Genetic determinants of antiviral immunity in dipteran insects – compiling the experimental evidence

A satellite repeat-derived piRNA controls embryonic development of Aedes

(2020) Rebecca Halbach et al.   NATURE

The impact of autophagy on arbovirus infection of mosquito cells

(2020) Doug E. Brackney et al.   PLoS Neglected Tropical Diseases

Non-retroviral Endogenous Viral Element Limits Cognate Virus Replication in Aedes aegypti Ovaries

(2020) Yasutsugu Suzuki et al.   CURRENT BIOLOGY

Role of autophagy during the replication and pathogenesis of common mosquito-borne flavi- and alphaviruses

(2019) Liliana Echavarria-Consuegra et al.   Open Biology

Mosquito Small RNA Responses to West Nile and Insect-Specific Virus Infections in Aedes and Culex Mosquito Cells

(2019) Giel Göertz et al.   Viruses-Basel

Regulation of the Drosophila Imd pathway by signaling amyloids

(2019) Anni Kleino et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Toll family members bind multiple Spätzle proteins and activate antimicrobial peptide gene expression in Drosophila

(2019) Munmun Chowdhury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small RNA responses of Culex mosquitoes and cell lines during acute and persistent virus infection

(2019) Claudia Rückert et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

JAK/STAT signaling in insect innate immunity

(2019) In Seok Bang   ENTOMOLOGICAL RESEARCH

A DNA virus-encoded immune antagonist fully masks the potent antiviral activity of RNAi in Drosophila

(2019) Alfred W. Bronkhorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

piRNA-Guided CRISPR-like Immunity in Eukaryotes

(2019) Youdiil Ophinni et al.   TRENDS IN IMMUNOLOGY

Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors

(2019) Laura R.H. Ahlers et al.   Cell Reports

Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements

(2019) Michel Tassetto et al.   eLife

Deducing the Role of Virus Genome-Derived PIWI-Associated RNAs in the Mosquito–Arbovirus Arms Race

(2019) Carol D. Blair   Frontiers in Genetics

Identification of Regulatory Host Genes Involved in Sigma Virus Replication Using RNAi Knockdown in Drosophila

(2019) Liao et al.   Insects

New insights on Drosophila antimicrobial peptide function in host defense and beyond

(2019) Mark Austin Hanson et al.   CURRENT OPINION IN IMMUNOLOGY

How are arbovirus vectors able to tolerate infection?

(2019) José Henrique Oliveira et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain

(2018) Yuan Liu et al.   Cell Host & Microbe

RNA-Interference Pathways Display High Rates of Adaptive Protein Evolution in Multiple Invertebrates

(2018) William H. Palmer et al.   GENETICS

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spindle-E Acts Antivirally Against Alphaviruses in Mosquito Cells

(2018) Margus Varjak et al.   Viruses-Basel

Natural Variation in Resistance to Virus Infection in Dipteran Insects

(2018) William Palmer et al.   Viruses-Basel

p38b and JAK-STAT signaling protect against Invertebrate iridescent virus 6 infection in Drosophila

(2018) Cara West et al.   PLoS Pathogens

Optimization of double-stranded RNAi intrathoracic injection method in Aedes aegypti

(2018) Seokyoung Kang et al.   ENTOMOLOGICAL RESEARCH

RNA-Interference Pathways Display High Rates of Adaptive Protein Evolution in Multiple Invertebrates

(2018) William H. Palmer et al.   GENETICS

The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila

(2018) Akira Goto et al.   IMMUNITY

piRNA-Guided Genome Defense: From Biogenesis to Silencing

(2018) Benjamin Czech et al.   Annual Review of Genetics

Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis

(2018) Sunny Trivedi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The antiviral piRNA response in mosquitoes?

(2018) Margus Varjak et al.   JOURNAL OF GENERAL VIROLOGY

Dicer-2 Regulates Resistance and Maintains Homeostasis against Zika Virus Infection in Drosophila

(2018) Sneh Harsh et al.   JOURNAL OF IMMUNOLOGY

Improved reference genome of Aedes aegypti informs arbovirus vector control

(2018) Benjamin J. Matthews et al.   NATURE

The Tudor protein Veneno assembles the ping-pong amplification complex that produces viral piRNAs in Aedes mosquitoes

(2018) Joep Joosten et al.   NUCLEIC ACIDS RESEARCH

Immune priming and clearance of orally acquired RNA viruses in Drosophila

(2018) Juan A. Mondotte et al.   Nature Microbiology

Control of dengue virus in the midgut of Aedes aegypti by ectopic expression of the dsRNA-binding protein Loqs2

(2018) Roenick P. Olmo et al.   Nature Microbiology

Argonaute 2 Suppresses Japanese Encephalitis Virus Infection in Aedes aegypti

(2017) Toshinori Sasaki et al.   JAPANESE JOURNAL OF INFECTIOUS DISEASES

Uncovering the Repertoire of Endogenous Flaviviral Elements in Aedes Mosquito Genomes

(2017) Yasutsugu Suzuki et al.   JOURNAL OF VIROLOGY

Loquacious-PD facilitatesDrosophilaDicer-2 cleavage through interactions with the helicase domain and dsRNA

(2017) Kyle D. Trettin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the Zika virus induced small RNA response in Aedes aegypti cells

(2017) Margus Varjak et al.   PLoS Neglected Tropical Diseases

The Antiviral RNAi Response in Vector and Non-vector Cells against Orthobunyaviruses

(2017) Isabelle Dietrich et al.   PLoS Neglected Tropical Diseases

Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus

(2017) Natapong Jupatanakul et al.   PLoS Neglected Tropical Diseases

An Aedes aegypti-associated fungus increases susceptibility to dengue virus by modulating gut trypsin activity

(2017) Yesseinia I Angleró-Rodríguez et al.   eLife

Aedes aegypti Molecular Responses to Zika Virus: Modulation of Infection by the Toll and Jak/Stat Immune Pathways and Virus Host Factors

(2017) Yesseinia I. Angleró-Rodríguez et al.   Frontiers in Microbiology

RNA Interference Restricts Rift Valley Fever Virus in Multiple Insect Systems

(2017) Isabelle Dietrich et al.   mSphere

Aedes aegypti Piwi4 Is a Noncanonical PIWI Protein Involved in Antiviral Responses

(2017) Margus Varjak et al.   mSphere

The RNAi pathway plays a small part in Wolbachia-mediated blocking of dengue virus in mosquito cells

(2017) Gerard Terradas et al.   Scientific Reports

The selective antifungal activity of Drosophila melanogaster metchnikowin reflects the species-dependent inhibition of succinate–coenzyme Q reductase

(2017) Mohammad-Reza Bolouri Moghaddam et al.   Scientific Reports

The diversity of insect antiviral immunity: insights from viruses

(2016) João T Marques et al.   CURRENT OPINION IN MICROBIOLOGY

Duplication and Diversification of Dipteran Argonaute Genes, and the Evolutionary Divergence of Piwi and Aubergine

(2016) Samuel H. Lewis et al.   Genome Biology and Evolution

Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity

(2016) Olivier Lamiable et al.   JOURNAL OF VIROLOGY

Diversity, evolution and medical applications of insect antimicrobial peptides

(2016) Eleftherios Mylonakis et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

piRNA pathway is not required for antiviral defense inDrosophila melanogaster

(2016) Marine Petit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yellow fever virus capsid protein is a potent suppressor of RNA silencing that binds double-stranded RNA

(2016) Glady Hazitha Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine Diedel and a viral homologue suppress the IMD pathway inDrosophila

(2016) Olivier Lamiable et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIWIs Go Viral: Arbovirus-Derived piRNAs in Vector Mosquitoes

(2016) Pascal Miesen et al.   PLoS Pathogens

Microbiota-Dependent Priming of Antiviral Intestinal Immunity in Drosophila

(2015) Christine L. Sansone et al.   Cell Host & Microbe

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

(2015) Andrew Hammond et al.   NATURE BIOTECHNOLOGY

Distinct sets of PIWI proteins produce arbovirus and transposon-derived piRNAs inAedes aegyptimosquito cells

(2015) Pascal Miesen et al.   NUCLEIC ACIDS RESEARCH

The hub protein loquacious connects the microRNA and short interfering RNA pathways in mosquitoes

(2015) Mary Etna Haac et al.   NUCLEIC ACIDS RESEARCH

Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis inAedes aegypti

(2015) Sanjay Basu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors

(2015) Sadeem Ahmad et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tissue Barriers to Arbovirus Infection in Mosquitoes

(2015) Alexander Franz et al.   Viruses-Basel

Genome Engineering with CRISPR-Cas9 in the Mosquito Aedes aegypti

(2015) Kathryn E. Kistler et al.   Cell Reports

Arbovirus–mosquito interactions: RNAi pathway

(2015) Ken E Olson et al.   Current Opinion in Virology

Cullin4 Is Pro-Viral during West Nile Virus Infection of Culex Mosquitoes

(2015) Prasad N. Paradkar et al.   PLoS Pathogens

The Epigenetic Regulator G9a Mediates Tolerance to RNA Virus Infection in Drosophila

(2015) Sarah H. Merkling et al.   PLoS Pathogens

Antiviral Autophagy Restricts Rift Valley Fever Virus Infection and Is Conserved from Flies to Mammals

(2014) Ryan H. Moy et al.   IMMUNITY

The Caspase-8 Homolog Dredd Cleaves Imd and Relish but Is Not Inhibited by p35

(2014) Chan-Hee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Drosophila Imd Signaling Pathway

(2014) H. Myllymaki et al.   JOURNAL OF IMMUNOLOGY

A dsRNA-binding protein of a complex invertebrate DNA virus suppresses the Drosophila RNAi response

(2014) Alfred W. Bronkhorst et al.   NUCLEIC ACIDS RESEARCH

Antiviral immunity ofAnopheles gambiaeis highly compartmentalized, with distinct roles for RNA interference and gut microbiota

(2014) Guillaume Carissimo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK/STAT Pathway inDrosophilaImmunity

(2014) H. Myllymäki et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The long and short of antiviral defense: small RNA-based immunity in insects

(2014) Alfred W Bronkhorst et al.   Current Opinion in Virology

Characterization of Aedes aegypti Innate-Immune Pathways that Limit Chikungunya Virus Replication

(2014) Melanie McFarlane et al.   PLoS Neglected Tropical Diseases

Dicer-2-Dependent Activation of Culex Vago Occurs via the TRAF-Rel2 Signaling Pathway

(2014) Prasad N. Paradkar et al.   PLoS Neglected Tropical Diseases

Complement-Related Proteins Control the Flavivirus Infection of Aedes aegypti by Inducing Antimicrobial Peptides

(2014) Xiaoping Xiao et al.   PLoS Pathogens

The Toll-Dorsal Pathway Is Required for Resistance to Viral Oral Infection in Drosophila

(2014) Álvaro Gil Ferreira et al.   PLoS Pathogens

The mosquito microbiota influences vector competence for human pathogens

(2014) Nathan J Dennison et al.   Current Opinion in Insect Science

Conventional and non-conventional Drosophila Toll signaling

(2013) Scott A. Lindsay et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The Drosophila IMD pathway in the activation of the humoral immune response

(2013) Anni Kleino et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Knockdown of piRNA pathway proteins results in enhanced Semliki Forest virus production in mosquito cells

(2013) E. Schnettler et al.   JOURNAL OF GENERAL VIROLOGY

An Antiviral Role for Antimicrobial Peptides during the Arthropod Response to Alphavirus Replication

(2013) Z. Huang et al.   JOURNAL OF VIROLOGY

Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms

(2013) Wojciech Stec et al.   MOLECULAR BIOLOGY OF THE CELL

The IRAK Homolog Pelle Is the Functional Counterpart of IκB Kinase in the Drosophila Toll Pathway

(2013) Jessica Daigneault et al.   PLoS One

ERK signaling couples nutrient status to antiviral defense in the insect gut

(2013) J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptomic Profiling of Diverse Aedes aegypti Strains Reveals Increased Basal-level Immune Activation in Dengue Virus-refractory Populations and Identifies Novel Virus-vector Molecular Interactions

(2013) Shuzhen Sim et al.   PLoS Neglected Tropical Diseases

Correction: Functional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection

(2013) Joao Trindade Marques et al.   PLoS Pathogens

Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila

(2012) Balázs Érdi et al.   Autophagy

Transcriptional Pausing Controls a Rapid Antiviral Innate Immune Response in Drosophila

(2012) Jie Xu et al.   Cell Host & Microbe

Regulation of small RNA stability: methylation and beyond

(2012) Lijuan Ji et al.   CELL RESEARCH

Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling

(2012) Annika Meinander et al.   EMBO JOURNAL

Virus Recognition by Toll-7 Activates Antiviral Autophagy in Drosophila

(2012) Margaret Nakamoto et al.   IMMUNITY

Autophagy and selective deployment of Atg proteins in antiviral defense

(2012) B. Yordy et al.   INTERNATIONAL IMMUNOLOGY

Broad RNA Interference-Mediated Antiviral Immunity and Virus-Specific Inducible Responses in Drosophila

(2012) C. Kemp et al.   JOURNAL OF IMMUNOLOGY

Endogenous viruses: insights into viral evolution and impact on host biology

(2012) Cédric Feschotte et al.   NATURE REVIEWS GENETICS

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway

(2012) P. N. Paradkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA virus Invertebrate iridescent virus 6 is a target of the Drosophila RNAi machinery

(2012) A. W. Bronkhorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anopheles gambiae Antiviral Immune Response to Systemic O'nyong-nyong Infection

(2012) Joanna Waldock et al.   PLoS Neglected Tropical Diseases

Reciprocal Tripartite Interactions between the Aedes aegypti Midgut Microbiota, Innate Immune System and Dengue Virus Influences Vector Competence

(2012) Jose Luis Ramirez et al.   PLoS Neglected Tropical Diseases

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3

(2011) Victoria M. Wright et al.   CELLULAR SIGNALLING

The entomopathogenic fungus Beauveria bassiana activate toll and JAK-STAT pathway-controlled effector genes and anti-dengue activity in Aedes aegypti

(2011) Yuemei Dong et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Drosophila Toll Signaling Pathway

(2011) S. Valanne et al.   JOURNAL OF IMMUNOLOGY

PIWI-interacting small RNAs: the vanguard of genome defence

(2011) Mikiko C. Siomi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Episodic radiations in the fly tree of life

(2011) B. M. Wiegmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti

(2011) X. Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative genetics of Aedes aegypti vector competence for dengue viruses: towards a new paradigm?

(2011) Louis Lambrechts   TRENDS IN PARASITOLOGY

Transcriptome Analysis of Aedes aegypti Transgenic Mosquitoes with Altered Immunity

(2011) Zhen Zou et al.   PLoS Pathogens

Induction of a Peptide with Activity against a Broad Spectrum of Pathogens in the Aedes aegypti Salivary Gland, following Infection with Dengue Virus

(2011) Natthanej Luplertlop et al.   PLoS Pathogens

The RNA interference pathway affects midgut infection- and escape barriers for Sindbis virus in Aedes aegypti

(2010) Cynthia CH Khoo et al.   BMC MICROBIOLOGY

Innate antiviral immunity in Drosophila

(2010) Leah R Sabin et al.   CURRENT OPINION IN IMMUNOLOGY

The Toll immune signaling pathway control conserved anti-dengue defenses across diverse Ae. aegypti strains and against multiple dengue virus serotypes

(2010) Jose L. Ramirez et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Genome-Wide RNA Interference in Drosophila Cells Identifies G Protein-Coupled Receptor Kinase 2 as a Conserved Regulator of NF- B Signaling

(2010) S. Valanne et al.   JOURNAL OF IMMUNOLOGY

Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-κB Signaling

(2010) Nicholas Paquette et al.   MOLECULAR CELL

RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila

(2010) S. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex

(2010) A. Missra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens

(2010) L. C. Bartholomay et al.   SCIENCE

Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics

(2010) P. Arensburger et al.   SCIENCE

Endogenous Viral Elements in Animal Genomes

(2010) Aris Katzourakis et al.   PLoS Genetics

Ars2 Regulates Both miRNA- and siRNA- Dependent Silencing and Suppresses RNA Virus Infection in Drosophila

(2009) Leah R. Sabin et al.   CELL

Autophagy, Immunity, and Microbial Adaptations

(2009) Vojo Deretic et al.   Cell Host & Microbe

Autophagy Is an Essential Component of Drosophila Immunity against Vesicular Stomatitis Virus

(2009) Spencer Shelly et al.   IMMUNITY

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS

Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila

(2009) João Trindade Marques et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Imd Pathway Is Involved in Antiviral Immune Responses in Drosophila

(2009) Alexandre Costa et al.   PLoS One

An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense

(2009) J. A. Souza-Neto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C3PO, an Endoribonuclease That Promotes RNAi by Facilitating RISC Activation

(2009) Y. Liu et al.   SCIENCE

Caspar Controls Resistance to Plasmodium falciparum in Diverse Anopheline Species

(2009) Lindsey S. Garver et al.   PLoS Pathogens

Dengue Virus Type 2 Infections of Aedes aegypti Are Modulated by the Mosquito's RNA Interference Pathway

(2009) Irma Sánchez-Vargas et al.   PLoS Pathogens

A Novel System for the Launch of Alphavirus RNA Synthesis Reveals a Role for the Imd Pathway in Arthropod Antiviral Response

(2009) Vasanthi Avadhanula et al.   PLoS Pathogens

Comparative genomics of small RNA regulatory pathway components in vector mosquitoes

(2008) Corey L Campbell et al.   BMC GENOMICS

Aedes aegypti uses RNA interference in defense against Sindbis virus infection

(2008) Corey L Campbell et al.   BMC MICROBIOLOGY

Structural Insight into the Mechanism of Activation of the Toll Receptor by the Dimeric Ligand Spätzle

(2008) Monique Gangloff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila

(2008) Safia Deddouche et al.   NATURE IMMUNOLOGY

The Aedes aegypti Toll Pathway Controls Dengue Virus Infection

(2008) Zhiyong Xi et al.   PLoS Pathogens

Argonaute proteins: key players in RNA silencing

(2007) Gyorgy Hutvagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY