Article
Obstetrics & Gynecology
Laura Buggio, Edgardo Somigliana, Greta Sergenti, Federica Ottolini, Dhouha Dridi, Paolo Vercellini
Summary: Our study failed to find an association between AGD and the presence of endometriosis. Therefore, AGD does not seem to be a reliable indicator of the presence of endometriosis in clinical practice.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Shai E. Elizur, Adva Aizer, Michal Yonish, Tal Shavit, Raoul Orvieto, Roy Mashiach, Shlomo B. Cohen, Elad Berkowitz
Summary: This retrospective cohort study aimed to evaluate the outcome of fertility-preservation treatments in women with endometrioma, particularly those with endometrioma larger than 4 cm. The results showed that women who underwent surgery for endometrioma before fertility-preservation treatment had a significant reduction in the number of MII oocytes. However, among those who did not undergo surgery, the size of endometrioma did not affect the outcomes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Biochemistry & Molecular Biology
Miriam Ayora, David Fraguas, Renzo Abregu-Crespo, Sandra Recio, Maria A. Blasco, Ana Moises, Aksinya Derevyanko, Celso Arango, Covadonga M. Diaz-Caneja
Summary: The meta-analysis found that leukocyte telomere length was significantly shorter in patients with schizophrenia and related disorders compared to healthy controls, with no significant effects of age or illness duration on this difference. The results support the hypothesis of accelerated cellular aging in schizophrenia and related disorders, highlighting the need for large longitudinal studies with repeated telomere length measurements and appropriate assessments of associated factors.
MOLECULAR PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Sharon Dixon, Tom A. Ranger, Judith Burchardt, Martina Patone, Andrew J. H. L. Snelling, Katy Vincent, Julia Hippisley-Cox
Summary: This study aims to improve the evidence base for adolescents presenting to primary care with dysmenorrhoea. It comprises three interlinked studies that will determine the prevalence of dysmenorrhoea in primary care, the association between dysmenorrhoea and endometriosis, and the preceding symptoms of endometriosis. The project has received ethics approval and the findings will be disseminated through academic journals and infographics.
Article
Medicine, General & Internal
Laura Buggio, Marco Reschini, Paola Vigano, Dhouha Dridi, Giulia Galati, Alessandra Chine, Francesca Giola, Edgardo Somigliana, Laura Benaglia
Summary: This study compared the 2D:4D ratio between women with endometriosis and healthy controls and found that women with endometriosis had a significantly higher 2D:4D ratio. This result supports the hypothesis that intrauterine hormonal and endocrine disruptor exposures may play a role in the onset of the disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Jill Koshiol, Bin Zhu, Renwei Wang, Allan Hildesheim, Yu-Tang Gao, Patricia A. Egner, Jian-Min Yuan, John D. Groopman
Summary: This study found that aflatoxin B1 (AFB1) exposure is associated with an increased risk of developing gallbladder cancer (GBC). Higher levels of AFB1-lysine albumin adducts were associated with a higher risk of GBC, and there was a dose-response relationship. Participants with detectable AFB1-lysine albumin adducts and self-reported gallstones had a greater risk of developing GBC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Sarah A. Palumbo, Janet D. Robishaw, Joanne Krasnoff, Charles H. Hennekens
Summary: The meta-analysis of observational studies on Opioid Use Disorder suggests that biases may differ between case-control and cohort studies, potentially due to greater selection bias in case-control studies. This finding has implications for the application of meta-analyses in common diseases, genomics, precision medicine, including OUD.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Dermatology
T. Datzmann, O. Schoffer, F. Meier, A. Seidler, J. Schmitt
Summary: The German programme for skin cancer screening was established in 2008 with the aim of reducing skin cancer mortality. A retrospective cohort study in Saxony, Germany found that patients with melanoma who participated in the screening programme had lower mortality rates and better survival rates compared to those who did not participate. However, these benefits may be influenced by factors such as healthy screen bias and overdiagnosis.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Review
Health Care Sciences & Services
Angela MacCarthy, Paula Dhiman, Shona Kirtley, Patricia Logullo, Bethan Copsey, Gary S. Collins
Summary: The reporting of case-control studies for risk factors of pancreatic cancer remains inconsistent and inadequate, with particular issues in addressing bias and study sample size determination. Study cases are described in more detail than study controls.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Seng Chan You, Seung In Seo, Thomas Falconer, Chen Yanover, Talita Duarte-Salles, Sarah Seager, Jose D. Posada, Nigam H. Shah, Phung-Anh Nguyen, Yeesuk Kim, Jason C. Hsu, Mui Van Zandt, Min-Huei Hsu, Hang Lak Lee, Heejoo Ko, Woon Geon Shin, Nicole Pratt, Rae Woong Park, Christin G. Reich, Marc A. Suchard, George Hripcsak, Chan Hyuk Park, Daniel Prieto-Alhambra
Summary: This cohort study found no increased risk of cancer associated with the use of ranitidine compared to other H2 receptor antagonists. Further research is needed to explore the long-term association between ranitidine and cancer development.
Article
Oncology
Nikos Papadimitriou, Marc J. Gunter, Neil Murphy, Audrey Gicquiau, David Achaintre, Stefanie Brezina, Tanja Gumpenberger, Andreas Baierl, Jennifer Ose, Anne J. M. R. Geijsen, Eline H. van Roekel, Andrea Gsur, Biljana Gigic, Nina Habermann, Cornelia M. Ulrich, Ellen Kampman, Matty P. Weijenberg, Per Magne Ueland, Rudolf Kaaks, Verena Katzke, Vittorio Krogh, Bas Bueno-de-Mesquita, Eva Ardanaz, Ruth C. Travis, Matthias B. Schulze, Maria-Jose Sanchez, Sandra M. Colorado-Yohar, Elisabete Weiderpass, Augustin Scalbert, Pekka Keski-Rahkonen
Summary: The study found that higher plasma tryptophan levels may be associated with a lower risk of colon cancer, while increased serotonin levels may be linked to a higher risk of colon cancer. Additionally, the kynurenine-to-tryptophan ratio may reflect altered tryptophan metabolism during colon cancer development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biology
Lu Wang, Jill Schnall, Aeron Small, Rebecca A. Hubbard, Jason H. Moore, Scott M. Damrauer, Jinbo Chen
Summary: Clinically relevant information from electronic health records allows for derivation of diverse phenotypes, but challenges arise from case contamination. An estimating equation approach is proposed for bias correction and has shown promising results in simulation studies and pilot applications.
Article
Health Care Sciences & Services
So Young Kim, Dae Myoung Yoo, Mi Jung Kwon, Ji Hee Kim, Joo-Hee Kim, Woo Jin Bang, Sung Kyun Kim, Hyo Geun Choi
Summary: This study investigated the risk of thyroid cancer in patients with gout and found that a prior history of gout was associated with an elevated risk of thyroid cancer in middle-aged and healthy populations without comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Clement T. Narh, Charles P. Dzamalala, Blandina T. Mmbaga, Diana Menya, Yohannie Mlombe, Peter Finch, Gissela Nyakunga, Joachim Schuz, Valerie McCormack
Summary: The study revealed that geophagia is more common in women in Africa, but is not a significant contributor to esophageal cancer risk in men. While the practice is common in women, there is currently no consistent evidence linking it to esophageal squamous cell carcinoma.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Clinical Neurology
Jonviea D. Chamberlain, Anais Rouanet, Bruno Dubois, Florence Pasquier, Olivier Hanon, Audrey Gabelle, Mathieu Ceccaldi, Pierre Krolak-Salmon, Yannick Bejot, Olivier Godefroy, David Wallon, Armelle Gentric, Genevieve Chene, Carole Dufouil
Summary: The study found that incident cancer was associated with a reduced risk of dementia, suggesting a protective relationship between cancer and dementia. Further investigations are encouraged to understand potential underlying mechanisms.
ALZHEIMERS & DEMENTIA
(2021)
Review
Food Science & Technology
Seyed Mohammad Mousavi, Pari Mokhtari, Omid Asbaghi, Somaye Rigi, Emma Persad, Ahmad Jayedi, Hamid Rezvani, Yahya Mahamat-Saleh, Omid Sadeghi
Summary: This study found that saffron supplementation can significantly reduce serum ALT concentrations, but does not have a significant effect on AST and ALP levels. There was no significant dose-response relationship between dosage and duration of saffron supplementation on liver enzyme levels. Further large randomized controlled trials on diverse populations are needed to better understand the effects of saffron on these enzymes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Health Care Sciences & Services
B. Swift, H. Naci, B. Taneri, C. M. Becker, K. T. Zondervan, N. Rahmioglu
Summary: This study aimed to describe the health-related quality of life of women aged 18-55 in Northern Cyprus. The researchers used SF-36v2 questionnaire and found that younger women had better physical health, while older women had better mental health. Women in employment and with higher educational attainment also had better health outcomes.
QUALITY OF LIFE RESEARCH
(2022)
Article
Medicine, General & Internal
Samvida S. Venkatesh, Teresa Ferreira, Stefania Benonisdottir, Nilufer Rahmioglu, Christian M. Becker, Ingrid Granne, Krina T. Zondervan, Michael V. Holmes, Cecilia M. Lindgren, Laura B. L. Wittemans
Summary: This study analyzed data on obesity and reproductive diseases in women of European ancestry and found that obesity is associated with increased risks of various reproductive disorders, including uterine fibroids, polycystic ovary syndrome, heavy menstrual bleeding, and pre-eclampsia. The study also identified associations between obesity, metabolic hormones, and reproductive diseases, and found that the relationship between obesity and reproductive disorders is influenced by genetic factors.
Review
Obstetrics & Gynecology
Krina T. Zondervan, Stacey Missmer, Mauricio S. Abrao, Jon Einarsson, Andrew W. Horne, Neil P. Johnson, Ted T. M. Lee, John Petrozza, Carla Tomassetti, Nathalie Vermeulen, Grigoris Grimbizis, Rudy Leon De Wilde
Summary: In the field of endometriosis, most clinicians would like a new simple surgical descriptive system for endometriosis, despite the existing classification systems.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Multidisciplinary Sciences
Waheed-Ul-Rahman Ahmed, Sam Kleeman, Michael Ng, Wei Wang, Adam Auton, Regent Lee, Ashok Handa, Krina T. Zondervan, Akira Wiberg, Dominic Furniss
Summary: This study describes the largest genome-wide association study of varicose veins, identifying 46 susceptibility loci and 49 signals. The study also maps 237 genes to these loci, providing potential targets for therapeutic interventions. Pathway analysis reveals several biological processes related to varicose veins.
NATURE COMMUNICATIONS
(2022)
Article
Obstetrics & Gynecology
Krina T. Zondervan, Stacey Missmer, Mauricio S. Abrao, Jon Einarsson, Andrew W. Horne, Neil P. Johnson, Ted T. M. Lee, John Petrozza, Carla Tomassetti, Nathalie Vermeulen, Grigoris Grimbizis, Rudy L. de Wilde
Summary: This study examined the current use of endometriosis classification systems in clinical practice and the motivations of clinicians. The findings showed that while existing systems are widely used, most clinicians expressed the need for a new simple surgical descriptive system.
FACTS VIEWS AND VISION IN OBGYN
(2022)
Correction
Medicine, General & Internal
Samvida S. Venkatesh, Teresa Ferreira, Stefania Benonisdottir, Nilufer Rahmioglu, Christian M. Becker, Ingrid Granne, Krina T. Zondervan, Michael V. Holmes, Cecilia M. Lindgren, Laura B. L. Wittemans
Article
Multidisciplinary Sciences
Waheed Ul-Rahman Ahmed, Manal I. A. Patel, Michael Ng, James McVeigh, Krina Zondervan, Akira Wiberg, Dominic Furniss
Summary: By performing a genome-wide association study on a large cohort of patients, we identified several susceptibility loci associated with abdominal hernias. These loci are involved in connective tissue and elastic fiber homeostasis, providing important insights into the pathogenesis of hernias.
Editorial Material
Endocrinology & Metabolism
Luz Garcia-Alonso, Krina T. Zondervan, Roser Vento-Tormo
Summary: A transcriptomic analysis of endometriosis and comparison tissues has provided a rich and complex catalogue of single-cell-based expression data. This resource is crucial for scaling up single cell profiling, advancing research on endometriosis pathogenesis, and exploring novel approaches for diagnosing and treating the disease.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Reproductive Biology
Lysia Demetriou, Christian M. Becker, Beatriz Martinez-Burgo, Adriana L. Invitti, Marina Kvaskoff, Razneen Shah, Emma Evans, Claire E. Lunde, Emma Cox, Kurtis Garbutt, Krina T. Zondervan, Elaine Fox, Katy Vincent
Summary: This study examines the impact of the COVID-19 pandemic on pain, fatigue symptoms, and mental health in people with endometriosis. The findings show that there has been a significant worsening of symptoms and mental health among participants compared to six months prior. The study also suggests that pain catastrophising plays a role in mediating the relationship between changes in mental health and changes in pain and fatigue.
REPRODUCTION AND FERTILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Chen-Yi Wang, Darragh P. O. Prime Brien, Anne Ndungu, Jessica Malzahn, Marina Maritati, Beatriz Martinez-Burgo, Kurtis Garbutt, Krina T. Zondervan, Christian M. Becker, Adrian Harris, Bianca De Leo, Maik Obendorf, Nicole Schmidt, Joerg Mueller, Thomas M. Zollner, Udo Oppermann, Adam P. Cribbs, Benedikt M. Kessler, Martin Philpott
REPRODUCTIVE SCIENCES
(2022)
Meeting Abstract
Obstetrics & Gynecology
Anne Ndungu, Nilufer Rahmioglu, Michal Krassowski, Cecilia Cheuk, Eshita Sharma, Helen Lockstone, Cecilia M. Lindegren, Christian M. Becker, Krina T. Zondervan
REPRODUCTIVE SCIENCES
(2022)
Meeting Abstract
Obstetrics & Gynecology
Martin Philpott, Chen-Yi Wang, Dylan Windell, Jessica Malzahn, Warren Baker, Marina Maritati, Salwa Lin, Anna James-Bott, Benedikt Kessler, Mark Coles, Christopher Buckley, Krina T. Zondervan, Christian M. Becker, Bianca De Leo, Joerg Mueller, Nicole Schmidt, Thomas M. Zollner, Adrian Harris, Adam P. Cribbs, Udo Oppermann
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Krina T. Zondervan, Stacey Missmer, Mauricio S. Abrao, Jon Einarsson, Andrew W. Horne, Neil P. Johnson, Ted T. M. Lee, John Petrozza, Carla Tomassetti, Nathalie Vermeulen, Grigoris Grimbizis, Rudy Leon De Wilde
Summary: The majority of clinicians managing endometriosis express a desire for a new simple surgical descriptive system, despite high uptake of existing classification systems.
HUMAN REPRODUCTION OPEN
(2022)
Review
Obstetrics & Gynecology
Mengni Shen, Elizabeth O'Donnell, Gabriela Leon, Ana Kisovar, Pedro Melo, Krina Zondervan, Ingrid Granne, Jennifer Southcombe
Summary: This study compares the similarities and differences in endometrial B cells between normal human endometrium and benign reproductive pathologies. The study found that B cells are present in both normal endometrium and benign pathologies, but their relative abundance and phenotypes vary, and the current evidence is inconsistent. A detailed study of endometrial B cells helps us better understand their function in the endometrial mucosal immune environment.
HUMAN REPRODUCTION OPEN
(2022)