Dipeptidyl nitrile derivatives suppress the Trypanosoma cruzi in vitro infection

Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement

(2019) Juliana C. Gomes et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

(2018) Bianca Zingales   ACTA TROPICA

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery

(2018) Lorna M. MacLean et al.   PLoS Neglected Tropical Diseases

Biological Activity and Physicochemical Properties of Dipeptidyl Nitrile Derivatives Against Pancreatic Ductal Adenocarcinoma Cells

(2018) José Carlos Quilles et al.   Anti-Cancer Agents in Medicinal Chemistry

Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors

(2017) Antonio C. B. Burtoloso et al.   PLoS Neglected Tropical Diseases

Current drug therapy and pharmaceutical challenges for Chagas disease

(2016) José Bermudez et al.   ACTA TROPICA

Cruzipain: An Update on its Potential as Chemotherapy Target against the Human Pathogen Trypanosoma cruzi

(2015) M.H. Branquinha et al.   CURRENT MEDICINAL CHEMISTRY

Cruzain inhibitors: efforts made, current leads and a structural outlook of new hits

(2015) Karina Martinez-Mayorga et al.   DRUG DISCOVERY TODAY

Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain

(2015) Brian D. Jones et al.   ACS Medicinal Chemistry Letters

Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors

(2015) Leandro A. A. Avelar et al.   PLoS Neglected Tropical Diseases

Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors

(2015) Marton Siklos et al.   Acta Pharmaceutica Sinica B

Odanacatib for the treatment of postmenopausal osteoporosis: development history and design and participant characteristics of LOFT, the Long-Term Odanacatib Fracture Trial

(2014) H. G. Bone et al.   OSTEOPOROSIS INTERNATIONAL

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

(2014) Carolina B. Moraes et al.   Scientific Reports

Leishmania (L.) amazonensis peptidase activities inside the living cells and in their lysates

(2012) Elide E. Caroselli et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Cruzipain Promotes Trypanosoma cruzi Adhesion to Rhodnius prolixus Midgut

(2012) Lívia Almeida Uehara et al.   PLoS Neglected Tropical Diseases

The peptidases of Trypanosoma cruzi: Digestive enzymes, virulence factors, and mediators of autophagy and programmed cell death

(2011) Vanina E. Alvarez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Trypanosoma cruzi Protease Cruzain Mediates Immune Evasion

(2011) Patricia S. Doyle et al.   PLoS Pathogens

Cruzipain, the Major Cysteine Protease of Trypanosoma cruzi: A Sulfated Glycoprotein Antigen as Relevant Candidate for Vaccine Development and Drug Target. A Review

(2009) Vilma Duschak et al.   CURRENT MEDICINAL CHEMISTRY