Article
Infectious Diseases
Atul Tyagi, Sudeep Roy, Sanjay Singh, Manoj Semwal, Ajit K. Shasany, Ashok Sharma, Ivo Provaznik
Summary: The study team developed an SVM-based model for designing and predicting plant-derived antifungal peptides. The analysis showed preferences for C, G, K, R, S in amino acid sequences, with G, K, R, A dominating the N-terminal and N, S, C, G preferring the C-terminal. Motif analysis revealed the presence of motifs like NYVF, NYVFP, YVFP, NYVFPA, VFPA.
Review
Pharmacology & Pharmacy
Xihui Gao, Junqiang Ding, Chongbing Liao, Jinliang Xu, Xiaoxiao Liu, Wuyuan Lu
Summary: Defensins are a family of cationic antimicrobial peptides with broad-spectrum activity against infectious microbes. Challenges in developing defensins as antibacterial therapeutics include pharmacological and technical obstacles, but various technologies and strategies have been developed to address these issues.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Immunology
Qing Yang, Amanda C. Burkardt, Lakshimi T. Sunkara, Kan Xiao, Guolong Zhang
Summary: The study found that certain natural cyclooxygenase-2 (COX-2) inhibitors can enhance the expression of host defense peptides (HDP) genes in chickens. These inhibitors demonstrated a strong synergistic effect with butyrate in increasing the expressions of multiple HDP genes. Additionally, they promoted the expressions of barrier function-related genes and suppressed inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Aetas Amponnawarat, Chalatip Chompunud Na Ayudhya, Hydar Ali
Summary: Pseudomonas aeruginosa infections are difficult to treat due to biofilm formation and antibiotic resistance, but a lipidated HDP mimetic called murepavadin has shown antibacterial activity against multi-drug-resistant strains. Murepavadin activates human MCs via MRGPRX2 and murine MCs via MrgprB2, potentially contributing to bacterial clearance and wound healing.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Ramon Roca-Pinilla, Leszek Lisowski, Anna Aris, Elena Garcia-Fruitos
Summary: Host defense peptides (HDPs) are small proteins with potent antibacterial and immunomodulatory activities, suitable for clinical applications. Traditional methods of producing antimicrobial peptides are expensive and toxic, making recombinant production of HDPs an alternative. This review explores different strategies for optimizing HDPs, including fine-tuning their activities, bioengineering, and recombinant production in various cell factories.
MICROBIAL CELL FACTORIES
(2022)
Review
Agronomy
Fernando Lobo, Alicia Boto
Summary: Host-defense peptides (HDP) are emerging as promising phytosanitaries due to their potency, low toxicity, and low induction of antimicrobial resistance. They are natural compounds that have been used by animals and plants for millions of years to defend against pathogens. HDPs are being discovered through genome mining and produced using biofactories. Truncated or modified peptides have been developed to improve their bioactivities and reduce production costs. The combination of HDP and other antimicrobials, as well as the development of hybrid molecules, has shown promising results. However, cautionary measures need to be taken for the sustainable use of HDPs.
Article
Pharmacology & Pharmacy
Roberto Bello-Madruga, Javier Valle, M. Angeles Jimenez, Marc Torrent, Vivian Montero-Alejo, David Andreu
Summary: Beta-defensins are a highly abundant and studied family of antimicrobial peptides. A study on a beta-defensin-like peptide (PaD) found in spiny lobsters shows that the C-terminus of the peptide is the main determinant of its antibacterial activity. Synthetic versions of PaD and its C-terminus were found to have enhanced antimicrobial activity and binding to bacterial membranes. These findings suggest that the C-terminus of PaD is a promising target for the development of novel anti-infective drugs.
Article
Nutrition & Dietetics
Kelsy Robinson, Qing Yang, Hong Li, Long Zhang, Bridget Aylward, Ryan J. Arsenault, Guolong Zhang
Summary: The combination of butyrate and forskolin shows a strong synergy in inducing the expressions of several chicken HDP genes and genes involved in barrier function, leading to significant alleviation of intestinal lesions and C. perfringens colonization in a chicken model of necrotic enteritis. RNA sequencing results demonstrate a preferential increase in HDP and barrier function genes with no induction of proinflammatory cytokines in response to butyrate and forskolin. The antiinflammatory and barrier protective properties of butyrate and forskolin were further confirmed by the kinome peptide array, suggesting their potential as novel antibiotic alternatives for enhancing intestinal health and disease resistance in poultry and other animals.
FRONTIERS IN NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Matthew Drayton, Julia P. Deisinger, Kevin C. Ludwig, Nigare Raheem, Anna Mueller, Tanja Schneider, Suzana K. Straus
Summary: The rapid rise of multidrug-resistant bacteria has raised concerns about the effectiveness of traditional antibiotics. Antimicrobial peptides, with their diverse mechanisms of actions, offer a promising solution to combat these pathogens. This review discusses the mechanisms of antibiotic resistance and the potential of antimicrobial peptides in providing a more robust treatment of bacterial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Felipe Stambuk, Claudia Ojeda, Gabriel Machado Matos, Rafael Diego Rosa, Luis Mercado, Paulina Schmitt
Summary: Big defensins are a family of antimicrobial peptides found in certain groups of invertebrates, especially mollusks, with activity against both bacteria and fungi. Studies have shown that these peptides have the ability to form nanonets that trap and kill bacteria, indicating a potential conservation of bactericidal activity across big defensins from bivalve mollusks.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ernest Y. Lee, Liana C. Chan, Huiyuan Wang, Juelline Lieng, Mandy Hung, Yashes Srinivasan, Jennifer Wang, James A. Waschek, Andrew L. Ferguson, Kuo-Fen Lee, Nannette Y. Yount, Michael R. Yeaman, Gerard C. L. Wong
Summary: This study confirms the antimicrobial role of PACAP and reveals its selective induction in the brain during infection. Through various mechanisms, including disruption of pathogen membrane integrity and activation of cell death pathways, PACAP exhibits antimicrobial activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Infectious Diseases
Isabel Tobin, Guolong Zhang
Summary: The rise of antimicrobial resistance has led to an urgent need for antibiotic alternatives in disease control and prevention. Host defense peptides (HDPs), with their antimicrobial and immunomodulatory properties, offer a promising solution to treating infections without the risk of developing resistance. Polyphenols, natural compounds found in plants, have been found to stimulate HDP synthesis and show potential as antibiotic alternatives.
Review
Pharmacology & Pharmacy
Hashem Etayash, Robert E. W. Hancock
Summary: Amphiphilic antimicrobial polymers and surface engineered polymeric-brush-tethered HDP are promising strategies that aim to overcome limitations of HDPs, enhance physicochemical properties and therapeutic performance, and address unmet therapeutic needs.
Article
Fisheries
Soohyung Lee, Inkyu Yoo, Yugyeong Cheon, Minsun Hong, Bo-Young Jeon, Hakhyun Ka
Summary: Members of the beta-defensin family are expressed specifically at the maternal-conceptus interface in pigs, protecting the maternal endometrial and conceptus tissues from pathogens and regulating innate immunity to preserve fertility.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Microbiology
Qing Yang, Li-An Fong, Wentao Lyu, Lakshmi T. Sunkara, Kan Xiao, Guolong Zhang
Summary: It was found that different sugars had differential regulatory effects on HDP gene expression in chicken HD11 macrophage cells, with galactose, trehalose, and lactose significantly upregulating certain gene expressions, and all sugars exhibiting a strong synergy with butyrate in enhancing AvBD9 expression.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Tracy Lackraj, Kathene Johnson-Henry, Philip M. Sherman, Steve D. Goodman, Anca M. Segall, Debora Barnett Foster
Editorial Material
Microbiology
Tracy Lackraj, Jee In Kim, Seav-Ly Tran, Debora E. Barnett Foster
Article
Microbiology
Julianne V. Kus, Ahferom Gebremedhin, Vica Dang, Seav-Ly Tran, Anca Serbanescu, Debora Barnett Foster
JOURNAL OF BACTERIOLOGY
(2011)
Article
Microbiology
B. House, J. V. Kus, N. Prayitno, R. Mair, L. Que, F. Chingcuanco, V. Gannon, D. G. Cvitkovitch, D. Barnett Foster
Article
Microbiology
M. Lino, J. V. Kus, S. L. Tran, Z. Naqvi, B. Binnington, S. D. Goodman, A. M. Segall, D. Barnett Foster
Article
Microbiology
Frances Chingcuanco, Yijing Yu, Julianne V. Kus, Lynn Que, Tracy Lackraj, Celine M. Levesque, Debora Barnett Foster
Article
Acoustics
Sebastian Brand, Bindiya Solanki, Debora B. Foster, Gregory J. Czarnota, Michael C. Kolios
ULTRASOUND IN MEDICINE AND BIOLOGY
(2009)
Review
Immunology
Debora Barnett Foster
Article
Microbiology
Tracy Lackraj, Sarah Birstonas, Michele Kacori, Debora Barnett Foster
JOURNAL OF BACTERIOLOGY
(2020)
Article
Multidisciplinary Sciences
Juan Puno-Sarmiento, Erin M. Anderson, Amber J. Park, Cezar M. Khursigara, Debora E. Barnett Foster
SCIENTIFIC REPORTS
(2020)
Article
Microbiology
Chhatra B. Kunwar, Sarah Birstonas, Joseph B. McPhee, Debora Barnett Foster
Article
Immunology
MC de Jesus, AA Urban, ME Marasigan, DEB Foster
JOURNAL OF INFECTIOUS DISEASES
(2005)
Article
Immunology
Y Wu, B Lau, S Smith, K Troyan, DEB Foster
INFECTION AND IMMUNITY
(2004)
Article
Immunology
M Abul-Milh, Y Wu, B Lau, CA Lingwood, DB Foster
INFECTION AND IMMUNITY
(2001)