Review
Toxicology
Kayke L. Barbosa, Raquel S. Dettogni, Charles S. da Costa, Eduardo L. Gastal, Lori T. Raetzman, Jodi A. Flaws, Jones B. Graceli
Summary: The HPG axis is crucial for reproductive function control, and exposure to TBT can lead to toxicity in the female reproductive axis components, affecting hypothalamic GnRH expression, folliculogenesis, steroidogenesis, and ovulation. Further research is needed to understand the mechanisms underlying the impairment caused by TBT in the HPG axis.
TOXICOLOGICAL SCIENCES
(2022)
Review
Endocrinology & Metabolism
Chang Shan, Jiang Yue, Wei Liu
Summary: Bones are now seen as an important endocrine organ, with osteocalcin playing a crucial role in influencing insulin secretion, glucose and lipid metabolism, testosterone biosynthesis, and male fertility. However, the detailed functional mechanisms of osteocalcin on the hypothalamic-pituitary-gonadal axis or the pancreas-bone-gonadal axis are not fully understood.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Ali Abbara, Maria Phylactou, Pei Chia Eng, Sophie A. Clarke, Toan D. Pham, Tuong M. Ho, Kah Yan Ng, Edouard G. Mills, Kate Purugganan, Tia Hunjan, Rehan Salim, Alexander N. Comninos, Lan N. Vuong, Waljit S. Dhillo
Summary: This study compared the endocrine response to triptorelin in women with different reproductive conditions. It found that women with PCOS had a lesser increase in FSH levels compared to healthy women and HA women after triptorelin administration. Additionally, women with polycystic ovaries had lower FSH levels after triptorelin, both with and without ovarian stimulation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Fisheries
Jiamin Pi, Huan Zhong, Yi Zhou, Tao Dai, Weiling Qin, Hui Liu, Yi Zhang, Yuling Zhou
Summary: This study aimed to investigate the regulatory role of ghrelin on ovarian development in grass carp and its mechanism on key hormonal receptors. The results showed high expression of ghrelin and ghrelin O-acyltransferase in the ovary, and stimulation of folliclestimulating hormone receptor expression by ghrelin treatment. Furthermore, acyl-ghrelin inhibited estrogen receptor-alpha expression, while octanoic acid treatment inhibited ER beta 1 and ER beta 2 expression in the ovary.
AQUACULTURE REPORTS
(2023)
Article
Nutrition & Dietetics
Yingxue Han, Hao Wu, Siyuan Sun, Rong Zhao, Yifan Deng, Shenming Zeng, Juan Chen
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in premenopausal women. It has a multifaceted etiology involving genetic and epigenetic factors, hormonal dysfunction, and insulin resistance. High-fat diets are associated with the development of metabolic disorders and worsen the consequences of PCOS by increasing insulin resistance and inflammatory adipokines. Effective management of PCOS requires lifestyle interventions and, in some cases, medical or surgical interventions.
Article
Biochemistry & Molecular Biology
Shih-Min Hsia, Yi-Fen Chiang, Hsin-Yuan Chen, Mohamed Ali, Paulus S. Wang, Kai-Lee Wang
Summary: The study found that a high-fructose diet can lead to decreased plasma testosterone levels in rats, affecting the responsiveness of Leydig cells to hormones and the activity of the hypothalamus-pituitary-gonadal (HPG) axis.
Review
Endocrinology & Metabolism
Maria Phylactou, Sophie A. Clarke, Bijal Patel, Caitlin Baggaley, Channa N. Jayasena, Tom W. Kelsey, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara
Summary: PCOS and FHA are two common causes of secondary amenorrhoea, with distinguishing between them presenting challenges in clinical practice. Factors such as BMI, AMH levels, and polycystic ovarian morphology may aid in differentiating between the two conditions.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ilaria Gentile, Valeria Vezzoli, Sara Martone, Maria Grazia Totaro, Marco Bonomi, Luca Persani, Federica Marelli
Summary: In this study, we investigated the effects of BaP on the HPG axis in zebrafish embryos. The results showed that BaP compromised the neuronal architecture of the GnRH3 network and upregulated antioxidant activity, oxidative DNA damage, and apoptosis pathways. These findings suggest that short-term exposure to BaP can adversely affect GnRH3 development in zebrafish embryos through a neurotoxic mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Katherine VanHise, Erica T. Wang, Keith Norris, Ricardo Azziz, Margareta D. Pisarska, Jessica L. Chan
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women worldwide. There are racial and ethnic differences in PCOS phenotypes and metabolic dysfunction. This review summarizes the current literature on disparities in PCOS diagnosis and outcomes in the United States. Future studies should focus on racial and ethnic-specific differences in PCOS and include a diverse population in PCOS research.
FERTILITY AND STERILITY
(2023)
Article
Reproductive Biology
Leandro M. Velez, Marcus Seldin, Alicia B. Motta
Summary: PCOS is a common endocrinopathy affecting 5-10% of women of reproductive age, characterized by ovarian cysts, ovulation disorders, and hyperandrogenism, along with metabolic abnormalities. Chronic inflammation may play a pivotal role in the pathogenesis of PCOS.
BIOLOGY OF REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Jia Zhu, Anders U. Eliasen, Izzuddin M. Aris, Sara E. Stinson, Jens-Christian Holm, Torben Hansen, Marie-France Hivert, Klaus Bonnelykke, Rany M. Salem, Joel N. Hirschhorn, Yee-Ming Chan
Summary: Genetic risk factors for PCOS are associated with alterations in metabolic, growth, and developmental traits in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Anju E. Joham, Nadira S. Kakoly, Helena J. Teede, Arul Earnest
Summary: This study found a significantly higher incidence of hypertension among women with PCOS compared to those without, especially among obese women. PCOS was independently associated with an increased risk of hypertension, further exacerbated by obesity. Including PCOS in hypertension risk assessments may help in early identification and management of the disorder.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Agronomy
Qiang Bao, Di Liu, Yujiao Guo, Wang Gu, Zhengfeng Cao, Yu Zhang, Yang Zhang, Qi Xu, Guohong Chen
Summary: This study investigates the regulation of circadian egg-laying in Yangzhou geese, finding that egg production exhibits rhythmic patterns related to light-driven melatonin secretion. The laying rates show diurnal fluctuations, with a peak during the early morning hours. Clock genes and melatonin secretion also display circadian rhythmicity, with melatonin receptor expression being higher during the night period.
Article
Medicine, General & Internal
Anne-Laure Barbotin, Nour El Houda Mimouni, Gregory Kuchcinski, Renaud Lopes, Romain Viard, Sowmyalakshmi Rasika, Daniele Mazur, Mauro S. B. Silva, Virginie Simon, Angele Boursier, Jean-Pierre Pruvo, Qiang Yu, Michael Candlish, Ulrich Boehm, Federica Dal Bello, Claudio Medana, Pascal Pigny, Didier Dewailly, Vincent Prevot, Sophie Catteau-Jonard, Paolo Giacobinia
Summary: Polycystic ovary syndrome (PCOS) is a common reproductive-endocrine disorder. This study investigates the brain structure and function in PCOS patients and reveals the role of AMH in regulating fertility and neuroendocrine dysfunction.
Article
Biochemistry & Molecular Biology
Tansel Sapmaz, Kubra Sevgin, Sude Topkaraoglu, Muhammetnur Tekayev, Fatma Gumuskaya, Fatima Efendic, Mahmud Esad Pence, Selman Aktas, Gulam Hekimoglu, Oktay Irkorucu
Summary: This study examined the effects of propolis on ovarian folliculogenesis, p53 expression, and serum LH and P levels in PCOS modeled rats. Treatment with 50 mg/kg of propolis ameliorated cystic and primary follicles, while 150 mg/kg increased LH levels. Low concentrations of propolis cannot completely improve the hormone profile and p53 expression associated with PCOS.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Leandro Ceotto Freitas-Lima, Alexandre Budu, Adriano Cleis Arruda, Mauro Sergio Perilhao, Jonatan Barrera-Chimal, Ronaldo Carvalho Araujo, Gabriel Rufino Estrela
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Veterinary Sciences
Lidianne Narducci Monteiro, Diego Carlos dos Reis, Breno Souza Salgado, Geovanni Dantas Cassali
Summary: High levels of intratumoral (iTAM), stromal (sTAM), and total macrophages (tTAM) are associated with advanced clinical stage and vascular invasion in canine mammary tumors. Additionally, tTAM is related to larger tumor size, while elevated levels of sTAM and tTAM are correlated with nodal metastasis and a poor prognosis based on survival analysis.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Toxicology
Oscar M. S. Nino, Charles S. da Costa, Karine M. Torres, Jordana F. Zanol, Leandro C. Freitas-Lima, Leandro Miranda-Alves, Jones B. Graceli
TOXICOLOGY LETTERS
(2020)
Article
Reproductive Biology
Jordana F. Zanol, Oscar M. S. Nin, Charles S. da Costa, Leandro C. Freitas-Lima, Leandro Miranda-Alves, Jones B. Graceli
Summary: The study revealed that exposure to TBT and HCD together can result in metabolic and reproductive abnormalities, exacerbating features of premature ovary failure in female rats.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Nutrition & Dietetics
Claudia Stela Medeiros, Ivo Vieira de Sousa Neto, Keemilyn Karla Santos Silva, Ana Paula Castro Cantuaria, Taia Maria Berto Rezende, Octavio Luiz Franco, Rita de Cassia Marqueti, Leandro Ceotto Freitas-Lima, Ronaldo Carvalho Araujo, Azize Yildirim, Richard Mackenzie, Jeeser Alves Almeida
Summary: High-protein diets combined with resistance training may lead to glucose intolerance and enlarged adipocytes, but these deleterious effects can be mitigated through resistance training, resulting in improved blood glucose control.
Article
Physiology
Nathalie Tristao Banhos Delgado, Wender do Nascimento Rouver, Leandro Ceotto Freitas-Lima, Ildernandes Vieira-Alves, Virginia Soares Lemos, Roger Lyrio dos Santos
Summary: The study reveals that the GPER agonist G-1 can induce a similar relaxing response in mesenteric arteries from hypertensive rats of both sexes, with differential involvement of endothelial mediators between males and females.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gabriel Rufino Estrela, Leandro Ceotto Freitas-Lima, Alexandre Budu, Adriano Cleis de Arruda, Mauro Sergio Perilhao, Ricardo Ambrosio Fock, Jonatan Barrera-Chimal, Ronaldo Carvalho Araujo
Summary: This study established three mouse models of CKD-induced anemia, showing that anemia can be induced regardless of the mechanism and severity of kidney injury.
Article
Medicine, Research & Experimental
Leandro Ceotto Freitas-Lima, Alexandre Budu, Gabriel Rufino Estrela, Thais Alves-Silva, Mauro Sergio Perilhao, Adriano Cleis Arruda, Ronaldo Carvalho Araujo
Summary: The absence of kinin B1 receptor (B1R) in mice modulates the metabolic shift under fasting conditions by reducing energy expenditure. The lack of B1R leads to a preference for carbohydrates as an energy source and increased serum triglycerides concentration. Enzymatic expression of glycolysis and lipolysis pathways is increased in fed B1KO animals, but no changes occur in gluconeogenesis, glyceroneogenesis, and ketogenesis pathways under fasting, indicating a lack of metabolic flexibility.
Article
Medicine, Research & Experimental
Adriano Cleis Arruda, Alexandre Budu, Thiago Nunes de Menezes, Michael Bader, Ronaldo Carvalho Araujo, Leandro Ceotto Freitas-Lima
Summary: The kinin B1 receptor (B1R) modulates mitochondrial activity under fasting and voluntary exercise conditions, reducing VO2 expenditure and heat production. B1KO animals showed a preference for lipids as an energy source and exhibited increased beta-oxidation. Lack of B1R did not induce mitochondrial activity and biogenesis, suggesting interference in metabolism responsiveness controlled by sirtuins under PGC-1 alpha control.
Article
Biochemistry & Molecular Biology
Thiago Fernandes de Oliveira, Emily Martineli Rossi, Charles Santos da Costa, Jones Bernardes Graceli, Maiara Krause, Maria Teresa Weitzel Dias Carneiro, Camila Cruz Pereira Almenara, Alessandra Simao Padilha
Summary: Cadmium exposure is associated with cardiovascular diseases, and its toxic effects vary depending on sex. This study revealed that 30 days of cadmium exposure induced sex-dependent cardiovascular abnormalities.
Article
Biology
A. Budu, L. C. Freitas-Lima, A. C. de Arruda, M. S. Perilhao, J. Barrera-Chimal, R. C. Araujo, G. R. Estrela
Summary: Cisplatin is a widely used chemotherapeutic drug, but its side effects, including nephrotoxicity, can exacerbate tubular injury and tubulointerstitial fibrosis. The study found that kinin B1 receptor inhibition worsened cisplatin-induced chronic renal dysfunction, reduced the expression of the M2 marker YM1, and possibly affected the wound healing process.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Review
Environmental Sciences
Attila Csaba Kondor, Anna Viktoria Vancsik, Laszlo Bauer, Lili Szabo, Zoltan Szalai, Gergely Jakab, Gabor Maasz, Marta Pedrosa, Maria Jose Sampaio, Ana Rita Lado Ribeiro
Summary: This review provides a critical overview of research on the removal efficiency of priority substances and compounds of emerging concern through bank filtration, discussing influencing factors and future challenges. The findings show that the efficiency of bank filtration is influenced by multiple factors and varies for different substances.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Xinyan Wang, Shuai Zhang, Huihui Yan, Zhao Ma, Yunshan Zhang, Haining Luo, Xueli Yang
Summary: This study investigated the association between ambient PM2.5, O3 pollution, and ovarian reserve in reproductive-aged Chinese women. The results showed that increased exposure to PM2.5 and O3 was associated with decreased AMH levels, indicating reduced ovarian reserve. Notably, the effects of O3 exposure on ovarian reserve were different from those of PM2.5 exposure.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Tingting Ma, Yanjuan Ding, Fengjiao Xu, Chen Zhang, Min Zhou, Ya Tang, Yanrong Chen, Yating Wen, Rufei Chen, Bin Tang, Shigui Wang
Summary: The dragonfly species Orthetrum albistylum can accumulate heavy metals, and its heat shock protein genes have the potential to serve as biomarkers for monitoring environmental pollutants.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Naoto Ishiwaka, Koya Hashimoto, Masayoshi K. Hiraiwa, Francisco Sanchez-Bayo, Taku Kadoya, Daisuke Hayasaka
Summary: Systemic insecticides and rising temperatures have combined effects on the abundance of Odonata nymphs in paddy fields. The standalone effect of insecticide exposure decreased the Odonata community, while nymphs decreased synergistically with temperature rise in paddy water. However, the impacts of each stressor alone varied among species.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Marco Vecchiato, Carlo Barbante, Elena Barbaro, Francois Burgay, Warren R. L. Cairns, Alice Callegaro, David Cappelletti, Federico Dallo, Marianna D'Amico, Matteo Feltracco, Jean-Charles Gallet, Andrea Gambaro, Catherine Larose, Niccolo Maffezzoli, Mauro Mazzola, Ivan Sartorato, Federico Scoto, Clara Turetta, Massimiliano Varde, Zhiyong Xie, Andrea Spolaor
Summary: The Arctic region is facing contamination from long-range pollution and local human activities. Polycyclic Aromatic Hydrocarbons (PAHs) are used as environmental indicators for emission, transport, and deposition processes. Research conducted in the Arctic surface snow in Ny-Ålesund, Svalbard from October 2018 to May 2019 shows that long-range inputs of PAHs mainly occur in winter, while the most abundant analyte retene exhibits opposite seasonal trends.
ENVIRONMENTAL POLLUTION
(2024)
Review
Environmental Sciences
Maoshui Zhuo, Zhijie Chen, Xiaoqing Liu, Wei Wei, Yansong Shen, Bing-Jie Ni
Summary: This paper discusses the application of three catalytic processes (photocatalysis, electrocatalysis, and biocatalysis) in the management of microplastic pollution, and introduces the efficiency and catalytic mechanisms of different catalysts. It also proposes the development prospects for sustainable management of microplastic pollution.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Shiyu Chen, Zhenzhen Shi, Qiang Zhang
Summary: In this study, a human physiologically based pharmacokinetic (PBPK) model of diethyl phthalate (DEP) was developed to assess its toxicity. The model considers the distribution and metabolism of DEP and its active metabolite monoethyl phthalate (MEP) in different tissue compartments. Sensitivity analysis and Bayesian Markov chain Monte Carlo (MCMC) simulations were performed to evaluate the uncertainty and variability of the model parameters. The results suggest that dermal absorption is an important route of exposure to DEP in the environment.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Bangguo Wang, Lijing Wang, Wenxi Cen, Tao Lyu, Peter Jarvis, Yang Zhang, Yuanxun Zhang, Yinghui Han, Lei Wang, Gang Pan, Kaili Zhang, Wei Fan
Summary: This study investigates the feasibility and mechanisms of a chemical-free nanobubble-based AOP for treating organic micropollutants in water. The results show that the oxygen nanobubble AOP has a significantly higher removal efficiency compared to air and nitrogen nanobubbles. The treatment performance is not affected by pH and the presence of ions. Higher initial concentrations of the micropollutant lead to slower treatment processes, but similar removal performance is achieved in the end. The presence of organic matter reduces the removal rate of the micropollutant. The results have practical feasibility for water and wastewater treatment.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Yingmei Huang, Jicai Yi, Yao Huang, Songxiong Zhong, Bin Zhao, Jing Zhou, Yuxuan Wang, Yiwen Zhu, Yanhong Du, Fangbai Li
Summary: This study investigates the impact of biochar on methylmercury (MeHg) accumulation in rice. The results show that biochar reduces MeHg levels in paddy soils by decreasing bioavailable Hg and microbial Hg methylation. Additionally, biochar decreases the uptake and translocation of MeHg in rice plants, resulting in a reduction of MeHg accumulation in rice grains.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Nengde Zeng, Fei Huang, Jiani Du, Chenghao Huang, Qian Yang, Xinhua Zhan, Baoshan Xing
Summary: This study investigates the protein targets and protein-ligand interactions related to PAH contamination in crop xylem sap using computational tools. The results show that phenanthrene has a more pronounced effect on the xylem sap proteins of maize and wheat, with maize DEPs associated with lipid biosynthesis and wheat DEPs exhibiting an increase in ABC transporters. This study provides insights into the regulation and movement of PAHs within plant xylem.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Xinwei Chen, Hao Ma, Run Wang, Man Wang, Binbin Zhu, Yanqing Cong, Xiayue Zhu, Guoqin Wang, Yi Zhang
Summary: Co3O4/TiO2-NRs electrodes with excellent photoresponse were prepared via plasma-assisted modification of Co3O4 on TiO2. The combination of Co3O4 and TiO2 improved the light utilization efficiency and showed potential for degradation of pollutants.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Wenjing Ji, Liying Song, Jing Wang, Hongqing Song
Summary: This study conducted a life-cycle assessment to examine the correlation between natural gas consumption and carbon emissions in different end uses in China. The results showed that both natural gas consumption and life-cycle carbon emissions have been increasing since 2017. Significant variations in NG life-cycle carbon emissions were found across different provinces and sectors, highlighting the need for targeted efforts to reduce carbon emissions.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Youyi Chen, Boxuan Zhang, Pojun Zhang, Guogui Shi, Hao Liang, Wu Cai, Jingyu Gao, Sumin Zhuang, Kaiyin Luo, Jiaqi Zhu, Chaoxiang Chen, Kunyu Ma, Jinrong Chen, Chun Hu, Xueci Xing
Summary: The synergistic effects of trace sulfadiazine and cast-iron corrosion scales on the formation of disinfection by-products in drinking water distribution systems were investigated. The presence of magnetite resulted in increased concentrations of DBPs due to the higher microbial activity and enhanced microbial extracellular electron transport pathway. The study highlights the importance of considering trace antibiotics pollution and corrosion scales in water sources for DBP control.
ENVIRONMENTAL POLLUTION
(2024)
Review
Environmental Sciences
Bishwa Raj Pokharel, Vijay Sheri, Manoj Kumar, Zhiyong Zhang, Baohong Zhang
Summary: This review summarizes the interactions, uptake, and transport of aluminum nanoparticles (Al-NPs) in plants, highlighting their negative effects on plant growth and development, as well as their potential to alter plant defense systems and gene expression.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Yonglu Wang, Fengsong Zhang, Xiaoyong Liao, Xiao Yang, Guixiang Zhang, Liyun Zhang, Chaojun Wei, Pengge Shi, Jiongxin Wen, Xiaorong Ju, Can Xu, Yang Liu, Ying Lan
Summary: This study aims to explore the effects of thiencarbazone-methyl center dot isoxaflutole on soil microflora and the potential mitigation mechanisms to bacterial communities. It was found that increasing the application of thiencarbazone-methyl center dot isoxaflutole resulted in increased stress on soil bacterial community structure and diversity. Increasing soil pH was recognized as a key factor in improving the diversity and structure of soil microflora. Supplemental use of nitrapyrin or modified attapulgite can increase soil pH and improve bacterial diversity.
ENVIRONMENTAL POLLUTION
(2024)