ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation

ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress

(2016) Michael G. Kemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice

(2015) Scott E. Williams et al.   DEVELOPMENT

Mutations in XRCC4 cause primary microcephaly, short stature and increased genomic instability

(2015) N. Rosin et al.   HUMAN MOLECULAR GENETICS

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

(2015) Margaret E Harley et al.   NATURE GENETICS

WikiPathways: capturing the full diversity of pathway knowledge

(2015) Martina Kutmon et al.   NUCLEIC ACIDS RESEARCH

Generation of aMagohconditional allele in mice

(2014) John J. McMahon et al.   GENESIS

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

(2013) F. B. Couch et al.   GENES & DEVELOPMENT

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Large-scale gene function analysis with the PANTHER classification system

(2013) Huaiyu Mi et al.   Nature Protocols

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013

(2013) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress

(2013) J. Willis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EnrichNet: network-based gene set enrichment analysis

(2012) Enrico Glaab et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

(2012) Tobias Rausch et al.   CELL

ATR maintains select progenitors during nervous system development

(2012) Youngsoo Lee et al.   EMBO JOURNAL

Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation

(2012) I Garcia et al.   ONCOGENE

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation

(2012) E Fokas et al.   Cell Death & Disease

ATR signalling: more than meeting at the fork

(2011) Edward A. Nam et al.   BIOCHEMICAL JOURNAL

Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration

(2011) Rong Chu et al.   BIOCHEMICAL PHARMACOLOGY

Paclitaxel sensitivity of breast cancer cells requires efficient mitotic arrest and disruption of Bcl-xL/Bak interaction

(2011) M. Luz Flores et al.   BREAST CANCER RESEARCH AND TREATMENT

Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme

(2011) John G. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents

(2011) Jean-Damien Charrier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development and cancer of the cerebellum

(2011) Mary E. Hatten et al.   TRENDS IN NEUROSCIENCES

Compromise in mRNA processing machinery in senescent human fibroblasts: implications for a novel potential role of Phospho-ATR (ser428)

(2010) Panagiotis Chandris et al.   BIOGERONTOLOGY

Doubly amphiphilic poly(2-oxazoline)s as high-capacity delivery systems for hydrophobic drugs

(2010) Robert Luxenhofer et al.   BIOMATERIALS

Radiation induced DNA DSBs: Contribution from stalled replication forks?

(2010) Jane V. Harper et al.   DNA REPAIR

Clearance of apoptotic cells: implications in health and disease

(2010) Michael R. Elliott et al.   JOURNAL OF CELL BIOLOGY

MapSplice: Accurate mapping of RNA-seq reads for splice junction discovery

(2010) Kai Wang et al.   NUCLEIC ACIDS RESEARCH

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

(2009) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Common mechanisms of PIKK regulation

(2009) Courtney A. Lovejoy et al.   DNA REPAIR

Tumour suppression by p53: the importance of apoptosis and cellular senescence

(2009) Valentina Zuckerman et al.   JOURNAL OF PATHOLOGY

Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency

(2009) Pierre-Olivier Frappart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Isolation and Culture of Post-Natal Mouse Cerebellar Granule Neuron Progenitor Cells and Neurons

(2009) Hae Young Lee et al.   Jove-Journal of Visualized Experiments

Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

(2008) Ulrich Schüller et al.   CANCER CELL

Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells

(2008) Zeng-Jie Yang et al.   CANCER CELL

Roles of Pofut1 andO-Fucose in Mammalian Notch Signaling

(2008) Mark Stahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY