Article
Endocrinology & Metabolism
Connor Grannis, Whitney I. Mattson, Scott F. Leibowitz, Leena Nahata, Diane Chen, John F. Strang, Heather Thobe, Justin A. Indyk, Eric E. Nelson
Summary: The study found that gender affirming hormone therapy (GAHT) can reduce internalizing symptoms in transgender youth. It also revealed a link between body image dissatisfaction, neural circuitry, and internalizing symptoms.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Jorge Trilles, Bachar F. Chaya, Hilliard Brydges, Augustus Parker, Laura L. Kimberly, Daniel Boczar, Ricardo Rodriguez Colon, Eduardo D. Rodriguez
Summary: In this study, the relationship between race and postoperative outcomes in transgender and gender expansive (TGE) patients undergoing gender affirming surgery (GAS) was evaluated using the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP). It was found that race was an independent predictor of important short-term postoperative outcomes in GAS, with black patients having higher odds of reoperation, readmission, and surgical site infection than white patients.
Article
Medicine, General & Internal
Kinnon R. MacKinnon, Hannah Kia, Travis Salway, Florence Ashley, Ashley Lacombe-Duncan, Alex Abramovich, Gabriel Enxuga, Lori E. Ross
Summary: This study examines the physical and mental health experiences of individuals who discontinued or sought to reverse gender-affirming medical or surgical interventions, highlighting the need for further research and clinical guidance.
Review
Neurosciences
Marc-Antoine Crocq
Summary: This article traces the historical evolution of medical and psychiatric diagnoses related to transgender individuals. From ancient Greek and Roman writings to the development of medical classifications in the nineteenth century, the understanding of transgender people has evolved over time. The distinction between sexual orientation and gender diagnosis started to emerge in the early 1900s and continued to evolve until the modern era.
DIALOGUES IN CLINICAL NEUROSCIENCE
(2021)
Article
Psychology, Clinical
Maria Garz, Johanna Schroeder, Timo Nieder, Inga Becker, Sarah Biedermann, Thomas Hildebrandt, Peer Briken, Matthias Auer, Johannes Fuss
Summary: The study found that gender-affirming treatment has a greater impact on the sexual desire of transgender men than transgender women, and body image does not mediate the effects of GAHT or GAS on sexual desire. Gender-affirming therapy has a significant direct impact on body image, but body image itself does not directly affect sexual desire.
JOURNAL OF SEX & MARITAL THERAPY
(2021)
Article
Medicine, General & Internal
Diana Klinger, Stefan Riedl, Heidi Elisabeth Zesch, Sofia-Marie Oehlke, Sabine Voelkl-Kernstock, Paul L. L. Plener, Andreas Karwautz, Oswald D. D. Kothgassner
Summary: This study aimed to assess and compare the mental health of transgender youth by sex assigned at birth. The results showed that assigned male at birth (AMAB) adolescents were more likely to have internalizing problems, while assigned female at birth (AFAB) adolescents were more likely to have externalizing problems.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jane Y. Xu, Michele A. O'Connell, Lauren Notini, Ada S. Cheung, Sav Zwickl, Ken C. Pang
Summary: Gender dysphoria is the distress associated with having a gender identity different from one's birth-assigned sex. Hormonal treatment guidelines primarily cater to those transitioning from male to female or vice versa, leaving limited options for non-binary trans individuals seeking an androgynous appearance. There is potential for Selective Estrogen Receptor Modulators (SERMs) to be a gender-affirming treatment for non-binary individuals assigned male at birth (AMAB), but further research is needed on their effects and safety.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Christina M. Roberts, David A. Klein, Terry A. Adirim, Natasha A. Schvey, Elizabeth Hisle-Gorman
Summary: Concerns about future regret and treatment discontinuation have led to restricted access to gender-affirming medical treatment for transgender and gender-diverse minors in some jurisdictions. However, few studies have examined gender-affirming hormone continuation rates among TGD individuals. This study analyzed medical and pharmacy records to find that over 70% of TGD individuals who start gender-affirming hormones continue use beyond 4 years, with higher continuation rates in transfeminine individuals and those who started hormones as minors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Takahiro Kirisawa, Koji Ichihara, Yasuyuki Sakai, Daichi Morooka, Takaya Iyoki, Naoya Masumori
Summary: This study shows that gender-affirming hormonal treatment using testosterone enanthate is effective and safe for Japanese transgender men, with desired physical effects appearing within 6 months and some undesirable effects also present.
Article
Psychology, Developmental
Inga Becker-Hebly, Saskia Fahrenkrug, Florentien Campion, Hertha Richter-Appelt, Michael Schulte-Markwort, Claus Barkmann
Summary: Empirical evidence on the psychosocial health outcomes of adolescents with GD after puberty suppression and gender-affirming medical interventions is limited. The study found that adolescents receiving gender-affirming interventions showed some improvement in psychosocial health outcomes, but there were still significant differences from the norm. This highlights the need for further longitudinal research on treatment decisions for transgender adolescents.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Letter
Hematology
Michael Oakes, Asad Arastu, Catherine Kato, Julia Somers, Hannah D. Holly, Benjamin K. Elstrott, Geolani W. Dy, Tia C. L. Kohs, Rishi R. Patel, Owen J. T. McCarty, Thomas G. DeLoughery, Christina Milano, Vikram Raghunathan, Joseph J. Shatzel
Summary: Exogenous testosterone therapy can lead to erythrocytosis, but the contribution of erythrocytosis to thrombosis in the context of gender-affirming hormonal therapy is unclear. A retrospective study on transgender and non-binary adults receiving testosterone showed that some patients developed elevated levels of hemoglobin and hematocrit, but thromboembolic events and hospitalizations related to erythrocytosis were uncommon.
THROMBOSIS RESEARCH
(2021)
Article
Psychiatry
Eliane D. Silva, Tayane M. Fighera, Roberta M. Allgayer, Maria Ines R. Lobato, Poli Mara Spritzer
Summary: This study aimed to evaluate perceived QoL, compare QoL scores between transgender women and men, and identify possible contributing factors related to GAHT. The results suggest that GAHT-related physical characteristics may impact QoL scores, and sociodemographic parameters may influence these associations. Healthcare providers should take these factors into consideration for interventions to improve QoL in transgender individuals.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Developmental
Landon D. Hughes, Kacie M. Kidd, Kristi E. Gamarel, Don Operario, Nadia Dowshen
Summary: The study found that the majority of providers delivering gender-affirming medical care to transgender and gender diverse youth oppose legislation that bans such care, citing concerns about the deterioration of mental health and increased suicide risk for TGDY, defiance of current care standards, worsening discrimination, and adverse effects on themselves.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Psychology, Clinical
Marijn Arnoldussen, Evelien C. Hooijman, Baudewijntje P. C. Kreukels, Annelou L. C. de Vries
Summary: This study aimed to examine the association between pre-treatment intelligence and educational achievement after gender-affirming treatment including puberty suppression in transgender adolescents. The results showed a positive association between pre-treatment IQ and educational achievement post-treatment, similar to the general population.
CLINICAL CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Review
Medicine, General & Internal
Laurens D'hoore, Guy T'Sjoen
Summary: With increasing demand for hormone treatment among transgender and gender nonbinary individuals, more research data is becoming available. A recent literature review found that gender-affirming hormone treatment can lead to increased life satisfaction and reduced psychological difficulties for those who feel it is necessary. The use of hormones can also change body composition and contours. Studies on bone health have shown reassuring results, but special attention is needed for adolescent and adult trans women in terms of hormone dosage and treatment compliance. The use of certain estrogens in trans women may increase the risk of myocardial infarction and stroke, highlighting the importance of lifestyle management in trans healthcare.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Selma Waaijers, Agustini Utari, Rick H. A. van der Doelen, Sultana M. H. Faradz, Renate Hensen-Lodewijk, Andre J. Olthaar, Paul J. Geutjes, Fred C. Sweep, Hedi L. Claahsen-van der Grinten, Antonius E. van Herwaarden
Summary: This study developed a method to measure steroids in hair and found that the concentration of 17OHP, androstenedione, and testosterone in hair can be used to confirm CAH in patients and monitor treatment effectiveness. These findings provide opportunities for using a simple noninvasive technique to diagnose and monitor CAH in developing countries.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Hanna Nowotny, Uta Neumann, Veronique Tardy-Guidollet, S. Faisal Ahmed, Federico Baronio, Tadej Battelino, Jerome Bertherat, Oliver Blankenstein, Marco Bonomi, Claire Bouvattier, Aude Brac de la Perriere, Sara Brucker, Marco Cappa, Philippe Chanson, Hedi L. Claahsen-van der Grinten, Annamaria Colao, Martine Cools, Justin H. Davies, Helmut-Gunther Dorr, Wiebke K. Fenske, Ezio Ghigo, Roberta Giordano, Claus H. Gravholt, Angela Huebner, Eystein Sverre Husebye, Rebecca Igbokwe, Anders Juul, Florian W. Kiefer, Juliane Leger, Rita Menassa, Gesine Meyer, Vassos Neocleous, Leonidas A. Phylactou, Julia Rohayem, Gianni Russo, Carla Scaroni, Philippe Touraine, Nicole Unger, Jarmila Vojtkova, Diego Yeste, Svetlana Lajic, Nicole Reisch
Summary: A survey conducted in Europe revealed a high degree of variability and discrepancy in the use of prenatal dexamethasone (Pdex) treatment for congenital adrenal hyperplasia (CAH). Only 36% of the surveyed medical centres provide Pdex treatment, and the starting point and dosage of the treatment vary among different centres. Limited availability of long-term follow-up registries was also observed. This highlights the importance of a European cooperation initiative to establish evidence-based guidelines for prenatal diagnostics, treatment, and follow-up of pregnancies at risk for CAH.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Uta Neumann, Annelieke van der Linde, Ruth E. Krone, Nils P. Krone, Ayla Guven, Tulay Guran, Heba Elsedfy, Sukran Poyrazoglu, Feyza Darendeliler, Tania A. S. S. Bachega, Antonio Balsamo, Sabine E. Hannema, Niels Birkebaek, Ana Vieites, Ajay Thankamony, Martine Cools, Tatjana Milenkovic, Walter Bonfig, Eduardo Correa Costa, Navoda Atapattu, Liat de Vries, Guilherme Guaragna-Filho, Marta Korbonits, Klaus Mohnike, Jillian Bryce, S. Faisal Ahmed, Bernard Voet, Oliver Blankenstein, Hedi L. Claahsen-van der Grinten
Summary: This study analyzed the use of salt supplementation, medication dosage, and growth indicators in children with CAH aged 0-3 years. The results showed that in children receiving additional salt supplementation, medication dosages were lower during the first months of life but there were no differences in weight, height, and blood pressure compared to those not receiving salt supplementation. All children showed an increase in BMI-SDS and a high proportion of blood pressure readings exceeding the normal range.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
A. Nordenstrom, S. F. Ahmed, E. van den Akker, J. Blair, M. Bonomi, C. Brachet, L. H. A. Broersen, H. L. Claahsen-van der Grinten, A. B. Dessens, A. Gawlik, C. H. Gravholt, A. Juul, C. Krausz, T. Raivio, A. Smyth, P. Touraine, D. Vitali, O. M. Dekkers
Summary: This study aimed to create practice guidelines for clinical assessment and puberty induction in individuals with congenital pituitary or gonadal hormone deficiency. A multidisciplinary approach was used to address medical, social, and psychological issues of these patients.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Salma Rashid Ali, Jillian Bryce, Nils P. P. Krone, Hedi L. L. Claahsen-van der Grinten, S. Faisal Ahmed
Summary: While there is variation in the definition and management of AI-related adverse events in children among centres, there is a good level of consensus on specific aspects that can lead to greater benchmarking of care. Over 90% of centres in high-income countries provided steroid management plans, one-to-one patient education, and contact details of health care staff. Additionally, the majority of centres recommended glucocorticoid stress dosing in the event of fever, and vomiting was the most common indication for intramuscular hydrocortisone injection.
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Review
Endocrinology & Metabolism
Kyriakie Sarafoglou, Deborah P. Merke, Nicole Reisch, Hedi Claahsen-van der Grinten, Henrik Falhammar, Richard J. Auchus
Summary: The most common form of congenital adrenal hyperplasia is 21-hydroxylase deficiency (21OHD), occurring in 1:16 000 newborns worldwide. Lifelong treatment aims to replace deficiencies and suppress androgen production, but balancing between androgen excess and chronic high glucocorticoid exposure is challenging. Clinical assessment and biochemical parameters guide therapy, and understanding adrenal biomarker values is important. The pathophysiologic and pharmacologic principles are utilized to manage complications and consequences of 21OHD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jiska van Schaik, Ichelle M. A. A. van Roessel, Iris D. Bos, Hedi Claashen-van Der L. Grinten, Sarah C. Clement, Laura van Iersel, Boudewijn Bakker, Lisethe Meijer, Leontien Kremer, A. Y. Netteke Schouten-van Meeteren, Hanneke M. van Santen
Summary: To evaluate the prevalence and clinical effects of elevated insulin-like growth factor 1 (IGF-1) concentrations in children with low grade glioma (LGG), a retrospective study collected tumor, treatment, endocrine, and auxological data from 358 children. The study found that 18.4% of children with available IGF-1 measurements had elevated IGF-1 concentrations, but no association was found between elevated IGF-1 concentrations and tumor behavior or height SDS at last follow-up. Elevated IGF-1 concentrations were associated with worsening hypothalamic dysfunction over time.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Pediatrics
Isabel C. Hageman, Hendrik J. J. van der Steeg, Ekkehart Jenetzky, Misel Trajanovska, Sebastian K. King, Ivo de Blaauw, ARM Net Consortium
Summary: The quality of the Anorectal Malformation Network (ARM-Net) registry was assessed, and it was found that while the collected data are valuable, they are susceptible to error and user variability. Continuous evaluations are needed to maintain relevant and high-quality data and achieve long-term sustainability.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Endocrinology & Metabolism
Rahim Karim Damji, Mohamed Zahir Alimohamed, Hedi L. van der Grinten, Dineke Westra, Ben Hamel
Summary: Pathogenic variants in the NR5A1 gene can cause differences in sex development. We report the clinical, endocrinological, and genetic characteristics of a patient with a novel likely pathogenic missense variant in the NR5A1 gene. This variant was inherited from the apparently unaffected mosaic father, which might have implications for the recurrence risk in this family.
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2023)
Article
Endocrinology & Metabolism
Mariska A. M. Schroeder, Mihaela Neacsu, Bas P. H. Adriaansen, Fred C. G. J. Sweep, S. Faisal Ahmed, Salma R. Ali, Tania A. S. S. Bachega, Federico Baronio, Niels Holtum Birkebaek, Christiaan de Bruin, Walter Bonfig, Jillian Bryce, Maria Clemente, Martine Cools, Heba Elsedfy, Evgenia Globa, Tulay Guran, Ayla Gueven, Nermine Hussein Amr, Dominika Janus, Nina Lenherr Taube, Renata Markosyan, Mirela Miranda, Suekran Poyrazoglu, Aled Rees, Mariacarolina Salerno, Marianna Rita Stancampiano, Ana Vieites, Liat de Vries, Zehra Yavas Abali, Paul N. Span, Hedi L. van der Grinten
Summary: The delayed diagnosis of congenital adrenal hyperplasia (CAH) for more than 1 year is associated with an increased risk of testicular adrenal rest tumor (TART) development.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Editorial Material
Public, Environmental & Occupational Health
Anke J. M. Oerlemans, Wyke J. P. Stommel, Chris M. Verhaak, Annelou L. C. De Vries, Floor A. H. Cuijpers, Mieke Breukelman, Marij A. Hillen
Summary: Research on uncertainty in medical practice lacks consensus and integration due to its scattered nature across disciplines. This hinders understanding of when and how uncertainty occurs, its impact on stakeholders and medical decision-making. The paper argues for a more integrated approach to uncertainty, using adolescent transgender care as an example.
PATIENT EDUCATION AND COUNSELING
(2023)
Article
Endocrinology & Metabolism
Sebastian Franik, Kathrin Fleischer, Barbara Kortmann, Nike M. Stikkelbroeck, Kathleen D'Hauwers, Claire Bouvattier, Jolanta Slowikowska-Hilczer, Solange Grunenwald, Tim van de Grift, Audrey Cartault, Annette Richter-Unruh, Nicole Reisch, Ute Thyen, Joanna IntHout, Hedi L. Claahsen-van der Grinten, Dsd LIFE Grp
Summary: The study investigated the quality of life (QOL) in men with Klinefelter syndrome (KS) and found lower scores in the physical, psychological, and social domains compared to a healthy reference population. Discrimination, reduced social activities, and chronic health problems were associated with decreased QOL.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Mariska A. M. Schroder, David Greenald, Renate Lodewijk, Antonius E. van Herwaarden, Paul N. Span, Fred C. G. J. Sweep, Rod T. Mitchell, Hedi L. Claahsen-van der Grinten
Summary: Testicular adrenal rest tumors (TARTs) may arise from chronic stimulation of adrenocorticotropic hormone (ACTH)-sensitive cells in the testes. However, this study found that the human fetal testis (HFT) is unresponsive to ACTH, suggesting that TARTs do not arise from fetal testicular cells chronically exposed to ACTH in utero.
Article
Pediatrics
Anouk J. W. Remmits, Ghislaine A. P. G. van Mastrigt, Silvia M. A. A. Evers, Hedi L. Claahsen-van Der Grinten, Petra A. van Setten
Summary: Reliable height measurement is crucial for assessing the effectiveness of costly growth hormone therapy. This observational study found a strong correlation between parentally performed height measurements and measurements in the outpatient setting, with only a minor underestimation observed.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Meeting Abstract
Endocrinology & Metabolism
Xanthippi Tseretopoulou, Salma R. Ali, Jillian Bryce, Atapattu Navoda, Niels H. Birkebaek, Federico Baronio, Walter Bonfig, Hedi L. Claahsen-van der Grinten, Martine Cools, Feyza Darendeliler, Sukran Poyrazoglu, Luisa de Sanctis, Heba Elsedfy, Martijn J. J. Finken, Christa E. Fluck, Evelien Gevers, Marta Korbonits, Tulay Guran, Ayla Guven, Ieuan A. Hughes, Rieko Tadokoro-Cuccaro, Ajay Thankamony, Violeta Iotova, Ruth Krone, Corina Lichiardopol, Berenice B. Mendonca, Tania A. S. S. Bachega, Mirela C. Miranda, Tatjana Milenkovic, Klaus Mohnike, Anna Nordenstrom, Hetty J. van der Kamp, Syed Faisal Ahmed
HORMONE RESEARCH IN PAEDIATRICS
(2022)
