Review
Microbiology
Melissa E. Munzen, Ariana D. Goncalves Garcia, Luis R. Martinez
Summary: Fungal infections are a global problem with significant economic and medical consequences. Developing new antifungal drugs is essential in combating this serious issue.
FUTURE MICROBIOLOGY
(2023)
Review
Microbiology
Paloma Osset-Trenor, Amparo Pascual-Ahuir, Markus Proft
Summary: Antifungal resistance is a significant concern due to limited antifungal agents and the emergence of drug resistance, highlighting the need for understanding the mechanisms and developing effective strategies.
Review
Microbiology
Cheng Zhen, Hui Lu, Yuanying Jiang
Summary: This review provides a comprehensive summary of novel promising target proteins and their inhibitors for treating invasive fungal infections, which include inositol phosphoramide synthases, glycosylphosphatidylinositol biosynthesis, Sec14, fungal heat shock protein 90, and dihydrolactate dehydrogenase.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Na Liu, Jie Tu, Yahui Huang, Wanzhen Yang, Qingwen Wang, Zhuang Li, Chunquan Sheng
Summary: Invasive fungal infections (IFIs) are a serious public health threat with high incidence and mortality, especially in cancer patients undergoing chemotherapy. However, the limited availability of effective and safe antifungal agents, coupled with the development of drug resistance, hinders successful antifungal therapy. Therefore, new antifungal agents with novel modes of action, favorable pharmacokinetic profiles, and anti-resistance activity are urgently needed. This review summarizes new antifungal targets, target-based inhibitor design, and prodrug design strategies to improve the physicochemical and pharmacokinetic properties of antifungal agents. Dual-targeting antifungal agents offer a promising strategy for the treatment of resistant infections and cancer-associated fungal infections.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Medicinal
Asiya Ramzan, Sajad Ahmad Padder, Khalid Z. Masoodi, Syed Shafi, Inayatullah Tahir, Reiaz Ul Rehman, Rajendra Prasad, Abdul Haseeb Shah
Summary: This study examined the antifungal potential of chemically synthesized beta-Nitrostyrene derivatives and found that they have strong inhibitory effects on pathogenic fungi and are effective against drug-resistant strains. Furthermore, the derivatives were found to impact cell wall morphology, enhance ROS generation, and modulate drug efflux.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Immunology
Sarah E. Murphy, Tihana Bicanic
Summary: This review presents current antifungal drugs for Candida infections, discusses mechanisms of resistance, introduces novel antifungal agents under development, and explores the use of combination therapy as a potential strategy against emerging drug-resistant Candida.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Microbiology
Ronen Ben-Ami
Summary: Antifungal therapy for pulmonary fungal diseases is undergoing changes, with newer drugs replacing the older standard of care. Voriconazole has become the treatment of choice for most pulmonary mold diseases, but posaconazole and itraconazole have shown similar efficacy with fewer adverse events. With the rise of azole-resistant Aspergillus fumigatus and infections with inherently resistant non-Aspergillus molds, the need for antifungal drugs with novel mechanisms of action is becoming more urgent.
Review
Biochemistry & Molecular Biology
Danish Khan, Aaron H. Nile, Ashutosh Tripathi, Vytas A. Bankaitis
Summary: The emergence of fungal superbugs resistant to current anti-fungal agents is diminishing our ability to treat infections effectively, highlighting the urgent need for new classes of anti-fungal drugs and targets. Recent evidence suggests that Sec14-like phosphatidylinositol transfer proteins (PITPs) could be unexplored portals for selectively disrupting phosphoinositide signaling in virulent fungi, offering exciting potential for next generation Sec14 inhibitors. Development of refined Sec14-directed inhibitors could enhance the chemical weaponry available for combating fungal pathogens and their interactions with human hosts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Katherine Cuenca-Leon, Edisson-Mauricio Pacheco-Quito, Yanela Granda-Granda, Eleonor Velez-Leon, Aranzazu Zarzuelo-Castaneda
Summary: The pathologies caused by fungi in the oral cavity have become a health problem in recent decades, mainly due to the imbalance of local microbiota. Conventional antifungal treatments have led to antifungal resistance instead of being beneficial. This study aims to explore and describe phytotherapy as a potential solution to oral antifungal resistance.
Article
Infectious Diseases
Milena Radunovic, Milena Barac, Jovana Kuzmanovic Pficer, Dusan Pavlica, Aleksandar Jovanovic, Ana Pucar, Sanja Petrovic
Summary: The aim of this study was to compare the antifungal susceptibility of Candida isolated from the tongue and subgingival biofilm. The results showed that both tongue and subgingival isolates were susceptible to amphotericin B. Tongue isolates were more susceptible to fluconazole, while subgingival isolates showed lower susceptibility to itraconazole. The study also found a correlation between the susceptibility of C. albicans to antifungals and oral hygiene and moderate periodontal destruction.
Review
Public, Environmental & Occupational Health
Xiangyi Cui, Lanlin Wang, Yuhong Lue, Changwu Yue
Summary: With the increasing use of immunosuppressive agents, fungal infections have become more common and drug resistance has become a major global health challenge. New antifungal drugs and targets are urgently needed to effectively control fungal infections and overcome drug resistance.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Review
Dermatology
Andreas H. Groll, Katharina Koerholz, Malcolm Holterhus, Thomas Lehrnbecher
Summary: Invasive fungal diseases (IFDs) play a crucial role in the care of paediatric patients, and it is important to have a solid understanding of available antifungal options. The development of new antifungal agents for paediatric patients is advancing, and there have been significant advancements in the prevention and treatment of IFDs.
Article
Infectious Diseases
Wenying Cai, Qianqian Ruan, Jiahao Li, Li Lin, Liyan Xi, Jiufeng Sun, Sha Lu
Summary: This study investigated the clinical characteristics, pathogen spectrum, and drug resistance of deep fungal infection in a hospital in Guangzhou, China. The main causative agents were Candida species. Echinocandins were the first choice for clinical therapy, followed by 5-fluorocytosine and amphotericin B. Caution should be taken when using azole antifungals in infections caused by Candida glabrata and Candida tropicalis.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Dermatology
Luana Rossato, Marielle Camargo dos Santos, Roxana G. Vitale, Sybren de Hoog, Kelly Ishida
Summary: Fungal infections pose a significant threat to immunocompromised and high-risk surgical patients, with increasing rates of treatment failures. Innovative strategies are needed to develop novel and effective antifungal drugs, such as through synergistic combinations of antifungals with non-antifungal agents.
Review
Medicine, Research & Experimental
E. Burchacka, P. Pieta, A. Lupicka-Slowik
Summary: There are four types of antifungal drugs targeting different aspects of fungi, but increasing resistance poses a challenge to treatment options. Thus, developing new drug strategies is crucial for addressing fungal diseases effectively.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
