Article
Veterinary Sciences
Wesley C. Sheley, Matthew J. Gray, Mark Q. Wilber, Carolyn Cray, E. Davis Carter, Debra L. Miller
Summary: This study investigated the pathophysiological effects and immune responses associated with Bsal chytridiomycosis in Taricha granulosa. The results showed that electrolyte imbalances and dehydration induced by damage to the epidermis played a major role in the pathogenesis of Bsal chytridiomycosis in this species. Additionally, Bsal-infected T. granulosa exhibited a systemic inflammatory response identified through alterations in complete blood counts and protein electrophoretograms.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Fisheries
Maribel Mendez-Tepepa, Karla Hernandez-Perez, Libertad Juarez-Santacruz, Senobia Rosalia Cruz-Lumbreras, Edelmira Garcia-Nieto, Arely Anaya-Hernandez, Cuauhtemoc Morales-Cruz
Summary: Atrazine is widely used in Mexico as an authorized herbicide, but it has been found to contaminate aquatic systems. Previous studies have shown its harmful effects on red blood cells and liver tissue in different aquatic species, mostly fish. This study aims to determine the effects of atrazine on a native Mexican species, the male frog (Lithobates spectabilis).
Article
Gastroenterology & Hepatology
Meritxell Ventura-Cots, Josepmaria Argemi, Patricia D. Jones, Carolin Lackner, Mohamed El Hag, Juan G. Abraldes, Edilmar Alvarado, Ana Clemente, Samitha Ravi, Antonio Alves, Mohamed Alboraie, Jose Altamirano, Sergio Barace, Francisco Bosques, Robert Brown, Juan Caballeria, Joaquin Cabezas, Sofia Carvalhana, Helena Cortez-Pinto, Adilia Costa, Delphine Degre, Carlos Fernandez-Carillo, Nathalie Ganne-Carrie, Guadalupe Garcia-Tsao, Joan Genesca, John Koskinas, Nicolas Lanthier, Alexandre Louvet, Juan Jose Lozano, Michael R. Lucey, Steven Masson, Philippe Mathurin, Nahum Mendez-Sanchez, Rosa Miquel, Christophe Moreno, Taofic Mounajjed, Gemma Odena, Won Kim, Pau Sancho-Bru, R. Warren Sands, Justyna Szafranska, Laurine Verset, Bern Schnabl, Christine Sempoux, Vijay Shah, Debbie Lindsay Shawcross, Rudolf E. Stauber, Beate K. Straub, Elizabeth Verna, Dina Tiniakos, Eric Trepo, Victor Vargas, Candid Villanueva, John T. Woosley, Marianne Ziol, Sebastian Mueller, Peter Starkel, Ramon Bataller
Summary: Despite comparable alcohol intake, AH patients presented with worse liver function compared with ndALD patients. Bilirubinostasis, severe fibrosis and ductular reaction were prominent features of AH. AH patients exhibited a more profound deregulation of gene expression compared with ndALD patients.
Article
Environmental Sciences
Saima Naz, Riaz Hussain, Qudrat Ullah, Ahmad Manan Mustafa Chatha, Ansar Shaheen, Rifat Ullah Khan
Summary: The study conducted in this research reveals that prolonged exposure to copper and cadmium can cause adverse hematological and histopathological changes in Catla catla fish.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Marina R. Sartori, Claudia D. C. Navarro, Roger F. Castilho, Anibal E. Vercesi
Summary: Hepatic lipidosis is common in captive reptiles, leading to NAFLD-like liver diseases. This study found that adult captive red-footed tortoises exhibited higher levels of lipids, histopathological alterations, and compromised mitochondrial function compared to juveniles, indicating the progression to NASH. These findings highlight the importance of mitochondria in liver disease progression in reptiles.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2022)
Article
Neuroimaging
M. Dylan Tisdall, Daniel T. Ohm, Rebecca Lobrovich, Sandhitsu R. Das, Gabor Mizsei, Karthik Prabhakaran, Ranjit Ittyerah, Sydney Lim, Corey T. McMillan, David A. Wolk, James Gee, John Q. Trojanowski, Edward B. Lee, John A. Detre, Paul Yushkevich, Murray Grossman, David J. Irwin
Summary: Frontotemporal lobar degeneration (FTLD) encompasses a range of neurodegenerative diseases characterized by proteinopathies, including Tau and TDP-43. Clinical differentiation between these subtypes is challenging, but integrated MRI and histopathology studies may help distinguish FTLD-Tau and FTLD-TDP.
NEUROIMAGE-CLINICAL
(2022)
Review
Nutrition & Dietetics
Faezah Sabirin, Siong Meng Lim, Chin Fen Neoh, Kalavathy Ramasamy
Summary: Probiotics have been found to have hepatoprotective potential against NAFLD in vivo, improving histopathology, liver enzymes, hepatic and serum lipid profiles, while modulating gut microbiota composition and intestinal permeability. Probiotics also contribute to better glycaemic control and reduced liver weight.
FRONTIERS IN NUTRITION
(2022)
Article
Environmental Sciences
Keiza Priscila Enes dos Santos, Isabella Ferreira Silva, Brayan Jonas Mano-Sousa, Joaquim Mauricio Duarte-Almeida, Whocely Victor de Castro, Rosy Iara Maciel de Azambuja Ribeiro, Helio Batista Santos, Ralph Gruppi Thom
Summary: The study evaluated the effects of the pesticide abamectin on adult zebrafish through acute and chronic exposure. The results showed that abamectin caused morphological changes in the liver cells, decreased expression of HSP70 and P-gp, and affected the behavior patterns of the fish. This highlights the potential harm of indiscriminate pesticide use on non-target organisms.
Article
Environmental Sciences
K. M. Sudesh Ruvinda, Asoka Pathiratne
Summary: The study found that both short term and chronic exposures to nanoTiO(2) had negative impacts on survival and development of tadpoles, resulting in reduced survival rates and histological alterations.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2021)
Article
Medicine, General & Internal
Jing Liu, Xiying Gong, Haifeng Lv, Shiyi Liu, Yanming Jiang, Geli Zhu, Xiaojie Ma, Jie Wang, Xiaoping Ye, Yidan Gao, Jie Li, Gongying Chen, Junping Shi
Summary: This study aimed to investigate the pathogenesis of chronic liver disease-related fatigue by examining the relationship between fatigue and inflammation severity. The results showed that fatigue burden in patients with chronic liver disease increased progressively with rising inflammation severity, particularly in young-aged and middle-aged patients.
Article
Dentistry, Oral Surgery & Medicine
Kristian Kniha, Eva Miriam Buhl, Benita Hermanns-Sachw, Faruk Al-Sibai, Anna Bock, Florian Peters, Frank Hoelzle, Ali Modabber
Summary: This pilot study identified temperature thresholds and durations, both in heat and cold, which induce bone necrosis, aiming to reduce the number of samples needed in further investigations on temperature-induced bone necrosis. Temperature inputs starting at 51 degrees C for 10 s and 5 degrees C for 30 s have shown significant matrix degeneration.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Medicine, Research & Experimental
Isaac M. Oderberg, Wolfram Goessling
Summary: In this study on a zebrafish model of severe hepatocyte injury, it is found that a population of biliary epithelial cells act as facultative liver stem cells in the regeneration process. These cells undergo transcriptional and morphological changes and are regulated by MAPK, PI3K, and mTOR signaling.
Article
Gastroenterology & Hepatology
Max Shen, Anna Lee, Jay H. Lefkowitch, Howard J. Worman
Summary: This study investigated the use of vibration-controlled transient elastography (VCTE) for assessing liver fibrosis in a clinical setting, finding that VCTE is reliable for ruling out cirrhosis but caution is needed when diagnosing cirrhosis due to its low positive predictive value. In some cases, the fibrosis stage determined by VCTE differed significantly from that determined by liver biopsy.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
D. Fanni, M. Guido, C. Gerosa, V. Vallascas, M. Moi, P. Coni, E. Vallebona, P. Van Eyken, D. Barcellona, A. Scano, G. Orru, P. Pampaloni, M. Castagnola, G. Faa
Summary: Wilson's Disease (WD) is difficult to diagnose due to its heterogeneous presentation, with histological patterns overlapping with other liver diseases. However, the preferential localization of steatosis and balloon cells in the periportal zone may be a useful clue for diagnosis. Variability in histological patterns was confirmed in WD, with lipogranuloma and fibrosis showing significant progression in follow-up biopsies.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Immunology
James B. Maurice, Robert Goldin, Andrew Hall, Jennifer C. Price, Giada Sebastiani, Caryn G. Morse, Laura Iogna Prat, Hugo Perazzo, Lucy Garvey, Patrick Ingiliz, Giovanni Guaraldi, Emmanouil Tsochatzis, Maud Lemoine
Summary: Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of liver disease in people living with human immunodeficiency virus (PLWH). This study found a strong association between body mass index and NAFLD, as well as between type 2 diabetes and advanced fibrosis in PLWH. Additionally, further optimization of serological markers for fibrosis is needed.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Entomology
Paulo Jose Balsamo, Felipe Lissoni de Andrade Nogueira, Leticia Ceschi-Bertoli, Raquel Fernanda Salla, Fabiana Martins Costa Maia, Silvia Pierre Irazusta, Guilherme Andrade Neto Schmitz Boeing, Fabio Camargo Abdalla
Summary: This study analyzed the effects of mercury (Hg) exposure on the hepato-nephrocitic system (HNS) of Bombus atratus workers. The results showed that exposure to Hg severely damaged the HNS of the bees, which could contribute to declines in their populations.
JOURNAL OF APICULTURAL RESEARCH
(2023)
Article
Ecology
Rafaela Tadei, Claudia Ines da Silva, Pamela Decio, Elaine C. M. Silva-Zacarin, Osmar Malaspina
Summary: Although solitary bees make up a significant percentage of bee species, research on the ecotoxicology of bees has mainly focused on social species. This study addresses the challenge of maintaining solitary bees under laboratory conditions by developing a method to maintain adult individuals of Centris analis. The study identifies cage models and optimal conditions for the survival and adaptation of these bees, providing a feasible method for future toxicological studies on solitary bees.
METHODS IN ECOLOGY AND EVOLUTION
(2022)
Article
Anatomy & Morphology
Rafael Oliveira Bordin, Carlos Eurico dos Santos Fernandes, Lilian Franco-Belussi, Taynara Ribeiro Farias Leao, Marciana Sanabria
Summary: This study evaluated the morphological characteristics of testes and sperm in an urban environment for Leptodactylus podicipinus. The results showed correlations between testis mass and spermatozoon length, as well as heterogeneity in the morphology of sperm heads and tails.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2022)
Article
Psychology, Biological
Lucas Rodriguez Forti, Maria Rita de Melo Sampaio, Clara Resende Pires, Judit K. Szabo, Luis Felipe Toledo
Summary: This study explores the effect of noise on amphibians' acoustic communication and finds that frogs can adjust their calls to minimize the masking effect of background noise by reducing the frequency bandwidth.
BEHAVIOURAL PROCESSES
(2022)
Article
Multidisciplinary Sciences
Gabriel Jorgewich-Cohen, Luis Felipe Toledo, Taran Grant
Summary: Non-native species are a significant problem in various biomes worldwide. Understanding their population genetics is essential to comprehend their invasion history and dynamics. This study assessed the population structure of the non-native American bullfrog in Brazil, using genetic analysis of samples collected from feral and captive groups. The results indicated that there are two distinct populations of bullfrogs in Brazil, with limited genetic exchange between them. Additionally, there was no genetic differentiation between feral and captive populations, suggesting continuous releases. The findings also highlighted the importance of preventing escapes from farms to control the feral bullfrog population.
SCIENTIFIC REPORTS
(2022)
Article
Biodiversity Conservation
Janaina de Andrade Serrano, Luis Felipe Toledo, Lilian Patricia Sales
Summary: This study investigates the influence of scale on different drivers affecting the occurrence of the chytrid fungus in the Atlantic Forest, Brazil. The Human Footprint Index was found to have a greater impact on the occurrence of the pathogenic species compared to biotic and abiotic factors. However, no differences in the relative influence of predictors were observed at the landscape scale.
PERSPECTIVES IN ECOLOGY AND CONSERVATION
(2022)
Article
Biodiversity Conservation
Matheus de Toledo Moroti, Marcos Rafael Severgnini, Joao Pedro Bolovon, Luis Felipe Toledo, Edelcio Muscat
Summary: We monitored a population of Paratelmatobius mantiqueira for 13 months, gathering new data on external morphology, acoustic repertoire, and behaviors of the species. We found that temperature and humidity influenced the detectability of the species.
JOURNAL OF NATURAL HISTORY
(2022)
Article
Biodiversity Conservation
Luis Felipe Toledo, Sergio Potsch de Carvalho-e-Silva, Ana Maria Paulino Telles de Carvalho-e-Silva, Joao Luiz Gasparini, Delio Baeta, Raoni Reboucas, Celio F. B. Haddad, C. Guilherme Becker, Tamilie Carvalho
Summary: Amphibian declines are a global problem, and Brazil's Atlantic Forest is a hotspot for these declines. Previous reports underestimated the extent and complexity of historical declines in amphibian populations. Our refined review reveals that the Atlantic Forest has one of the highest rates of amphibian declines and extinctions globally.
BIOLOGICAL CONSERVATION
(2023)
Article
Environmental Sciences
Heidi Samantha Moraes Utsunomiya, Joao Victor Cassiel Ferraz, Gabriel Hiroshi Fujiwara, Davi Marques Gutierres, Isabela Ferreira Fernandes, Bruno Serra de Lacerda Valverde, Classius de Oliveira, Lilian Franco-Belussi, Marisa Narciso Fernandes, Cleoni dos Santos Carvalho
Summary: This study evaluated the effects of exposure to water from different sites of the Sorocaba River on genetic damage, oxidative stress, neurotoxicity, and energy metabolism in bullfrog tadpoles. The results indicated that exposure to water from different sites caused changes in various indicators, which may have effects on the development of tadpoles.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Marine & Freshwater Biology
Joelma S. Prado, Julia R. Ernetti, Mariana Retuci Pontes, L. Felipe Toledo
Summary: This research provides evidence that fog water may serve as a pathway for the transmission of the amphibian-killing fungus Bd. The study shows the passive transport of live Bd zoospores through artificial fog can infect susceptible hosts and lead to lethal chytridiomycosis. These findings are important for understanding the exposure mechanisms of direct-developing amphibians to aquatic pathogens and can aid in the development of control measures.
Article
Biodiversity Conservation
Lucas M. Botelho, Ana Clara F. Barbosa, Joelma S. Prado, Mariana Pedrozo, Matheus de Toledo Moroti, L. Felipe Toledo, Edelcio Muscat
Summary: The genus Dendrophryniscus includes 16 species of frogs endemic to the Atlantic Forest. They have different habitat preferences and reproductive strategies. Additional information such as natural history, larval morphology, and molecular and acoustic data would contribute to better species identification.
JOURNAL OF NATURAL HISTORY
(2023)
Article
Biochemistry & Molecular Biology
Coby A. McDonald, C. Guilherme Becker, Carolina Lambertini, L. Felipe Toledo, Celio F. B. Haddad, Kelly R. Zamudio
Summary: Infectious diseases of wildlife pose a threat to biodiversity globally, but the virulence and host responses to pathogens are not uniform. Batrachochytrium dendrobatidis (Bd), a fungus that causes amphibian decline, consists of a highly virulent lineage (Bd-GPL) and multiple geographically restricted lineages. This study examines the host immune response to Bd-GPL and a geographically restricted lineage (Bd-Brazil) in pumpkin toadlets.
Article
Biodiversity Conservation
Carlos Henrique de-Oliveira-Nogueira, Ubirata Ferreira Souza, Thaynara Mendes Machado, Caio Antonio Figueiredo-de-Andrade, Alexander Tamanini Monico, Ivan Sazima, Marlies Sazima, Luis Felipe Toledo
Summary: Pollination and seed dispersal are crucial for plant survival, with mammals and birds being the main players. Surprisingly, the amphibian species Xenohyla truncata has been observed consuming various plant parts, including fruits, flowers, and nectar, and carrying pollen grains on its back. This unexpected interaction suggests that the treefrog may serve as a potential pollinator, in addition to its known role as a seed disperser. This unique finding highlights unforeseen relationships between amphibians and plants.
Article
Zoology
Sandriely F. Marcondes, Mayara S. Siqueira, Taynara R. F. Leao, Robson A. Rodrigues, Karine N. N. Farias, Andre L. N. Silva, Lilian Franco-Belussi, Carlos E. Fernandes
Summary: This study compared the histological characteristics of caudal kidneys between male and female Pygocentrus nattereri fish and associated them with the renosomatic index. The results showed that there were no biometric differences between the sexes, but body weight and standard length were correlated with the renosomatic index. Female fish had higher renal corpuscle area and glomerulus area, indicating possible metabolic differences between males and females.
NEOTROPICAL ICHTHYOLOGY
(2023)
Article
Multidisciplinary Sciences
Rodrigo Zieri, Lilian Franco-Belussi, Classius De Oliveira
Summary: In this study, the researchers investigated the short-term effects of alpha-MSH on melanophores, melanocytes, and melanomacrophages in the South American frog Physalaemus nattereri. They found that these melanin-containing cells increased their pigmentation after receiving the hormone, but the response varied among different organs.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2023)