Progress in the development of stabilization strategies for nanocrystal preparations

In recent years, nanocrystal technology has been extensively investigated. Due to the submicron particle size and unique physicochemical properties of nanocrystals, they overcome the problems of low drug solubility and poor bioavailability. Although the structures of nanocrystals are simple, the further development of these materials is hindered by their stability. Drug nanocrystals with particle sizes of 1 similar to 1000 nm usually require the addition of stabilizers such as polymers or surfactants to enhance their stability. The stability of nanocrystal suspensions and the redispersibility of solid nanocrystal drugs are the key factors for the large-scale production of nanocrystal preparations. In this paper, the factors that affect the stability of drug nanocrystal preparations are discussed, and related methods for solving the stability problem are put forward.

Automated summary

In recent years, nanocrystal technology has been extensively researched due to its ability to overcome the problems of low drug solubility and poor bioavailability. The stability of nanocrystals is a key challenge for their further development, with the addition of stabilizers being necessary to enhance their stability. The stability of nanocrystal suspensions and the redispersibility of solid nanocrystal drugs are crucial factors for large-scale production of nanocrystal preparations.