Review
Chemistry, Inorganic & Nuclear
Thimma Subramanian Prathima, Badruzzaman Choudhury, Md. Gulzar Ahmad, Kaushik Chanda, M. M. Balamurali
Summary: Numerous biologically active metal complexes have been reported for their unique features and enhanced functions in inhibiting cancer progression. However, many of these drugs have failed at various levels of clinical trials despite performing well in the laboratory.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Inorganic & Nuclear
Urszula K. Komarnicka, Sandra Koziel, Barbara Pucelik, Agata Barzowska, Milosz Siczek, Magdalena Malik, Daria Wojtala, Alessandro Niorettini, Agnieszka Kyziol, Victor Sebastian, Pavel Kopel, Stefano Caramori, Alina Bienko
Summary: Novel heteronuclear Ir-III-Cu-II coordination compounds containing phosphines derived from fluoroquinolones have been synthesized and studied as potential anticancer chemotherapeutics. The compounds were characterized using various analytical techniques and their ability to accumulate in cancer cells and induce cell cycle changes was demonstrated. The study highlights the potential of these compounds as targeted cancer therapies.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Anastasia Yu. Gitlina, Viktoria Khistiaeva, Alexey Melnikov, Mariia Ivonina, Vladimir Sizov, Dar'ya Spiridonova, Anna Makarova, Denis Vyalikh, Elena Grachova
Summary: Two methods of post-synthetic modification (Suzuki coupling and CuAAC click-reaction) were applied to Ir(iii) complexes to introduce a highly selective donor site. The potential of post-synthetic modification for controlled construction of d-d and d-f binuclear complexes was demonstrated using functionalized complexes. Characterization techniques such as elemental analysis, NMR spectroscopy, mass spectrometry, FTIR spectroscopy, and X-ray diffraction analysis were used to analyze the obtained complexes. The coordination of the diimine donor site to the Ln(iii) center was confirmed through XPS and NEXAFS spectroscopy. The photophysical properties and luminescent characteristics of the complexes were investigated, and TDDFT calculations were used to explain the luminescence mechanism.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Anna Bonfiglio, Conor McCartin, Ulises Carrillo, Cristina Cebrian, Philippe C. Gros, Sylvie Fournel, Antoine Kichler, Chantal Daniel, Matteo Mauro
Summary: A novel family of Ir-III complexes containing a pyridoannelated N-heterocyclic carbene has been synthesized and characterized, showing rare dual emission behavior. These compounds exhibit significantly higher anticancer activity in vitro compared to a market drug, with one compound demonstrating powerful mitochondrial dysfunctioning activity and efficient reactive oxygen species production leading to cell death through apoptosis.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Daria Wojtala, Sandra Koziel, Maciej Witwicki, Alessandro Niorettini, Katarzyna Guz-Regner, Gabriela Bugla-Ploskonska, Stefano Caramori, Urszula K. Komarnicka
Summary: The synthesized complexes, IrPNMPEA and RuPNMPEA, have shown promising antimicrobial activity and interactions with biomolecules. This study provides potential candidates for new therapeutic approaches.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Applied
Elisabetta Rosadoni, Fabio Bellina, Marco Lessi, Cosimo Micheletti, Francesco Ventura, Andrea Pucci
Summary: This article describes the synthesis of three compounds modified with typical electron-donating and electron-withdrawing groups and their evaluation as fluorescent dyes for solar concentrators. These compounds showed good fluorescence properties and device efficiencies in poly(methyl methacrylate) films.
Article
Biochemistry & Molecular Biology
Brondwyn S. McGhie, Janice R. Aldrich-Wright
Summary: Cancer is responsible for over 9 million deaths worldwide each year. Current treatment options have low success rates, especially for late-stage cancers. Researchers globally are continuously searching for alternative treatment options. This study focuses on innovations in inorganic anticancer therapies with photoactive and luminescent properties. Transition metals offer advantages in both chemotherapeutics and luminescence. The study explores the effects of structural changes on the properties and the use of inherent luminescent properties for monitoring cellular localization in photodynamic therapy.
Article
Chemistry, Inorganic & Nuclear
Nilmadhab Roy, Utsav Sen, Prithvi Moharana, Lavanya Thilak Babu, Binoy Kar, Seshu Vardhan, Suban K. Sahoo, Bipasha Bose, Priyankar Paira
Summary: By synthesizing 2,2'-bipyrimidine-based complexes, LRuIr was found to exhibit inhibitory effects on both MDA-MB-468 and Caco-2 cells, with apoptotic events occurring in MDA-MB-468 cancer cells through cell cycle arrest.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Bishnu Das, Parna Gupta
Summary: Square planar Pt(II) complexes were reported as luminescent biosensors for DNA detection, with the bright red photoluminescence induced by aggregation serving as the sensing mechanism. The study explored terpyridine-appended geminal bistriazoles for metal coordination, resulting in tetranuclear and dinuclear Pt(II) complexes with different ligand environments. This is the first report of terpyridine-appended geminal bistriazoles in the literature.
DALTON TRANSACTIONS
(2021)
Review
Chemistry, Multidisciplinary
Lawrence Cho-Cheung Lee, Kenneth Kam-Wing Lo
Summary: There has been a growing interest in utilizing the photophysical and photochemical properties of transition metal complexes for diagnostic and therapeutic applications. This Perspective highlights the recent advances in developing luminescent and photofunctional transition metal complexes, particularly those of rhenium(I), ruthenium(II), osmium(II), iridium(III), and platinum(II) as bioimaging reagents and phototherapeutic agents. The focus is on molecular design strategies that harness and modulate the interesting photophysical and photochemical behavior of these complexes. The current challenges and future outlook of transition metal complexes for both fundamental research and clinical applications are also discussed.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Inorganic & Nuclear
Urszula K. Komarnicka, Sandra Koziel, Agnieszka Skorska-Stania, Agnieszka Kyziol, Francesco Tisato
Summary: In this study, new complexes based on ruthenium(II) and iridium(III) with phosphine ligands and phenyl rings with/without methoxy motifs were synthesized and characterized. The complexes showed high catalytic efficiency in the oxidation of NADH to NAD(+) and exhibited potential applications in biological and medical fields. Furthermore, they demonstrated redox activity and significant cytotoxicity against various cancer cell lines.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Rajeeva Lochana Panchangam, Ramdas Nishanth Rao, Musuvathi Motilal Balamurali, Tejashri B. Hingamire, Dhanasekaran Shanmugam, Venkatraman Manickam, Kaushik Chanda
Summary: A series of novel iridium and ruthenium complexes were synthesized and most of them showed good activity against TNBC cell lines, with iridium complexes generally more active than the corresponding ruthenium complexes. Complexes with methyl and isopropyl substituents displayed increased potency in all cell lines.
INORGANIC CHEMISTRY
(2021)
Article
Materials Science, Biomaterials
Jaypalsing Ingle, Bhawna Uttam, Reha Panigrahi, Saumyakanti Khatua, Sudipta Basu
Summary: A dog-bone shaped gold nanoparticle was engineered to induce mitochondrial impairment and apoptotic cancer cell death, opening a new direction for organelle-targeted cancer therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Inorganic & Nuclear
Pravinkumar Selvam, Sourav De, Priyankar Paira, S. K. Ashok Kumar, Selva R. Kumar, Anbalagan Moorthy, Arjita Ghosh, Yung-Chih Kuo, Subhasis Banerjee, Shantha Kumar Jenifer
Summary: In recent years, Ru(II) complexes have gained high importance in medicinal chemistry due to their significant anti-cancer activities, which are directly related to their DNA binding ability. This report discusses the chemistry and cytotoxicity of two new Ru(II) complexes and analyzes their structural and photophysical properties, as well as their binding abilities with DNA and BSA. The results show that these Ru(II) complexes exhibit superior cytotoxicity to cisplatin against cancer cells and have minimal impact on normal cells.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Organic
Nilanjan Dey, Jiri Kulhanek, Filip Bures, Santanu Bhattacharya
Summary: The newly designed dye shows a dark yellow color in solution, but emits a blue fluorescence when nerve agents are added. The interaction between the nerve agents and the dye involves nucleophilic attack and hydrolysis, leading to altered electronic behavior and the release of a less-toxic organophosphate compound.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Environmental Sciences
B. B. Kanrar, S. Singh, S. K. Pal, D. Panda
Summary: This article presents an effective Organosolv method for better management of agricultural residue in India, such as rice-straw. The method extracts and modifies residual biomass simultaneously and also provides a user-friendly method for quantification of cellulose, hemicellulose, and lignin. The extracted product exhibits excitation-energy-dependent photoluminescence properties that can be used for ultraviolet light-blocking and fluorescence imaging.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Cell Biology
Utsav Sen, Shanooja Shanavas, Apoorva H. Nagendra, Muhammad Nihad, Debajit Chaudhury, Hari K. Rachamalla, Rajkumar Banerjee, Sudheer Shenoy, Bipasha Bose
Summary: Breast cancer is a deadly and frequently diagnosed metastatic cancer, and cancer stem cells play a crucial role in its progression. This study identified Oct-4 as a promising marker for survival in breast cancer stem cells (bCSCs) and found that Oct-4 knockdown induced cell death and inhibited mammosphere formation. The study also suggests a direct interaction between Oct-4 and Vitamin C. These findings contribute novel information about Oct-4 as a survival factor in bCSCs.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Materials Science, Multidisciplinary
Vinita Bhardwaj, S. K. Ashok Kumar, Suban K. Sahoo
Summary: This study prepared red-emitting rod-type aggregates L and found that the restriction of intramolecular motion and the ESIPT phenomenon played a key role in emitting red fluorescence at 597 nm. The aggregates L showed red-emitting fluorescence between pH 5.4 and 9.1, green-emitting fluorescence above pH 9.9, and non-fluorescent behavior in acidic pH. L in HEPES buffer showed a selective turn-off response towards Cu2+ with a detection limit of 2.7 μM.
Article
Nanoscience & Nanotechnology
Utpal Das, Shanooja Shanavas, Apoorva H. Nagendra, Binoy Kar, Nilmadhab Roy, Seshu Vardhan, Suban K. Sahoo, Debashis Panda, Bipasha Bose, Priyankar Paira
Summary: A luminescent metal complex IrL has been developed for HCT-116 colorectal cancer stem cell therapy. It was found that IrL can induce apoptosis and inhibit autophagy of cancer stem cells, indicating its potential as an effective anticancer agent.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Analytical
Domngam Boje, Suban K. Sahoo, Ananta Kumar Atta
Summary: A simple water-soluble carboxamidoquinoline derivative selectively binds to Cu2+ and Au3+ ions in different binding modes. With excellent selectivity and sensitivity, it can identify Cu2+ and Au3+ ions in water medium over a wide pH range. The association constants for both ions were determined and confirmed through mass spectra. The sensor shows low detection limits for Cu2+ and Au3+ ions and exhibits different sensing strategies for the two ions based on photophysical properties, FT-IR spectra, and theoretical (DFT) observations. Its usefulness was tested in various water samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Energy & Fuels
Pooja Jaiswala, Raman Shuklaa, Debashis Panda, K. D. P. Nigama, Koushik Guha Biswas
Summary: In recent years, microfluidic systems have gained popularity due to their multifunctional advantages, such as higher process intensification. The presence of slug flow regime in microdomains has been explored to improve the mass-transfer properties of biphasic flow systems. This study investigates the combined effects of microdomain, slug flow, and non-Newtonian nanofluids (NNnF) on hydrodynamic and mass transfer studies of two-phase flow systems. The addition of 0.5% (w/v) carboxy methyl cellulose (CMC) and Nickel (Ni) nanoparticles resulted in a fifteen-fold enhancement of mass transfer coefficient.
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2023)
Article
Chemistry, Physical
Pooja Jaiswal, Prerna Yogeshwar, Koushik Guha Biswas, Debashis Panda
Summary: In this study, a cost-effective non-lithographic method for the fabrication of a PDMS-based microchannel-coupled-millreactor was developed. The millireactors showed strong catalytic activity for reduction of resazurin and p-nitrophenol. Catalytic poisoning was found to be prevalent, while complete catalytic deactivation of magnetic Ni-microparticles occurred instantaneously.
Review
Biochemical Research Methods
Bipasha Bose, Muhammad Nihad, P. Sudheer Shenoy
Summary: Pluripotent stem cell research has been a game-changer in the modern era, especially with the discovery of induced pluripotent stem cells. The expression of marker proteins and the use of flow cytometry are crucial for identifying and sorting pure populations of stem cells. Flow cytometry is also essential for assessing the differentiation of stem cells and sorting out potentially dangerous teratoma-forming cells. Overall, analytical flow cytometry and cell sorting are indispensable tools in pluripotent stem cell research and cell therapy.
Article
Integrative & Complementary Medicine
Seshu Vardhan, Suban K. Sahoo
Summary: This study aimed to identify phytochemicals as antagonists to target the DNA polymerase protein of monkeypox virus. Molecular docking and molecular dynamics simulations were performed to evaluate the interactions between protein and ligand. The results supported the potential use of phytochemicals as an adjuvant therapy for monkeypox virus.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2023)
Article
Chemistry, Inorganic & Nuclear
Sonkeshriya Dhanshri, Suban K. Sahoo
Summary: This study introduces a fluorescent nanoprobe PLP@l-Cyst-Mn-ZnS obtained through post-functionalization of lcysteine capped Mn-doped ZnS quantum dots (l-Cyst-Mn-ZnS QDs) with pyridoxal 5'-phosphate (PLP). The nanoprobe serves as a highly sensitive fluorescent turn-on probe for ALP and ATP, with the ability to accurately quantify their concentrations in human serum and plasma.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Chemistry, Inorganic & Nuclear
Pragyan Parimita Dash, Dhvani A. Patel, Patitapaban Mohanty, Rubi Behura, Suban K. Sahoo, Bigyan R. Jali
Summary: Cu2+ is an important trace metal ion that plays numerous roles in biological systems. Deficiency or excessive accumulation of Cu2+ in the human body can lead to serious diseases. Various analytical techniques, particularly optical chemosensors based on UV-Vis absorption and fluorescence spectroscopy, are developed for the detection of Cu2+ in different samples. This review presents a compilation of more than 114 Schiff bases that can be easily synthesized and used as chromogenic and/or fluorogenic sensors for Cu2+ detection.
INORGANICA CHIMICA ACTA
(2023)
Article
Medicine, Research & Experimental
Akash Mitra, Shanooja Shanavas, Debajit Chaudhury, Bipasha Bose, Undurti N. Das, P. Sudheer Shenoy
Summary: This study explored the molecular mechanisms associated with reversing the effects of glucotoxicity on muscle myogenesis through arachidonic acid (AA). The results showed that AA supplementation suppressed inflammation and ROS production induced by high glucose, and enhanced protein synthesis, suggesting its cytoprotective actions against hyperglycemia-induced cytotoxicity.
Article
Reproductive Biology
Muhammad Nihad, Utsav Sen, Debajit Chaudhury, Undurti N. Das, P. Sudheer Shenoy, Bipasha Bose
Summary: This study investigated the protective effects of arachidonic acid (AA) against the embryotoxic drug valproic acid (VA). The results showed that AA played an important regulatory role in the proliferation and differentiation of induced pluripotent stem cells (iPSCs) and pluripotent NTERA-2 embryonal carcinoma (EC) cells, and protected the embryoid bodies (EBs) from cytotoxic damage, ensuring normal embryogenesis.
REPRODUCTIVE TOXICOLOGY
(2023)
Review
Oncology
Utsav Sen, Charles Coleman, Triparna Sen
Summary: Cancer progression relies on finely tuned metabolic pathways, and the enzyme SCD1 plays a critical role in modulating the fatty acid metabolic pathway. SCD1 expression is associated with poor prognosis in various types of cancer, and it protects cancer cells against a cell death process called ferroptosis. Inhibition of SCD1 shows promise as a potential anticancer therapy, either alone or in combination with chemotherapy, as demonstrated in preclinical models.
