期刊
INORGANIC CHEMISTRY
卷 60, 期 3, 页码 1664-1671出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.0c03156
关键词
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资金
- National Natural Science Foundation of China [21761023]
- Inner Mongolia Autonomous Region Fund for Natural Science [2017ZD01]
A multifunctional MOF-based drug-delivery system (DDS) with controlled pore size of 100-200 nm was successfully synthesized for therapeutic and bioimaging purposes, demonstrating high drug-loading/release rate and magnetic resonance imaging capability.
Owing to their characteristic structures, metal-organic frameworks (MOFs) are considered as the leading candidate for drug-delivery materials. However, controlling the synthesis of MOFs with uniform morphology and high drug-loading/release efficiencies is still challenging, which greatly limits their applications and promotion. Herein, a multifunctional MOF-based drug-delivery system (DDS) with a controlled pore size of 100-200 nm for both therapeutic and bioimaging purposes was successfully synthesized in one step. Fe-MOF-based microcapsules were synthesized through a competitive coordination method, which was profited from the intrinsic coordination characteristics of the Fe element and the host-guest supramolecular interactions between Fe3+ and polyoxometalates anions. This as-synthesized macroporous DDS could greatly increase the drug-loading/release rate (77%; 83%) and serve as a magnetic resonance (MR) contrast agent. Because an Fe-containing macroporous DDS presents ultrahigh drug loading/release, the obtained 5-FU/Fe-MOF-based microcapsules displayed good biocompatibility, extremely powerful inhibition of tumor growth, and satisfactory MR imaging capability. Given all these advantages, this study integrates high therapeutic effect and diagnostic capability via a simple and effective morphology-controlling strategy, aiming at further facilitating the applications of MOFs in multifunctional drug delivery.
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