Pharmacological reversal of synaptic and network pathology in human MECP2 ‐KO neurons and cortical organoids

An atlas of the protein-coding genes in the human, pig, and mouse brain

(2020) Evelina Sjöstedt et al.   SCIENCE

Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice

(2019) Xin Tang et al.   Science Translational Medicine

Conserved cell types with divergent features in human versus mouse cortex

(2019) Rebecca D. Hodge et al.   NATURE

Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders

(2019) Jason W. Adams et al.   PHYSIOLOGY

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

(2019) Cleber A. Trujillo et al.   Cell Stem Cell

Simple framework for constructing functional spiking recurrent neural networks

(2019) Robert Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of spontaneous activity in random networks with multiple neuron subtypes and synaptic noise

(2018) Rodrigo F. O. Pena et al.   JOURNAL OF COMPUTATIONAL NEUROSCIENCE

Alpha-7 nicotinic acetylcholine receptor agonist treatment in a rat model of Huntington's disease and involvement of heme oxygenase-1

(2018) Laura Foucault-Fruchard et al.   Neural Regeneration Research

Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2 -null mice, a model of Rett syndrome

(2018) Chao-Yin Chen et al.   NEUROBIOLOGY OF DISEASE

Impact on GABA systems in monogenetic developmental CNS disorders: Clues to symptomatic treatment

(2018) Dietmar Benke et al.   NEUROPHARMACOLOGY

Placebo-controlled crossover assessment of mecasermin for the treatment of Rett syndrome

(2018) Heather M. O'Leary et al.   Annals of Clinical and Translational Neurology

Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC–Derived Neural 3D Cultures

(2018) Oksana Sirenko et al.   TOXICOLOGICAL SCIENCES

Towards a better diagnosis and treatment of Rett syndrome: a model synaptic disorder

(2018) Abhishek Banerjee et al.   BRAIN

Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing

(2018) William Renthal et al.   NATURE NEUROSCIENCE

A Double-Blind, Randomized, Placebo-Controlled Clinical Study of Trofinetide in the Treatment of Rett Syndrome

(2017) Daniel G. Glaze et al.   PEDIATRIC NEUROLOGY

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

(2017) Michael J. McConnell et al.   SCIENCE

MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice

(2017) Keerthi Krishnan et al.   Nature Communications

Biologically plausible learning in recurrent neural networks reproduces neural dynamics observed during cognitive tasks

(2017) Thomas Miconi   eLife

Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus

(2016) Ying Zhang et al.   CELL RESEARCH

A human neurodevelopmental model for Williams syndrome

(2016) Thanathom Chailangkarn et al.   NATURE

Pharmacologic Treatment of Rett Syndrome With Glatiramer Acetate

(2016) Aleksandra Djukic et al.   PEDIATRIC NEUROLOGY

Rett Syndrome: Crossing the Threshold to Clinical Translation

(2016) David M. Katz et al.   TRENDS IN NEUROSCIENCES

Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

(2016) Chongyuan Luo et al.   Cell Reports

Altered neuronal network and rescue in a human MECP2 duplication model

(2015) S Nageshappa et al.   MOLECULAR PSYCHIATRY

The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders

(2015) Sien Braat et al.   NEURON

Rett Syndrome: Reaching for Clinical Trials

(2015) Lucas Pozzo-Miller et al.   Neurotherapeutics

Swimming muscles power suction feeding in largemouth bass

(2015) Ariel L. Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatic mutation in single human neurons tracks developmental and transcriptional history

(2015) M. A. Lodato et al.   SCIENCE

Alterations in the cholinergic system of brain stem neurons in a mouse model of Rett syndrome

(2014) Max F. Oginsky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Double-Blind Treatment of Apathy in Patients with Poststroke Depression Using Nefiracetam

(2014) Robert G. Robinson et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome

(2014) O. S. Khwaja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

(2013) Yun Li et al.   Cell Stem Cell

Robust timing and motor patterns by taming chaos in recurrent neural networks

(2013) Rodrigo Laje et al.   NATURE NEUROSCIENCE

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

(2013) Ira Espuny-Camacho et al.   NEURON

MeCP2 Is Critical for Maintaining Mature Neuronal Networks and Global Brain Anatomy during Late Stages of Postnatal Brain Development and in the Mature Adult Brain

(2012) M. V. C. Nguyen et al.   JOURNAL OF NEUROSCIENCE

Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior

(2012) Marina R. Picciotto et al.   NEURON

MeCP2 Mutation Results in Compartment-Specific Reductions in Dendritic Branching and Spine Density in Layer 5 Motor Cortical Neurons of YFP-H Mice

(2012) David P. Stuss et al.   PLoS One

Pharmacological Study on Alzheimer’s Drugs Targeting Calcium/Calmodulin-Dependent Protein Kinase II

(2011) Shigeki Moriguchi   JOURNAL OF PHARMACOLOGICAL SCIENCES

Somatic coding mutations in human induced pluripotent stem cells

(2011) Athurva Gore et al.   NATURE

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Piracetam and Piracetam-Like Drugs

(2010) Andrei G. Malykh et al.   DRUGS

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

The Role of MeCP2 in Brain Development and Neurodevelopmental Disorders

(2010) Michael L. Gonzales et al.   Current Psychiatry Reports

Intact Long-Term Potentiation but Reduced Connectivity between Neocortical Layer 5 Pyramidal Neurons in a Mouse Model of Rett Syndrome

(2009) V. S. Dani et al.   JOURNAL OF NEUROSCIENCE

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE