Structure analysis of thymidylate synthase from white spot syndrome virus reveals WSSV-specific structural elements

Drug repurposing for antimicrobial discovery

(2019) Maya A. Farha et al.   Nature Microbiology

Inter-Active Site Communication Mediated by the Dimer Interface β-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase

(2019) Paul J. Sapienza et al.   BIOCHEMISTRY

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R

(2019) Cecilia Pozzi et al.   Biomolecules

Drug Repurposing for Viral Infectious Diseases: How Far Are We?

(2018) Beatrice Mercorelli et al.   TRENDS IN MICROBIOLOGY

Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states

(2017) Dan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme

(2016) Anna Dowierciał et al.   STRUCTURAL CHEMISTRY

Hotspots in an Obligate Homodimeric Anticancer Target. Structural and Functional Effects of Interfacial Mutations in Human Thymidylate Synthase

(2015) Outi M. H. Salo-Ahen et al.   JOURNAL OF MEDICINAL CHEMISTRY

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Drug repurposing: a better approach for infectious disease drug discovery?

(2013) G Lynn Law et al.   CURRENT OPINION IN IMMUNOLOGY

Mg2+ Binds to the Surface of Thymidylate Synthase and Affects Hydride Transfer at the Interior Active Site

(2013) Zhen Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structure ofEnterococcus faecalisthymidylate synthase provides clues about folate bacterial metabolism

(2012) Cecilia Pozzi et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Historic emergence, impact and current status of shrimp pathogens in the Americas

(2012) D.V. Lightner et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

Disease will limit future food supply from the global crustacean fishery and aquaculture sectors

(2012) G.D. Stentiford et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

Mechanistic and structural basis for inhibition of thymidylate synthase ThyX

(2012) T. Basta et al.   Open Biology

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability,

(2010) Xiao Huang et al.   BIOCHEMISTRY

White spot syndrome virus: an overview on an emergent concern

(2010) Arturo Sánchez-Paz   VETERINARY RESEARCH