xuejun Xie, Xiaobo Li, Guangyuan Xu, Daolong Dou, Xiaodan Wang
Summary: The study demonstrated that chitosan can enhance potato resistance and reduce Phytophthora infestans infection by activating important plant defence response pathways. In addition, chitosan triggers pattern recognition immune responses, induces systemic resistance, and alters gene expression related to plant defence in potato. These findings provide insights into chitosan-mediated activation of the immune system in potato and offer a potential eco-friendly strategy for controlling late blight in the field.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Plant Sciences
Xinyi Hu, Kristian Persson Hoden, Zhen Liao, Anna Asman, Christina Dixelius
Summary: Phytophthora spp. cause damage to plants by using effector proteins and small RNAs. The study found that the sRNA encoded by P. infestans can affect potato mRNA, expanding our understanding of the strategies used by this species to facilitate infection.
Article
Agronomy
Miaomiao He, Yun Zhou, Guangji Ye, Jie Zheng, Yuling Meng, Jian Wang, Weixing Shan
Summary: The transcriptomic dynamics of Chinese potato cultivar Qingshu 9 infected with late blight pathogen Phytophthora infestans revealed 2027 differentially expressed genes (DEGs) with diverse functions in response to the infection. Pathway analysis showed enrichment in secondary metabolites biosynthesis, plant-pathogen interaction, and photosynthesis, while transcription factor genes like AP2-EREBP and MYB were highly abundant among the DEGs. These results provide insights into the resistance mechanism of Qingshu 9 against late blight.
Article
Microbiology
Artemii A. Ivanov, Egor O. Ukladov, Tatiana S. Golubeva
Summary: Phytophthora infestans is a major pathogen in agriculture, with significant impact on Solanaceae species like potatoes and tomatoes. Research shows annual crop losses caused by this pathogen, particularly affecting potatoes. Further studies are needed to delve deeper into this interaction.
Article
Plant Sciences
Matanel Hipsch, Yaron Michael, Nardy Lampl, Omer Sapir, Yigal Cohen, David Helman, Shilo Rosenwasser
Summary: Late blight caused by Phytophthora infestans is a devastating disease of potatoes. This study used whole-plant redox imaging to detect the initial biotrophic growth stage of the pathogen on potato leaves. The mislocalization of chloroplast-targeted proteins was found to be an efficient marker of late blight infection, enabling non-destructive monitoring of the disease.
Article
Agriculture, Multidisciplinary
Min Jeong Kim, Chang Ki Shim, Jong-Ho Park
Summary: This study focused on the biological control of late blight in eco-friendly potato cultivation in Korea. The AFB2-2 strain showed the ability to inhibit the growth of plant pathogens and demonstrated high control efficacy in experiments. The genetic sequences of AFB2-2 strain were found to be highly similar to other Bacillus species.
PLANT PATHOLOGY JOURNAL
(2021)
Article
Plant Sciences
Loukas Kanetis, Lambros Pittas, Nikolaos Nikoloudakis, David E. L. Cooke, Nikolaos Ioannou
Summary: Cyprus, located in the Mediterranean, relies on potato production as a significant source of agricultural revenue. During a late blight epidemic period, the population structure of Phytophthora infestans shifted towards A2 dominance, with reduced sensitivity to the fungicide mefenoxam. The high prevalence of the mefenoxam-insensitive EU_13_A2 lineage suggests the need for updated disease management strategies.
Article
Agronomy
S. Sundaresha, Sanjeev Sharma, Aarti Bairwa, Maharishi Tomar, Ravinder Kumar, Vinay Bhardwaj, A. Jeevalatha, Rahul Bakade, Neha Salaria, Kajal Thakur, Bir Pal Singh, S. K. Chakrabarti
Summary: The study developed target-specific RNA interference molecules for late blight, along with nanoclay carriers, which effectively reduced infection when sprayed on plants. By targeting specific genes and using multigene targeted dsRNA-nanoclay, the plants showed enhanced disease resistance, reduced sporulation, and symptom expression. The use of nanoclay with multigene targeted dsRNA was effective in delivering and enhancing RNAi as a spray-induced gene silencing approach, showing potential as an environmentally friendly alternative to chemical fungicides for late blight protection.
PEST MANAGEMENT SCIENCE
(2022)
Article
Plant Sciences
Ramadan A. Arafa, Said M. Kamel, Dalia Taher, Svein O. Solberg, Mohamed T. Rakha
Summary: Late blight-resistant wild tomato produces a higher number of volatile organic compounds (VOCs) compared to susceptible genotypes. This study provides promising insights for the management of late blight and suggests that metabolic profiling can contribute to a better understanding of resistance mechanisms.
Article
Plant Sciences
Linxuan Li, Tingting Zhu, Yun Song, Li Feng, Essam Ali Hassan Farag, Maozhi Ren
Summary: Inhibition of AtTOR gene increases ABA content and activates ABA-responsive genes, while ABI5 interacts with S6K2 to positively regulate ABA responses during seedling growth in Arabidopsis. Overexpression of AtS6K2 enhances drought resistance, indicating a crosstalk between TOR and ABA signaling pathways in modulating seedling growth.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Xiumei Luo, Tingting Tian, Maxime Bonnave, Xue Tan, Xiaoqing Huang, Zhengguo Li, Maozhi Ren
Summary: This study investigated the mechanism underlying the response to ROS stress in oomycete pathogens using Phytophthora infestans as a model system. It was found that the TOR signaling pathway plays a significant role in the response to ROS stress in oomycetes, with potential implications for disease control in these pathogens.
Review
Biochemistry & Molecular Biology
Yun Song, Mohammed Salem Alyafei, Khaled Masmoudi, Abdul Jaleel, Maozhi Ren
Summary: The target of rapamycin (TOR) protein kinase is an atypical Ser/Thr protein kinase that is evolutionarily conserved among yeasts, plants, and mammals. TOR plays a central role in integrating nutrient, energy, hormone, and environmental signals in eukaryotes, with recent research highlighting its multifaceted roles in plant-specific features, particularly in photosynthesis. Research has revealed TOR signaling's involvement in carbon nutrient sense, light absorptions, and leaf and chloroplast development, while also identifying gaps in understanding TOR function in photosynthesis that need further exploration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Linxuan Li, Tingting Zhu, Yun Song, Xiumei Luo, Raju Datla, Maozhi Ren
Summary: Fusarium oxysporum TOR signaling pathway components, including FoTORC1 and FoTORC2, play important roles in regulating metabolic processes, cell growth, and pathogenicity. FoTOR1 and FoTIP4 are crucial for hyphal growth and pathogenicity of F. oxysporum, providing new insights for controlling Fusarium wilt in plants.
MOLECULAR PLANT PATHOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yun Song, Yaohua Zhai, Linxuan Li, Zhaoen Yang, Xiaoyang Ge, Zuoren Yang, Chaojun Zhang, Fuguang Li, Maozhi Ren
Summary: The research showed that the plant protein kinase BIN2 plays a negative regulatory role in plant resistance to the pathogen Verticillium dahliae. Through regulating the endogenous JA content and influencing the expression of JA responsive genes, BIN2 affects plant resistance against Verticillium dahliae.
PLANT BIOTECHNOLOGY JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Yongming Liu, Jingtao Qu, Ziwen Shi, Peng Zhang, Maozhi Ren
Summary: The study analyzed TCA cycle genes in four important Solanaceae vegetable crops and found a total of 180 genes, with unique subgroup members in Solanaceae crops. The expression analysis of potato TCA cycle genes revealed tissue-specific expression and regulation by hormones and stressors. The subcellular localization of three potato citrate synthases showed different locations for each enzyme.
Review
Biochemistry & Molecular Biology
Xiulan Xie, Ying Wang, Raju Datla, Maozhi Ren
Summary: Root development in plants involves a complex interplay of growth, hormones, and signaling pathways, with auxin and the TOR pathway playing key roles in regulating root growth. Studying the crosstalk between auxin and TOR is crucial for understanding root morphogenesis, development, and architecture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Wenxian Wu, Xiumei Luo, Maozhi Ren
Summary: This review analyzes the role of autophagy in antiviral defenses in animals and plants, as well as how viruses evade host immune responses by disrupting and manipulating host autophagy. The review provides novel insights into the role of autophagy in virus-host interactions and offers potential targets for the prevention and control of viral infection in both plants and animals.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Linxuan Li, Tingting Zhu, Yun Song, Li Feng, Philip James Kear, Rooallah Saberi Riseh, Mahmoud Sitohy, Raju Datla, Maozhi Ren
Summary: This study explored the potential mechanisms of salicylic acid (SA) as a biofungicide by using the highly pathogenic Fusarium oxysporum as a model system. The results showed that SA could inhibit key targets of the pathogen, modify the metabolic activity within pathogen cells, and induce pathogen cell death. This research provides insights into the application of SA in controlling various fungal diseases by targeting the SNF1-TORC1 pathway of pathogens.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Multidisciplinary Sciences
Xiumei Luo, Tingting Tian, Li Feng, Xingyong Yang, Linxuan Li, Xue Tan, Wenxian Wu, Zhengguo Li, Haim Treves, Francois Serneels, I-Son Ng, Kan Tanaka, Maozhi Ren
Summary: During the arms race between plants and pathogens, PR1 proteins in host plants play a crucial role in disease resistance. This study investigates the anti-oomycete activity of secretory PR1 proteins and elucidates their underlying mechanisms by studying the potato-Phytophthora infestans pathosystem. The results provide novel insights into the molecular function of PR1 in protecting plants against pathogen infection and uncover a potential target for preventing late blight.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Plant Sciences
Muhammad Mubashar Zafar, Abdul Rehman, Abdul Razzaq, Aqsa Parvaiz, Ghulam Mustafa, Faiza Sharif, Huijuan Mo, Yuan Youlu, Amir Shakeel, Maozhi Ren
Summary: This study investigated the AP2/ERF genes in cotton on a genome-wide scale, revealing their importance in plant growth, development, and stress responses. Through identification and distribution analysis of the genes, the evolutionary process of the ERF gene family was revealed. Additionally, experimental evidence demonstrated the potential role of certain genes in improving salinity stress tolerance in cotton.
Review
Biochemistry & Molecular Biology
Xiulan Xie, Hao Cheng, Chenyang Hou, Maozhi Ren
Summary: With urbanization intensifying globally, the security of food supply is threatened by population growth, frequent extreme climate events, limited agricultural land, insufficient use of urban space, and other factors. Plant scientists urgently need to find ways to produce high-yielding and high-quality crops in limited space. Dense planting, vertical production, and indoor cultivation are effective methods to optimize space utilization and increase crop yield. This study focuses on the molecular mechanisms of shade avoidance and tolerance in plants, and discusses biotechnological strategies to enhance shade tolerance. Developing crop varieties with strong shade tolerance could provide effective strategies for urban agriculture in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Plant Sciences
Wenxian Wu, Xiumei Luo, Maozhi Ren
Review
Otorhinolaryngology
L. Q. Li, O. Hilmi, J. England, N. Tolley
Summary: This review aims to provide an overview of currently accepted practices for the initial investigation and subsequent management of patients with thyroid nodules for non-specialists, as well as address the areas of variation between common clinical systems and newer technologies in the evaluation of malignancy in thyroid nodules.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
