Review
Immunology
Fei Li Kuang, Bruce S. Bochner
Summary: Eosinophils, a subset of the granulocyte lineage, play a crucial role in innate immunity and other physiological responses. Recent research has advanced our understanding of the functions of eosinophils in health and disease, highlighting their significance in maintaining homeostasis and responding to pathological conditions.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Cell Biology
Shang-Hsin Wu, Mei-Hwei Chang, Ya-Hui Chen, Hui-Lin Wu, Huey-Huey Chua, Chin-Sung Chien, Yen-Hsuan Ni, Hui-Ling Chen, Huey-Ling Chen
Summary: This study identified charged multivesicular body protein 5 (CHMP5) as a molecule that interacts with BSEP, affecting its canalicular targeting and retention, resulting in impaired post-Golgi trafficking and bile acid secretion. These findings suggest that ESCRT-III-mediated BSEP sorting is essential for the trafficking of apical membrane proteins, providing new targets for therapeutic interventions in BSEP-associated cholestasis.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Damon C. Brown, Raymond J. Turner
Summary: This study describes a new approach for creating universal primer sets targeting mobile, nonconserved genes, compared to traditional methods used for highly conserved genes. The approach can be adapted to any unique gene set and aid in creating a wider, more robust library of primer sets for PCR-based screening research.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Biochemical Research Methods
Radoslaw P. Nowak, Lyn H. Jones
Summary: Proteolysis targeting chimeras (PROTACs) are emerging as a promising strategy for targeted protein degradation in drug discovery. However, challenges such as complex physicochemistry and the development of orally bioavailable drugs need to be addressed for PROTACs to reach their full potential.
Article
Biochemistry & Molecular Biology
Yuwen Yin, Fei Zhu, Meiling Pan, Jiaqi Bao, Qing Liu, Yi Tao
Summary: This study investigates the anti-osteoporosis mechanism of different components of Achyranthes bidentata Blume (AB) using network pharmacology, metabolomics, and microbiomics. The results suggest that the polysaccharide components of AB regulate the abundance of gut microbiota, thus exerting a bone-protective effect.
Article
Pharmacology & Pharmacy
Sara M. Soliman, Shaimaa Mosallam, Mohamed A. Mamdouh, Mohammed Abdalla Hussein, Shady M. Abd El-Halim
Summary: The study aimed to encapsulate cranberry extract into bile salt augmented liposomes to enhance its hepatoprotective effect against liver injury in rats. The encapsulation significantly potentiated the protective effect of the extract against liver damage.
Article
Ophthalmology
Marko Lukic, Maria Eleftheriadou, Robin D. Hamilton, Ranjan Rajendram, Kajo Bucan, Praveen J. Patel
Summary: The study found that good long-term morphological and functional treatment outcomes can be achieved using intravitreal aflibercept for nAMD in a real-life clinical setting, with a mean number of injections received over 4 years of 19.3 and significant improvements in visual acuity and macular thickness observed over the 4-year follow-up period.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Magdalini Kreouzi, Nikolaos Theodorakis, Constantina Constantinou
Summary: This paper compares the principles of Blue Zones with the six pillars of Lifestyle Medicine and reviews new studies on the association between behavioral factors and longevity. It also emphasizes the important role of genetics and the need for further research on the molecular pathways that affect wellbeing and longevity.
AMERICAN JOURNAL OF LIFESTYLE MEDICINE
(2022)
Review
Medicine, General & Internal
Tom H. Karlsen, Nick Sheron, Shira Zelber-Sagi, Patrizia Carrieri, Geoffrey Dusheiko, Elisabetta Bugianesi, Rachel Pryke, Sharon J. Hutchinson, Bruno Sangro, Natasha K. Martin, Michele Cecchini, Mae Ashworth Dirac, Annalisa Belloni, Miquel Serra-Burriel, Cyriel Y. Ponsioen, Brittney Sheena, Alienor Lerouge, Marion Devaux, Nick Scott, Margaret Hellard, Henkjan J. Verkade, Ekkehard Sturm, Giulio Marchesini, Hannele Yki-Jarvinen, Chris D. Byrne, Giovanni Targher, Aviad Tur-Sinai, Damon Barrett, Michael Ninburg, Tatjana Reic, Alison Taylor, Tim Rhodes, Carla Treloar, Claus Petersen, Christoph Schramm, Robert Flisiak, Marieta Y. Simonova, Albert Pares, Philip Johnson, Alessandro Cucchetti, Isabel Graupera, Christos Lionis, Elisa Pose, Nuria Fabrellas, Ann T. Ma, Juan M. Mendive, Vincenzo Mazzaferro, Harry Rutter, Helena Cortez-Pinto, Deirdre Kelly, Robyn Burton, Jeffrey Lazarus, Pere Gines, Maria Buti, Philip N. Newsome, Patrizia Burra, Michael P. Manns
Article
Multidisciplinary Sciences
Maaike Blankestijn, Vincent W. Bloks, Dicky Struik, Nicolette Huijkman, Niels Kloosterhuis, Justina C. Wolters, Ronald J. A. Wanders, Frederic M. Vaz, Markus Islinger, Folkert Kuipers, Bart van de Sluis, Albert K. Groen, Henkjan J. Verkade, Johan W. Jonker
Summary: The study of a Pxmp4 knockout mouse model suggests that PXMP4 is not critical for overall peroxisome function but may have a role in the metabolism of (ether)lipids.
SCIENTIFIC REPORTS
(2022)
Letter
Gastroenterology & Hepatology
Onne A. H. O. Ronda, Vincent W. Bloks, Jan-Freark De Boer, Folkert Kuipers, Henkjan J. Verkade
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Nachiket Vartak, Ronald Oude Elferink, Stan van de Graaf, Dirk Drasdo, Jan Hengstler
Article
Gastroenterology & Hepatology
Stefan G. Hubscher, Sandy Feng, Annette S. H. Gouw, Hironori Haga, Hyo Jeong Kang, Deirdre A. Kelly, Mina Komuta, Andrew Lesniak, Benjamin A. Popp, Henkjan J. Verkade, Eunsil Yu, Anthony J. Demetris
Summary: This study aimed to establish a standardized approach for assessing long-term graft histology in pediatric liver transplant recipients. The results showed a high level of agreement among pathologists in assessing various histological features relevant to graft health. This standardized assessment could aid in improving outcomes for children undergoing liver transplantation.
LIVER TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Rumei Li, Milaine Hovingh, Martijn Koehorst, Pim de Blaauw, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers
Summary: OCA treatment alters the hydrophobicity of bile acid pool in Cyp2c70(-/-) mice, but does not improve or worsen the sex-dependent liver pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Gastroenterology & Hepatology
Hedayatullah Esmati, Marieke van Rosmalen, Patrick F. van Rheenen, Marieke T. de Boer, Aad P. van den Berg, Hubert P. J. van der Doef, Michel Rayar, Ruben H. J. de Kleine, Robert J. Porte, Vincent E. de Meijer, Henkjan J. Verkade
Summary: The Eurotransplant (ET) allocation prioritization for patients with biliary atresia (BA) younger than 2 years has significantly reduced the waitlist mortality by decreasing the proportion of deceased donor liver transplantations (DDLT) and increasing the proportion of living donor liver transplantations (LDLT). The waitlist mortality decreased from 6.7% to 2.3% after the implementation of the new allocation rule, and the median waitlist duration also decreased.
LIVER TRANSPLANTATION
(2023)
Article
Pediatrics
Valentina Gracchi, Sophie M. van den Belt, Eva Corpeleijn, Dick de Zeeuw, Hiddo J. L. Heerspink, Henkjan J. Verkade
Summary: Mildly increased albuminuria is common in adults and 2-year-old children. This study aims to evaluate the longitudinal persistence of albuminuria from infancy to school age, and found that albuminuria at 2 years of age does not largely persist until the age of 12.
PEDIATRIC NEPHROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Besrat Berhane, Patrick F. van Rheenen, Henkjan J. Verkade
Summary: A decrease of more than 25% in gamma-glutamyl transferase (GGT) within 1 year of diagnosis in pediatric-onset primary sclerosing cholangitis (PSC) is associated with a lower occurrence of complications within 5 years.
HEALTH SCIENCE REPORTS
(2023)
Article
Obstetrics & Gynecology
Marloes H. J. Dibbits, Lyan H. Rodijk, Anne E. den Heijer, Arend F. Bos, Henkjan J. Verkade, Ruben H. de Kleine, Behrooz Z. Alizadeh, Jan B. F. Hulscher, Janneke L. M. Bruggink
Summary: The aim of this study was to assess neurodevelopment in young patients with biliary atresia (BA) and determine the predictive value of General Movement Assessment (GMA) at infant age for neurodevelopmental impairments at toddler age. The results showed that one-third of toddlers with BA exhibited impaired motor skills. GMA after Kasai porto-enterostomy (KPE) had a high predictive value for identifying BA infants at risk of neurodevelopmental impairments.
EARLY HUMAN DEVELOPMENT
(2023)
Article
Gastroenterology & Hepatology
Antonia Felzen, Daan B. E. van Wessel, Emmanuel Gonzales, Richard J. Thompson, Irena Jankowska, Benjamin L. Shneider, Etienne Sokal, Tassos Grammatikopoulos, Agustina Kadaristiana, Emmanuel Jacquemin, Anne Spraul, Patryk Lipinski, Piotr Czubkowski, Nathalie Rock, Mohammad Shagrani, Dieter Broering, Emanuele Nicastro, Deirdre Kelly, Gabriella Nebbia, Henrik Arnell, Bjoern Fischler, Jan B. F. Hulscher, Daniele Serranti, Cigdem Arikan, Esra Polat, Dominique Debray, Florence Lacaille, Cristina Goncalves, Loreto Hierro, Gema Munoz Bartolo, Yael Mozer-Glassberg, Amer Azaz, Jernej Brecelj, Antal Dezsofi, Pier Luigi Calvo, Enke Grabhorn, Steffen Hartleif, Wendy J. van der Woerd, Binita M. Kamath, Jian-She Wang, Liting Li, Ozlem Durmaz, Nanda Kerkar, Marianne Horby Jorgensen, Ryan Fischer, Carolina Jimenez-Rivera, Seema Alam, Mara Cananzi, Noemie Laverdure, Cristina Targa Ferreira, Felipe Ordonez Guerrero, Heng Wang, Valerie Sency, Kyung Mo Kim, Huey-Ling Chen, Elisa de Carvalho, Alexandre Fabre, Jesus Quintero Bernabeu, Aglaia Zellos, Estella M. Alonso, Ronald J. Sokol, Frederick J. Suchy, Kathleen M. Loomes, Patrick J. McKiernan, Philip Rosenthal, Yumirle Turmelle, Simon Horslen, Kathleen Schwarz, Jorge A. Bezerra, Kasper Wang, Bettina E. Hansen, Henkjan J. Verkade
Summary: This study aimed to evaluate the relationship between genetic mutations related to BSEP deficiency and clinical features. The results showed that the combination of one relatively mild mutation and one severe mutation resulted in a clinical presentation similar to patients with two severe mutations, and they had a poor response to surgical interruption of the enterohepatic circulation.
Review
Gastroenterology & Hepatology
Weihao Li, Reinoud P. H. Bokkers, Rudi A. J. O. Dierckx, Henkjan J. Verkade, Dewey H. Sanders, Ruben de Kleine, Hubert P. J. van der Doef
Summary: This study evaluated the effectiveness of different treatments for hepatic artery thrombosis and stenosis after pediatric liver transplantation. The findings highlight the significant issue of hepatic artery thrombosis and the need for further research on the efficacy of treatment methods.
LIVER TRANSPLANTATION
(2023)
Article
Pediatrics
Valentina Gracchi, Sophie M. van den Belt, Eva Corpeleijn, Hiddo J. L. Heerspink, Henkjan J. Verkade
Summary: This study aims to evaluate albuminuria in a population-based pediatric cohort and investigate its association with cardiovascular risk factors. The results show a lower prevalence of albuminuria in 12-year-olds compared to previous studies, and it is negatively associated with body mass index. Additionally, there is no significant association between albuminuria and antenatal factors.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Buket Dalgic, Henkjan J. Verkade, Alain Lachaux, Ulrich Baumann, Lorenzo D'Antiga, Piotr Czubkowski, Reha Artan, Jennifer Vittorio, Hasan Ozen, Girish Gupte, Tassos Grammatikopoulos, Quanhong Ni, Lise Kjems, Patrick Horn
Meeting Abstract
Gastroenterology & Hepatology
Richard J. Thompson, Emmanuel Gonzales, Reha Artan, Winita Hardikar, Florence Lacaille, Alain Lachaux, Bertrand Roquelaure, Ulrich Baumann, Ekkehard Sturm, Eyal Shteyer, Pier Luigi Calvo, Henkjan J. Verkade, Mohammad Ali Shagrani, Janis M. Stoll, Piotr Czubkowski, Buket Dalgic, Girish Gupte, Tassos Grammatikopoulos, Patrick McKiernan, Qifeng Yu, Lise Kjems, Patrick Horn
JOURNAL OF HEPATOLOGY
(2022)