Nuclear pore complexes in development and tissue homeostasis

Drosophila ELYS regulates Dorsal dynamics during development

(2020) Saurabh Jayesh Kumar Mehta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

(2020) Lindsey R Hayes et al.   eLife

Nuclear Export of Cyclin B Mediated by the Nup62 Complex Is Required for Meiotic Initiation in Drosophila Males

(2020) Ryotaro Okazaki et al.   Cells

Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination

(2019) Zhixiong Liu et al.   NEURON

Altered Nup153 Expression Impairs the Function of Cultured Hippocampal Neural Stem Cells Isolated from a Mouse Model of Alzheimer’s Disease

(2019) Lucia Leone et al.   MOLECULAR NEUROBIOLOGY

Mutations in NUP160 Are Implicated in Steroid-Resistant Nephrotic Syndrome

(2019) Feng Zhao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Structure of the Nuclear Pore Complex (An Update)

(2019) Daniel H. Lin et al.   Annual Review of Biochemistry

Structure and Assembly of the Nuclear Pore Complex

(2019) Bernhard Hampoelz et al.   Annual Review of Biophysics

POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation

(2019) Wenlong Ge et al.   EXPERIMENTAL CELL RESEARCH

Molecular assay for an intronic variant in NUP93 that causes steroid resistant nephrotic syndrome

(2019) Rini Rossanti et al.   JOURNAL OF HUMAN GENETICS

The Nuclear Pore Complex in Cell Type-Specific Chromatin Structure and Gene Regulation

(2019) Jiayu Sun et al.   TRENDS IN GENETICS

Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses

(2019) Warunthorn Monwan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis

(2019) Bernhard Hampoelz et al.   CELL

Nucleoporin insufficiency disrupts a pluripotent regulatory circuit in a pro-arrhythmogenic stem cell line

(2019) Claudia C. Preston et al.   Scientific Reports

Nuclear Pore Proteins in Regulation of Chromatin State

(2019) Terra M. Kuhn et al.   Cells

NUP155 insufficiency recalibrates a pluripotent transcriptome with network remodeling of a cardiogenic signaling module

(2018) Claudia C. Preston et al.   BMC Systems Biology

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

(2018) Ke Zhang et al.   CELL

The Rules and Functions of Nucleocytoplasmic Shuttling Proteins

(2018) Xuekun Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity

(2018) Nicholas J. Kramer et al.   NATURE GENETICS

Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis

(2018) Joana Borlido et al.   NATURE IMMUNOLOGY

Genetic diagnosis of steroid-resistant nephrotic syndrome in a longitudinal collection of Czech and Slovak patients: a high proportion of causative variants in NUP93

(2018) Martin Bezdíčka et al.   PEDIATRIC NEPHROLOGY

First report of recurrent nephrotic syndrome after kidney transplantation in a patient with NUP93 gene mutations – A case report

(2018) T. Seeman et al.   TRANSPLANTATION PROCEEDINGS

Sec13 is a positive regulator of VISA-mediated antiviral signaling

(2018) Tian Chen et al.   VIRUS GENES

Nup133 Is Required for Proper Nuclear Pore Basket Assembly and Dynamics in Embryonic Stem Cells

(2018) Benoit Souquet et al.   Cell Reports

Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes

(2018) Kazuyuki Hirai et al.   G3-Genes Genomes Genetics

Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome

(2018) Daniela A. Braun et al.   JOURNAL OF CLINICAL INVESTIGATION

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

(2018) Bahareh Eftekharzadeh et al.   NEURON

Direct Conversion of Mouse Fibroblasts into Neural Stem Cells by Chemical Cocktail Requires Stepwise Activation of Growth Factors and Nup210

(2018) Yuewen Tang et al.   Cell Reports

Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations

(2018) Annemarie van Nieuwenhuijze et al.   Frontiers in Immunology

Homozygous splicing mutation in NUP13 3 causes Galloway-Mowat syndrome

(2018) Atsushi Fujita et al.   ANNALS OF NEUROLOGY

Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells

(2018) Brandon H. Toyama et al.   JOURNAL OF CELL BIOLOGY

Coaching from the sidelines: the nuclear periphery in genome regulation

(2018) Abigail Buchwalter et al.   NATURE REVIEWS GENETICS

Mechanisms of nuclear pore complex assembly - two different ways of building one molecular machine

(2017) Shotaro Otsuka et al.   FEBS LETTERS

Homozygous mutation in NUP107 leads to microcephaly with steroid-resistant nephrotic condition similar to Galloway-Mowat syndrome

(2017) Rasim Ozgur Rosti et al.   JOURNAL OF MEDICAL GENETICS

Mutant Huntingtin Disrupts the Nuclear Pore Complex

(2017) Jonathan C. Grima et al.   NEURON

The roles of the nuclear pore complex in cellular dysfunction, aging and disease

(2017) Stephen Sakuma et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex

(2017) Paula Upla et al.   STRUCTURE

A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy

(2016) Ian A. Parish et al.   AMERICAN JOURNAL OF PATHOLOGY

Pre-assembled Nuclear Pores Insert into the Nuclear Envelope during Early Development

(2016) Bernhard Hampoelz et al.   CELL

Congenital Heart Disease Genetics Uncovers Context-Dependent Organization and Function of Nucleoporins at Cilia

(2016) Florencia del Viso et al.   DEVELOPMENTAL CELL

The Structure Inventory of the Nuclear Pore Complex

(2016) Thomas U. Schwartz   JOURNAL OF MOLECULAR BIOLOGY

Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome

(2016) Daniela A Braun et al.   NATURE GENETICS

NUP107mutations in children with steroid-resistant nephrotic syndrome

(2016) Eujin Park et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis

(2016) Dong-Hyun Kim et al.   Nature Communications

B-type nuclear lamin and the nuclear pore complex Nup107-160 influences maintenance of the spindle envelope required for cytokinesis inDrosophilamale meiosis

(2016) Daisuke Hayashi et al.   Biology Open

Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome

(2015) Noriko Miyake et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex

(2015) Vincent Géli et al.   BIOESSAYS

Nuclear Pore Basket Proteins Are Tethered to the Nuclear Envelope and Can Regulate Membrane Curvature

(2015) Noémi Mészáros et al.   DEVELOPMENTAL CELL

The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing

(2015) Filipe V. Jacinto et al.   GENES & DEVELOPMENT

The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis

(2015) J. Sebastian Gomez-Cavazos et al.   JOURNAL OF CELL BIOLOGY

The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells

(2015) Hebin Liu et al.   MOLECULAR CELL

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

(2015) Ke Zhang et al.   NATURE

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

(2015) Brian D. Freibaum et al.   NATURE

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

(2015) Ana Jovičić et al.   NATURE NEUROSCIENCE

Nucleoporin 35 regulates cardiomyocyte pH homeostasis by controlling Na+-H+exchanger-1 expression

(2015) Liang Xu et al.   Journal of Molecular Cell Biology

Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo

(2015) Thais G. Moreira et al.   Scientific Reports

Sumoylation and transcription regulation at nuclear pores

(2014) Lorane Texari et al.   CHROMOSOMA

Components and regulation of nuclear transport processes

(2014) Bastien Cautain et al.   FEBS Journal

The Nuclear Pore Complex Function of Sec13 Protein Is Required for Cell Survival during Retinal Development

(2014) Xubo Niu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Impairment of a Subset of Ran-GTP-binding Domains of Ran-binding Protein 2 (Ranbp2) Suffices to Recapitulate the Degeneration of the Retinal Pigment Epithelium (RPE) Triggered byRanbp2Ablation

(2014) Hemangi Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nup98 promotes antiviral gene expression to restrict RNA viral infection inDrosophila

(2014) Debasis Panda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures

(2013) Brandon H. Toyama et al.   CELL

Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors

(2013) Kyoung-in Cho et al.   PLoS Genetics

Early stages of retinal development depend on Sec13 function

(2013) K. Schmidt et al.   Biology Open

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations

(2012) Manuela Neumann et al.   ACTA NEUROPATHOLOGICA

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

(2012) Kyoung-in Cho et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nuclear pore dynamics during the cell cycle

(2012) Naoko Imamoto et al.   CURRENT OPINION IN CELL BIOLOGY

A Change in Nuclear Pore Complex Composition Regulates Cell Differentiation

(2012) Maximiliano A. D'Angelo et al.   DEVELOPMENTAL CELL

Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions

(2012) Marcela Raices et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extremely Long-Lived Nuclear Pore Proteins in the Rat Brain

(2012) J. N. Savas et al.   SCIENCE

Nucleoporins: Leaving the nuclear pore complex for a successful mitosis

(2011) Guillaume Chatel et al.   CELLULAR SIGNALLING

The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis

(2011) S. Senger et al.   DEVELOPMENT

The Nuclear Pore Complex Protein Elys Is Required for Genome Stability in Mouse Intestinal Epithelial Progenitor Cells

(2011) Nan Gao et al.   GASTROENTEROLOGY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins

(2011) Izhak Kehat et al.   JOURNAL OF CELL BIOLOGY

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Nucleoporin98-96 Function Is Required for Transit Amplification Divisions in the Germ Line of Drosophila melanogaster

(2011) Benjamin B. Parrott et al.   PLoS One

Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning

(2011) K. A. Fakhro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila nucleoporin Nup154 controls cell viability, proliferation and nuclear accumulation of Mad transcription factor

(2011) Gabriele Colozza et al.   TISSUE & CELL

Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration

(2010) Agnes L. Nishimura et al.   BRAIN

Cell Cycle-Dependent Differences in Nuclear Pore Complex Assembly in Metazoa

(2010) Christine M. Doucet et al.   CELL

The zebrafish flotte lotte mutant reveals that the local retinal environment promotes the differentiation of proliferating precursors emerging from their stem cell niche

(2010) K. L. Cerveny et al.   DEVELOPMENT

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis

(2010) Munehiro Asally et al.   FEBS Journal

Live imaging of single nuclear pores reveals unique assembly kinetics and mechanism in interphase

(2010) Elisa Dultz et al.   JOURNAL OF CELL BIOLOGY

The nuclear pore complex: bridging nuclear transport and gene regulation

(2010) Caterina Strambio-De-Castillia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells

(2009) Maximiliano A. D'Angelo et al.   CELL

The Structure of the Scaffold Nucleoporin Nup120 Reveals a New and Unexpected Domain Architecture

(2009) Nina C. Leksa et al.   STRUCTURE

Mutation in Nuclear Pore Component NUP155 Leads to Atrial Fibrillation and Early Sudden Cardiac Death

(2008) Xianqin Zhang et al.   CELL

Nuclear Pore Composition Regulates Neural Stem/Progenitor Cell Differentiation in the Mouse Embryo

(2008) Floria Lupu et al.   DEVELOPMENTAL CELL

Abnormal Nuclear Pore Formation Triggers Apoptosis in the Intestinal Epithelium of elys-Deficient Zebrafish

(2008) Tanya A. de Jong–Curtain et al.   GASTROENTEROLOGY

Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells

(2008) Elisa Dultz et al.   JOURNAL OF CELL BIOLOGY

Mutation of the Zebrafish Nucleoporin elys Sensitizes Tissue Progenitors to Replication Stress

(2008) Gangarao Davuluri et al.   PLoS Genetics