Article
Neurosciences
Frances S. Hausmann, John M. Barrett, Megan E. Martin, Huiqing Zhan, Gordon M. G. Shepherd
Summary: This study used MAPseq to investigate the diversity of brainstem branching patterns of the pyramidal tract projections from the forelimb-related areas of the motor cortex. The results showed high yet systematic diversity in PT axons at the level of brainstem projection patterns. The projections from M1 and M2 were qualitatively similar, but with quantitative differences in subclasses and clusters.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Rosa Manzoli, Lorenzo Badenetti, Michela Rubin, Enrico Moro
Summary: This review discusses the crucial role of lysosomes in the regulation of axonal guidance cue delivery, localization, and function, providing evidence to understand the relationship between lysosomal storage disorders and neurodegenerative diseases.
Article
Multidisciplinary Sciences
Sabrina Schlienger, Patricia T. Yam, Nursen Balekoglu, Hugo Ducuing, Jean-Francois Michaud, Shirin Makihara, Daniel K. Kramer, Baoyu Chen, Alfonso Fasano, Alfredo Berardelli, Fadi F. Hamdan, Guy A. Rouleau, Myriam Srour, Frederic Charron
Summary: Mirror movements (MM) disorder is characterized by involuntary movements on one side of the body that mirror intentional movements on the opposite side. In this study, we identified ARHGEF7 as a candidate MM gene and demonstrated its role in Netrin-1-mediated axon guidance. We further showed that Arhgef7/Git1 acts as a multifunctional effector complex, activating Rac1 and Cdc42 and inhibiting Arf1 downstream of Netrin-1.
Article
Chemistry, Analytical
Diletta Balta, HsinHung Kuo, Jing Wang, Ilaria Giuseppina Porco, Olga Morozova, Manon Maitland Schladen, Andrea Cereatti, Peter Stanley Lum, Ugo Della Croce
Summary: This study explored the potential of using low-cost instrumentation to analyze infants' general movements in a familiar environment for early identification of movement disorders.
Article
Biochemistry & Molecular Biology
Silvia Vicenzi, Lisa Foa, Robert J. Gasperini
Summary: The neurotransmitter serotonin can act as both an attractive and repulsive guidance cue for rodent sensory neurons in vitro, with extracellular gradients of 50 mu M serotonin inducing attraction mediated by the serotonin 5-HT2a receptor and 100 mu M serotonin inducing repulsion mediated by the 5-HT1b receptor. High resolution imaging of growth cones showed that these receptors signal through their canonical pathways to shape neuronal circuit formation during development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Genetics & Heredity
Oriane Trouillard, Pauline Dupaigne, Margaux Dunoyer, Mohamed Doulazmi, Morten Krogh Herlin, Solene Frismand, Audrey Riou, Veronique Legros, Guillaume Chevreux, Xavier Veaute, Didier Busso, Coralie Fouquet, Cecile Saint-Martin, Aurelie Meneret, Alain Trembleau, Isabelle Dusart, Caroline Dubacq, Emmanuel Roze
Summary: Mirror movements are involuntary movements of one hand that mirror intentional movements of the other hand. Congenital mirror movements (CMM) is a rare genetic disorder with autosomal dominant inheritance, in which mirror movements are the main neurological manifestation. RAD51 haploinsufficiency, including loss-of-function of non-truncating variants, results in CMM.
JOURNAL OF MEDICAL GENETICS
(2023)
Review
Clinical Neurology
Ping Liu, Yuan Yuan, Ning Zhang, Xiaoyan Liu, Lihua Yu, Benyan Luo
Summary: Mirror movements (MMs) refer to involuntary movements on one side of homologous muscles when performing unilateral movements with the contralateral limb. They are considered soft neurological signs and are commonly pathological, occurring in both congenital syndromes and age-related neurological diseases.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Boli Chen, Fuxiang Li, Bin Jia, Kwok-Fai So, Ji-An Wei, Yuchu Liu, Yibo Qu, Libing Zhou
Summary: This study investigated the impact of inactivating Celsr3 in the brainstem, revealing a reduction in rubrospinal and corticospinal axons in Celsr3 cKO animals. The mutant mice exhibited increased branching of dopaminergic fibers and decreased spinal motoneurons, neuromuscular junctions, and electromyographic signal amplitude. They also showed impaired motor coordination and response to heavy mechanical stimulation.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Neurosciences
Alisha Vartak, Divya Goyal, Hemant Kumar
Summary: Guidance molecules are essential for neural development, particularly in guiding axons to their target regions during spinal cord development. Defects in these molecules' expression or function can lead to abnormalities in axonal pathfinding, growth cone navigation, axonal branching, and synapse formation, affecting neuronal circuit construction and function after central nervous system traumas such as spinal cord injury (SCI).
Review
Cell Biology
Melody Atkins, Xavier Nicol, Coralie Fassier
Summary: The establishment of neuronal connectivity relies on the microtubule cytoskeleton, which plays multiple roles in providing support, transport, and signaling for neuronal growth. The precise regulation of microtubule functions is crucial for neuronal wiring and connectivity refinement, and defects in this regulation can lead to neurodevelopmental disorders. This review summarizes recent studies on how microtubule composition, post-translational modifications, and associated proteins influence axon guidance and pruning to build functional neuronal circuits. It also highlights the importance of the tubulin code and molecular links between microtubule regulation and guidance signals in wiring the nervous system.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Miguel E. Dominguez-Romero, Paula G. Slater
Summary: The growth cone is a critical structure during neuronal development and regeneration, detecting and integrating signals to reach its final destination. After neuronal injuries in mammals, only axons in the peripheral nervous system are able to regenerate, while the ones from the central nervous system fail to do so.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Emily Holt, Danielle Stanton-Turcotte, Angelo Iulianella
Summary: This article discusses the importance of integrating sensory information for an animal's movement through their environment and maintenance of homeostatic physiology. It covers the origins and development of the dorsal root ganglia (DRG) and the cells that populate it, as well as the diverse developmental and molecular processes that control sensory connectivity to the spinal cord.
Article
Neurosciences
Ankang Hu, Rui Zhao, Baihui Ren, Yang Li, Jiangteng Lu, Yilin Tai
Summary: Two types of pyramidal neurons (PyNs) in the prelimbic cortex (PL) of mice, projecting to either the contralateral PL or the ipsilateral basal lateral amygdala, possess distinct axon initial segment (AIS) properties including morphology, ion channel expression, action potential initiation, and axo-axonic synaptic inputs from chandelier cells. The heterogeneity of AISs is more prominent in the superficial layer compared to the deep layer. These findings reveal the cortical layer- and axon projection-specific heterogeneity of PyN AISs, which may contribute to the modulation of spiking properties in different PyN types.
NEUROSCIENCE BULLETIN
(2023)
Article
Biology
Tetsushi Yamagata, Ikuo Ogiwara, Tetsuya Tatsukawa, Toshimitsu Suzuki, Yuka Otsuka, Nao Imaeda, Emi Mazaki, Ikuyo Inoue, Natsuko Tokonami, Yurina Hibi, Shigeyoshi Itohara, Kazuhiro Yamakawa, Michelle Antoine
Summary: The expressions of voltage-gated sodium channels Nav1.1 and Nav1.2 are mutually exclusive in most brain regions. In the neocortex, Nav1.1 is expressed in inhibitory neurons while Nav1.2 is expressed in excitatory neurons. A subpopulation of neocortical excitatory neurons in layer V also express Nav1.1, but their characteristics are unknown. In the hippocampus, Nav1.1 is only expressed in inhibitory neurons. These findings have implications for understanding diseases related to SCN1A and SCN2A mutations, such as epilepsy and neurodevelopmental disorders.
Review
Cell Biology
Eloisa Herrera, Augusto Escalante
Summary: The development of the nervous system involves neurogenesis, neuronal specification, axonal navigation, and circuits assembly. The growth cone located at the tip of the axon plays a crucial role in guiding axons towards their final targets. The transcriptional control and epigenetic regulation of axon guidance molecules are important for determining specific axonal behaviors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Aurelie Meneret, Elizabeth A. Franz, Orlane Trouillard, Thomas C. Oliver, Yvrick Zagar, Stephen P. Robertson, Quentin Welniarz, R. J. MacKinlay Gardner, Cecile Gallea, Myriam Srour, Christel Depienne, Christine L. Jasoni, Caroline Dubacq, Florence Riant, Jean-Charles Lamy, Marie-Pierre Morel, Raphael Guerois, Jessica Andreani, Coralie Fouquet, Mohamed Doulazmi, Marie Vidailhet, Guy A. Rouleau, Alexis Brice, Alain Chedotal, Isabelle Dusart, Emmanuel Roze, David Markie
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Genetics & Heredity
Ashley P. L. Marsh, Delphine Heron, Timothy J. Edwards, Angelique Quartier, Charles Galea, Caroline Nava, Agnes Rastetter, Marie-Laure Moutard, Vicki Anderson, Pierre Bitoun, Jens Bunt, Anne Faudet, Catherine Garel, Greta Gillies, Ilan Gobius, Justine Guegan, Solveig Heide, Boris Keren, Fabien Lesne, Vesna Lukic, Simone A. Mandelstam, George McGillivray, Alissandra McIlroy, Aurelie Meneret, Cyril Mignot, Laura R. Morcom, Sylvie Odent, Annalisa Paolino, Kate Pope, Florence Riant, Gail A. Robinson, Megan Spencer-Smith, Myriam Srour, Sarah E. M. Stephenson, Rick Tankard, Oriane Trouillard, Quentin Welniarz, Amanda Wood, Alexis Brice, Guy Rouleau, Tania Attie-Bitach, Martin B. Delatycki, Jean-Louis Mandel, David J. Amor, Emmanuel Roze, Amelie Piton, Melanie Bahlo, Thierry Billette de Villemeur, Elliott H. Sherr, Richard J. Leventer, Linda J. Richards, Paul J. Lockhart, Christel Depienne
Article
Neurosciences
Majistor Raj Luxman Maglorius Renkilaraj, Lucas Baudouin, Claire M. Wells, Mohamed Doulazmi, Rosine Wehrle, Vidjeacoumary Cannaya, Corinne Bachelin, Jean-Vianney Barnier, Zhengping Jia, Brahim Nait Oumesmar, Isabelle Dusart, Lamia Bouslama-Oueghlani
NEUROBIOLOGY OF DISEASE
(2017)
Article
Multidisciplinary Sciences
Quentin Welniarz, Marie-Pierre Morel, Oriane Pourchet, Cecile Gallea, Jean-Charles Lamy, Massimo Cincotta, Mohamed Doulazmi, Morgane Belle, Aurelie Meneret, Oriane Trouillard, Marta Ruiz, Vanessa Brochard, Sabine Meunier, Alain Trembleau, Marie Vidailhet, Alain Chedotal, Isabelle Dusart, Emmanuel Roze
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Quentin Welniarz, Cecile Gallea, Jean-Charles Lamy, Aurelie Meneret, Traian Popa, Romain Valabregue, Benoit Beranger, Vanessa Brochard, Constance Flamand-Roze, Oriane Trouillard, Cecilia Bonnet, Norbert Brueggemann, Pierre Bitoun, Bertrand Degos, Cecile Hubsch, Elodie Hainque, Jean-Louis Golmard, Marie Vidailhet, Stephane Lehericy, Isabelle Dusart, Sabine Meunier, Emmanuel Roze
HUMAN BRAIN MAPPING
(2019)
Article
Cell Biology
Oriane Pourchet, Marie-Pierre Morel, Quentin Welniarz, Nadege Sarrazin, Fabio Marti, Nicolas Heck, Cecile Gallea, Mohamed Doulazmi, Sergi Roig Puiggros, Juan Antonio Moreno-Bravo, Marie Vidailhet, Alain Trembleau, Philippe Faure, Alain Chedotal, Emmanuel Roze, Isabelle Dusart
Summary: Depletion of floor plate Netrin-1 in the brainstem disrupts CST midline crossing and leads to abnormal motor control, particularly causing symmetric movements. This study reveals the role of Netrin-1 in CST development and provides a mouse model replicating the characteristics of human congenital mirror movements.
Review
Neurosciences
Quentin Welniarz, Yulia Worbe, Cecile Gallea
Summary: For over two decades, mounting evidence has shown the essential role of the cerebellum in non-motor functions such as learning, conditional learning, reward, and sense of agency. While a unified model explaining its role is yet to be fully established, the forward model theory from the field of motor control provides a valuable perspective. Serving as an interface between sensorimotor function and cognition, the cerebellum participates in building expectations about behavioral outcomes and cognitive processes.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2021)
Article
Neurosciences
Quentin Welniarz, Emmanuel Roze, Benoit Beranger, Aurelie Meneret, Marie Vidailhet, Stephane Lehericy, Pierre Pouget, Mark Hallett, Sabine Meunier, Cecile Gallea
Summary: The modality of movement selection may influence the brain networks involved during the execution phase, with freely chosen movements showing increased activation in the pre-supplementary motor area, parietal, and cerebellar regions. Freely chosen movements also exhibit increased information flow between the right posterior parietal cortex and the cerebellum compared to instructed movements. This suggests that the parieto-cerebellar network is particularly engaged during freely chosen movements to monitor the congruence between intentional content and outcome.
Article
Clinical Neurology
Asya Ekmen, Aurelie Meneret, Romain Valabregue, Benoit Beranger, Yulia Worbe, Jean-Charles Lamy, Sofien Mehdi, Anais Herve, Isaac Adanyeguh, Gizem Temiz, Philippe Damier, Domitille Gras, Agathe Roubertie, Juliette Piard, Vincent Navarro, Eugenie Mutez, Florence Riant, Quentin Welniarz, Marie Vidailhet, Stephane Lehericy, Sabine Meunier, Cecile Gallea, Emmanuel Roze
Summary: This study aimed to investigate the role of the cerebellum in the pathogenesis of PRRT2-related dyskinesia. The results showed that patients had structural and functional abnormalities in the cerebellum, and cerebellar stimulation could modulate communication within the cerebellar networks and restore it to the level observed in healthy controls.
Letter
Clinical Neurology
Quentin Welniarz, Domitille Gras, Agathe Roubertie, Maria T. T. Papadopoulou, Eleni Panagiotakaki, Emmanuel Roze
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Maria T. Papadopoulou, Quentin Welniarz, Agathe Roubertie, Domitille Gras, Mathieu Milh, Eleni Panagiotakaki, Emmanuel Roze
MOVEMENT DISORDERS
(2023)
Review
Behavioral Sciences
Claire Delnatte, Emmanuel Roze, Pierre Pouget, Cecile Gallea, Quentin Welniarz
Summary: Free will has long been a topic of discussion in philosophy and science. Recent advances in neuroscience, however, pose a threat to the common understanding of free will by challenging the notions of determinism and mental causation. This article presents classical philosophical positions on these concepts and explores how neuroscience can contribute to the ongoing debate. Ultimately, the current evidence is deemed insufficient to undermine the existence of free will.
Letter
Clinical Neurology
Quentin Welniarz, Domitille Gras, Agathe Roubertie, Maria T. Papadopoulou, Eleni Panagiotakaki, Emmanuel Roze
MOVEMENT DISORDERS
(2023)