Article
Endocrinology & Metabolism
David Rodbard
Summary: The study found that continuous glucose monitoring (CGM) metrics, such as interstitial fluid Mean Glucose level, proportion of time above range (%TAR), and proportion of time in range (%TIR), correlated with glycated haemoglobin (HbA1c) and can be used to evaluate therapeutic efficacy. Mean Glucose showed the highest correlation with %TAR but weaker correlations with %TIR or HbA1c. These metrics can be combined with indicators of hypoglycaemia and/or glycaemic variability to provide a more comprehensive assessment of glycaemic control.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
I. Dicembrini, C. Cosentino, M. Monami, E. Mannucci, L. Pala
Summary: This study evaluated the impact of CGM and FGM on glycemic control in patients with type 1 diabetes, showing that CGM can reduce HbA1c levels and decrease the risk of severe hypoglycemia.
ACTA DIABETOLOGICA
(2021)
Article
Public, Environmental & Occupational Health
Alejandra Marco, Marcos Pazos-Couselo, Jesus Moreno-Fernandez, Ana Diez-Fernandez, Manuela Alonso-Sampedro, Carmen Fernandez-Merino, Arturo Gonzalez-Quintela, Francisco Gude
Summary: This study investigated the prognostic value of time range metrics measured by continuous glucose monitoring for the development of type 2 diabetes. The results showed that time above range provides additional information to glycated hemoglobin in identifying individuals at higher risk of developing type 2 diabetes in a population-based study.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Xiaofang Wen, Tingting Ou, Nan Zeng, Xiaowei Li, Ai Luo, Xiaojia Xu, Wangen Li, Tao Du
Summary: This study evaluated the accuracy and clinic profile of FCGM data out of range in T2DM patients, and found significant differences in the distribution and consistency rate between LO and HI cases at different time points. It is recommended to interpret the results and treatment regarding FCGM LO data with caution.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Lalantha Leelarathna, Mark L. L. Evans, Sankalpa Neupane, Gerry Rayman, Sarah Lumley, Iain Cranston, Parth Narendran, Katharine Barnard-Kelly, Christopher J. J. Sutton, Rachel A. A. Elliott, Vicky P. P. Taxiarchi, Georgios Gkountouras, Matthew Burns, Womba Mubita, Naresh Kanumilli, Maisie Camm, Hood Thabit, Emma G. G. Wilmot
Summary: This study investigated the efficacy of intermittently scanned continuous glucose monitoring in patients with type 1 diabetes. The results showed that compared to traditional fingerstick testing, the use of intermittently scanned continuous glucose monitoring significantly reduced glycated hemoglobin levels and improved blood glucose control.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Akemi Tokutsu, Yosuke Okada, Keiichi Torimoto, Yoshiya Tanaka
Summary: The study found that HbA1c variability is associated with hypoglycemia, suggesting the need to evaluate low blood sugar in patients with high HbA1c variability and reconsider their treatment regimen.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Endocrinology & Metabolism
Tomoya Mita, Naoto Katakami, Yosuke Okada, Hidenori Yoshii, Takeshi Osonoi, Keiko Nishida, Toshihiko Shiraiwa, Akira Kurozumi, Naohiro Taya, Satomi Wakasugi, Fumiya Sato, Ryota Ishii, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada
Summary: This study found a significant association between CGM-derived indices, such as time in range (TIR) and coefficient of variation (CV), and changes in the tissue characteristics of the carotid artery wall, providing further evidence for the association between glucose variability and atherosclerosis progression.
Article
Endocrinology & Metabolism
Marco Marigliano, Riccardo Pertile, Enza Mozzillo, Alda Troncone, Claudio Maffeis, Elisa Morotti, Francesca Di Candia, Ludovica Fedi, Dario Iafusco, Angela Zanfardino, Vittoria Cauvin, Giulio Maltoni, Stefano Zucchini, Valentino Cherubini, Valentina Tiberi, Nicola Minuto, Marta Bassi, Ivana Rabbone, Silvia Savastio, Davide Tinti, Gianluca Tornese, Riccardo Schiaffini, Stefano Passanisi, Fortunato Lombardo, Riccardo Bonfanti, Andrea Scaramuzza, Roberto Franceschi
Summary: This study investigated the relationship between satisfaction with continuous glucose monitoring (CGM) and glucose control in pediatric patients with type 1 diabetes (T1D). The results showed that satisfaction was positively correlated with time in range and negatively correlated with glycemia risk index.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Diana Tundidor, Claire L. Meek, Jennifer Yamamoto, Cecilia Martinez-Bru, Ignasi Gich, Denice S. Feig, Helen R. Murphy, Rosa Corcoy
Summary: The CONCEPTT trial found that pregnant women with type 1 diabetes had low rates of CGM and HbA(1c) target attainment, but these rates increased with RT-CGM use and throughout gestation. However, achieving the TBR target was associated with increased risk of pre-eclampsia and neonatal hypoglycemia, indicating the need for further study. Achievement of ADA HbA(1c) target was independently associated with better perinatal outcomes.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Anna McLean, Elizabeth Barr, Georgina Tabuai, Helen R. Murphy, Louise Maple-Brown
Summary: This study aimed to describe glucose metrics in a high-risk population of women with type 2 diabetes (T2DM) in pregnancy and explore their associations with neonatal outcomes. The results showed that CGM metrics only improved during pregnancy in women with greater sensor use and were associated with large for gestational age (LGA) in early pregnancy and neonatal hypoglycemia. Culturally appropriate health care strategies are critical for successful use of CGM technology.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Elizabeth Selvin, Dan Wang, Mary R. Rooney, Justin Echouffo-Tcheugui, Michael Fang, Scott Zeger, Joseph Sartini, Olive Tang, Josef Coresh, R. Nisha Aurora, Naresh M. Punjabi
Summary: This study examined the associations between mean glucose and time in range from continuous glucose monitoring (CGM) and HbA1c in adults with type 2 diabetes. The results showed a strong correlation between mean glucose and HbA1c, but there were individual-level discrepancies. Clinicians can use HbA1c and CGM together to assess blood glucose control.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Marina Valenzano, Ivan Cibrario Bertolotti, Adriano Valenzano, Giorgio Grassi
Summary: The study confirmed a strong correlation between continuous glucose monitoring (CGM) metrics and hemoglobin A1c (HbA1c) using real-world data, but also noted statistical differences between different devices, suggesting the need for tailored models. Further investigations are needed to explore the predictive power of A1C as a TIR estimator.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Endocrinology & Metabolism
Joshi Prabhu Navis, Lalantha Leelarathna, Womba Mubita, Andrea Urwin, Martin K. Rutter, Jonathan Schofield, Hood Thabit
Summary: Sensor-based glycaemic outcomes in people with T1D improved during the COVID-19 lockdown, potentially due to positive changes in self-management strategies. Further research is needed to assess long-term sustainability and support.
ACTA DIABETOLOGICA
(2021)
Article
Endocrinology & Metabolism
Melanie A. Jackson, Andrew Ahmann, Viral N. Shah
Summary: Continuous glucose monitoring plays a crucial role in managing type 1 diabetes, and recent studies suggest its potential benefits in type 2 diabetes as well, improving glycemic control and reducing the risk of hypoglycemia. Further research is needed to explore the utility of CGM in this population.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Article
Chemistry, Analytical
Yiqun Liu, Li Yang, Yue Cui
Summary: Diabetes is a prevalent and chronic metabolic disease, and continuous monitoring is crucial for its management. Transdermal glucose biosensors offer accurate monitoring, but face challenges in biosensing principles, device configuration, and material integration. This review aims to address these questions and explore the practical applications of transdermal glucose biosensors.
Article
Endocrinology & Metabolism
Angela Napoli, Laura Sciacca, Basilio Pintaudi, Andrea Tumminia, Maria Grazia Dalfra, Camilla Festa, Gloria Formoso, Raffaella Fresa, Giusi Graziano, Cristina Lencioni, Antonio Nicolucci, Maria Chiara Rossi, Elena Succurro, Maria Angela Sculli, Marina Scavini, Ester Vitacolonna, Matteo Bonomo, Elisabetta Torlone
Summary: The study aimed to assess the proportion of women with gestational diabetes (GDM) who develop postpartum dysglycemia (PPD) and identify high-risk GDM phenotypes. Results showed that 23.0% of women who underwent OGTT developed PPD, with insulin-treated women with a family history of diabetes having the highest risk. Insulin-treated women without family history and those with a higher pre-pregnancy BMI also showed increased risk.
ACTA DIABETOLOGICA
(2021)
Correction
Endocrinology & Metabolism
Vasudha Ahuja, Pasi Aronen, T. A. Pramodkumar, Helen Looker, Angela Chetrit, Aini H. Bloigu, Auni Juutilainen, Cristina Bianchi, Lucia La Sala, Ranjit Mohan Anjana, Rajendra Pradeepa, Ulagamadesan Venkatesan, Sarvanan Jebarani, Viswanathan Baskar, Teresa Vanessa Fiorentino, Patrick Timpel, Ralph A. DeFronzo, Antonio Ceriello, Stefano Del Prato, Muhammad Abdul-Ghani, Sirkka Keinanen-Kiukaanniemi, Rachel Dankner, Peter H. Bennett, William C. Knowler, Peter Schwarz, Giorgio Sesti, Rie Oka, Viswanathan Mohan, Leif Groop, Jaakko Tuomilehto, Samuli Ripatti, Michael Bergman, Tiinamaija Tuomi
Article
Endocrinology & Metabolism
Pierpaolo Falcetta, Michele Aragona, Alessandra Bertolotto, Cristina Bianchi, Fabrizio Campi, Monia Garofolo, Stefano Del Prato
Summary: The discovery of insulin in 1921 by a Canadian research team in Toronto has been a significant achievement in medical history. Insulin has transformed the lives of people with diabetes, who previously faced a fatal condition. It was the first hormone to be purified for human use, unraveled in its amino acid sequence, and synthesized using DNA-recombinant technique. The discovery of insulin represents a pivotal point in medical history and continues to be improved for better effectiveness and safety.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Endocrinology & Metabolism
Cristina Bianchi, Francesco Raggi, Chiara Rossi, Simona Frontoni, Riccardo C. Bonadonna, Stefano Del Prato, Anna Solini
Summary: The study reveals that MG53 is associated with glucose tolerance, and higher levels of MG53 are related to worsened glucose regulation and impaired beta-cell function. Among individuals at high risk of T2DM, those with higher baseline MG53 levels are more likely to progress to T2DM.
DIABETES & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Rumyana Dimova, Nevena Chakarova, Giuseppe Daniele, Cristina Bianchi, Angela Dardano, Stefano Del Prato, Tsvetalina Tankova
Summary: This study aimed to assess the relationship between insulin secretion and sensitivity, and daily glucose variability (GV) in the early stages of dysglycemia. The results showed that impairment of glucose tolerance was associated with worsening GV, and the increase in GV was inversely related to insulin secretion and action.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Multidisciplinary Sciences
Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C. Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F. Markmann, Emanuela Orsi, Jan Skrha, Maria Gabriella Camboni, Reza Abdi, A. M. James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zuccotti, Paolo Fiorina
Summary: In this study, the Authors demonstrated that the IGFBP3/TMEM219 pathway plays a crucial role in regulating pancreatic beta cell homeostasis and its dysregulation is associated with diabetes. Targeting the IGFBP3/TMEM219 pathway may be a potential therapeutic option for treating diabetes.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Francesca Nicoli, Alessandro Prete, Fabrizia Citro, Alessandra Bertolotto, Lorella Battini, Giovanni de Gennaro, Stefano Del Prato, Cristina Bianchi
Summary: This study evaluated the association between sleep disturbances and gestational diabetes. The study found that short sleep duration was associated with a higher prevalence of gestational diabetes, but it did not persist as an independent risk factor for gestational diabetes in high-risk women.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Letter
Endocrinology & Metabolism
Fabrizia Citro, Alessandra Bertolotto, Michele Aragona, Francesca Nicoli, Cristina Bianchi
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Cristina Bianchi, Alex Brocchi, Walter Baronti, Francesca Nicoli, Fabrizia Citro, Michele Aragona, Vito Cela, Stefano Del Prato, Alessandra Bertolotto
Summary: This study aimed to evaluate the impact of assisted reproductive technology (ART) on the risk of gestational diabetes mellitus (GDM) in single pregnancies. The study found that ART women had a significantly higher prevalence of GDM compared to women with spontaneous conception, and ART women above the age of 40 were more likely to develop GDM. Additionally, ART treatment appeared to be associated with an increased rate of preterm delivery, lower neonatal birth weight, and Apgar score, especially in women with GDM.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Cristina Bianchi, Veronica Resi, Elisa Manicardi, Silvia Burlina, Maria Angela Sculli, Gloria Formoso, Laura Sciacca
Summary: This article reviews two recent papers published in the New England Journal of Medicine on the screening and diagnostic methods for gestational diabetes mellitus (GDM), and discusses their implications for the management of pregnant women.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Cristina Bianchi, Olga Vaccaro, Mariarosaria Distaso, Laura Franzini, Francesco Raggi, Anna Solini
Summary: MG53 is not associated with cardiovascular risk profile or long-term mortality in Caucasian individuals with T2D.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Daniela Lucchesi, Emioli Randazzo, Stefano Del Prato, Cristina Bianchi
Summary: Maturity Onset Diabetes of the Young (MODY) is a monogenic autosomal dominant disorder that affects 1-5% of all diabetes mellitus patients. GCK and HNF1A gene mutations are the most common causes of MODY in Caucasians. This study reports on two family members with genetic variants in both GCK and HNF1A genes and their nine-year clinical follow-up. The findings highlight the importance of caution when encountering variants in two genes in a single patient and emphasize the need for collaboration with MODY genetics experts for accurate diagnosis and treatment.
ACTA DIABETOLOGICA
(2023)
Article
Endocrinology & Metabolism
Pierpaolo Falcetta, Francesca Nicoli, Fabrizia Citro, Annamaria Ciccarone, Monia Garofolo, Stefano Del Prato, Cristina Bianchi
Summary: The study aimed to evaluate the impact of adding a GLP-1 RA in individuals with T2D on a BB insulin regimen. The results showed that HbA1c and body weight significantly decreased at 6 months after starting GLP-1 RA therapy and remained stable up to 24 months. In addition, at 24 months, a large percentage of subjects discontinued prandial and basal insulin. The findings suggest that replacing prandial insulin with GLP-1 RA is a valuable strategy to simplify the BB insulin regimen, improve glycemic control, and promote weight loss in people with T2D.
ACTA DIABETOLOGICA
(2023)
Article
Endocrinology & Metabolism
Laura Sciacca, Cristina Bianchi, Silvia Burlina, Gloria Formoso, Elisa Manicardi, Maria Angela Sculli, Veronica Resi
Summary: This document provides a comprehensive review on the role of metformin therapy in pregnancy complicated by obesity, gestational diabetes, type 2 diabetes mellitus, polycystic ovary syndrome, and assisted reproductive technology. The study suggests that metformin can improve maternal glycemic control and reduce birth weight, but the long-term effects of in utero exposure to metformin need further research.
ACTA DIABETOLOGICA
(2023)
Article
Endocrinology & Metabolism
Gloria Formoso, Cristina Bianchi, Silvia Burlina, Elisa Manicardi, Maria Angela Sculli, Veronica Resi, Laura Sciacca
Summary: This study aimed to investigate the knowledge, attitude, and practice of Italian healthcare professionals managing nutritional therapy in pregnancies complicated by diabetes regarding the recommendations of the Institute of Medicine (IOM). The survey found that personalized diet plans were more common than standard diet plans or healthy dietary advice for pregnant women with diabetes. Most participants evaluated appropriate gestational weight gain based on pre-pregnancy BMI, gestational weight gain at the first prenatal visit, and the presence of twin pregnancy. Maternal weight gain was regularly assessed and compared with IOM recommendations.
ACTA DIABETOLOGICA
(2022)