Article
Multidisciplinary Sciences
Ae-Young Her, Youngjune Bhak, Eun Jung Jun, Song Lin Yuan, Scot Garg, Semin Lee, Jong Bhak, Eun-Seok Shin
Summary: In South Korea, women hospitalized with COVID-19 infection have a significantly lower risk of in-hospital death.
Article
Chemistry, Multidisciplinary
Saloni Bhatia, Padmini Gokhale, Teesta Katte, Shreeshanthi Acharya, Avinash Arvind Rasalkar, Soumya Vidapanakal, Ram Manas, Sampath Chinnam, Prathibha Narayanan, Ashok Kumar Shettihalli, Vijayakumar Kadappa, Divijendra Natha Reddy Sirigiri
Summary: This study analyzed the expression status of genes related to the infectivity and propagation of SARS-CoV-2 to assess the susceptibility of certain cancer patients to COVID-19 infection and subsequent complications. The findings suggest that patients with specific types of cancer are more at risk for COVID-19, and the genes responsible for severe COVID-19 are highly expressed in various cancer types.
Review
Neurosciences
Shreya Mukherjee, Kalipada Pahan
Summary: Sex differences in ACE2 receptor and TMPRSS2 expression, as well as immunological responses, may explain the disparities in COVID-19 severity and fatality between males and females. Behaviors such as smoking and comorbidities may also contribute to gendered differences in clinical outcomes of COVID-19 infections. An understanding of these sex and gender sensitivities is crucial for the development of effective treatments and therapies for the virus.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Medical Laboratory Technology
Maria Westerhoff, Dan Jones, Steven M. Hrycaj, May P. Chan, Liron Pantanowitz, Huolin Tu, Karen Choi, Joel Greenson, Laura Lamps
Summary: This study evaluated the histopathology and in situ hybridization for SARS-CoV-2 in gastrointestinal samples from COVID-19 patients. The findings suggest a varied range of gastrointestinal manifestations in patients with COVID-19, but no distinct histologic findings were identified.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Charlotte Steenblock, Stefanie Richter, Ilona Berger, Marko Barovic, Janine Schmid, Undine Schubert, Natalia Jarzebska, Anne von Maessenhausen, Andreas Linkermann, Annette Schuermann, Jessica Pablik, Thomas Dienemann, Katja Evert, Roman N. Rodionov, Natalia Y. Semenova, Vsevolod A. Zinserling, Raul R. Gainetdinov, Gustavo Baretton, Dirk Lindemann, Michele Solimena, Barbara Ludwig, Stefan R. Bornstein
Summary: This study comprehensively analyzed pancreatic tissues from COVID-19 patients and found detectable SARS-CoV-2 viral infiltration in beta-cells, potentially contributing to metabolic dysregulation. Even in the absence of overt new-onset diabetes, viral infection of pancreatic beta-cells may lead to varying degrees of metabolic abnormalities.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Andrew L. Schmidt, Matthew D. Tucker, Ziad Bakouny, Chris Labaki, Chih-Yuan Hsu, Yu Shyr, Andrew J. Armstrong, Tomasz M. Beer, Ragneel R. Bijjula, Mehmet A. Bilen, Cindy F. Connell, Scott Joseph Dawsey, Bryan Faller, Xin Gao, Benjamin A. Gartrell, David Gill, Shuchi Gulati, Susan Halabi, Clara Hwang, Monika Joshi, Ali Raza Khaki, Harry Menon, Michael J. Morris, Matthew Puc, Karen B. Russell, Neil J. Shah, Nima Sharifi, Justin Shaya, Michael T. Schweizer, John Steinharter, Elizabeth M. Wulff-Burchfield, Wenxin Xu, Jay Zhu, Sanjay Mishra, Petros Grivas, Brian I. Rini, Jeremy Lyle Warner, Tian Zhang, Toni K. Choueiri, Shilpa Gupta, Rana R. McKay
Summary: This cohort study found that the use of ADT was not associated with decreased mortality from SARS-CoV-2 infection in patients with prostate cancer. Ongoing clinical trials will provide further evidence on the role of ADT or other androgen-targeted therapies in reducing the severity of COVID-19 infection.
Article
Genetics & Heredity
Yiming Meng, Jing Sun, Guirong Zhang, Tao Yu, Haozhe Piao
Summary: The new coronavirus may be linked to malignant tumors, and the expression changes of the TMPRSS2 gene in different tumors are also associated with tumor prognosis.
FRONTIERS IN GENETICS
(2022)
Article
Cardiac & Cardiovascular Systems
Anissa Viveiros, Mahmoud Gheblawi, Preetinder K. Aujla, Deanna K. Sosnowski, John M. Seubert, Zamaneh Kassiri, Gavin Y. Oudit
Summary: Research indicates that aged males are more susceptible to the impacts of COVID-19 compared to females, possibly due to higher levels of ACE2 in their bodies. The study aims to begin elucidating the gender bias in the severity of COVID-19 by investigating the expression and activity of ACE2 and TMPRSS2 in mice and humans of different ages and sexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Cell Biology
Madeleine F. Jennewein, Anna J. MacCamy, Nicholas R. Akins, Junli Feng, Leah J. Homad, Nicholas K. Hurlburt, Emily Seydoux, Yu-Hsin Wan, Andrew B. Stuart, Venkata Viswanadh Edara, Katharine Floyd, Abigail Vanderheiden, John R. Mascola, Nicole Doria-Rose, Lingshu Wang, Eun Sung Yang, Helen Y. Chu, Jonathan L. Torres, Gabriel Ozorowski, Andrew B. Ward, Rachael E. Whaley, Kristen W. Cohen, Marie Pancera, M. Juliana McElrath, Janet A. Englund, Andres Finzi, Mehul S. Suthar, Andrew T. McGuire, Leonidas Stamatatos
Summary: The study identified 14 neutralizing antibodies against SARS-CoV-2, with 3 able to cross-neutralize SARS-CoV-1. The in vivo protective potential of antibodies is regulated by neutralization potency and epitope specificity. The study also suggests that epitopes in S2 can be used as blueprints for designing immunogens capable of eliciting cross-neutralizing coronavirus antibodies.
Article
Multidisciplinary Sciences
Stephane Le Vu, Marion Bertrand, Marie-Joelle Jabagi, Jeremie Botton, Jerome Drouin, Berangere Baricault, Alain Weill, Rosemary Dray-Spira, Mahmoud Zureik
Summary: Cases of myocarditis and pericarditis have been reported following COVID-19 mRNA vaccination, with increased risks during the first week after vaccination, particularly after the second dose. The mRNA-1273 vaccine shows the largest association with myocarditis, especially in individuals aged 18 to 24 years. The burden of both myocarditis and pericarditis attributable to vaccination is significant across different age groups and in both males and females.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Laksmi Wulandari, Berliana Hamidah, Cennikon Pakpahan, Nevy Shinta Damayanti, Neneng Dewi Kurniati, Christophorus Oetama Adiatmaja, Monica Rizky Wigianita, Soedarsono, Dominicus Husada, Damayanti Tinduh, Cita Rosita Sigit Prakoeswa, Anang Endaryanto, Ni Nyoman Tri Puspaningsih, Yasuko Mori, Maria Inge Lusida, Kazufumi Shimizu, Delvac Oceandy
Summary: The study investigated the correlation between a genetic variant within the human TMPRSS2 gene and COVID-19 severity and viral load. The results showed a significant association between the genetic variant and SARS-CoV-2 viral load, but not with disease severity. Additionally, a trend of association was observed between the presence of the C allele and mortality rate in patients with severe COVID-19.
Review
Immunology
Hasnat Khan, Shivangi Patel, Anuradha Majumdar
Summary: COVID-19 is a pandemic that requires immediate treatment due to its complex pathophysiology. Novel targets and regulators are crucial for saving lives. The virus enters the host through TMPRSS2 and ACE2, while NRF2 plays a key role in anti-inflammatory actions.
CLINICAL IMMUNOLOGY
(2021)
Review
Dermatology
Kinnor Das, Anant Patil, Andy Goren, Clay J. Cockerell, Mohamad Goldust
Summary: This review article explores the link between androgens and COVID-19, finding that males infected with COVID-19 are more likely to be hospitalized in intensive care units. Androgens play a significant role in the pathogenesis and severity of COVID-19, making them a potential target for treatment.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Urology & Nephrology
Ahmet Emre Cinislioglu, Saban Oguz Demirdogen, Nazan Cinislioglu, Mehmet Sefa Altay, Emre Sam, Fatih Akkas, Ibrahim Hakki Tor, Hasan Riza Aydin, Ibrahim Karabulut, Isa Ozbey
Summary: This study found that SARS-CoV-2 infection in men with BPH leads to significant increases in serum PSA levels during the active period of the disease. Measurement of PSA values during the acute period of infection and in the early period after infection treatment may affect the diagnosis and treatment steps of prostate diseases in these patients.
Article
Medicine, Research & Experimental
Jonathan J. Hernandez, Doyle E. Beaty, Logan L. Fruhwirth, Ana P. Lopes Chaves, Neil H. Riordan
Summary: In this study, expression of ACE2 and TMPRSS2 in hUC-MSCs derived from multiple donors was quantified. The results showed that these stem cells had minimal to no expression of ACE2, and low expression of TMPRSS2, which is crucial for designing future therapeutic options for COVID-19.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Genetics & Heredity
Giulia Occhipinti, Emanuela Romagnoli, Matteo Santoni, Alessia Cimadamore, Giulia Sorgentoni, Monia Cecati, Matteo Giulietti, Nicola Battelli, Alessandro Maccioni, Nadia Storti, Liang Cheng, Giovanni Principato, Rodolfo Montironi, Francesco Piva
FRONTIERS IN GENETICS
(2020)
Article
Oncology
Berina Sabanovic, Matteo Giulietti, Francesco Piva
INTERNATIONAL JOURNAL OF ONCOLOGY
(2020)
Article
Oncology
Francesco Piva, Francesca Tartari, Matteo Giulietti, Marco Maria Aiello, Liang Cheng, Antonio Lopez-Beltran, Roberta Mazzucchelli, Alessia Cimadamore, Roy Cerqueti, Nicola Battelli, Rodolfo Montironi, Matteo Santoni
Review
Medicine, General & Internal
Matteo Santoni, Francesco Piva, Alessia Cimadamore, Matteo Giulietti, Nicola Battelli, Rodolfo Montironi, Laura Cosmai, Camillo Porta
Review
Medicine, General & Internal
Matteo Giulietti, Monia Cecati, Berina Sabanovic, Andrea Scire, Alessia Cimadamore, Matteo Santoni, Rodolfo Montironi, Francesco Piva
Summary: Studies have shown that AI-based predictors for renal cancer diagnosis and prognosis have slightly better performance compared to non-AI-based predictors, with only minor improvements in accuracy and AUC over the last decade. Different studies with the same goal achieve similar performance despite using different discriminating genes.
Review
Biology
Berina Sabanovic, Francesco Piva, Monia Cecati, Matteo Giulietti
Summary: Extracellular vesicles (EVs) can serve as a novel vaccine strategy by presenting antigens to induce specific immune responses, with biotech companies developing EV-based vaccines against COVID-19. EV-based vaccines offer higher bio-safety and efficiency as antigen-presenting systems and adjuvants, showing promise for future vaccine design.
Article
Gastroenterology & Hepatology
Monia Cecati, Matteo Giulietti, Alessandra Righetti, Berina Sabanovic, Francesco Piva
Summary: This study investigates the specific roles of different splicing isoforms of CXCL12 in the onset of PDAC. The results show that the gamma isoform has a greater impact on the migration ability of tumor cells compared to the alpha and beta isoforms. Further research is needed to confirm these initial observations.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemical Research Methods
Roberto Maria Pellegrino, Matteo Giulietti, Husam B. R. Alabed, Sandra Buratta, Lorena Urbanelli, Francesco Piva, Carla Emiliani
Summary: LC/MS-based analysis techniques combined with specialized lipid tools allow for the qualitative and quantitative determination of thousands of lipid molecules. This article introduces a new lipidomic tool called LipidOne, which can analyze the qualitative and quantitative changes in lipid building blocks among all detected lipid classes and experimental groups. This tool enables the linking of differences in lipid building blocks to the activity of specific classes of enzymes, transcripts, and genes.
Article
Biochemistry & Molecular Biology
Berina Sabanovic, Matteo Giulietti, Monia Cecati, Gaya Spolverato, Clara Benna, Salvatore Pucciarelli, Francesco Piva
Summary: This study suggests that the blood of PDAC patients may contain elements capable of transforming healthy cells by transferring oncogenes. The results support the genometastasis theory and suggest that these transforming elements could be useful biomarkers in liquid biopsy assays.
Article
Oncology
Matteo Santoni, Francesco Piva, Camillo Porta, Sergio Bracarda, Daniel Y. Heng, Marc R. Matrana, Enrique Grande, Veronica Mollica, Gaetano Aurilio, Mimma Rizzo, Matteo Giulietti, Rodolfo Montironi, Francesco Massari
Summary: The incidence of renal-cell carcinoma (RCC) is increasing, and an artificial neural network was implemented to predict new cases in the population based on demographic and health data. Preventing hypertension was found to have the greatest impact on reducing RCC incidence, highlighting the importance of studying risk factors for accurate prevention efforts.
CLINICAL GENITOURINARY CANCER
(2021)