OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development

Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

(2020) Xiaoyan Guo et al.   NATURE

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

(2020) Evelyn Fessler et al.   NATURE

JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction

(2020) Luca Simula et al.   CELL DEATH AND DIFFERENTIATION

Targeted OMA1 therapies for cancer

(2019) Marcel V. Alavi   INTERNATIONAL JOURNAL OF CANCER

Sam50–Mic19–Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact

(2019) Junhui Tang et al.   CELL DEATH AND DIFFERENTIATION

Lipid signalling drives proteolytic rewiring of mitochondria by YME1L

(2019) Thomas MacVicar et al.   NATURE

Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells

(2019) Amita Daverey et al.   Scientific Reports

Ablation of the stress protease OMA1 protects against heart failure in mice

(2018) Rebeca Acin-Perez et al.   Science Translational Medicine

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer

(2018) Kathryn T. Baker et al.   MOLECULAR CANCER RESEARCH

Reduced mitochondrial activity in colonocytes facilitates AMPKα2-dependent inflammation

(2017) Sandra Heller et al.   FASEB JOURNAL

Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer

(2017) Xiang Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Global patterns and trends in colorectal cancer incidence and mortality

(2016) Melina Arnold et al.   GUT

Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis

(2016) Kellie E. Cunningham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria

(2016) Anne Korwitz et al.   JOURNAL OF CELL BIOLOGY

Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses

(2016) Iryna Bohovych et al.   MOLECULAR AND CELLULAR BIOLOGY

Accessory subunits are integral for assembly and function of human mitochondrial complex I

(2016) David A. Stroud et al.   NATURE

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress

(2016) T. Kelly Rainbolt et al.   Cell Reports

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization

(2015) H Li et al.   CELL DEATH AND DIFFERENTIATION

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

(2015) Tatiana Varanita et al.   Cell Metabolism

HIF-1 at the crossroads of hypoxia, inflammation, and cancer

(2015) Kuppusamy Balamurugan   INTERNATIONAL JOURNAL OF CANCER

The role of hypoxia in inflammatory disease (Review)

(2015) JOHN BIDDLESTONE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Regulation of Hypoxia-Inducible Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate

(2015) Shahrzad Movafagh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

(2015) T. Wai et al.   SCIENCE

Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation

(2014) Prashant Mishra et al.   Cell Metabolism

Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics

(2014) M. J. Baker et al.   EMBO JOURNAL

Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage

(2014) K. Zhang et al.   EMBO REPORTS

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis

(2014) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase

(2013) Lena Böttinger et al.   MOLECULAR BIOLOGY OF THE CELL

Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria

(2013) H.-J. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain

(2012) Eduardo Balsa et al.   Cell Metabolism

Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice

(2012) Pedro M Quirós et al.   EMBO JOURNAL

Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia

(2012) Helene Niecknig et al.   FREE RADICAL RESEARCH

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

The NDUFB6 subunit of the mitochondrial respiratory chain complex I is required for electron transfer activity: A proof of principle study on stable and controlled RNA interference in human cell lines

(2011) Sandrine Loublier et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIF1A Overexpression Is Associated with Poor Prognosis in a Cohort of 731 Colorectal Cancers

(2010) Yoshifumi Baba et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia and mitochondrial oxidative metabolism

(2010) Giancarlo Solaini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Respiratory Active Mitochondrial Supercomplexes

(2008) Rebeca Acín-Pérez et al.   MOLECULAR CELL