Review
Cell Biology
Sarah A. Neely, David A. Lyons
Summary: Glia are a diverse collection of cells that play essential roles in the nervous system. Recent advances in animal models, particularly using zebrafish, have provided important insights into the function and interactions of glial cells, contributing to our understanding of their complex roles in development and throughout life.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jordan A. Munroe, Mubarak H. Syed, Chris Q. Doe
Summary: This study focuses on the mechanism of exiting quiescence in Drosophila brain neuroblasts, particularly type II neuroblasts. Researchers found that Insulin-like growth factor II mRNA-binding protein (Imp) plays an important role in the exit from quiescence in type II neuroblasts.
Article
Pharmacology & Pharmacy
Wen Liu, Aaron R. Rohlman, Ryan Vetreno, Fulton T. Crews
Summary: The study found that adolescent binge drinking affects adult OL markers in PFC regions, while also impacting OPC marker expression; furthermore, these effects could lead to lasting changes in PFC function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Developmental Biology
Li He, Jennifer Jones, Weiguo He, Bryan C. Bjork, Jiayu Wen, Qi Dai
Summary: PRDM16 is a crucial transcriptional regulator that promotes the transition from early to late phase of neurogenesis in the mouse neocortex. It regulates a subset of genes involved in neuronal specification, cell cycle regulation, and neuronal migration by limiting chromatin accessibility of permissive enhancers. This study provides evidence to support the temporal shift in gene expression program of neural progenitors to achieve neural cell diversity.
Article
Biochemistry & Molecular Biology
Kazuhiko Sawada
Summary: The present study found that neonatal exposure to valproic acid (VPA) may promote the proliferation of basal radial glia (bRG) in the premature cortex of ferrets, and these neural cells can differentiate into upper layer cortical neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Kyoji Ohyama, Hiroshi M. Shinohara, Shoichiro Omura, Tomomi Kawachi, Toru Sato, Keiko Toda
Summary: In the mouse dentate gyrus, a specific subpopulation of neural progenitors and radial glia-like cells can be marked by the expression of PSmad3. PSmad3+ cells in the subgranular zone (SGZ) are predominantly quiescent from P14 onwards, while PSmad3+/GFP+ astrocytes co-express Olig2 and S100 beta.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Varun Suresh, Bhavana Muralidharan, Saurabh J. Pradhan, Mahima Bose, Leora D'Souza, Arpan Parichha, Puli Chandramouli Reddy, Sanjeev Galande, Shubha Tole
Summary: We investigated the differences between the hippocampal primordium (Hcp) and the neocortical primordium (Ncp) in the mouse during early neurogenesis. Our results showed that the Hcp was more accessible than the Ncp at this stage. We identified LHX2 as a candidate transcription factor that regulates gene expression in the Hcp and Ncp, controlling fundamental aspects of development.
Review
Biochemistry & Molecular Biology
Chih-Wei Zeng
Summary: The human nervous system has limited regenerative capabilities, while zebrafish exhibit remarkable regenerative abilities, making them an ideal model for studying inflammatory processes after injury. Such research has significant translational potential to enhance our understanding of recovery from damage and disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Matteo Bozzo, Thurston C. Lacalli, Valentina Obino, Federico Caicci, Emanuela Marcenaro, Tiziana Bachetti, Lucia Manni, Mario Pestarino, Michael Schubert, Simona Candiani
Summary: The study reveals that amphioxus glial lineages express genes typical of vertebrate astroglia and radial glia, segregate early in development, and form a spatially separate cell proliferation zone. This provides strong evidence for the presence of vertebrate-type glial cells in amphioxus, shedding light on the role of segregated progenitor cell pools in CNS development and offering insights into precursor cell deployment in the chordate nerve cord in an evolutionary context.
Editorial Material
Developmental Biology
Alex Eve
Summary: Tom Nowakowski, an Assistant Professor at UCSF, utilizes single-cell sequencing technologies to investigate neurodevelopment. He is a Chan Zuckerberg Biohub Investigator and a Next Generation Leader at the Allen Institute for Brain Science. During our Zoom meeting, he discussed his career, transitioning into a group leader role, and his future plans.
Article
Genetics & Heredity
Christina A. Kearns, Macie Walker, Andrew M. Ravanelli, Kayt Scott, Madeline R. Arzbecker, Bruce Appel
Summary: The vertebrate neural tube axis is patterned by a gradient of Shh signaling, with the pMN domain progenitors expressing Olig2 and producing motor neurons and oligodendrocytes. A mutant allele of the boc gene in zebrafish disrupts oligodendrocyte development by affecting the maintenance of pMN progenitors, demonstrating the importance of boc in shaping the Shh signaling gradient for neural tube patterning.
Article
Biology
Laura Fontenas, Sarah Kucenas
Summary: MEP glia are derived from lateral floor plate precursors and require foxd3 for delamination and migration out of the spinal cord. Their development also depends on axonally derived neuregulin1, and overexpressing axonal cues can generate additional MEP glia in the spinal cord.
Editorial Material
Neurosciences
Victor Borrell
Summary: Researchers have found that a population of neural progenitor cells co-expressing Neurog2 and Ascl1 play a key role in the implementation of cortex folding during embryonic development.
Article
Multidisciplinary Sciences
Mercedes F. Paredes, Cristina Mora, Quetzal Flores-Ramirez, Arantxa Cebrian-Silla, Ashley Del Dosso, Phil Larimer, Jiapei Chen, Gugene Kang, Susana Gonzalez Granero, Eric Garcia, Julia Chu, Ryan Delgado, Jennifer A. Cotter, Vivian Tang, Julien Spatazza, Kirsten Obernier, Jaime Ferrer Lozano, Maximo Vento, Julia Scott, Colin Studholme, Tomasz J. Nowakowski, Arnold R. Kriegstein, Michael C. Oldham, Andrea Hasenstaub, Jose Manuel Garcia-Verdugo, Arturo Alvarez-Buylla, Eric J. Huang
Summary: Research has revealed that the human embryonic ventral forebrain contains nests of proliferative neuroblasts which play a crucial role in generating a sufficient number of functional interneurons for the human brain.
Article
Cell Biology
Leah Schembs, Ariane Willems, Kerstin Hasenpusch-Theil, James D. Cooper, Katie Whiting, Karen Burr, Sunniva M. K. Bostrand, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Thomas Theil
Summary: This study reveals the importance of primary cilia in dorsal and ventral patterning in human corticogenesis, identifies the tissue-specific role of the INPP5E gene as a negative regulator of SHH signaling, and suggests implications for the pathogenesis of neurodevelopmental disorders.
Article
Developmental Biology
Peter Walentek, Tina Beyer, Cathrin Hagenlocher, Christina Mueller, Kerstin Feistel, Axel Schweickert, Richard M. Harland, Martin Blum
DEVELOPMENTAL BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Weiping Su, Scott C. Foster, Rubing Xing, Kerstin Feistel, Reid H. J. Olsen, Summer F. Acevedo, Jacob Raber, Larry S. Sherman
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Developmental Biology
Martin Blum, Kerstin Feistel, Thomas Thumberger, Axel Schweickert
Article
Anatomy & Morphology
Kerstin Feistel, Martin Blum
DEVELOPMENTAL DYNAMICS
(2008)
Article
Cell Biology
Romia Hassoun, Peter Schwartz, Kerstin Feistel, Martin Blum, Christoph Viebahn
Article
Developmental Biology
Alice H. Reis, Bryan T. Macdonald, Kerstin Feistel, Jose M. Brito, Nathalia G. Amado, Chiwei Xu, Jose G. Abreu, Xi He
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Jerome Gros, Kerstin Feistel, Christoph Viebahn, Martin Blum, Clifford J. Tabin
Article
Developmental Biology
Izabela Kowalczyk, Chanjae Lee, Elisabeth Schuster, Josefine Hoeren, Valentina Trivigno, Levin Riedel, Jessica Gorne, John B. Wallingford, Annette Hammes, Kerstin Feistel
Summary: Pathogenic mutations in the endocytic receptor LRP2 cause severe neural tube closure defects in humans, affecting neuroepithelial morphogenesis and impeding neural tube closure. Loss of LRP2 significantly impacts apical constriction and proper localization of core PCP proteins, highlighting the crucial role of this receptor in neural tube formation.
Review
Biochemistry & Molecular Biology
Jay Gopalakrishnan, Kerstin Feistel, Benjamin M. Friedrich, Anne Grapin-Botton, Nathalie Jurisch-Yaksi, Elvira Mass, David U. Mick, Roman-Ulrich Mueller, Helen May-Simera, Bernhard Schermer, Miriam Schmidts, Peter Walentek, Dagmar Wachten
Summary: Primary cilia are dynamic cellular protrusions that play a crucial role in sensing and processing extracellular signals, controlling cell fate, and function during tissue development.
Article
Developmental Biology
Angela Prager, Cathrin Hagenlocher, Tim Ott, Alexandra Schambony, Kerstin Feistel
DEVELOPMENTAL BIOLOGY
(2017)
Review
Developmental Biology
Elena Sena, Kerstin Feistel, Beatrice C. Durand
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2016)
Article
Multidisciplinary Sciences
Peter Walentek, Cathrin Hagenlocher, Tina Beyer, Christina Mueller, Kerstin Feistel, Axel Schweickert, Richard M. Harland, Martin Blum
Article
Cell Biology
Martin Blum, Philipp Andre, Kerstin Muders, Axel Schweickert, Anja Fischer, Eva Bitzer, Susanne Bogusch, Tina Beyer, Henny W. M. van Straaten, Christoph Viebahn
Article
Biochemistry & Molecular Biology
Axel Schweickert, Thomas Weber, Tina Beyer, Philipp Vick, Susanne Bogusch, Kerstin Feistel, Martin Blum
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)