Article
Engineering, Environmental
Fengbang Wang, Zihan Chen, Yuanyuan Wang, Chunyan Ma, Lei Bi, Maoyong Song, Guibin Jiang
Summary: In this study, the toxic effects of two citrate-coated AgNPs and Ag+ on HepG2 cells were investigated. The results showed that AgNPs and Ag+ induced cell apoptosis through different pathways, and the toxicity of AgNPs was mainly attributed to their specific effects on mitochondria.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Susu Wang, Yang Zhang, Jufang Gao, Jingdi Zhang, Liming Tao, Wenping Xu
Summary: Acetochlor, a widely used chiral herbicide, can induce toxicity in human liver cells primarily through its S configuration, leading to cell apoptosis. The study provides a theoretical basis for reducing the impact on human health through the production of single pesticides.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Energy & Fuels
Venkatachalam Balamurugan, Govindasamy Balasubramani
Summary: The study demonstrated the synthesis of silver and gold nanoparticles using Pandanus canaranus leaf extract. The properties and morphology of the nanoparticles were characterized, and their ability to induce apoptosis in lung cancer cells was observed. This research provides a potential method for cancer therapy using this extract.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Environmental Sciences
Lakshmi Thangavelu, Royapuram Veeraragavan Geetha, Ezhilarasan Devaraj, Kamal Dua, Dinesh Kumar Chellappan, Sri Renukadevi Balusamy
Summary: The study evaluates the cytotoxic potentials of Acacia catechu ethanolic seed extract in human hepatocellular carcinoma cells, finding that it induces cytotoxicity through increased ROS production, oxidative stress regulation, and apoptosis pathways.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Fatih Altintas, Melek Tunc-Ata, Mucahit Secme, Vural Kucukatay
Summary: The study evaluated the cytotoxic, genotoxic, apoptotic, oxidant and antioxidant effects of thymol on HepG2 cell line. Thymol showed cytotoxic and genotoxic effects on HepG2 cells, while having no lethal effect on healthy cells. It also decreased oxidative stress and induced apoptosis in HepG2 cells, without altering the gene expressions associated with apoptosis. The results suggest the potential of thymol in the treatment of liver cancer.
Article
Toxicology
Kadmad Abdul Hameed Mohamed Azar, Devaraj Ezhilarasan, Karthik Shree Harini
Summary: This study investigated the anticancer effect of Coleus vettiveroides (CV) ethanolic root extract in HepG2 cells. The results showed that CV can exert its anticancer effect by inducing mitochondrial dysfunction, oxidative stress, cytoskeletal disorganization, cell cycle arrest, and mitochondria-mediated apoptosis, suggesting it as a potential therapeutic option for hepatocellular carcinoma (HCC).
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Materials Science, Textiles
XueMei He, Ting Zhu, HaiYan Mao, Lu Cai
Summary: A simple and fast method using chitin whisker (WSK) and dopamine hydrochloride (DA) was proposed to enhance the generation and deposition of silver nanoparticles on silk fabrics. The structural features of the prepared silk fabrics were characterized. The effects of different treatment conditions on the color strength (K/S), ultraviolet protection factor (UPF), and electrical conductivity of the silk fabrics were discussed. The modified silk fabrics showed improved UPF and surface resistance, making them suitable for functional and e-textile products.
FIBERS AND POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Jun Bao, Ziyu Jiang, Wenlong Ding, Yuepeng Cao, Liu Yang, Jingbing Liu
Summary: This study synthesized AgNPs using gallic acid as a reductant and characterized them using various techniques. The synthesized AgNPs exhibited cytotoxicity on colorectal adenocarcinoma cells (HT-29) and induced apoptosis and non-canonical autophagy. Further research using animal models is needed to understand the exact mechanisms of AgNPs in the treatment of digestive tract neoplasms.
NANOTECHNOLOGY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Lidia Struzynska
Summary: In recent years, silver nanoparticles (AgNPs) have been considered as a potential option for new anti-cancer therapies due to their cytotoxic potential in inducing autophagy and apoptotic cell death. This review summarizes the dual role of AgNP-induced autophagy and highlights the factors that may influence its protective vs. its toxic potential. However, there is still insufficient understanding of the cellular and molecular mechanisms of autophagy machinery in both cancer and normal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elcin Bakir, Tugbagul Cal, Sevtap Aydin Dilsiz, Hande Canpinar, Ayse Eken, Ulku Undeger Bucurgat
Summary: The study found that flurbiprofen has cytotoxic, genotoxic, and apoptotic effects in human cancer cells, potentially inducing apoptosis at the gene level.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Oncology
Nouf M. Alyami, Hanadi M. Alyami, Rafa Almeer
Summary: The study aimed to green-synthesize silver nanoparticles and investigate their anti-cancer activity in hepatocellular carcinoma. The results showed that kaempferol-coated silver nanoparticles could induce oxidative stress-mediated apoptosis, demonstrating a potential anti-cancer effect.
CANCER NANOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Reda F. A. Abdelhameed, Mohamed S. Nafie, Dina M. Hal, Ali M. Nasr, Shady A. Swidan, Maged S. Abdel-Kader, Amany K. Ibrahim, Safwat A. Ahmed, Jihan M. Badr, Enas E. Eltamany
Summary: This study compared the aerial and root parts of Zygophyllum album L., finding that the aerial parts had higher levels of total phenolic and flavonoid content. By synthesizing AgNPs, the cytotoxicity of the plant extracts was enhanced, with the aerial parts showing strong cytotoxicity against lung and prostate cancer cells.
Article
Environmental Sciences
Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Deepika Joshi, V Saranya, G. K. Jhanani, Ruangwong On-uma, Kumchai Jutamas, Wongchai Anupong
Summary: The biosynthesis of silver nanoparticles using a methanolic extract of Naringi crenulata was described in this study. The synthesized nanoparticles were spherical in shape with an average diameter of 32.75 nm, and they exhibited antibacterial activity against multidrug-resistant bacteria pathogens.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Chemical
Negin Nazari, Fereshteh Jookar Kashi
Summary: Utilizing a bacterial strain obtained from Kashan textile industry effluent, silver nanoparticles (AgNPs) were synthesized and exhibited antimicrobial properties against standard and multidrug resistant bacteria. Immobilized AgNPs showed 100% efficiency in decolorizing Disperse Blue 183, highlighting their potential in environmental remediation applications.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tianyu Hou, Yurong Guo, Wanyu Han, Yang Zhou, Vasudeva Reddy Netala, Huizhen Li, He Li, Zhijun Zhang
Summary: The present study reports a simple, cost-effective and eco-friendly method for biomimetic synthesis of silver nanoparticles using Perilla frutescens flavonoid extract as a bioreduction agent. The synthesized PFFE-AgNPs exhibited good physical and chemical properties and demonstrated significant anticancer and antibacterial effects against cancer cells and pathogens. Moreover, PFFE-AgNPs showed in vitro antioxidant activity. These findings suggest that PFFE-AgNPs have potential as a multi-functional nanomaterial for biomedical applications, but further research is needed to evaluate their safety and efficacy in vivo.
Article
Pharmacology & Pharmacy
Subramanian Mutheeswaran, Antony Mariappan, Kamaraj Ragavendran, Vedapuri Porchezhiyan, Poovan Elankani, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Savarimuthu Ignacimuthu
Summary: An ethnobotanical survey was conducted in Sathuragiri hills, India, revealing 139 medicinally useful plant species. The study highlighted the importance of Fabaceae, Euphorbiaceae, and Apocynaceae families, which contained numerous important medicinal plants. Dermatological ailments, gastrointestinal problems, joint pain, fever, and poisonous bites were among the important diseases treated by these species. The study emphasized the need for conservation of these medicinal plants and local knowledge.
ADVANCES IN TRADITIONAL MEDICINE
(2023)
Article
Biodiversity Conservation
David Milda, Tharmalingam Ramesh, Riddhika Kalle, V Gayathri, M. Thanikodi, K. Ashish
Summary: The expanding population of wild pigs and the resulting economic loss has posed a challenge to governments and conservation biologists worldwide for over a decade. Unlike many other wildlife species, wild pigs have been able to thrive due to increasing human activities. This has led to an increase in conflicts between humans and wild pigs in certain areas. Understanding the ecological factors that drive these conflicts is crucial for effective management strategies. A study conducted in Tamil Nadu, India, revealed that the probability of human-wild pig conflicts was influenced by factors such as crop diversity, crop cover, distance to water bodies, slope of the landscape, and annual rainfall. By identifying areas with high conflict intensity, authorities can prioritize and concentrate mitigation measures where they are most needed.
BIOLOGICAL INVASIONS
(2023)
Article
Anatomy & Morphology
Gokul Sudhakaran, Ravi Rajesh, Ajay Guru, Mariadhas Valan Arasu, Pusparathinam Gopinath, Jesu Arockiaraj
Summary: The aim of this study was to evaluate the anti-adipogenic activity of semi-natural Nimbin analogs, N5 and N7, on zebrafish larvae induced with oxidative stress due to a high-fat diet. The results showed that N5 and N7 suppressed adipogenesis, reduced intracellular ROS and superoxide anion production, and restored glutathione levels. Additionally, they lowered total TC and TG levels, prevented inflammatory macrophage build-up, and enhanced glucose absorption.
Article
Ecology
Jesse M. Alston, Christen H. Fleming, Roland Kays, Jarryd P. Streicher, Colleen T. Downs, Tharmalingam Ramesh, Bjorn Reineking, Justin M. Calabrese
Summary: Resource selection functions (RSFs) are widely used in animal ecology, but autocorrelation in tracking data can lead to biased estimates and narrow confidence intervals. This study proposes a likelihood weighting method to mitigate the negative effects of autocorrelation on RSFs. The method improves the quality of inferences derived from RSFs and provides a workflow for applying the method to animal tracking data.
METHODS IN ECOLOGY AND EVOLUTION
(2023)
Article
Oncology
Akshaya Murugesan, Sana Kari, Anita Shrestha, Benedicta Assoah, Konda Mani Saravanan, Monica Murugesan, Ramesh Thiyagarajan, Nuno R. Candeias, Meenakshisundaram Kandhavelu
Summary: A novel library of dioxocin derivatives was developed as glutaminase inhibitors for treating glioblastoma. These compounds exhibited significant growth inhibition effect in glioblastoma cells and showed stronger anti-tumor activity compared to the standard drug temozolomide. The most promising compound interacted with key residues of glutaminase and demonstrated potential anti-proliferative properties.
Article
Multidisciplinary Sciences
Subramaniyam Nithyananthan, Sen Somenath, Biddika Sreenadh, Chinnasamy Thirunavukkarasu, Nasraddin Othman Bahakim, Mohammad Shahid, Mohammad Hassan Abdelzaher, Abubucker Peer Mohideen, Thiyagarajan Ramesh, Valluru Lokanatha
Summary: This study investigates the effect of Selenium (Se) on the germination of Macrotyloma uniflorum and Vigna radiate seeds. The results reveal that higher concentrations of Se decrease germination efficacy through oxidative stress, while lower concentrations delay germination and increase carbohydrate and starch content in the seeds.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Environmental Sciences
Rengasamy Sathya, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Ponnuswamy Vijayaraghavan, Soundharrajan Ilavenil, T. S. Rejiniemon
Summary: Water is vital for all living things on earth, and protecting water from pollution has become an essential need due to rapid urbanization and industrialization. Traditional methods of water treatment have drawbacks, but biological methods have gained more attention in recent years. This paper aims to review the role of bio-remedies in wastewater treatment, along with their advantages and limitations.
Article
Medicine, Research & Experimental
Sana Kari, Jeyalakshmi Kandhavelu, Akshaya Murugesan, Ramesh Thiyagarajan, Srivatsan Kidambi, Meenakshisundaram Kandhavelu
Summary: Guanine nucleotide binding protein (G protein) coupled receptor 17 (GPR17) plays a crucial role in regulating reactive oxidative species (ROS) production and cell death in Glioblastoma multiforme (GBM). This study investigates the link between GPR17 and mitochondrial electron transport chain (ETC) complexes in regulating intracellular ROS level in GBM cells. The findings suggest that ETC III bypasses ETC I to increase ROS production in GPR17 signaling activation, providing new insights for targeted therapy development in GBM.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Sana Kari, Akshaya Murugesan, Ramesh Thiyagarajan, Srivatsan Kidambi, Jamoliddin Razzokov, Chandrabose Selvaraj, Meenakshisundaram Kandhavelu, Parthiban Marimuthu
Summary: Glioblastoma Multiforme (GBM) is the most aggressive brain tumor in adults, with a median survival rate of less than 15 months. The GBM cells develop resistance to chemo-and radiotherapy, indicating the need for novel preventative measures. The study identified potential GPR17 modulators using virtual screening and molecular dynamics simulations, and validated their effectiveness in inhibiting GBM cell accumulation. This research provides new insights into the development of targeted therapies for deadly diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Monica Murugesan, Meenakshisundaram Kandhavelu, Ramesh Thiyagarajan, Sankar Natesan, Priyatharsini Rajendran, Akshaya Murugesan
Summary: The present study focused on the phytochemical analysis, quantitative estimation and profiling of secondary metabolites of leaf extract, as well as the antioxidant and cytotoxic activity of halophytes. The results showed that the extracts of Avicennia marina and Ceriops tagal possessed higher phenol content and antioxidant activity. Moreover, Ipomoea pes-caprae showed promising anti-cytotoxic activity. These findings suggest that the extracts of these halophytes have the potential to be used as therapeutic drugs in the treatment of various diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Jeyalakshmi Kandhavelu, Kumar Subramanian, Vivash Naidoo, Giulia Sebastianelli, Phuong Doan, Saravanan Konda Mani, Hande Yapislar, Ebru Haciosmanoglu, Leman Arslan, Samed Ozer, Ramesh Thiyagarajan, Nuno R. Candeias, Clement Penny, Meenakshisundaram Kandhavelu, Akshaya Murugesan
Summary: This study identified a potent EGFR inhibitor called HNPMI, which modulates the apoptosis and oncogenesis processes in CRC cell lines by regulating proteins such as BCL-2/BAX and p53. The results indicate that HNPMI has the potential to be a therapeutic agent for the treatment of CRC.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Antonia Ho, Richard Orton, Rachel Tayler, Patawee Asamaphan, Vanessa Herder, Chris Davis, Lily Tong, Katherine Smollett, Maria Manali, Jay Allan, Konrad Rawlik, Sarah E. McDonald, Elen Vink, Louisa Pollock, Louise Gannon, Clair Evans, Jim McMenamin, Kirsty Roy, Kimberly Marsh, Titus Divala, Matthew T. G. Holden, Michael Lockhart, David Yirrell, Sandra Currie, Maureen O'Leary, David Henderson, Samantha J. Shepherd, Celia Jackson, Rory Gunson, Alasdair MacLean, Neil McInnes, Amanda Bradley-Stewart, Richard Battle, Jill A. Hollenbach, Paul Henderson, Miranda Odam, Primrose Chikowore, Wilna Oosthuyzen, Meera Chand, Melissa Shea Hamilton, Diego Estrada-Rivadeneyra, Michael Levin, Nikos Avramidis, Erola Pairo-Castineira, Veronique Vitart, Craig Wilkie, Massimo Palmarini, Surajit Ray, David L. Robertson, Ana da Silva Filipe, Brian J. Willett, Judith Breuer, Malcolm G. Semple, David Turner, J. Kenneth Baillie, Emma C. Thomson
Summary: An investigation found a possible association between AAV2 infection and host genetics in a recent outbreak of acute hepatitis in children in Scotland. The study used various methods to detect AAV2 infection in plasma and liver samples, and identified pathological features related to the virus in liver biopsy samples.
Review
Nutrition & Dietetics
Vaibhav Kumar Maurya, Amita Shakya, David Julian Mcclements, Ramachandran Srinivasan, Khalid Bashir, Thiyagarajan Ramesh, Jintae Lee, Ezhaveni Sathiyamoorthi
Summary: Vitamin C plays a multifaceted role in human health, including antioxidant activity and various synthesis functions. Due to the lack of a biosynthetic pathway, humans must obtain vitamin C from dietary sources. However, food processing and storage can cause vitamin C degradation, leading to a growing prevalence of deficiency worldwide. Different strategies, such as dietary diversification, biofortification, supplementation, and food fortification, have been tested to address this issue. Nanotechnology offers potential delivery systems for encapsulating and fortifying vitamin C. Therefore, it is crucial to develop and design vitamin C fortified foods with improved stability and bioavailability.
FRONTIERS IN NUTRITION
(2023)
Review
Engineering, Multidisciplinary
Sivakamavalli Jeyachandran, Ramachandran Srinivasan, Thiyagarajan Ramesh, Arumugam Parivallal, Jintae Lee, Ezhaveni Sathiyamoorthi
Summary: Nanozymes are a category of artificial enzymes with remarkable properties, including high catalytic potency and stability, low cost, biocompatibility, and degradability. They have extensive applications in medical, industrial, technological, and biological fields. Extensive research has been conducted to explore their attributes and potential applications, leading to insights and innovations in detection mechanisms, biosensing techniques, and device development. With the emergence of novel methodologies and technologies, the deployment of nanozymes is expected to continue growing, providing enhanced comprehension in the future.
Article
Food Science & Technology
Vijayan Raji, Chitra Loganathan, Thiyagarajan Ramesh, Palvannan Thayumanavan
Summary: This study aimed to understand the protective effect of fucoxanthin purified from brown algae against diabetes with hypertension. The results showed that fucoxanthin significantly reduced blood pressure and ACE activity, alleviated hyperglycemia, normalized enzyme activity and lipid profile, and ameliorated oxidative stress in rat models of diabetes with hypertension.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
