Review
Engineering, Biomedical
Jinsong Wang, Guobao Chen, Zhong M. Chen, Fu P. Wang, Bin Xia
Summary: The role of periosteum in the treatment of bone defects has been gradually discovered, but there are still challenges due to limited transplantable periosteum. Biomimetic periosteal scaffolds that mimic the composition and structure of natural periosteum have emerged. This article reviews the current preparation methods of biomimetic periosteal scaffolds based on various biomaterials, providing a systematic perspective for future preparation.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Engineering, Biomedical
Zonghan Xu, Liang Wu, Yu Tang, Kun Xi, Jincheng Tang, Yichang Xu, Jingzhi Xu, Jian Lu, Kaijin Guo, Yong Gu, Liang Chen
Summary: This study presents a hybridized biphasic bionic periosteum for regulating the bone immune microenvironment and promoting bone regeneration. The biomimetic membrane intercepts IL-4 release, maintains moderate inflammatory response, and promotes M2 macrophage polarization, which improves vascular maturation and osteogenesis. The controlled regulation of the bone immune microenvironment leads to faster and better bone defect repair.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell Biology
Trey Polvadore, Malcolm Maden
Summary: This study reveals the impact of retinoic acid treatment on the control of positional information during axolotl limb regeneration. Through RNA sequencing, the genes interacting with RAR alpha were identified, shedding light on the mechanism of action for future research.
Article
Engineering, Biomedical
Laijun Liu, Yuna Shang, Chaojing Li, Yongjie Jiao, Yanchen Qiu, Chengyi Wang, Yuge Wu, Qiuyun Zhang, Fujun Wang, Zhimou Yang, Lu Wang
Summary: The developed hierarchical nanostructured electrospun membrane with periosteum-mimic microenvironment, incorporating a calcium-binding peptide, showed enhanced osteogenic differentiation of rat-bone marrow-derived mesenchymal stem cells (rBMSCs) and promoted the regeneration of vascularized bone tissue.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Physiology
Reut Shainer, Vardit Kram, Tina M. Kilts, Li Li, Andrew D. Doyle, Inbal Shainer, Daniel Martin, Carl G. Simon, Jinyang Zeng-Brouwers, Liliana Schaefer, Marian F. Young, Genomics and Computational Biol Core
Summary: Biglycan is a small proteoglycan found in the extracellular matrix and plays an important role in bone development. Our study reveals that biglycan is involved in osteoblast maturation during embryonic development, affecting bone integrity and strength. Deletion of the biglycan gene reduces the inflammatory response after fracture, leading to impaired periosteal expansion and callus formation. Additionally, biglycan is crucial for the cartilage phase preceding bone formation, as its absence leads to accelerated bone development with high levels of osteopontin, which negatively impacts bone structural integrity.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Huifan Liu, Yihua Shi, Yufan Zhu, Ping Wu, Zhouming Deng, Qi Dong, Minhao Wu, Lin Cai
Summary: A novel biomimetic periosteum was developed using functionalized piezoelectric materials to enhance the bone regeneration effect. The periosteum was fabricated using a biocompatible and biodegradable polymer matrix, antioxidized polydopamine-modified hydroxyapatite, and barium titanate. This periosteum demonstrated favorable biocompatibility, osteogenic activity, and immunomodulatory functions, and accelerated bone regeneration through endogenous piezoelectric stimulation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Gaojie Yang, Haoming Liu, Yi Cui, Jiaqi Li, Xuan Zhou, Nuoxin Wang, Feige Wu, Yan Li, Yu Liu, Xingyu Jiang, Shengmin Zhang
Summary: The functional biomimetic membrane with micropatterns of site-specific biomineralization mimics the role of natural periosteum in bone regeneration. It can sustainably release calcium phosphate and growth factors, enhancing cell recruitment and differentiation, leading to improved vascularized ossification and accelerated new bone formation in a rat model.
Article
Multidisciplinary Sciences
Jiawei Li, Huiming Jiang, Zhongyang Lv, Ziying Sun, Chaoqun Cheng, Guihua Tan, Maochun Wang, Anlong Liu, Heng Sun, Hu Guo, Fufei Chen, Zizheng Liu, Yuxiang Fei, Yuan Liu, Rui Wu, Xingquan Xu, Wenjin Yan, Qing Jiang, Dongquan Shi
Summary: This study proposed a new strategy for cartilage regeneration by hyalinizing fibrocartilage through stabilizing the cytoskeleton. The use of docetaxel was found to inhibit cartilage fibrosis and promote the regeneration of hyaline cartilage.
Article
Chemistry, Physical
Shu Yang, Zhijie Chen, Pengzhen Zhuang, Yunkai Tang, Zehao Chen, Fei Wang, Zhengwei Cai, Jie Wei, Wenguo Cui
Summary: In this study, seamless adhesive biomimetic periosteum patches were developed to fill microcracks in defective bone and promote bone regeneration. The patches exhibited excellent self-healing properties, enhanced osteogenesis and angiogenesis, and significantly promoted blood vessel and new bone formation in a rat cranial defect model. Therefore, the proposed biomimetic periosteum patch is a promising clinical strategy for promoting bone repair.
Article
Cell Biology
Warren A. Vieira, Michael Raymond, Kristina Kelley, Matthew A. Cherubino, Hande Sahin, Catherine D. McCusker
Summary: This study investigates the failure of integration in the regeneration of limb tissues in the Mexican axolotl, finding significant differences in the complexity of limb structures and gene expression. They also discover that anterior positional information is more abundant at the limb base, and that anterior patterning genes are more highly expressed in proximally located blastemas compared to blastemas in the more distal regions of the limb. These findings provide valuable insights into the underlying causes of integration failure and the distribution of positional identities in the mature limb.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Warren A. Vieira, Shira Goren, Catherine D. McCusker
Summary: The Mexican Axolotl exhibits remarkable regenerative abilities, and in the process of limb regeneration, positional communication between cells occurs in two types: one involving memory retention within connective tissue cells and another involving the transmission of positional cues to other cell types in the regenerate. The extracellular matrix likely plays a role in facilitating the latter type of communication during limb regeneration.
Article
Dentistry, Oral Surgery & Medicine
Lucas T. Duong, Stephane Petit, Stephane Kerner, Melodie M. Clerc, Christophe Arnoult, Nunthawan Nowwarote, Thanaphum Osathanon, Benjamin P. J. Fournier, Juliane Isaac, Francois C. Ferre
Summary: A standardized critical size defect (CSD) model was developed in the mandibular alveolar bone of minipigs to investigate the role of periosteum in bone healing process. It was found that the removal of periosteum resulted in a significant decrease in bone volume and density, indicating the important role of periosteum in bone regeneration.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
C. Tsutsumi-Arai, Y. Arai, A. Tran, M. Salinas, Y. Nakai, S. Orikasa, W. Ono, N. Ono
Summary: The mandibular condylar cartilage (MCC) plays a crucial role in the vertical growth of the mandibular ramus. In this study, researchers investigated the role of parathyroid hormone-related protein (PTHrP) in MCC chondrogenesis. They found that PTHrP released from cells in the superficial layer directly promotes proliferation of chondrocyte precursor cells and prevents their premature differentiation. This study uncovers a unique mechanism by which PTHrP regulates MCC chondrogenesis.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Orthopedics
Hongri Wu, Jiulin Tan, Dong Sun, Xiaohua Wang, Jie Shen, Shulin Wang, Qijie Dai, Zhiyuan Wei, Gang Li, Sien Lin, Fei Luo, Zhao Xie
Summary: This study found that the insertion of polymethyl methacrylate (PMMA) bone cement can form an induced membrane (IM) containing multipotent progenitor cells similar to periosteum, and these cells share similar characteristics with periosteum stem cells (PSCs) in bone regeneration. The study also revealed the existence of multiple subsets with differences in osteogenic differentiation.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Materials Science, Biomaterials
Jingjing Wu, Mengyu Yao, Yonggang Zhang, Zefeng Lin, Wenwu Zou, Jiaping Li, Pamela Habibovic, Chang Du
Summary: Distinct structural properties and osteogenic capacity are important for developing guided bone regeneration membranes. The three-layered membranes designed in this study demonstrated good integration, tensile properties similar to natural periosteum, and supported attachment, proliferation, ingrowth, and osteogenic differentiation of human bone marrow-derived stromal cells.
REGENERATIVE BIOMATERIALS
(2021)
Article
Evolutionary Biology
Carlos Diaz-Castillo
EVOLUTIONARY BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Raquel Chamorro-Garcia, Carlos Diaz-Castillo, Bassem M. Shoucri, Heidi Kach, Ron Leavitt, Toshi Shioda, Bruce Blumberg
NATURE COMMUNICATIONS
(2017)
Article
Biochemical Research Methods
Qixuan Wang, William R. Holmes, Julian Sosnik, Thomas Schilling, Qing Nie
PLOS COMPUTATIONAL BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Carlos Diaz-Castillo
Article
Evolutionary Biology
Carlos Diaz-Castillo
EVOLUTIONARY BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Julian Sosnik, Warren A. Vieira, Kaitlyn A. Webster, Kellee R. Siegfried, Catherine D. McCusker
Article
Multidisciplinary Sciences
Carlos Diaz-Castillo, Raquel Chamorro-Garcia, Toshi Shioda, Bruce Blumberg
SCIENTIFIC REPORTS
(2019)
Article
Reproductive Biology
Ana M. Salicioni, Maria G. Gervasi, Julian Sosnik, Darya A. Tourzani, Saman Nayyab, Diego A. Caraballo, Pablo E. Visconti
BIOLOGY OF REPRODUCTION
(2020)
Review
Toxicology
Daniel D. Davis, Carlos Diaz-Castillo, Raquel Chamorro-Garcia
Summary: The role of environment in the development of diseases has long been known, but it is still unclear how different environmental factors interact to cause diseases. Metabolic disorders such as obesity and type 2 diabetes are associated with exposure to environmental chemicals during critical windows of susceptibility, such as the periconception, prenatal, and early life periods, and this effect can persist through development and across generations.
FRONTIERS IN TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Catherine D. McCusker, Carlos Diaz-Castillo, Julian Sosnik, Anne Phan, David M. Gardiner
Article
Cell Biology
Anne Q. Phan, Maurizio Pacifici, Jeffrey D. Esko
CONNECTIVE TISSUE RESEARCH
(2018)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)
